Gene interactions and pathways from curated databases and text-mining

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BMP2 — HES5

Text-mined interactions from Literome

Nakashima et al., Proc Natl Acad Sci U S A 2001 : In telencephalic neuroepithelial cells, BMP2 up-regulated the expression of negative helix-loop-helix ( HLH ) factors Id1, Id3, and Hes-5 ( where Hes is homologue of hairy and Enhancer of Split ) that inhibited the transcriptional activity of neurogenic HLH transcription factors Mash1 and neurogenin
Takizawa et al., Nucleic Acids Res 2003 : In this paper, we show that BMP2 enhances Notch induced transcriptional activation of Hes-5 and Hesr-1 in mouse neuroepithelial cells ... BMP2 stimulation, in addition to the introduction of the intracellular domain of Notch ( NIC ), resulted in enhanced activation of the Hes-5 gene promoter ... Recruitment of p300 to the NIC containing complex was facilitated by activated Smad1, which is suggested to contribute to BMP2 mediated enhancement of Notch induced Hes-5 expression