Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Devin et al., Mol Cell Biol 2001 : Importantly, IKKgamma is not essential for TNF induced IKK recruitment to TNF-R1, as this occurs efficiently in IKKgamma-deficient cells
Tegethoff et al., Mol Cell Biol 2003 : However, the oligomeric composition of the IKK complex and its regulation by IKKgamma are poorly understood
Krappmann et al., J Biol Chem 2000 : Whereas specific down-regulation of IKK gamma protein levels by antisense oligonucleotides significantly reduced cytokine mediated activation of the IKK complex and subsequent NF-kappa B activation, a similar reduction of IKAP protein levels had no effect on NF-kappa B signaling
Varfolomeev et al., J Biol Chem 2005 : Apo2L/TRAIL stimulation of JNK and p38 further depended on RIP1 and TRAF2, whereas IKK activation required NEMO
Wu et al., Nat Cell Biol 2006 : Here, we show that NEMO binds to Lys 63- but not Lys 48-linked polyubiquitin, and that single point mutations in NEMO that prevent binding to Lys 63-linked polyubiquitin also abrogates the binding of NEMO to RIP in tumour necrosis factor (TNF)-alpha stimulated cells, the recruitment of IKK to TNF receptor (TNF-R) 1, and the activation of IKK and NF-kappaB
Verma et al., J Biol Chem 2004 : These results indicate that, in addition to the key role of IKK gamma/NEMO in regulating cytokine induced IKK activity, its ability to shuttle between the cytoplasm and the nucleus and to bind to CBP can lead to transcriptional repression of the NF-kappa B pathway
Wu et al., Mol Cell Biol 2002 : Taken together, our results not only reveal the IKK mediated phosphorylation of SRC-3 to be a regulated event that plays an important role but also substantiate the role of SRC-3 in multiple signaling pathways
Lee et al., Mol Cell 2011 : SENP2 null cells display biphasic NEMO SUMOylation and activation of IKK and NF-?B, and higher resistance to DNA damage induced cell death
Rothwarf et al., Nature 1998 : IKK-gamma interacts preferentially with IKK-beta and is required for the activation of the IKK complex ... An IKK-gamma carboxy-terminal truncation mutant that still binds IKK-beta blocks the activation of IKK and NF-kappaB
Valente et al., Cell Signal 2013 : We investigated the role of TRAF3 interacting protein 2 (TRAF3IP2) , a redox-sensitive adapter protein and an upstream regulator of IKK and JNK in interleukin (IL)-18 induced smooth muscle cell migration, and the mechanism of its inhibition by simvastatin
Harhaj et al., J Biol Chem 1999 : IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein ... Expression of NEMO/IKKgamma greatly promotes binding of Tax to IKKalpha and IKKbeta and stimulates Tax mediated IKK activation ... These findings suggest that the physical interaction of Tax with NEMO/IKKgamma may play an important role in Tax mediated IKK activation
Wyler et al., Protein Sci 2007 : Previously, we showed that oligomerization of NEMO is necessary for IKK activation and defined a minimal oligomerization domain ( CC2-LZ ) for NEMO, and we developed NEMO peptides inhibiting NF-kappaB activation at the level of the IKK complex
Qin et al., J Biol Chem 2006 : We postulate that TLR8 mediated MEKK3 dependent IKKgamma phosphorylation might play an important role in the activation of IKK complex , leading to IkappaBalpha phosphorylation
Hai et al., J Virol 2006 : IKKgamma is required for IKK activity by mediating kinase oligomerization and serving to couple the core catalytic subunits to upstream mitogen activated protein 3-kinase cascades ... Similarly, IKKgamma-delta mediates IKK kinase activity and downstream NF-kappaB dependent transcription in response to tumor necrosis factor (TNF) and the NF-kappaB inducing kinase-IKKalpha signaling pathway