Gene interactions and pathways from curated databases and text-mining

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HES5 — IL6

Text-mined interactions from Literome

Lv et al., Anesth Analg 2006 (Endotoxemia) : HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha, IL-6 , cytokine induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats
Lv et al., J Int Med Res 2005 (Endotoxemia...) : HES significantly reduced the LPS induced increase in intestinal levels of TNF-alpha, IL-1beta, IL-6 , IL-8 and their corresponding mRNAs
Wang et al., Int Immunopharmacol 2009 (Disease Models, Animal...) : In addition, both HES and BL could attenuate the increase in TNF-alpha, IL-6 , MPO levels and NF-kappaB activation
Feng et al., Int Immunopharmacol 2010 (Disease Models, Animal...) : Meanwhile, HES could significantly reduce TNF-alpha, IL-6 , and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain
Lv et al., Acta Anaesthesiol Scand 2005 : HES significantly reduced the increased hepatic levels of TNF-alpha, IL-1beta, IL-6 , IL-8 and the mRNAs in the endotoxemic rats
Schick et al., BMC gastroenterology 2012 (Blood Coagulation Disorders...) : HES improved liver microcirculation, cardiac index and DO2-I, but significantly increased IL-1ß, IL-6 and TNF-a levels and resulted in a mortality rate of 33 %
Grainger et al., J Exp Med 2010 (Chronic Disease...) : HES induced IL-17 in the presence of IL-6 but did not promote Th1 or Th2 development under any conditions