Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Yang et al., Carcinogenesis 2012 (Ovarian Neoplasms) : In addition, the tectorigenin-paclitaxel combination inhibited the phosphorylation of I?B and IKK and the activation of Akt in paclitaxel-resistant cancer cells
Chen et al., J Biol Chem 2002 : Furthermore, a dominant negative mutant of Akt abolishes IKKbeta inhibition by CaMKKc and ionomycin, suggesting that Akt acts as a mediator of CaMKK signaling to inhibit IL-1beta induced IKK activity at an upstream target site
Ouyang et al., Carcinogenesis 2006 (Skin Neoplasms) : Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade
Madrid et al., Mol Cell Biol 2000 : Inhibition of IkappaB kinase (IKK), using an IKKbeta dominant negative protein, demonstrated that activated Akt requires IKK to efficiently stimulate the transactivation domain of the p65 subunit of NF-kappaB
Takada et al., J Immunol 2006 : AKBA also did not directly modulate IKK activity but suppressed the activation of IKK through inhibition of Akt
Inoue et al., Br J Pharmacol 2005 (Osteosarcoma) : The drug also partially inhibited the activity of IKK , but almost fully inhibited the phosphorylation of Akt and the production of PtdIns ( 3,4,5 ) P ( 3 )
Äijö et al., Bioinformatics 2013 (Carcinoma, Hepatocellular...) : Our analysis of the hepatocellular liver carcinoma data predict a regulatory connection where AKT activity is dependent on IKK in TGFa stimulated cells, which is supported by the original data but not included in the original model
Pianetti et al., Oncogene 2001 (Breast Neoplasms...) : Inhibition of Akt did not affect IKK activity
Noman et al., Innate Immun 2009 : Thalidomide prevented the activation of nuclear factor (NF)-KB by down regulating phosphorylation of inhibitory KB factor ( IKB ), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS induced phosphorylation of AKT , p38 and stress activated protein kinase ( SAPK ) /JNK
Shao et al., Cancer Res 2001 (Ovarian Neoplasms) : Thus, our results suggest that inhibition of IKK activity and IkappaB degradation is the predominant mechanism for E1A mediated inhibition of radiation induced NF-kappaB activity and that radiation induced Akt activation can not be inhibited by E1A and is likely independent of radiation induced NF-kappaB activity
Reddy et al., J Cell Physiol 2011 (Hyperplasia) : In addition to inducing its own expression via phosphatidylinositol 3-kinase/Akt dependent IKK/NF-?B activation, IL-18 stimulated glycogen synthase kinase 3ß phosphorylation and degradation, ß-catenin nuclear translocation and stabilization, T-cell factor-lymphoid enhancer binding factor ( TCF-LEF ) activation, and WISP1 induction
Ottonello et al., Br J Pharmacol 2009 : The activity of oxaprozin was related to inhibition of Akt activation that, in turn, prevented p38 MAPK, IKK and NF-kappaB activation
Romashkova et al., Nature 1999 : We show that, upon PDGF stimulation, Akt transiently associates in vivo with IKK and induces IKK activation
Tong et al., Respir Res 2006 : In addition, HIMF strongly induced Akt phosphorylation, and suppression of Akt activation by specific inhibitors and dominant negative mutants for PI-3K, and IKK or IkappaBalpha blocked HIMF induced NF-kappaB activation and attenuated HIMF induced VEGF production