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CA2 — IFNG

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Aas et al., Cell Signal 1999 (Calcium Signaling) : Interferon-gamma (IFN-gamma) has multiple effects on Ca2+ signalling in polymorphonuclear neutrophils ( PMNs ), including evoked cytosolic Ca2+ transients, increased capacitative calcium influx and increased sequestration of Ca2+ in intracellular stores ... As assessed by N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -stimulated Ca2+ release, the intracellular stores were depleted during this incubation period, and the extent of depletion correlated well with the appearance of IFN-gamma induced Ca2+ signals ... This store dependence of the IFN-gamma induced Ca2+ signals was confirmed by the appearance of IFN-gamma evoked Ca2+ signals in the presence of extracellular Ca2+ after store depletion by thapsigargin ... The appearance of IFN-gamma mediated Ca2+-signals in the presence of EGTA indicates that IFN-gamma stimulates Ca2+ release from intracellular stores
Nagano et al., J Neurochem 2004 : Up-regulation of Na(+)-Ca2+ exchange activity by interferon-gamma in cultured rat microglia
Kaldy et al., J Immunol 1991 : Analyses of IFN-gamma mRNA transcription by `` run-on '' experiments on nuclei isolated after activation of the CTL indicated that the Ca2+ signal alone induces maximal transcription of the IFN-gamma gene, which is not increased by either PKC activation or an increase in cAMP, but that further processing or stabilization of the IFN-gamma precursor or mature mRNA require an additional signal, provided either via a PKC or via a PKA activation pathway
Ou et al., J Agric Food Chem 2009 : In conclusion, Ca2+ release and PKC-alpha activation are required for IFN-gamma production induced by FIP-fve in PBMCs
Klein et al., J Immunol 1990 : IFN-gamma caused a rapid and concentration dependent increase in [ Ca2+ ] i, which was partly inhibited by calcium-free medium, diltiazem, and TMB-8
Dunn et al., J Immunol 1989 : Finally, as with the previously described variant clone, IL-2 mediated induction of IFN-gamma production by the normal T lymphocyte clones is independent of normal extracellular Ca2+ levels and insensitive to cyclosporine A
Kelso et al., Growth Factors 1989 : The data suggest that Ca2 ( + ) -independent ( CsA-resistant ) T cell activation induces synthesis of GM-CSF and IFN-gamma but is a poor stimulus for IL-3 production
Klein et al., Biochem Biophys Res Commun 1987 : Interferon-gamma (IFN-gamma) at a concentration of 50 U/ml increased internal Ca2+ in the monocyte-like cell line U937 by about 100 % within 3 min of addition, as determined by indo-1 fluorescence
Koide et al., Proc Natl Acad Sci U S A 1988 (Leukemia, Myeloid, Acute) : In fact, IFN-gamma evoked a calcium influx into HL-60 cells, whereas depletion of Ca2+ from culture medium resulted in a failure of IFN-gamma to induce DR expression
Ina et al., J Immunol 1987 (Leukemia, Myeloid, Acute) : In fact, the measurement of calcium influx into HL-60 cells showed that a remarkable and time dependent calcium accumulation was caused by IFN-gamma , and that depletion of Ca2+ from culture medium resulted in failure of IFN-gamma to induce class II antigen expression
Dunn et al., J Immunol 1987 : Unlike IFN-gamma production induced by Con A, IFN-gamma production induced by IL-2 was not accompanied by an elevation of intracellular Ca2+ levels, did not require physiologic extracellular Ca2+ levels, and was not inhibited by the immunosuppressive agent cyclosporin A
Kung et al., Endocrinology 1995 : IFN gamma increased the production of inositol mono-, bis-, and trisphosphates and caused a dose dependent increase in intracellular Ca2+ ( [ Ca2+ ] i ) at 37 C. Preincubation with 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, resulted in the abolition of the IFN gamma response, suggesting that protein kinase C was involved in a negative feedback loop resulting in inhibition of IFN gamma induced [ Ca2+ ] i rise