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HDAC3 — STAT3

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by HDAC Class I: HDAC3 (HDAC3) → STAT3 (dimer non-phopshorylated) complex (STAT3) (modification, collaborate)
  Yuan et al., Science 2005*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by HDAC Class I: HDAC3 (HDAC3) → STAT3 (dimer non-phopshorylated)/HDAC3 complex (STAT3-HDAC3) (modification, collaborate)
  Yuan et al., Science 2005*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by HDAC Class I: STAT3 (dimer non-phopshorylated) complex (STAT3) → STAT3 (dimer non-phopshorylated)/HDAC3 complex (STAT3-HDAC3) (modification, collaborate)
  Yuan et al., Science 2005*
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: STAT3 — HDAC3 Yuan et al., Science 2005*
• IRef Bind_translation Interaction: STAT3 — HDAC3 (coimmunoprecipitation) Yuan et al., Science 2005*
• IRef Bind_translation Interaction: STAT3 — HDAC3 (experimental interaction detection) Yuan et al., Science 2005*
• IRef Biogrid Interaction: HDAC3 — STAT3 (physical association, affinity chromatography technology) Tsuruma et al., Oncogene 2008*
• IRef Biogrid Interaction: HDAC3 — STAT3 (physical association, affinity chromatography technology) Yuan et al., Science 2005*
• IRef Biogrid Interaction: HDAC3 — STAT3 (physical association, affinity chromatography technology) Gupta et al., Leukemia 2012*
• IRef Hprd Interaction: Complex of 11 proteins (in vivo) Nagl et al., EMBO J 2007
• IRef Hprd Interaction: Complex of 100 proteins (in vivo) Nagl et al., EMBO J 2007
• IRef Hprd Interaction: STAT3 — HDAC3 (in vivo) Yuan et al., Science 2005*

Text-mined interactions from Literome

Dong et al., Oncogene 2003 : Studies comparing NuMA-RARalpha with NuMA-RARalpha ( deltaCC ) demonstrated that the dimerization or alpha-helical coiled-coil domain of NuMA was required for homodimer formation, transcriptional repression of wild-type RARalpha, transcriptional activation of STAT3 , and stability of the NuMA-RARalpha/SMRT complex
Gupta et al., Leukemia 2012 (Lymphoma, Large B-Cell, Diffuse) : Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma : implications for therapy