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HSPG2 — IL1B

Text-mined interactions from Literome

Amin et al., Int J Oncol 2003 : IL-1beta also increased tyrosine phosphorylation of PLC-gamma in Src kinase dependent manner ... Moreover, IL-1beta induced association of PLC-gamma with SHPS-1
Ginnan et al., Am J Physiol Cell Physiol 2006 : Stimulation of rat aortic VSM cells with IL-1beta activated PLC-gamma and pharmacological inhibition of PLC attenuated IL-1beta induced ERK1/2 activation and subsequent iNOS expression
Liu et al., Am J Respir Cell Mol Biol 2007 : In this study we investigated the role of phosphatidylcholine-specific phospholipase C ( PC-PLC ) in silica stimulated induction of TNF-alpha and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model ... We demonstrated that inhibition of PC-PLC , which was achieved with tricychodecan-9-yl-xanthate ( D609 ), blocked the silica stimulated induction of TNF-alpha and IL-1beta in alveolar macrophage, suggesting that PC-PLC is involved in the silica associated inflammatory response
Hu et al., Am J Physiol Cell Physiol 2007 : Knockdown of RGS4 by siRNA in both muscle strips and cultured muscle cells blocked the inhibitory effect of IL-1beta on initial contraction and PLC-beta activation, whereas overexpression of RGS4 inhibited PLC-beta activation
Hu et al., Biochem J 2008 : An IKK2-specific inhibitor or effective siRNA prevented IL-1beta induced inhibition of acetylcholine stimulated PLC-beta ( phopsholipase C-beta ) activation
Tschaikowsky et al., J Pharmacol Exp Ther 1998 (Shock, Septic) : Inhibition of PC-PLC by the specific inhibitor tricyclodecan-9-yl-xanthogenate ( D609 ) before LPS reduced the release of interleukin-1 beta , interleukin-6 and nitric oxide ( NO ) in vivo