Gene interactions and pathways from curated databases and text-mining

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IL1A — IL6

Text-mined interactions from Literome

Haynesworth et al., J Cell Physiol 1996 : In contrast, IL-1 alpha increased the expression of G-CSF, M-CSF, LIF, IL-6 and IL-11 and induced the expression of GM-CSF
Goodman , Proc Soc Exp Biol Med 1994 : Both IL-1 and TNF can induce the synthesis of IL-6 by a variety of cells
Matsumori et al., Circ J 2010 : Amlodipine and diltiazem significantly increased production of IL-1alpha stimulated with concanavalin A. Nifedipine inhibited production of IL-1alpha, IL-6 , and IFN-gamma
Aarden et al., Eur Cytokine Netw 1991 : Only IL-1 induces IL-6 production in monocytes as well as in endothelial cells and smooth muscle cells ... Whereas PMA induced IL-6 production in endothelial cells and it potentiated the induction of IL-6 by IL-1 in these cells, it inhibited LPS stimulated IL-6 production in monocytes
Taga et al., J Exp Med 1987 (Astrocytoma...) : Binding of 125I-BSF-2 to CESS was competitively inhibited by unlabeled BSF-2 but not by IL-1 , IL-2, IFN-beta, IFN-gamma, and G-CSF, indicating the presence of the receptors specific for BSF-2
Yoshimatsu et al., Int J Mol Med 2001 (Osteoarthritis) : IL-1alpha induced the production of IL-6 , GM-CSF and TNFalpha from immortalized chondrocytes
Gustavsson et al., Retina 2008 (Diabetes Mellitus, Experimental...) : Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Evans et al., J Leukoc Biol 1992 (Rhabdomyosarcoma) : Tumor cell IL-6 gene expression is regulated by IL-1 alpha/beta and TNF alpha : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages
Eckes et al., FEBS Lett 1992 : Stimulation of fibroblast cultures with IL-1 alpha resulted in enhanced IL-6 production in both systems, but the fibroblasts embedded into the 3D network continued to exhibit higher levels
Feng et al., J Bone Miner Metab 2003 (Genetic Predisposition to Disease...) : Moreover, the stromal cells in the CC genotype showed higher IL-1alpha stimulated IL-6 production than did the stromal cells in the GC genotype
Onozaki et al., Cancer Res 1989 (Leukemia, Myeloid) : IL-6 did not stimulate the expression of IL-1 mRNA or IL-1 activity in U937 cells
Nawata et al., Ann N Y Acad Sci 1989 (Arthritis, Rheumatoid) : Glucocorticoids strongly inhibit and PGE2 slightly inhibits IL-1 induced IL-6 mRNA expression in synoviocytes
Ward et al., J Surg Res 2011 (Tissue Adhesions) : Enzyme linked immunoassay ( ELISA ) was used to evaluate interleukin-6 (IL-6) expression in response to IL-1ß and tumor necrosis factor-a (TNF-a) stimulation in vitro to validate MK2 kinase inhibition
Castelli et al., Cancer Res 1994 (Melanoma) : In addition, IL-1 alpha and IL-6 were negatively regulated by soluble IL-6 and TNF-alpha
Gautam et al., Oncol Res 1993 (Astrocytoma) : Interferon gamma (IFN gamma), transforming growth factor beta 1 ( TGF-beta 1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ) and granulocyte-colony stimulating factor ( G-CSF ) did not induce IL6 mRNA production ; however, IL6 mRNA expression and protein production was strongly induced by IL1 alpha and to a lesser extent by IFN alpha ... The IL6 mRNA expression induced by IL1 alpha was potentiated by TGF-beta 1 and IFN alpha and slightly decreased by IFN gamma
Zhang et al., Proc Natl Acad Sci U S A 1988 : TNF, IL-1 , and forskolin all stimulated interleukin 6 (IL-6) mRNA levels in FS-4 cells ... In addition, our data on IL-6 induction by TNF and IL-1 suggest that other, yet unidentified, signal transduction mechanisms contribute to TNF and IL-1 actions on gene expression in human fibroblasts
