Gene interactions and pathways from curated databases and text-mining

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COL2A1 — IFNG

Text-mined interactions from Literome

Osaki et al., Biochem J 2003 : IFN-gamma inhibited the mRNA levels of COL2A1 and aggrecan, but not Sox9, L-Sox5 and Sox6, all of which were expressed by these cells as markers of the differentiated phenotype ... IFN-gamma had no effect on COL2A1 promoter expression in Jak1 ( U4A ) -, Jak2 ( gamma 2A ) - and Stat1 alpha ( U3A ) -deficient cell lines ... Our results indicate that repression of COL2A1 gene transcription by IFN-gamma requires Jak1, Jak2 and Stat1 alpha and suggest that this response involves indirect interaction of activated Stat1 alpha with the general transcriptional machinery that drives constitutive COL2A1 expression
Goldring et al., J Cell Biochem 1994 : Data reported here show that these effects of IL-1 and IFN-gamma on the expression of the human type II collagen gene ( COL2A1 ) are mediated primarily at the transcriptional level