◀ Back to IL1B
HSD11B2 — IL1B
Text-mined interactions from Literome
Cooper et al., J Bone Miner Res 2001
(Inflammation...) :
In MG-63 cells,
interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently
inhibited 11beta-HSD2 activity ( cortisol-cortisone conversion ) and messenger RNA ( mRNA ) levels in a dose dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity ( cortisone-cortisol conversion )
Friedberg et al., J Clin Endocrinol Metab 2003
:
IL-1 beta also
up-regulated 11 beta-HSD-1 activity maximally at 0.6 x 10 ( -9 ) M ( 160 +/- 33 % ; P < 0.001 ) and caused an increase in glycerol levels ( 159 +/- 11 % of control ; P < 0.001 )
Johnstone et al., J Soc Gynecol Investig 2005
(Chorioamnionitis...) :
In JEG-3 cells,
11beta HSD-1 32-kd expression was
increased with interleukin
(IL)-1beta and tumor necrosis factor alpha (TNF-alpha), while 11beta HSD-2 expression was unaffected
Chisaka et al., J Soc Gynecol Investig 2005
(Choriocarcinoma...) :
Therefore, we have evaluated the
effect of tumor necrosis factor-alpha (TNF-alpha) and
interleukin-1beta (IL-1beta) on
11beta-HSD2 in cultured human placental trophoblast and in human choriocarcinoma JEG-3 cells ... In placental trophoblast, TNF-alpha and
IL-1beta down-regulated
11beta-HSD2 mRNA expression and activity ( both P < .05 )
Li et al., Endocrinology 2006
:
Using real-time PCR and enzyme activity assay, we found that cortisol ( 1 mum ) and
IL-1beta ( 10 ng/ml ) for 24 h significantly
increased 11beta-HSD1 mRNA expression and reductase activity in cultured human chorionic trophoblasts ... We conclude that cortisol up-regulates
11beta-HSD1 expression through induction of promoter activity, and the effect was
enhanced by
IL-1beta , suggesting that more biologically active glucocorticoids could be generated in the fetal membranes in the presence of infection, which may consequently feed forward in up-regulation of prostaglandin synthesis
Yang et al., J Clin Endocrinol Metab 2009
:
We examined the expression of
11beta-HSD1 and its
regulation by cortisol and
IL-1beta in human fetal lung ... The
induction of
11beta-HSD1 by
IL-1beta was further increased by cortisol, whereas the induction of cyclooxygenase 2 by IL-1beta was inhibited by cortisol ... Nuclear factor kappaB activation inhibitor could only block the
induction of cyclooxygenase 2 but not
11beta-HSD1 by
IL-1beta , suggesting that different mechanisms were utilized by IL-1beta in the regulation of 11beta-HSD1 versus proinflammatory mediators ... Global inhibition of CCAAT-enhancer binding proteins ( C/EBPs ) with transfection of C/EBP-specific dominant negative expression plasmid could attenuate the
induction of
11beta-HSD1 by
IL-1beta , suggesting that C/EBPs may mediate the induction of 11beta-HSD1 by IL-1beta