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IGF2 — NFKB1
Text-mined interactions from Literome
Kaliman et al., J Biol Chem 1999
:
Here we show that
IGF-II induces
nuclear factor-kappaB (NF-kappaB) and nitric-oxide synthase (NOS) activities downstream from PI 3-kinase and that these events are critical for myogenesis ... Regarding the mechanisms involved in
IGF-II activation of
NF-kappaB , PI 3-kinase inhibition prevented NF-kappaB activation, iNOS expression, and NO production
Kwon et al., Biochem Biophys Res Commun 2000
(Psoriasis) :
Interestingly, IL-6 promoter activity and the binding activity of
NFkappaB were remarkably
increased by
IGF-II ... Western blot data that IkappaB was reduced by IGF-II significantly suggest that
NFkappaB activation by
IGF-II may be mediated through the downregulation of IkappaB
Kim et al., Biochem Biophys Res Commun 2004
(MAP Kinase Signaling System) :
Furthermore,
IGF-II remarkably
increased the DNA binding activities of
NF-kappaB and AP-1, and the IL-8 promoter activity
Wu et al., J Biol Chem 2008
:
In rat growth plate chondrocytes,
IGF-I induced
NF-kappaB-p65 nuclear translocation