Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Vannier et al., J Clin Invest 1993 : IL-1 alpha induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10 ( -6 ) -10 ( -4 ) M. Cimetidine, an H2 receptor antagonist, reversed the histamine ( 10 ( -5 ) M ) -mediated increase in IL-1 alpha induced IL-1 beta synthesis ... Indomethacin, a cyclooxygenase inhibitor, significantly reduced IL-1 alpha induced IL-1 beta synthesis, but had no effect on the histamine mediated increase in IL-1 alpha induced IL-1 beta synthesis ... However, histamine reduced IL-1 beta mRNA half-life ( 2.4 vs 1.2 h ), suggesting that histamine enhances IL-1 alpha induced IL-1 beta synthesis at the level of transcriptional activation
Chin et al., J Clin Invest 1988 (Arthritis, Rheumatoid) : In competitive binding experiments, IL-1 alpha inhibited binding of 125I-IL-1 alpha with a Ki of 33-36 pM ( n = 2 ) and binding of 125I-IL-1 beta with a Ki of 51-63 pM ( n = 2 ) ... IL-1 beta inhibited binding of 125I-IL-1 alpha with a Ki of 2-3 pM ( n = 2 ) and binding of 125I-IL-1 beta with a Ki of 7 pM ( n = 2 )
Turner et al., Am J Physiol Heart Circ Physiol 2009 (MAP Kinase Signaling System...) : IL-1alpha ( 0.001-10 ng/ml, 0-6 h ) stimulated IL-1beta , TNF-alpha, and IL-6 mRNA expression with distinct temporal and concentration profiles, resulting in increased cytokine secretion
Wang et al., Endocrinology 1991 : Interleukin-1 beta induces interleukin-1 alpha messenger ribonucleic acid expression in primary cultures of Leydig cells ... In the present study we found that human recombinant IL-1 beta ( 1-100 ng/ml ) caused dose dependent increases in IL-1 alpha mRNA expression in Leydig cells
Mauviel et al., Biochem Biophys Res Commun 1988 : Both recombinant IL-1 alpha and IL-1 beta caused a dramatic increase in IL-1 beta mRNA levels, IL-1 alpha being more efficient than IL-1 beta
Gustavsson et al., Retina 2008 (Diabetes Mellitus, Experimental...) : Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Gu et al., J Biol Chem 2003 : IL-1beta rapidly increased tyrosine phosphorylation of IL-1 type I receptor associated proteins, suggesting that oxidants may operate through inactivation of local protein-tyrosine phosphatases in the proximal IL-1beta signaling pathway leading to RelA activation
Estrov et al., Blood 1995 (Leukemia, Myeloid, Acute...) : We found that these cells produce IL-1 beta and bind the biotinylated cytokine and that IL-1 inhibitors, such as IL-1 neutralizing antibodies, IL-1 receptor antagonist, and soluble IL-1 receptors, specifically inhibit OCI/AML3 proliferation, indicating that IL-1 beta is an autocrine growth factor for OCI/AML3 cells
Maas-Szabowski et al., J Invest Dermatol 1996 : By semiquantitative reverse transcriptase PCR, we demonstrated that IL-1alpha and IL-1beta stimulated the expression of KGF, HGF, IL-1alpha , IL-1beta, IL-1RI, and IL-8 in fibroblasts regardless of their physiologic condition, whereas that of TGF-beta remained unaffected
Rotteveel et al., Cell Immunol 1991 : We conclude that ( a ) IL-1 alpha and IL-1 beta are both necessary accessory signals for T-cell proliferation to antigen in vitro ; ( b ) in T-cell proliferation IL-1 alpha and IL-1 beta are interchangeable ; and ( c ) T-cell proliferation to antigen is only partially dependent on IL-1 as signal
Dube et al., Proc Natl Acad Sci U S A 2001 (Yersinia Infections) : Furthermore, a bacterial mutant that does not induce IL-1 alpha expression but induces normal levels of IL-1 beta , TNF-alpha, and IFN-gamma, causes greatly reduced intestinal inflammation and is attenuated by LD ( 50 ) analysis in the C57BL/6 mouse model