Suzuki et al., Br J Cancer 1992 : These results indicate that IL-1 alpha regulates G-CSF and IL-6 production in these tumour cell lines, and suggest that the IL-1 production plays an important role in CSF producing tumours
Reiter et al., Cell Immunol 1990 : The protective effect of TNF-alpha and IL-1 alpha is not mediated by the induction of IFN-beta 2/IL-6
Theoharides et al., Biochim Biophys Acta 2012 (Inflammation...) : In particular, IL-1 induces selective release of IL-6 , while corticotropin releasing hormone secreted under stress induces the release of vascular endothelial growth factor
Isumi et al., Biochem Biophys Res Commun 1998 (Inflammation) : Furthermore, AM remarkably potentiated stimulatory effects of tumor necrosis factor-alpha, IL-1 beta and lipopolysaccharide on IL-6 production
Becker et al., Am J Respir Crit Care Med 2004 (Cystic Fibrosis...) : Constitutive or interleukin (IL)-1beta induced IL-8 or IL-6 secretion or nuclear factor-kappaB activity was not significantly different between non-CF and CF cells
Carter et al., Vet Immunol Immunopathol 1999 (Arthritis, Rheumatoid...) : Canine IL-1 was detected by its induction of proliferation of D10 ( N4 ) M cell line, whilst IL-6 had a proliferative effect on B9 cell line ... Analysis of synovial fluids from dogs with osteoarthritis ( OA ) and rheumatoid arthritis ( RA ) showed that IL-1 and TNFalpha bioactivity was not readily detectable at increased levels in diseased joints but that IL-6 was significantly increased in both diseases
Stephanou et al., J Endocrinol 1995 : When added to placental cultures during the first 6 days of culture, IL-6 markedly inhibited IL-6, IL-1 alpha and IL-1 beta mRNA expression ... However, when added to the cells during days 6-9 of culture, when most of the cells were syncytiotrophoblast cells, IL-6 stimulated IL-1 alpha and IL-1 beta mRNA expression
Demyanets et al., Thromb Haemost 2006 : The effect of 17beta-dihydroequilenin on IL-1alpha induced production of IL-6 , IL-8 and MCP-1 was reversed by the estrogen receptor antagonist ICI 182,780
Thalmeier et al., Exp Hematol 1996 : IL-1 alpha induced GM-CSF, IL-1 beta, IL-6 , IL-11, and LIF mRNA levels were reduced by the addition of dexamethasone, whereas dexamethasone had no influence on the amounts of IL-1 alpha induced G-CSF mRNA
Tipton et al., Toxicol In Vitro 2003 (Inflammation) : This study determined myrrh oil ( MO ) cytotoxicity to human gingival fibroblasts and epithelial cells and its effect, measured by ELISA, on interleukin (IL)-1beta stimulated IL-6 and IL-8 production
Yamagishi et al., Nihon Jibiinkoka Gakkai Kaiho 2000 (Rhinitis, Allergic, Perennial) : [ IL-1 and TNF-alpha mediated regulation of IL-6 , IL-8, and GM-CSF release from cultured nasal epithelial cells ]
Pujols et al., J Pharmacol Exp Ther 2012 (Nasal Polyps) : MG262 concentration-dependently inhibited basal and transforming growth factor-ß induced collagen mRNA expression and interleukin (IL)-1ß induced production of IL-6 , IL-8, monocyte chemoattractant protein-1, regulated on activation normal T cell expressed and secreted, and granulocyte/macrophage colony stimulating factor in both fibroblast types
Benigni et al., Blood 1996 (Acute-Phase Reaction) : CNTF also potentiates IL-1 induced serum IL-6 ... Here, we report that four other cytokines ( leukemia inhibitory factor [ LIF ], oncostatin M [ OSM ], interleukin-11 and cardiotrophin-1 ) also potentiated the elevation of serum corticosterone and IL-6 levels induced by IL-1
Sironi et al., Eur J Immunol 1993 : Murine IL-10 induced low levels of IL-6 production and amplified induction of IL-6 by lipopolysaccharide (LPS) or IL-1 in the murine tEND.1 endothelioma line, used for these studies because it retains properties of normal endothelium
