Gene interactions and pathways from curated databases and text-mining

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EPHB2 — IFI27

Text-mined interactions from Literome

Wolf et al., Diabetologia 2003 (Hypertrophy) : Activation of Erk 1,2 leads to phosphorylation of p27 ( Kip1 ) in vitro and in vivo
Khan et al., J Lipid Res 2006 (Mammary Neoplasms, Animal...) : Indeed, inhibition of ERK1/ERK2 phosphorylation by DHA, U0126 [ chemical MAPK extracellularly signal regulated kinase kinase ( MEK ) inhibitor ], and MEK ( SA ) ( cells expressing dominant negative constructs of MEK ) resulted in the accumulation of p27 ( Kip1 )
Yin et al., Biol Pharm Bull 2007 : OR-heparin also inhibited high glucose activated ERK1/2 phosphorylation, induced p27 ( Kip1 ) expression, and suppressed reactive oxygen species ( ROS ) accumulation in a dose dependent manner
Lee et al., Invest Ophthalmol Vis Sci 2011 : ERK1/2 was also involved in FGF-2 stimulated CEC proliferation and phosphorylation of p27 at Ser10 and Thr187 in parallel to phosphatidylinositol (PI) 3-kinase