Parker et al., Br J Pharmacol 2002 (MAP Kinase Signaling System) : 5. These data demonstrate that IL-1RI is essential for IL-1beta signalling in cultured mixed glial cells
Marucha et al., J Immunol 1991 : We have previously demonstrated that Il-1 and TNF could rapidly, but transiently, induce gene expression of Il-1 beta in human polymorphonuclear leukocytes ( PMN ) at both the protein and mRNA level ... Using nuclear run-on transcription analysis, we found that within 1 h Il-1, TNF, and TNF plus Il-1 induced the transcription of the Il-1 beta gene by 33-, 61-, and 99-fold, respectively ... Thus, we report that Il-1 and TNF regulate IL-1 beta gene expression via both transcriptional and post-transcriptional mechanisms in vitro
Cremona et al., Am J Physiol 1998 : Brain type I but not type II IL-1 receptors mediate the effects of IL-1 beta on behavior in mice
Piquette et al., Fertil Steril 1994 : In contrast, IL-1 beta had no effect on IL-1 beta and IL-1 receptor type 1 mRNA levels in macrophage depleted granulosa-luteal cells
Imagawa et al., Biochem Biophys Res Commun 2011 (Osteoarthritis) : In the presence of BAY, IL-1ß induced IL1B mRNA levels were decreased by 6-fold
Kawano et al., Blood 1989 (Bone Resorption...) : Sandwich enzyme immunoassay for IL-1 alpha or IL-1 beta revealed that IL-1 beta was responsible for IL-1 activity of these culture supernatants
Suzuki et al., Am J Pathol 1989 : IL-1 , tumor necrosis factor (TNF), and LPS not only enhanced the accumulation of c-sis mRNA, but also induced IL-1 beta gene expression
Attur et al., J Biol Chem 2000 (Osteoarthritis) : Human chondrocytes that overexpressed IL-1RII were resistant to IL-1 induced IL-1beta mRNA accumulation and inhibition of proteoglycan synthesis
Boswell et al., J Immunol 1988 (Lupus Nephritis...) : IL-1 alpha was not detected in the total RNA extracted from freshly excised kidney, whereas IL-1 beta transcripts were detected in both the renal cortex of MRL-lpr as well as MRL-++ animals
Pinteaux et al., J Neurochem 2002 : Bacterial lipopolysaccharide (LPS) caused increased expression of IL-1RI, IL-1RII and IL-1RAcP mRNAs, induced the release of IL-1beta , IL-6 and prostaglandin-E2 ( PGE2 ), and activated nuclear factor kappaB (NF-kappaB) and the mitogen activated protein kinases ( MAPKs ) p38, and extracellular signal regulated protein kinase ( ERK1/2 ), but not c-Jun N-terminal kinase (JNK) in microglial cultures
Brown et al., Cell Immunol 1991 : Furthermore, the combination of ADX and splenic nerve section resulted in a potent stimulatory effect of ICV IL-1 beta on splenic macrophage IL-1 secretion which was greater than either ADX or splenic nerve section alone
Lynch et al., J Neurochem 2004 (MAP Kinase Signaling System) : Consistent with the LPS induced increases in IL-1beta concentration and receptor expression, were downstream changes which included enhanced phosphorylation of IRAK and the stress activated kinases, JNK and p38 ; these LPS induced changes were reversed by IL-10, which concurs with the idea that these events are triggered by increased activation of IL-1RI by IL-1beta
Modéer et al., Cytokine 1993 : IL-1 alpha , IL-1 beta and TNF-alpha, but not EGF nor TGF-alpha, stimulated prostaglandin E2 ( PGE2 ) formation in the gingival fibroblasts
Marucha et al., J Immunol 1990 (Inflammation) : In the present study, we demonstrate that human peripheral blood PMN produce IL-1 beta in response to IL-1 alpha , IL-1 beta, and TNF-alpha