Hagiwara et al., Am J Pathol 1990 : Because IL-1 induces interleukin-6 (IL-6) in certain cell types, the IL-1 effect might be mediated by IL-6 ... These results strongly suggest that the in vivo effect of IL-1 on Fn synthesis is mediated by IL-6
Zhu et al., Am J Respir Cell Mol Biol 2011 (Asthma) : Troglitazone dose-dependently reduced the IL-1ß induced release of IL-6 and vascular endothelial growth factor, the TNF-a induced release of eotaxin and regulated on activation, normal T expressed and secreted ( RANTES ), and the IL-4 induced release of eotaxin
Kauma et al., Endocrinology 1994 : In summary, IL-1 beta stimulates VCMC IL-6 production in a specific dose- and time dependent manner
Ling et al., Cytokine 1993 : When added with Fc fragments, IL-1 and IFN-gamma increased IL-6 production
Galy et al., J Immunol 1991 : IL-1 alpha strongly up-regulated the production of granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), IL-6 , and IL-8, as measured by specific immunoenzymetric assays and by increased steady state mRNA levels ... In contrast, both IL-4 and IFN-gamma enhanced the IL-1 induced IL-6 production
Syed et al., Endocrinology 1993 : FSH, phorbol myristate acetate, and IL-1 alpha augmented Sertoli cell IL-6 secretion in a dose dependent manner
Zhou et al., Malaria journal 2012 (Malaria, Falciparum) : Unopsonized IE induced secretion of IL-6 ( median= 622 pg/ml [ IQR=1,250-240 ], n=9 ) but no IL-1ß or TNF, whereas PPS opsonized IE induced secretion of IL-1ß ( 18.6 pg/mL [ 34.2-14.4 ] ) and TNF ( 113 pg/ml [ 421-17.0 ] ) and increased IL-6 secretion ( 2,195 pg/ml [ 4,658-1,095 ] )
Csala et al., Scand J Immunol 1998 : The stimulatory effect of FDP-P on IL-6 production might be the consequence of elevated IL-1 levels
Coe , Mech Ageing Dev 2004 : For example, when endothelial cell cultures were generated from cerebral blood vessels, those derived from aged donors produced significantly more IL-6 in response to IL-1 , LPS, and hypoxia
Krause et al., J Biol Chem 1998 : Stress activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1 induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB ... In untransfected and vector transfected KB cells, IL-1 induced a strong increase in expression of IL-6 and IL-8 mRNA, along with the synthesis of high amounts of the proteins ... In two KB cell clones stably overexpressing the mutant SAPKbeta ( K-R ), and three clones stably overexpressing antisense RNA to SAPKbeta, expression of IL-6 and IL-8 in response to IL-1 was strongly reduced at both the mRNA and protein level ... These data indicate that the SAPK/JNK pathway provides an indispensable signal for IL-1 induced expression of IL-6 and IL-8
Wiernas et al., Br J Pharmacol 1998 : However, while interleukin-1alpha ( IL-1alpha ; 10 ng ml(-1) ) potently stimulated the release of IL-6 , IL-8 and granulocyte macrophage colony stimulating factor from CEPI cells, BK ( 0.1 nM-10 microM ) was without effect
Ruef et al., Am J Pathol 1992 : IL-6 secretion is stimulated in a dose dependent manner by IL-1 alpha , TNF-alpha, and PDGF
Smith et al., Am J Physiol 1992 (Fever) : Based on our previous finding that preadministration of antiserum to IL-1 beta markedly suppressed plasma IL-6 after LPS, and recent evidence that molar excesses of IL-1ra blocked IL-1 induced circulating IL-6 levels, the possibility that IL-1 is responsible for the induction of bioactive IL-6 during inflammation can not be ruled out
Bauer et al., J Exp Med 1989 : Stimulation of monocytes by endotoxin or IL-1 causes a rapid downregulation of IL-6-R mRNA levels and a concomitant enhancement of IL-6 mRNA expression ... We show that downregulation of IL-6-R mRNA levels by IL-1 and IL-6 is monocyte specific, since IL-6-R expression is stimulated by both IL-1 and IL-6 in cultured human primary hepatocytes
