Gene interactions and pathways from curated databases and text-mining

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HES5 — IL1A

Text-mined interactions from Literome

Sun et al., Chin Med J (Engl) 2011 (Reperfusion Injury) : HES130/0.4 lessened the release of TNF-a and IL-1ß consistent with the reduction of MPO activity, and HES 130/0.4 inhibited the activity of NF-?B in H-I/R group
Schick et al., BMC gastroenterology 2012 (Blood Coagulation Disorders...) : HES improved liver microcirculation, cardiac index and DO2-I, but significantly increased IL-1ß , IL-6 and TNF-a levels and resulted in a mortality rate of 33 %