Thalmeier et al., Exp Hematol 1996 : IL-1 alpha induced GM-CSF, IL-1 beta , IL-6, IL-11, and LIF mRNA levels were reduced by the addition of dexamethasone, whereas dexamethasone had no influence on the amounts of IL-1 alpha induced G-CSF mRNA
Peters et al., Immunology 2003 : Mitogen stimulation of embryonic day 18 and day 1 post-hatch thymocytes induced up-regulation of IFN-gamma, IL-1beta and TGF-beta transcripts, and down-regulation of IFN-alpha, IFN-beta and IL-2 transcripts, with a higher induction of IFN-gamma, IL-1beta and TGF-beta transcripts in more immature T-cell-receptor negative ( TCR- ) than TCR+ ( TCR1+, TCR2+, or TCR3+ ) subsets
Hurme et al., Scand J Immunol 1991 : LPS induced production of high levels of both IL-1 alpha and IL-1 beta protein ( quantitated with type-specific ELISA assays ), while after PMA stimulation only IL-1 beta protein could be detected
Seo et al., Biol Reprod 2012 : Collectively, the results indicated that IL1B regulates expression of IL1R1 and IL1RAP and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs
Heitmeier et al., J Biol Chem 2001 (Diabetes Mellitus, Type 1...) : The viral replicative intermediate dsRNA stimulates beta-cell production of pro-IL-1beta , and following cleavage to its mature form by IFN-gamma activated ICE, IL-1 then initiates beta-cell damage in a nitric oxide dependent fashion
Nold-Petry et al., J Biol Chem 2009 (MAP Kinase Signaling System) : Stable lines of IL-18Ralpha depleted human A549 cells were generated using shRNA, resulting in an increase of IL-1beta induced IL-1alpha , IL-6, and IL-8 compared to scrambled small hairpin RNA
Lederer et al., J Leukoc Biol 1992 : Competitive receptor binding studies demonstrated that unlabeled recombinant bovine IL-1 beta, murine IL-1 alpha , and human IL-1 beta competitively blocked neutrophil binding of 125I labeled bovine IL-1 beta
Horai et al., J Exp Med 1998 (Body Weight...) : These observations suggest that IL-1beta but not IL-1alpha is crucial in febrile and neuro-immuno-endocrine responses, and that this is because IL-1alpha expression in the brain is dependent on IL-1beta
Burýsek et al., Cytokine 1996 : The expression of the IL-1A gene in cultured brown adipocytes was increased 6-8-fold by IL-1 beta , TNF-alpha, LPS and by noradrenaline
Yucel-Lindberg et al., J Periodontal Res 1995 : Addition of BK, in the presence of TNF alpha, for 1 h and 6 h, respectively, synergistically enhanced the TNF alpha induced IL-1 beta production, whereas BK alone did not induce IL-1 production
Yu et al., Clin Diagn Lab Immunol 1997 : IL-1RI mRNA levels were up-regulated in PBMCs by recombinant bovine IL-1beta ( rBoIL-1beta ), recombinant bovine granulocyte-macrophage colony stimulating factor ( rBoGM-CSF ), rBoIL-4, recombinant bovine gamma interferon ( rBoIFN-gamma ), and dexamethasone
Furse et al., J Immunol 2001 (Arthritis, Rheumatoid) : LPS induced IL-1beta release is followed by IL-1 induced IL-1beta release, an amplification process termed autoinduction
Stashenko et al., J Periodontol 1991 (Alveolar Bone Loss...) : As determined by ELISA of tissue extracts, IL-1 beta and TNF alpha were detected in all diseased sites, whereas IL-1 alpha was present in 8/22 sites, IL-1 beta was present in highest concentration ( mean +/- SEM : 11,695 +/- 2,888 pg/ml ; 672 pM ), followed by TNF alpha ( 434 +/- 135 pg/ml ; 26 pM ), and IL-1 alpha ( 342 +/- 160 pg/ml ; 20 pM )
