Gene interactions and pathways from curated databases and text-mining

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IGF2 — NFKB1

Text-mined interactions from Literome

Kaliman et al., J Biol Chem 1999 : Here we show that IGF-II induces nuclear factor-kappaB (NF-kappaB) and nitric-oxide synthase (NOS) activities downstream from PI 3-kinase and that these events are critical for myogenesis ... Regarding the mechanisms involved in IGF-II activation of NF-kappaB , PI 3-kinase inhibition prevented NF-kappaB activation, iNOS expression, and NO production
Kwon et al., Biochem Biophys Res Commun 2000 (Psoriasis) : Interestingly, IL-6 promoter activity and the binding activity of NFkappaB were remarkably increased by IGF-II ... Western blot data that IkappaB was reduced by IGF-II significantly suggest that NFkappaB activation by IGF-II may be mediated through the downregulation of IkappaB
Kim et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : Furthermore, IGF-II remarkably increased the DNA binding activities of NF-kappaB and AP-1, and the IL-8 promoter activity
Wu et al., J Biol Chem 2008 : In rat growth plate chondrocytes, IGF-I induced NF-kappaB-p65 nuclear translocation