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HSPD1 — IL8
Text-mined interactions from Literome
Kamiya et al., Scand J Gastroenterol 1999
:
Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion,
IL-8 inducibility , and expression of
HSP60 by Helicobacter pylori ...
HSP60 induced
IL-8 secretion was significantly inhibited by co-magaldrox in a dose dependent manner ... These results show that co-magaldrox suppressed the expression of the following virulence factors : adhesion,
IL-8 inducibility , and expression of extracellular
HSP60
Yamaguchi et al., J Gastroenterol 1999
(Gastritis...) :
Reactivity of monoclonal antibody to
HSP60 homologue of Helicobacter pylori with human gastric epithelial cells and
induction of
IL-8 from these cells by purified H. pylori HSP60
Lin et al., J Med Microbiol 2005
:
Helicobacter pylori
heat-shock protein 60 induces production of the pro-inflammatory cytokine
IL8 in monocytic cells
Yokota et al., Int Immunol 2006
(Autoimmune Diseases) :
We found that a murine anti-HSP60 mAb enhanced the production of
IL-8 and tumor necrosis factor-alpha
induced by human
HSP60 in the human monocytic cell lines THP-1 and U937, and human peripheral blood monocytes ... We also found that sera from patients with rheumatic autoimmune diseases, which contained higher anti-HSP60 auto-antibody titers than sera from healthy donors, significantly enhanced the
IL-8 production
induced by human
HSP60 in THP-1 cells
Zhao et al., J Med Microbiol 2007
(MAP Kinase Signaling System) :
Previous reports have indicated that Helicobacter pylori
heat-shock protein 60 ( H. pylori-HSP60 ), as an immunodominant antigen,
induces interleukin (IL)-8 production in human monocytes ... The exact mechanism by which H.
pylori-HSP60 induces
IL-8 production in monocytes has not been fully elucidated ... In the present study, the downstream pathway by which H.
pylori-HSP60 induces
IL-8 secretion in human monocytic cell lines was investigated ... Taken together, the results suggest that ERK and p38 MAPK signalling linked to the TLR2 recognition receptor in human monocytes may be an important pathway in H.
pylori-HSP60 induced
IL-8 secretion