Omari et al., Brain 2005 (Hypertrophy...) : CXCL8 and CXCL1 production by human astrocytes at both the RNA and protein levels could be induced by interleukin (IL)-1beta , while CXCL10 was induced by both IL-1beta and interferon-gamma
Kobayashi et al., J Dent Res 1999 : Recombinant human ( rh ) IL-1 beta stimulated membrane IL-1 activity, which was mainly attributed to IL-1 alpha
Delomenie et al., Exp Cell Res 1993 : Intracellular IL-1 alpha and IL-1 beta levels were markedly enhanced by IL-1 beta and TNF alpha
Boehm et al., Exp Dermatol 1996 (Dermatitis, Toxicodendron...) : The data provide evidence for an in vivo role for epidermal IL-1 alpha , IL-1 beta and TNF-alpha transcription in the regulation of IL-1 beta and TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen
Rodriguez et al., J Cell Physiol 1996 : Several lines of evidence suggest that the biologic effects of IL-1 beta are mediated by activation of type I IL-1 receptors ( IL-1RI ) and induction of GM-CSF production
Hissong et al., Cell Immunol 1995 : While neither IL-1 alpha or IL-1 beta was detected in culture supernatants from macrophages treated with either LPS or MTP ( alone or in combination with IFN ), IL-1 alpha was detected in cell lysates of macrophages treated with these upregulators
Granowitz et al., Blood 1992 : A 10-fold molar excess of IL-1ra over IL-1 beta reduced IL-1 beta induced IL-1 alpha by 95 % ( P = .01 ) and IL-1 alpha induced IL-1 beta by 73 % ( P less than .01 )
Aman et al., Blood 1994 : Production of granulocyte-macrophage colony stimulating factor ( GM-CSF ), granulocyte-CSF (G-CSF), and interleukin-1 beta (IL-1 beta) in stromal cell layers was induced by incubation with IL-1 alpha , tumor necrosis factor (TNF), or lipopolysaccharide (LPS)
Pang et al., Clin Exp Immunol 1994 : The increased mRNA expression of GM-CSF, IL-1 alpha, IL-1 beta , IL-6 and IL-8 in response to IL-1 alpha and LPS stimulation was time- and dose dependent
Nazarenko et al., Neoplasia (New York, N.Y.) 2008 (Fibrosarcoma...) : Recruitment of myeloid cells requires IL-1beta but is regulated by IL-1alpha , because inflammatory chemokine and cytokine expression is stronger in IL-1alpha ( -/- ) beta ( comp ) than in IL-1 ( wt ) lines
Zeyse et al., Biol Reprod 2000 : In the present study we examined the involvement of interleukin (IL)-1alpha , -1beta, FSH, and lipopolysaccharide (LPS) in the regulation of IL-1alpha and -1beta production by Sertoli cells under in vitro conditions
Setty et al., Semin Arthritis Rheum 2005 (Rheumatic Diseases) : Gammalinolenic acid suppresses inflammation by acting as a competitive inhibitor of prostaglandin E2 and leukotrienes ( LTs ) and by reducing the auto-induction of interleukin1alpha (IL-1alpha) induced pro-IL-1beta gene expression
Shingu et al., Life Sci 1991 : Recombinant human IL-1 beta and TNF-alpha stimulate production of IL-1 alpha and IL-1 beta by vascular smooth muscle cells and IL-1 alpha by vascular endothelial cells
Ikejima et al., J Infect Dis 1990 : IL-1 alpha stimulated both IL-1 beta and TNF-alpha, but there was no correlation in the amount of TNF-alpha or IL-1 beta synthesized in the PBMC of 29 individuals
Kunz et al., J Clin Invest 1997 : Northern blot analyses demonstrate that bFGF strongly potentiates the formation of IL-1beta induced IL-1 type I receptor mRNA levels, whereas PDGF-BB has no effect
Mauviel et al., J Cell Biochem 1991 : Induction of interleukin-1 beta production in human dermal fibroblasts by interleukin-1 alpha and tumor necrosis factor-alpha
