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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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HSPD1 — IL8

Text-mined interactions from Literome

Kamiya et al., Scand J Gastroenterol 1999 : Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion, IL-8 inducibility , and expression of HSP60 by Helicobacter pylori ... HSP60 induced IL-8 secretion was significantly inhibited by co-magaldrox in a dose dependent manner ... These results show that co-magaldrox suppressed the expression of the following virulence factors : adhesion, IL-8 inducibility , and expression of extracellular HSP60
Yamaguchi et al., J Gastroenterol 1999 (Gastritis...) : Reactivity of monoclonal antibody to HSP60 homologue of Helicobacter pylori with human gastric epithelial cells and induction of IL-8 from these cells by purified H. pylori HSP60
Lin et al., J Med Microbiol 2005 : Helicobacter pylori heat-shock protein 60 induces production of the pro-inflammatory cytokine IL8 in monocytic cells
Yokota et al., Int Immunol 2006 (Autoimmune Diseases) : We found that a murine anti-HSP60 mAb enhanced the production of IL-8 and tumor necrosis factor-alpha induced by human HSP60 in the human monocytic cell lines THP-1 and U937, and human peripheral blood monocytes ... We also found that sera from patients with rheumatic autoimmune diseases, which contained higher anti-HSP60 auto-antibody titers than sera from healthy donors, significantly enhanced the IL-8 production induced by human HSP60 in THP-1 cells
Zhao et al., J Med Microbiol 2007 (MAP Kinase Signaling System) : Previous reports have indicated that Helicobacter pylori heat-shock protein 60 ( H. pylori-HSP60 ), as an immunodominant antigen, induces interleukin (IL)-8 production in human monocytes ... The exact mechanism by which H. pylori-HSP60 induces IL-8 production in monocytes has not been fully elucidated ... In the present study, the downstream pathway by which H. pylori-HSP60 induces IL-8 secretion in human monocytic cell lines was investigated ... Taken together, the results suggest that ERK and p38 MAPK signalling linked to the TLR2 recognition receptor in human monocytes may be an important pathway in H. pylori-HSP60 induced IL-8 secretion