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IL17A — IL8
Text-mined interactions from Literome
Tartour et al., Cancer Res 1999
(Melanoma...) :
We showed that in vitro,
IL-17 increases IL-6 and
IL-8 secretion by cervical carcinoma cell lines at both protein and mRNA levels
Kehlen et al., J Neuroimmunol 1999
(Glioblastoma) :
Furthermore,
IL-17 stimulated the secretion of IL-6 and
IL-8 in glial cells, and IL-17 and IL-1beta in combination showed a superadditive effect
Kontny et al., Arthritis Rheum 1999
(Arthritis, Rheumatoid) :
However,
IL-17 induced production of
IL-8 was not affected by Tau-Cl
Andoh et al., Clin Exp Immunol 2001
:
IL-17 induced a dose dependent increase in
IL-8 and MCP-1 secretion ...
IL-17 and IFN-gamma synergistically
increased IL-8 and MCP-1 secretion and mRNA abundance ... In conclusion, it becomes clear that
IL-17 is an
inducer of
IL-8 and MCP-1 secretion by human fetal intestinal epithelial cells
Katz et al., Arthritis Rheum 2001
(Inflammation) :
Unlike TNFalpha and IL-1beta,
IL-17 hardly
affected the expression of
IL-8 and IL-1beta mRNA ... ELISA measured secretion of IL-6 and
IL-8 increased by 6.7 and 5.8 times, respectively, with
IL-17 , compared with 52 and 269 times with TNFalpha stimulation and 1,356 and 1,084 times with IL-1beta stimulation
Kawaguchi et al., J Allergy Clin Immunol 2001
(MAP Kinase Signaling System) :
We showed first that
IL-17 induced time dependent expression of IL-6 and
IL-8 but not of the chemokines eotaxin and RANTES
Takaya et al., Scand J Gastroenterol 2002
:
IL-17 induced a dose dependent increase in
IL-8 and MCP-1 secretion ...
IL-17 and IFN-gamma synergistically
increased IL-8 secretion and additively enhanced MCP-1 secretion ... In conclusion, it becomes clear that
IL-17 is an
inducer of
IL-8 and MCP-1 secretion in human pancreatic periacinar myofibroblasts
Kehlen et al., Clin Exp Immunol 2002
(Arthritis, Rheumatoid...) :
The inhibitors genistein ( tyrosine kinase inhibitor ) and calphostin C ( inhibitor of protein kinase C ) reduced significantly the
IL-17 stimulated mRNA expression of
IL-8 , GRO-alpha and GRO-beta in SFC, whereas PD98059 ( inhibitor of MEK-1/2 ) was without effect ... Pharmacological drugs used in therapy of RA, such as cyclosporin and methotrexate, induced a fourfold increase of IL-17R mRNA expression and augmented the
IL-17 stimulated
IL-8 expression
Hata et al., Am J Physiol Gastrointest Liver Physiol 2002
(Inflammatory Bowel Diseases) :
IL-6,
IL-8 , and MCP-1 secretions were rapidly
induced by
IL-17 ... In conclusion, human SEMFs secreted IL-6,
IL-8 , and MCP-1 in
response to
IL-17
Jones et al., Am J Respir Cell Mol Biol 2002
:
Secretion of
IL-8 , Groalpha, and G-CSF in
response to
IL-17 was measured in HBEC cell culture supernatants by enzyme linked immunosorbent assay ... In addition,
IL-17 was found to synergistically
enhance TNF-alpha induced production of
IL-8 , Groalpha, and G-CSF
Andoh et al., J Immunol 2002
:
IL-17 enhances the TNF-alpha induced IL-6 and
IL-8 secretion in human colonic subepithelial myofibroblasts
Maertzdorf et al., J Immunol 2002
(Keratitis, Herpetic) :
IL-17 exhibited a strong synergistic
effect with TNF-alpha on the induction of IL-6 and
IL-8 secretion by cultured HCF
Steiner et al., Prostate 2003
(Carcinoma...) :
The
effect of
IL-17 on IL-6,
IL-8 , TGF-beta1, and fibroblast growth factor ( FGF-2 ) mRNA expression and/or release of SC was analyzed using real-time PCR and/or ELISA
Vanaudenaerde et al., J Heart Lung Transplant 2003
(Bronchiolitis Obliterans...) :
This
IL-17 mediated
IL-8 release could not be inhibited by dexamethasone
Wuyts et al., J Heart Lung Transplant 2004
:
N-acetylcysteine (NAC) was able to decrease IL-17 induced 8-isoprostane production, with a maximum decrease of 59.3 +/- 9 % ( p < 0.001, n = 12 ) with 10 mmol/liter of N-acetylcysteine, which also decreased
IL-17 induced
IL-8 production in a concentration dependent manner ( with maximum inhibition of 86.3 % when combined with NAC 10 mmol/liter as compared with IL-17 alone ) ... We demonstrated that human airway smooth muscle cells, when stimulated with IL-17, are able to produce 8-isoprostane, which could be inhibited by adding N-acetylcysteline, and which was also able to decrease
IL-17 induced
IL-8 production
Hwang et al., Arthritis Res Ther 2004
(Arthritis, Rheumatoid) :
IL-17 induces production of IL-6 and
IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt dependent pathways ...