Walch et al., Endocrinology 2002 : Cyclooxygenase 2 pathway mediates IL-1beta regulation of IL-1alpha , -1beta, and IL-6 mRNA levels in Leydig cell progenitors
Endres et al., Immunology 1996 : Three weeks after ending aspirin medication, ex vivo IL-1 beta and TNF synthesis induced by exogenous IL-1 alpha was elevated threefold compared to the pre-aspirin value ( P = 0.01 and P = 0.005, respectively ) ... However, IL-1 alpha induced synthesis of IL-1 beta was elevated to a mean individual increase of 538 % ( P < 0.001 ) and synthesis of TNF was elevated to 270 % ( P < 0.001 ) at the end of ibuprofen medication and 2 weeks after discontinuation of ibuprofen
Burger et al., J Clin Invest 1995 : Type I IL-1sR ( IL-1sRI ) preferentially inhibited IL-1 alpha, whereas type II IL-1sR ( IL-1sRII ) mainly inhibited IL-1 beta
Shikhman et al., Am J Physiol Endocrinol Metab 2004 : Although both IL-1beta and TGF-beta1 enhance glucose transport in chondrocytes to a similar magnitude, IL-1beta induces significantly higher levels of lactate
Gatto et al., Skin Pharmacol 1993 : Radioimmunoassay showed that after stimulation by RA, the IL-1 beta intracellular level is predominantly increased , with no significant modification of IL-1 alpha expression
Annunziato et al., Blood 2009 (Autoimmune Diseases) : While murine Th17 cells develop in response to IL-6, IL-1 , and transforming growth factor ( TGF ) -beta, human Th17 cells originate from these CD161 ( + ) precursors in response to IL-1beta and IL-23, the need for TGF-beta being controversial
Qian et al., Biol Reprod 2004 (MAP Kinase Signaling System) : These data indicate that, in normal human cytotrophoblast cells, IL-1 beta induces HIF- 1 alpha mediated VEGF secretion and that IL-1 beta stimulated ERK1/2 activation may be involved in this process
Watanabe et al., Pharmacol Res 1993 (Arthritis, Experimental...) : PAL significantly inhibited the IL-1 beta production induced by IL-1 alpha or PMA without inhibition of total protein synthesis and cytotoxicity ... A protein kinase C ( PKC ) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha induced IL-1 beta production ... The calcium ionophore A23187 ( A23187 ) potentiated the IL-1 beta production induced by IL-1 alpha
Rice et al., Shock 1994 (Inflammation) : CT-1501R also inhibited IL-1 alpha or IL-1 beta induction of either TNF-alpha or IL-1 beta and inhibited the synergistic effects of stimulation with both human IL-1 beta and murine TNF-alpha on release of human TNF-alpha
Yodlowski et al., J Rheumatol 1990 (Arthritis, Rheumatoid) : We conclude ( 1 ) rheumatoid synovial catabolin activity is due to a form of IL-1
Santtila et al., Scand J Immunol 1998 : However, IL-1RA allele 2 strongly increased in vitro production of IL-1beta , regardless of the presence or absence of these alleles
Lin et al., Mol Cell Endocrinol 1993 (Inflammation) : When purified Leydig cells from normal rats were cultured for 24 h and then treated with IL-1 beta ( 1-100 ng/ml ) for 6 h, IL-1 beta induced dose dependent increases in IL-1 beta mRNA levels ... IL-1 beta also induced IL-1 alpha mRNA accumulation ; however, the level of IL-1 alpha mRNA was much lower than that of IL-1 beta mRNA
Singh et al., Am J Hypertens 1996 : Thus, IL-1 beta controls iNOS gene expression at the transcriptional level, and an intermediate labile protein, whose synthesis is inhibited by cycloheximide, is required for IL-1 beta stimulated induction of iNOS mRNA transcription in WKY cells but not in SHR
