Gene interactions and pathways from curated databases and text-mining

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HDAC8 — IL6

Text-mined interactions from Literome

Frost et al., Am J Physiol Endocrinol Metab 2004 : Optimal IL-6 synthesis may require both stress kinase and histone deacetylase activity
Rehni et al., Naunyn Schmiedebergs Arch Pharmacol 2012 (Opioid-Related Disorders...) : The present study has been designed to investigate the effect of selective inhibitors of histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al ( Ac-DEVD-CHO ), a selective interleukin-1ß converting enzyme inhibitor , on the development of naloxone induced opioid withdrawal syndrome both in vitro and in vivo and the effect of histone deacetylase inhibition on histone H3 acetylation in brain