Gene interactions and pathways from curated databases and text-mining

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HRH1 — MAPK15

Text-mined interactions from Literome

Pype et al., Am J Respir Crit Care Med 2001 (Bronchial Hyperreactivity) : An inhibitor of NF-kappaB activation, pyrrolidine dithiocarbamate, and a p38 MAPK inhibitor, blocked the IL-1beta induced H(1)R desensitization, whereas anisomycin, an SAPK/JNK and p38 MAPK activator, mimicked the effect of IL-1beta ... Here, we have demonstrated that IL-1beta desensitizes H(1)R , which involves the activation of p38 MAPK and NF-kappaB, leading to the expression of cox-2 and the synthesis of PGE ( 2 )
Noubade et al., J Clin Invest 2007 (Encephalomyelitis, Autoimmune, Experimental...) : Moreover, H1R signaling at the time of TCR ligation was required for activation of p38 MAPK , a known regulator of IFN-gamma expression