Gene interactions and pathways from curated databases and text-mining

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HDAC1 — IL8

Text-mined interactions from Literome

Ashburner et al., Mol Cell Biol 2001 : Finally, we show that inhibition of HDAC activity with TSA causes an increase in both basal and TNF induced expression of the NF-kappaB regulated interleukin-8 (IL-8) gene
Rahman et al., Biochem Pharmacol 2002 (Pneumonia) : Pharmacological inhibition of HDAC leads to the increased HAT activity, AP-1 and NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments
Gilmour et al., Am J Physiol Lung Cell Mol Physiol 2003 : PM ( 10 ) and H ( 2 ) O ( 2 ) increased IL-8 protein release from A549 cells after 24-h treatment, and this was enhanced by histone deacetylase inhibition by trichostatin A ( cotreatment )
Schmeck et al., J Immunol 2008 : Legionella induced histone modification as well as HAT-/HDAC dependent IL-8 release could also be shown in primary lung epithelial cells
Chavey et al., Mol Pharmacol 2008 (Breast Neoplasms) : Moreover, run-on and transfection experiments demonstrated that IL-8 induction by HDAC inhibitors was transcriptional and involved mainly the nuclear factor-kappaB (NF-kappaB) site of the IL-8 promoter ... In addition, blocking NF-kappaB pathway by adenoviral delivery of a dominant negative IkappaBorIkappaB kinase complex 2 (IKK2) mutant abolished IL-8 gene induction by histone deacetylase inhibitors ... In summary, our results demonstrate that NF-kappaB pathway repression by HDAC is responsible for the low expression of IL-8 in ERalpha positive breast cancer cells
Rehni et al., Naunyn Schmiedebergs Arch Pharmacol 2012 (Opioid-Related Disorders...) : The present study has been designed to investigate the effect of selective inhibitors of histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al ( Ac-DEVD-CHO ), a selective interleukin-1ß converting enzyme inhibitor , on the development of naloxone induced opioid withdrawal syndrome both in vitro and in vivo and the effect of histone deacetylase inhibition on histone H3 acetylation in brain
Venza et al., Pigment Cell Melanoma Res 2013 (Melanoma...) : Here, we explored the effects of the novel class II-specific histone deacetylase inhibitors ( HDACis ) MC1568 and MC1575 on interleukin-8 (IL-8) expression and cell proliferation in cutaneous melanoma cell line GR-M and uveal melanoma cell line OCM-3 upon stimulation with phorbol 12-myristate 13-acetate ( PMA )