Billingsley et al., Ann Surg Oncol 1996 (Cachexia...) : 4JK tumor was further tested to determine if IL-1 , tumor necrosis factor (TNF), or cocultivation with RAW 264 cells augmented IL-6 or LIF production
Linkhart et al., J Bone Miner Res 1991 (Bone Resorption) : Previous reports that IL-6 was secreted in murine osteoblast and bone organ cultures in response to IL-1 and PTH suggested that IL-6 has paracrine effects on bone resorption or formation
Rougier et al., Cytokine 1998 : IL-1 alpha , IL-1 beta, and IL-3, tumour necrosis factor alpha (TNF-alpha), Stem cell factor (SCF) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) ( at 10 ng/ml ) stimulated IL-6 and IL-8 production in 0 % and 10 % FCS
Senaldi et al., Proc Natl Acad Sci U S A 1999 (Body Weight) : In mice, it induces serum amyloid A, potentiates the induction by IL-1 of corticosterone and IL-6 , and causes body weight loss and B cell hyperplasia with serum IgG and IgM increase
Lazzerini et al., Joint Bone Spine 2013 (Bone Resorption...) : Rosuvastatin inhibits spontaneous and IL-1ß induced interleukin-6 production from human cultured osteoblastic cells ... Moreover, the drug decreased both spontaneous and IL-1ß induced IL-6 mRNA expression in osteoblasts
Grabiec et al., Ann Rheum Dis 2012 (Arthritis, Rheumatoid...) : HDACi ( 0.25-1.0 µM ) suppressed RA FLS IL-6 production induced by IL-1ß , TNFa and Toll-like receptor ligands
McGillicuddy et al., Diabetes 2011 (Inflammation...) : Coculture of WT, but not IL-1RI ( -/- ) macrophages, with 3T3L1 adipocytes enhanced IL-6 and TNF-a secretion, reduced adiponectin secretion, and impaired adipocyte insulin sensitivity
Katz et al., J Immunol 1989 : IL-1 and TNF induced concentration related increases in the synthesis of factor B, C3, and IFN-beta 2/IL-6 in human skin fibroblasts ... Effects of both stimuli were apparent with concentrations as low as 0.1 ng/ml and maximal responses were observed between 1 and 10 ng/ml ; only for IL-1 induction of IFN-beta 2/IL-6 was there a further increase in response up to 100 ng/ml ... In contrast to the similarities between the effects of IL-1 and TNF on synthesis of factor B, C3, and IFN-beta 2/IL-6 , only TNF increased synthesis of factor H
Beasley , J Cardiovasc Pharmacol 1997 : IL-1 , a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA ( mRNA ) levels, which was sustained at 24 h. PMA induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide ... VSMC derived from human saphenous vein ( HSVSMC ) released substantial amounts of immunoreactive IL-6 in the absence of stimulation by exogenous growth factors, and both PMA and IL-1 markedly increased IL-6 release ... In contrast, IL-1 and Ang II activate IL-6 gene expression by a pathway distinct from that of phorbol ester-responsive PKC
Olivadoti et al., Neuroscience 2008 (Fever) : Collectively, these data demonstrate IL-6 is necessary for IL-1 to induce fever, but IL-6 is not necessary for IL-1 to alter NREM sleep
McClellan et al., Cytokine 2012 (Adenomatous Polyposis Coli...) : Gene expression ( mRNA ) of MCP-1, IL-1ß , IL-6 and TNF-a was increased in sections 2 and 3 starting at week 12 ( P < 0.05 ), with further increases in MCP-1, IL-1ß and IL-6 at 16 weeks ( P < 0.05 )
Ling et al., Br J Ophthalmol 2013 (Inflammation) : AS101 inhibited IL-1ß induced mRNA expression and protein production of IL-6 and IL-8 in RPE cells
Braciak et al., FEBS Lett 1991 : The IL6 mRNA level in RMSV1 cell lines was induced 20-fold within 4 h by LPS, whereas IL1 had no effect
