Gene interactions and pathways from curated databases and text-mining

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AKT1 — IGFBP4

Text-mined interactions from Literome

Mochizuki et al., Growth Horm IGF Res 2006 (Endometrial Neoplasms) : Although EGF stimulated HHUA cell proliferation and Akt phosphorylation, IGFBP-3 inhibited cell proliferation and Akt phosphorylation that had been stimulated by EGF
Fu et al., J Cell Physiol 2010 (MAP Kinase Signaling System...) : In contrast, IGFBP-6 had no effect on Akt phosphorylation and an Akt inhibitor had no effect on migration
Hermani et al., Cell Signal 2013 (Breast Neoplasms) : In addition, overexpression or addition of recombinant IGFBP-4 or IGFBP-5 resulted in reduction of E2-induced phosphorylation of Akt/PKB , GSK-3a/ß and ERa in MCF-7 cells