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HCL2 — IL6
Text-mined interactions from Literome
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2005
(Acute Disease...) :
IL-6 levels increased significantly in normal mucosa and supernatants in
response to
HCl , suggesting increased production and release of IL-6 by the mucosa
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2006
(Disease Models, Animal...) :
Platelet activating factor (PAF) and
interleukin-6 (IL-6) are produced in the esophagus in
response to
HCl and affect ACh release, causing changes in esophageal motor function similar to esophagitis ( Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, and Harnett KM. Am J Physiol Gastrointest Liver Physiol 289 : G418-G428, 2005 )
Cheng et al., J Pharmacol Exp Ther 2006
(Esophagitis) :
HCl increased PAF and interleukin (IL)-1beta ( but not
IL-6 , prostaglandin E ( 2 ), or H ( 2 ) O ( 2 ) ) in mucosa, and only PAF was released into the supernatant, presumably to affect circular muscle