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HMGB1 — IL1B
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Abraham et al., J Immunol 2000
(Disease Models, Animal...) :
In the present studies,
HMG-1 given intratracheally produced acute inflammatory injury to the lungs, with neutrophil accumulation, the development of lung edema, and
increased pulmonary production of
IL-1beta , TNF-alpha, and macrophage-inflammatory protein-2
Taniguchi et al., Arthritis Rheum 2003
(Arthritis, Rheumatoid...) :
SFMs expressed RAGE and released TNFalpha,
interleukin-1beta (IL-1beta) , and IL-6 upon
stimulation with
HMGB-1
El Gazzar et al., Inflamm Res 2007
(Inflammation) :
LPS
induced HMGB1 release at 8 h and reached a peak at 48 h. Significant ( p < 0.05 ) production of TNFalpha,
IL-1beta , IL-10, and TGF-beta1 was seen after 8 h
Barkauskaite et al., Lupus 2007
(Inflammation...) :
HMGB1 can
induce expression of TNF-alpha and
IL-1beta , and formation of a pro-inflammatory loop between HMGB1, TNF-alpha, and IL-1beta may be responsible for the prolonged and sustained inflammation in CLE
Mouri et al., Eur J Haematol 2008
:
Intracellular
HMGB1 transactivates the human
IL1B gene promoter through association with an Ets transcription factor PU.1
García-Arnandis et al., Rheumatology (Oxford) 2010
(Osteoarthritis) :
IL-1beta stimulation of synoviocytes
increased HMGB1 expression, its translocation into the cytoplasm and secretion
Hayakawa et al., Glia 2010
:
Western blots confirmed that
IL-1beta induced a release of
HMGB1 into astrocyte conditioned media ... Blockade of
IL-1beta stimulated
HMGB1 release with the ERK inhibitor U0126 was accompanied by a downregulation of CRM1