Howells et al., Immunol Lett 1988 : We have demonstrated that recombinant interleukin 1 (IL-1) induces IL-1 alpha and IL-1 beta production by human vascular endothelial cells ( EC ) in vitro
Yang et al., Br J Haematol 2000 : This study investigated the in vitro effects of IL-1beta on megakaryocytopoiesis and the expression of IL-1 type I and type II receptors ( IL-1 RI and RII ) on mega-karyocytic cell lines and primary cells ... This study demonstrated for the first time the presence of IL-1 receptors on megakaryocytic cells and the induction of NF-E2 by IL-1beta
Nishida et al., FEBS Lett 1989 (Astrocytoma) : BSF-2/IL-6, GM-CSF and IL-1 beta mRNAs were induced by recombinant IL-1 in human astrocytoma cell line U373MG
Seitz et al., Br J Rheumatol 1995 (Arthritis, Rheumatoid) : In addition, clinical improvement was associated with decreased synthesis of IL-1 beta , TNF-alpha and IL-8 induced by bacterial lipopolysaccharide, IL-1 alpha and IL-1 beta in PBMC in vitro
Ando et al., Mol Cell Endocrinol 1999 : The upregulation by IL-1 of IL-1beta , IL-1R and IL-1RA transcripts was similarly inhibited by indomethacin
Ludwiczek et al., Scand J Gastroenterol 2008 (Chronic Disease...) : Cultures of human primary hepatocytes showed that IL-1sRII is induced by IL-1beta , but not IL-6
Jobin et al., J Immunol 1998 : Induction of inducible nitric-oxide synthase (iNOS), IL-1beta , and IL-8 genes by IL-1beta , TNF-alpha, or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA
Kahlke et al., Cytokine 2000 (Hemorrhage...) : In contrast, IL-1beta and IL-6 production by Mbeta from young males was suppressed and IL-10 production enhanced following trauma-haemorrhage, whereas Mstraight phi from aged males produced elevated levels of IL-1beta and IL-6 and suppressed levels of IL-10 following trauma-haemorrhage
Lemke et al., Glia 1999 (Encephalitis) : Following cholinergic lesion neither IL-1 beta nor IL-6 expression could be detected in any of the activated glial cell types, whereas IL-1 alpha was found to be expressed in astroglial cells only
Yoon et al., J Immunol 1998 : Whereas IL-1 beta down-regulated IL-1RI surface expression ( p < 0.05 ), there was no change in the surface expression of IL-1RAcP
Aveleira et al., Cytokine 2010 (Diabetic Retinopathy) : Therefore, we investigated the effect of high glucose and IL-1beta on the IL-1RI regulation in retinal endothelial cells ... High glucose and IL-1beta also enhance the translocation of IL-1RI to the nucleus
Brynskov et al., Dig Dis Sci 1991 (Crohn Disease) : Inhibitor of interleukin-1 alpha and interleukin-1 beta induced T-cell activation in serum of patients with active Crohn 's disease
Lotem et al., Leuk Res 1989 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : The present experiments with recombinant IL-1 alpha and recombinant IL-1 beta show that, ( a ) that there are clones of myeloid leukemic cells which can be induced to differentiate to mature cells by the myeloid cell differentiation inducing protein MGI-2 and can also be induced to differentiate to mature macrophages and granulocytes by both types of IL-1 ; ( b ) this IL-1 induced differentiation is mediated by endogenous production of differentiation inducing protein MGI-2 ; ( c ) IL-1 and MGI-2 induce production of GM-CSF in these leukemic cells ; and ( d ) IL-1 also induces cell differentiation and production of MGI-2 and GM-CSF in normal myeloid precursor cells
Mizuno et al., FEBS Lett 1989 : The binding of 125I-IL-1 beta was inhibited by IL-1 alpha and -1 beta with Ki values of 0.27 +/- 0.020 nM and 0.74 +/- 0.12 nM