Corsini et al., Toxicol Appl Pharmacol 1996 (Dermatitis, Contact) : By reverse transcription-polymerase chain reaction we were able to show that the neutralizing antibody also partially prevented TBT induced in vivo IL-6 expression but no TBT induced TNF-alpha expression, suggesting a paracrine effect of IL-1alpha on IL-6 production but not TNF-alpha expression and indicating that other inflammatory mediators are involved
Gastl et al., Int J Cancer 1993 : LPS, IL-1 alpha , and TNF-alpha strongly enhanced the release of IL-6 by RCC cells, but only marginally affected IL-10 production in colon-carcinoma cells
Ballow et al., J Clin Immunol 1996 : While RA had no effect on IL-1 production, IL-6 synthesis was greatly enhanced ( 20- to 45-fold ), which was also reflected by an increase in steady-state mRNA levels for IL-6 but not TNF-alpha or TGF-beta on Northern blot analysis
Hoffmann et al., Biochem Pharmacol 2011 (Adenocarcinoma...) : Proinflammatory IL-6 and PGHS-2 as well as proangiogenic IL-8 and VEGF were induced by IL-1 , whereas the secretion of invasion promoting MMP-2 remained unaffected
Gross et al., J Clin Immunol 1993 (Carcinoma, Squamous Cell...) : Furthermore, in monocytes, protein kinase C ( PKC ) activation by PMA even reduced IL-1 induced IL-6 mRNA, and IL-1 induced IL-6 synthesis was increased by the PKC inhibitor staurosporine ... IL-6 synthesis in HEp-2 cells was induced by IL-1 , PMA, and calcium ionophore A 23187 but not by dibutyryl-cAMP ... PMA-, but not IL-1 induced IL-6 synthesis in HEp-2 cells was inhibited by staurosporine
Choi et al., Rheumatol Int 2010 : Differential effect of IL-1ß and TNFa on the production of IL-6 , IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages
Li et al., J Oral Pathol Med 1996 (Mouth Diseases...) : For all cytokines the levels of IL-6 production were greater for OK than SK and OK, but not SK, produced IL-6 in response to IL-1 alpha stimulation
Iizuka et al., Int J Cancer 2002 (Adenocarcinoma...) : An in vitro study showed that C. rhizoma and its major component, berberine, inhibited IL-1 induced IL-6 mRNA expression in a dose dependent manner in colon 26/clone 20 cells
Jones et al., Eur J Endocrinol 1997 (Goiter, Nodular...) : The secretion of IL-6 can be stimulated by interleukin-1 (IL-1) , tumour necrosis factor-alpha (TNF), serum, TSH and agents which increase intracellular cyclic AMP levels
Walker et al., J Immunol 1992 (Mycobacterium Infections) : The effect of in vitro exposure of these cells to the immunizing Ag was also investigated ; again, IL-1 , IL-2, TNF, and IFN-gamma mRNA were abundant, but in addition, IL-3, IL-6 , and granulocyte-macrophage colony stimulating factor mRNA were greatly increased , suggesting an important role in the recall response
Akahane et al., Exp Hematol 1993 : IL-1 also enhances IL-6 mRNA accumulation in these cells, although by increasing its transcription rate
Shu et al., Thymus 1996 : Recombinant IL-1 , anti ICAM-1, and anti LFA-3 alone and collectively induced modest but significant increases in the secretions of 14C labelled peptides and of IL-6 and IL-8 which were not inhibited by HC
Nakamura , Vet Parasitol 1998 (Trypanosomiasis, African) : Serum interleukin (IL)-1-like activity was occasionally detected, and IL-6-like activity increased in the middle stages of infection in some of the infected animals
Timper et al., Am J Physiol Endocrinol Metab 2013 (Insulin Resistance) : Furthermore, GIP potentiated IL-6 and IL-1Ra secretion in the presence of LPS, IL-1ß , and TNFa