IL-17 mediated
induction of IL-6 and
IL-8 was transduced via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB, while CD40 ligation and p38 MAPK ( mitogen activated protein kinase ) are not likely to partake in the process
Sebkova et al., Infect Immun 2004
(Helicobacter Infections) :
Extracellular signal regulated protein kinase mediates
interleukin 17 (IL-17) induced
IL-8 secretion in Helicobacter pylori infected human gastric epithelial cells ... The aim of this study was to investigate signaling pathways by which
IL-17 regulates
IL-8 production in human gastric epithelial cells ... In H. pylori colonized gastric epithelial cells,
IL-17 induced
IL-8 synthesis is associated with and depends at least in part on the activation of ERK 1/2 MAP kinase
van den Berg et al., Am J Respir Cell Mol Biol 2005
(Asthma...) :
We show here for both cell types that
IL-17 was a weak stimulus of IL-8 and IL-6 production, but markedly
enhanced IL-8 and IL-6 responses to another stimulus, such as tumor necrosis factor-alpha ... In conclusion,
IL-17 particularly
affects post-transcriptional regulation of
IL-8 and IL-6 expression leading to enhanced IL-8 and IL-6 responses to secondary stimuli, and is only a weak proinflammatory stimulus by itself
Kira et al., RinshÅ shinkeigaku = Clinical neurology 2005
(Multiple Sclerosis) :
IL-17 is produced by autoreactive memory T cells and
induces IL-8 production in a variety of cells
Henness et al., Am J Physiol Lung Cell Mol Physiol 2006
(Lung Neoplasms) :
Here, we perform an in vitro study to show that although
IL-17A did not
induce secretion of the CXC chemokine
IL-8 from ASM cells, IL-17A significantly potentiates TNF-alpha induced IL-8 protein secretion and gene expression in a concentration- and time dependent manner ( P < 0.05 ) ... We found that
IL-17A significantly
augmented TNF-alpha induced
IL-8 mRNA stability
Vanaudenaerde et al., Am J Transplant 2007
:
Macrolides inhibit
IL17 induced
IL8 and 8-isoprostane release from human airway smooth muscle cells ...
IL17 induced
IL8 production was decreased by both erythromycin and azithromycin ... We conclude that macrolides ( but not steroids/immunosuppressive agents ) inhibit
IL17 induced
IL8 production in human primary airway smooth muscle cells via a reduction in MAPK activation and 8-isoprostane production
Beklen et al., J Dent Res 2007
(Periodontitis) :
IL-17 was less potent as a direct MMP inducer than IL-1beta and TNF-alpha, but it
induced IL-1beta and TNF-alpha production from macrophages, and IL-6 and
IL-8 from gingival fibroblasts
Wiehler et al., Am J Physiol Lung Cell Mol Physiol 2007
(MAP Kinase Signaling System...) :
IL-8 induction by
IL-17A or HRV-16, alone and in combination, was reduced by inhibitors of the p38 and p44/42 MAPK pathways
Yagi et al., J Gastroenterol 2007
(Colitis) :
IL-17A and IL-17F significantly
enhanced IL-6,
IL-8 , LIF, MMP-1, and MMP-3 secretion ... Both
IL-17A and IL-17F
augmented IL-1beta induced secretion of IL-6,
IL-8 , LIF, MMP-1, and MMP-3
Hirata et al., Endocrinology 2008
(Endometriosis) :
To investigate the role of IL-17A in the development of endometriosis, we then studied the
effect of
IL-17A on
IL-8 production, cyclooxygensase-2 expression, and cell proliferation of cultured endometriotic stromal cells ( ESCs ) ...
IL-17A enhanced
IL-8 secretion from ESCs in a dose dependent manner ... The
IL-17A induced secretion of
IL-8 from ESCs was suppressed by anti-IL-17 receptor A antibodies or inhibitors of p38 MAPK, p42/44 MAPK, and stress activated protein kinase/c-Jun N-terminal kinase ... Addition of TNFalpha synergistically increased
IL-17A induced
IL-8 secretion from ESCs
Zrioual et al., J Immunol 2008
(Arthritis, Rheumatoid) :
Thus,
IL-17A induced IL-6,
IL-8 , and CCL20 secretion was dependent on both IL-17RA and IL-17RC, which are overexpressed in RA patients
Mahanonda et al., J Dent Res 2008
:
IL-17 induced
IL-8 and minimal intercellular adhesion molecule (ICAM)-1 expression
Gu et al., Br J Haematol 2008
(Anemia, Aplastic) :
The
effect of
IL-17 on IL-6 and
IL-8 production by macrophages was also studied ...
IL-17 induced the production of IL-6 and
IL-8 by macrophages both from patients with AA and normal controls
Hölttä et al., Inflamm Bowel Dis 2008
(Crohn Disease) :
The
effect of
IL-17 on
IL-8 and TNF-alpha mRNA expression in epithelial cell line Caco-2 was studied ...
