Gene interactions and pathways from curated databases and text-mining

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EPHB2 — ICAM1

Text-mined interactions from Literome

Lee et al., J Dermatol Sci 2002 (Behcet Syndrome) : Specific MAPK/ERK kinase inhibitor PD98059 inhibited IgM-AECA induced ERK1/2 activities and ICAM-1 expression on HDMEC at a concentration of 60 microM ... ERK1/2 are involved in expression of ICAM-1 on HDMEC stimulated with IgM-AECA
Walsh et al., Am J Respir Cell Mol Biol 2004 (Neuroblastoma) : Eosinophil binding to neuronal ICAM-1 led to a rapid activation of ERK1/2 in nerve cells
Tsang et al., J Leukoc Biol 2005 (Inflammation...) : Selective inhibitor of ERK , PD098059, and c-kit inhibitors, STI571 and PP1, suppressed the combined SCF and TNF-alpha induced ICAM-1 expression
Traore et al., J Cell Biochem 2007 (Leukemia, Myeloid) : Together, these observations demonstrated that TPA, a potent activator of PKC, induces ICAM-1 expression via a ROS- and ERK1/2 dependent signaling mechanism in ML-1 cells
Nizamutdinova et al., Int Immunopharmacol 2007 (Atherosclerosis) : The inhibitory effect of paeonol on ICAM-1 production might be mediated by inhibiting p38, ERK and NF-kappaB signaling pathways, which are involved in TNF-alpha induced ICAM-1 production
Tsou et al., Toxicol Appl Pharmacol 2007 : Inhibition of ERK , JNK, or NF-kappaB attenuates TNF-alpha induced ICAM-1 promoter activation and monocyte-endothelial monolayer binding
Tyagi et al., Mol Cell Biochem 2008 (Cardiovascular Diseases) : In cultured ECs, Fg binding to intercellular adhesion molecule-1 and to alpha(5)beta(1) integrin, caused phosphorylation of ERK
Ishizuka et al., J Pharmacol Exp Ther 2008 : Inhibition of NF-kappaB activation and inhibition of ERK1/2 phosphorylation inhibited 20-HETE induced ICAM expression
Chae et al., Cell Physiol Biochem 2007 : PD98059, an inhibitor of ERK1/2 inhibited the Ang II-induced increase of VCAM-1 but not of ICAM-1 in the plasma membranes
Pazdrak et al., J Immunol 2008 : Moreover, inhibition of ICAM-1 expression with either antisense oligonucleotide or an ICAM-1 blocking Ab effectively inhibited ERK activation and eosinophil survival
Ho et al., Immunobiology 2008 (Inflammation...) : Selective inhibitors of p38 MAPK ( SB203580 ), JNK ( SP600125 ) and ERK ( PD98059 ) could suppress TNF-alpha induced CCL2 and ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha induced VCAM-1 expression
Yang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010 (HIV Infections...) : p-ERK inhibitor PD98059 almost completely blocked the Nef up-regulation of the p-ERK and ICAM-1
Zhao et al., Invest Ophthalmol Vis Sci 2010 (Graves Ophthalmopathy...) : Inhibition of the ERK1/2 , p38, JNK, and NF-kappaB pathways blocked CD40L induced ICAM-1 secretion
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : These results suggest that in human RASFs, activation of ERK , JNK, AP-1, and NF-kappaB are essential for IL-1beta induced ICAM-1 expression and leukocyte adhesion
Kim et al., J Ethnopharmacol 2011 : These results suggest that WEHE induces ICAM-1 expression in human monocytes through ERK- and ROS dependent signaling pathways, resulting in the subsequent activations of NF-?B, AP-1, SP-1, and STAT-1 transcription factors
Vitiello et al., Microbiol Immunol 2011 : Using two potent and selective inhibitors of MEK activation by Raf-1 ( PD-098059 ) and p38 ( SB-203580 ), it was also demonstrated that both ERK1/2 and p38 pathways play key roles in the production of IL-6 as well as in ICAM-1 , VCAM-1 and E-selectin expression by Hib porin
Watanabe et al., Acta Med Okayama 2011 (Diabetes Mellitus, Experimental...) : Expression of ICAM-1 was significantly attenuated by inhibitors of ERK , p38 and JNK ... We conclude that activation of ERK1/2 , p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions
Abdala-Valencia et al., PloS one 2012 : Interestingly, d-a-tocopherol inhibited ICAM-1 activation of PKCa but not the upstream signal ERK1/2
Zhong et al., Biochem Biophys Res Commun 2012 (MAP Kinase Signaling System) : Omentin, NF-kB inhibitor ( BAY11-7082 ) and ERK inhibitor ( PD98059 ) reduced the up-regulation of ICAM-1 and VCAM-1 induced by TNF-a
Sun et al., J Atheroscler Thromb 2012 (Disease Models, Animal...) : HDL isolated from ELKO, ELTg, and WT mice inhibited expression of intercellular adhesion molecule-1 , angiotensin II-induced activation of Erk , and growth of cultured vascular smooth muscle cells, whereas EL expression itself did not affect cell migration or growth.Conclusion : EL expression modulates vascular remodeling as well as plasma HDL-C levels