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IFI27 — TNF

Text-mined interactions from Literome

Mei et al., Zhonghua Nei Ke Za Zhi 2002 : [ The effect of cyclin kinase inhibitor p27 on tumor necrosis factor-alpha induced mesangial cell proliferation ]
Kokkinakis et al., Cancer Lett 2006 (Neoplasms) : The response of tumors to MET-stress depends on their mutational status, however, it always involves inhibition of CDK1 and in most cases the upregulation of p21, p27 , GADDs and 14-3-3sigma in response to upregulation of TGF-beta, IRF-1, TNF-alpha , Rb and/or MDA-7 and the downregulation of PI3K, RAS and NF-kappaB
Pang et al., Acta Virol 2010 : Avian leukosis virus p27 inhibits tumor necrosis factor alpha expression in RAW264.7 macrophages after stimulation with lipopolysaccharide ... It was found that the ALV p27 expression markedly reduced the production of TNF-alpha , but did not affect the production of IL-1beta, IL-6, and 12, and cell proliferative activity ... These results demonstrate that ALV p27 specifically inhibits TNF-alpha expression in the macrophages stimulated by LPS, suggesting a possible contribution of ALV p27 to immunosuppression detected in ALV infected hosts
Lee et al., Immunopharmacol Immunotoxicol 2012 : TNF-a induced the expression of CDK2/CDK4, and reduced the expression of p21 ( waf1/cip1 ) /p27 ( kip1 )