IL-17 enhanced the
IL-8 and TNF-alpha response of the epithelial cell line to lipopolysaccharide (LPS) in vitro
Inozume et al., J Immunother 2009
(Carcinoma, Renal Cell...) :
IL-17 secreted by tumor reactive T cells
induces IL-8 release by human renal cancer cells ... This led to the discovery that
IL-8 was being produced by the RCC cells in
response to T-cell derived
IL-17 ... This
effect of exogenous
IL-17 on
IL-8 release from tumor was seen in 5 of 8 RCCs, but not in other tumors tested
Tohyama et al., Eur J Immunol 2009
(Psoriasis) :
Furthermore,
IL-17 and IL-22 coordinately
enhanced MIP-3alpha,
IL-8 , and heparin binding EGF-like growth factor ( HB-EGF ) production, depending on the amount of IL-22R expression
Toh et al., Ann Rheum Dis 2010
(Arthritis, Rheumatoid) :
In RA synovial cells,
IL-17 induced IL-6, IL-1,
IL-8 and MMP-8, whereas IFNgamma had minimal or inhibitory effects
Zhang et al., Arch Oral Biol 2010
:
The expression of COX-2, IL-1alpha, IL-6,
IL-8 , IL-11, and TNF-alpha, as well as PGE ( 2 ) production
increased in the presence of
IL-17A , whereas COX-1 expression did not change ... Celecoxib blocked the stimulatory
effect of
IL-17A on the expression of COX-2, IL-1alpha, IL-6,
IL-8 , and IL-11 as well as PGE ( 2 ) production, whereas it did not block TNF-alpha expression
Bian et al., Stem Cells 2010
(Inflammation) :
Exogenous
IL-17A stimulated the expression and production of inflammatory cytokines ( TNF-a, IL-6, and IL-1ß ) and chemokine
IL-8 by HLECs
Freches et al., Clinical and vaccine immunology : CVI 2011
(Tuberculosis) :
Increased pulmonary tumor necrosis factor alpha,
interleukin-6 (IL-6), and
IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice
Mirandola et al., Lab Invest 2011
(MAP Kinase Signaling System...) :
Interleukin (IL)-17 and IL-22 produced by Th1/Th17 lymphocytes
induce IL-8 secretion by keratinocytes, a key event in the pathogenesis of the disease ... It is now clear that mitogen activated protein kinase ( MAPK ) ( extracellular signal regulated kinases ( ERK ) 1 and 2 ) activity is required for
IL-17 induced
IL-8 synthesis by keratinocytes, and, in fact, MAPK activity is increased in lesional psoriatic skin
Zijlstra et al., Eur Respir J 2012
(Asthma) :
We demonstrated that
IL-17A induced
IL-8 production is normally sensitive to GCs, while IL-17A pre-treatment significantly reduced the sensitivity of TNF-a induced IL-8 production to budesonide
Lai et al., Int J Gynecol Cancer 2011
(Genital Neoplasms, Female...) :
Our results showed that in HEC-1-B ( human endometrial cancer ) cells,
IL-17 stimulation
induced mRNA level increases of CCL2, CCL5, CCL20, CXCL2, and
IL-8
Mizunoe et al., J Pharmacol Sci 2012
(Cystic Fibrosis) :
Since overproduction of IL-8 in CF contributes to massive bronchial infiltrates of neutrophils, identification of the pathways underlying IL-8 induction could provide novel drug targets for treatment of neutrophil dominated inflammatory diseases such as CF. Here, we show that
IL-17A synergistically
increases IL-8 production induced by a toll-like receptor (TLR) 2 agonist, peptidoglycan ( PGN ), or TLR4 agonist, lipopolysaccharide (LPS), in a human CF bronchial epithelial cell line ( CFBE41o- )
Hot et al., Ann Rheum Dis 2013
(Atherosclerosis...) :
Simvastatin decreased
IL-17 induced IL-6,
IL-8 , CX3CL-1, RANTES mRNA and CX3CL-1 and CCL20 production
Shimizu et al., Eur J Oral Sci 2013
(Dermatitis, Atopic...) :
In addition, CD4 ( + ) T cells, including IL-17 production cells, were obtained from patients with AD and from healthy donors, and the
effects of
IL-17 on the production of IL-6 and
IL-8 were investigated using a co-culture of CD4 ( + ) T cells with human dental pulp ( hDP ) cells stimulated with substance P ( SP )
Albano et al., PloS one 2013
(Asthma...) :
Budesonide with Formoterol reduced IL-17A and ROR? ( t ), while increased FOXP3 in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis, and reduced the
IL-8 release
mediated by
IL-17A present in NW and Ss from mild-moderate asthma/persistent rhinitis in nasal and bronchial epithelial cells
Albanesi et al., J Immunol 1999
:
In addition,
IL-17 , both directly and in synergism with IFN-gamma and/or TNF-alpha,
stimulated synthesis and release of
IL-8 by keratinocytes