Gene interactions and pathways from curated databases and text-mining

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IKBKG — IL6

Text-mined interactions from Literome

Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Zhang et al., EMBO Rep 2005 : Using IKK(beta)-deficient bone-marrow derived macrophages and mouse embryo fibroblasts ( MEFs ), we show that IKK(beta) is essential for IKK and NF-(kappa)B activation as well as efficient IL-6 induction
Catley et al., Mol Pharmacol 2006 (Pulmonary Disease, Chronic Obstructive) : As observed above, ICAM-1, IL-6 , IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors
Lamothe et al., J Biol Chem 2007 : Reconstituting TRAF6-deficent cells with various TRAF6 mutants, we clearly demonstrate the requirement for the TRAF6 RING domain and site-specific auto-ubiquitination of TRAF6 to activate IKK in response to interleukin-1
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38, and IKK inhibitors block TNF-alpha induced IL-8, IL-6 , and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
O'Connell et al., J Biol Chem 1998 : Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2