Blanco et al., J Neurochem 2008 : Here we show that stimulation of astrocytes with IL-1beta , lipopolysaccharide or ethanol ( 10 and 50 mM ), triggers the translocation of IL-1RI and/or TLR4 into lipid rafts caveolae enriched fractions, promoting the recruitment of signalling molecules ( phospho-IL-1R associated kinase and phospho-extracellular regulated-kinase ) into these microdomains
Kim et al., Arch Dermatol Res 1992 (Psoriasis) : Psoriatic epidermal extracts, however, contained virtually no IL-1 bioactivity and inhibited the activity of recombinant human IL-1 beta
Fleshner et al., J Neuroimmunol 1998 : The hypothesis states that following infection and the release of cytokines such as IL-1beta into local tissue or microvasculature, IL-1beta stimulates IL-1 receptors on vagal afferent terminals, or more likely on cells of vagal paraganglia
Rambukkana et al., Lab Invest 1996 : After 24 hours, contact allergens not only increased the expression of IL-1 beta but also induced the expression of IL-1 alpha , TNF-alpha, GM-CSF, and IL-6 proteins mainly by suprabasal keratinocytes
Kim et al., Biochem Pharmacol 2008 : Furthermore, LYR-71 down-regulated LPS induced transcription of interleukin (IL)-1beta or other cytokines in the cells, and inhibited expression vector IKKbeta elicited IL-1beta promoter activity
Brunius et al., Life Sci 1993 : IL-1 alpha , IL-1 beta and TNF alpha, dose-dependently, stimulated PGE2 formation in gingival fibroblasts ... The metabolite, p-HPPH ( 1.2-2.4 micrograms/ml ), did not induce PGE2 formation itself but potentiated IL-1 alpha and IL1 beta induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentration of both IL-1 and p-HPPH
Estrov et al., Blood 1991 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In this study, we investigated the role of interleukin-1 beta (IL-1 beta) in the malignant evolution of chronic myelogenous leukemia ( CML ) and the functional activity of IL-1 inhibitors
Fantuzzi et al., Am J Physiol 1997 (Inflammation) : To evaluate the role of residual IL-1 alpha production in IL-1 beta -/- mice, we used IL-1-receptor antagonist (IL-1ra)
Liu et al., J Immunol 1998 : Like IFN-beta, IFN-gamma suppresses the expression of both LPS and IL-1 induced IL-1beta
Fujiwara et al., Lab Invest 2002 (Arthritis, Experimental) : GROalpha does not seem to initiate TNFalpha, IL-1beta , and IL-8 in an early phase, but induces IL-1beta and IL-8 in a late phase
Böni-Schnetzler et al., J Clin Endocrinol Metab 2008 (Diabetes Mellitus, Type 2) : Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation
Kuo et al., Hinyokika Kiyo 1998 (Carcinoma, Renal Cell...) : This study suggested that the patients with bladder cancer renal cell carcinoma and prostatic cancer did not spontaneously produce IL-1 alpha or IL-1 beta, but that the ability to produce IL-1 alpha and IL-1 beta in response to LPS stimulation was not significantly impaired
Páez Pereda et al., Neuroimmunomodulation 1996 : Using recombinant IL-1 receptor antagonist we established that endogenously produced IL-1 affects induction of IL-1beta protein by lipopolysaccharide (LPS) at the level of mRNA expression
Ghezzi et al., J Immunol 1988 : IFN-gamma inhibited IL-1 beta induced IL-1 alpha as well as IL-1 alpha induced IL-1 beta production ; furthermore, this inhibitory effect of IFN-gamma was unaffected by indomethacin
Shams et al., Reg Immunol 1989 : The results indicate that human corneal E- and FLE-type cells can produce and release IL-1 and that FLE cells can be induced by inflammatory mediators to increase production of IL-1 beta
