Mochizuki et al., Growth Horm IGF Res 2006
(Endometrial Neoplasms) :
Although EGF stimulated HHUA cell proliferation and Akt phosphorylation, IGFBP-3 inhibited cell proliferation and Akt phosphorylation that had been stimulated by EGF
Fu et al., J Cell Physiol 2010
(MAP Kinase Signaling System...) :
In contrast, IGFBP-6 had no effect on Akt phosphorylation and an Akt inhibitor had no effect on migration
Hermani et al., Cell Signal 2013
(Breast Neoplasms) :
In addition, overexpression or addition of recombinant IGFBP-4 or IGFBP-5 resulted in reduction of E2-induced phosphorylation of Akt/PKB , GSK-3a/ß and ERa in MCF-7 cells