Gene interactions and pathways from curated databases and text-mining

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HDC — TNF

Text-mined interactions from Literome

Endo et al., Immunol Lett 1992 : IL-1 alpha, IL-1 beta, TNF alpha and TNF beta induced HDC and ODC, as does LPS
Endo et al., Br J Pharmacol 1992 (Drug-Induced Liver Injury) : 6. The induction of HDC in the liver by LPS, IL-1 or TNF was not suppressed by GalN and, at high doses, the response to LPS was enhanced
Hornyak et al., Vascul Pharmacol 2005 (Capillary Leak Syndrome...) : In addition, the systemic effect on serum cytokine levels showed that HDC only moderately lowered IL-2 induced IFN-gamma, IL-6, IL-10, IL-18 and TNF-alpha
Endo et al., Br J Pharmacol 1995 : 3. In macrophage depleted mice, the induction of HDC by LPS, IL-1 alpha or TNF-alpha was not impaired in the liver, and was potentiated in the lung and bone marrow