Quill et al., J Immunol 1989 : This response to IL-1 plus IL-2 could be induced by IL-1 alpha or IL-1 beta and by membrane bound IL-1 on macrophages
Granowitz et al., J Immunol 1993 : This suppression was not specific for endotoxin ; IL-1 beta induced IL-1 alpha and TNF-alpha were reduced by 84 % ( p = 0.01 ) and 68 % ( p < 0.001 ), respectively
Parker et al., J Immunol 1989 (Inflammation) : Binding of 125I-IL-1 alpha to the mouse and human PMN is inhibited by both recombinant human IL-1 alpha and IL-1 beta , indicating that both IL-1 proteins bind to the same receptor on these cells
Elias et al., Proc Natl Acad Sci U S A 1989 : Recombinant IL-1 ( alpha and beta ) stimulated fibroblast IL-1 beta mRNA accumulation, whereas recombinant TNF did not ... In addition, simultaneous stimulation with recombinant IL-1 ( alpha or beta ) and recombinant TNF resulted in a synergistic increase in IL-1 beta mRNA levels
Yamada et al., Nitric Oxide 2007 : Interleukin (IL)-1beta markedly augmented the mRNA levels of long and short IL-1RI with time, but was less effective for soluble IL-1RI
Ilyin et al., Biochem Biophys Res Commun 1996 : The fine regulation of the CNS IL-1 beta system may depend on a balance between the ligand ( IL-1 beta ) action on the IL-1RI and the induction of inhibitory mechanisms ( IL-1RII and IL-1Ra )
Kwak et al., Infect Immun 2000 (Streptococcal Infections) : In contrast to the response to LPS, where TNF-alpha, IL-1beta , IL-6, and IL-8 appear almost simultaneously, the human monocyte response to GBS results in the production of TNF-alpha but delayed appearance of IL-1beta , IL-6, and IL-8
Planck et al., Curr Eye Res 1993 : Retinal pigment epithelial cells produce interleukin-1 beta and granulocyte-macrophage colony stimulating factor in response to interleukin-1 alpha
Churchill et al., Brain Res 2006 : Relative to saline administration, IL1beta increased IL1beta , TNFalpha and IL6 mRNAs in the nucleus tractus solitarius (NTS), hypothalamus, hippocampus and somatosensory cortex ( SSctx ), but did not induce any changes in IL10
Maret et al., Cytokine 2004 : We compared the production of IL-1alpha, IL-1beta , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in response to IL-1alpha , TNF-alpha, or direct T cell membrane contact
Del Rey et al., Proc Natl Acad Sci U S A 2006 (Diabetes Mellitus) : We show that ( i ) blockade of IL-1 receptors in the brain partially counteracted IL-1 induced hypoglycemia ; ( ii ) peripheral administration or induction of IL-1 production resulted in IL-1beta gene expression in the hypothalamus of normal and insulin-resistant, leptin receptor-deficient, diabetic db/db mice ; ( iii ) IL-1 treated normal and db/db mice challenged with glucose did not return to their initial glucose levels but remained hypoglycemic for several hours
Schotanus et al., Endocrinology 1993 : We conclude that 1 ) IL-1 receptors are involved in the ACTH and IL-6 responses to rat IL-1 beta ; 2 ) the ACTH response, but not the IL-6 response, to a low dose dose of endotoxin in rats requires IL-1 receptor activation by endogenous produced IL-1 ; and 3 ) circulating IL-6 is not a prime mediator involved in ACTH and CORT responses to low doses of rIL-1 beta and endotoxin
Kenney et al., J Immunol 1987 : This discrepancy with the bioassay used was reflected by the three fold higher maximum stimulation of thymocyte proliferation by HMCS as compared with recombinant IL 1 alpha or IL 1 beta , and only 45 % inhibition of HMCS IL 1 activity by McAb