Laird et al., Hum Reprod 1994 : The effect of interleukin 1 (IL1) and placental protein 14 (PP14) on the production of interleukin 6 (IL6) by cultured human endometrial epithelial cells prepared from endometrial biopsy material obtained at different stages in the menstrual cycle was investigated ... IL1 ( 0.025-2.5 ng/ml ) caused a dose dependent increase in IL6 production by cells prepared from both proliferative and secretory endometrium, but cells prepared from secretory endometrium responded to a lower concentration of IL1 than those prepared from proliferative endometrium ... IL-1 stimulated IL6 production by epithelial cells prepared from secretory endometrium typically reached 10 times basal values, while in cells prepared from proliferative endometrium stimulated levels were approximately twice the basal values ... This suggests that PP14 and IL1 act via different mechanisms in the stimulation of IL6 production
Kasahara et al., Biochem Biophys Res Commun 1990 (Astrocytoma) : IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line : positive and negative modulation by chorela toxin and cAMP ... Chorela toxin ( CT ) and pertussis toxin ( PT ) -pretreatment markedly inhibited IL1 induced proliferation, while CT enhanced IL1 induced IL6 mRNA expression significantly ... Drugs raising cellular cAMP level or cAMP analogues augmented IL1 mediated IL6 mRNA expression but much less ... Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1 mediated IL6 gene activation
Larner-Svensson et al., Respir Res 2010 : We have therefore examined the role of miR-146a during the interleukin (IL)-1beta stimulated IL-6 and IL-8 release and proliferation in primary human airway smooth muscle ( HASM ) cells
Brown et al., J Immunol 1991 : IL-1 alpha and TNF-alpha are also potent inducers of IL-6 production in these cells, the order of potency being IL-1 alpha greater than Onco M greater than TNF-alpha
Marquette et al., Int J Radiat Biol 2003 (Encephalitis) : Six hours after irradiation, IL-1beta levels had increased in the hypothalamus, thalamus and hippocampus, and TNFalpha and IL-6 levels had increased significantly in the hypothalamus
Voronov et al., J Immunotoxicol 2010 (Fibrosarcoma...) : SDF-1 and IL-6 , each induced by IL-1 , were the two major cytokines whose levels differed in cell lines with or without IL-1
Perlstein et al., Lymphokine Cytokine Res 1991 : Because IL-1 induces IL-6 in vivo, the extent to which IL-6 mediates the effects of IL-1 has come under investigation
Ogawa , Hematol Oncol Clin North Am 1989 : Available evidence indicates that the effects of IL-1 on stem cells are indirectly mediated in part by IL-6 and G-CSF
Yamamoto et al., Arthritis Rheum 2003 (Arthritis, Experimental...) : The effects of RasDN overexpression on cellular proliferation, interleukin-1 (IL-1) induced activation of mitogen activated protein kinases ( extracellular signal regulated kinase [ ERK ], p38, c-Jun N-terminal kinase [ JNK ] ), and IL-6 production by synovial cells were analyzed
Ahmed et al., J Leukoc Biol 2002 (MAP Kinase Signaling System) : We have previously reported IL-1 induced inhibition of IL-6 signaling in monocytes, and herein we use inhibitors of protein synthesis to demonstrate that inhibition of IL-6 signaling can occur in the absence of new protein synthesis ... IL-1 induced inhibition of IL-6 signaling was not mediated by the activation of tyrosine phosphatases or by p38 dependent activation of phospholipase A ( 2 ) or cyclooxygenases, which could lead to indirect inhibition via production of prostaglandins
Danis et al., Clin Exp Immunol 1991 : Effects of granulocyte-macrophage colony stimulating factor ( GM-CSF ), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes ... The effects of GM-CSF, IL-2, IFN-gamma, TNF-alpha and IL-6 on the production of IL-1 ( both secreted and cell associated ) and TNF-alpha by peripheral blood monocytes were studied
Savage et al., Frontiers in immunology 2012 : In vivo, after cerebral ischemia, IL-1 production contributed to increased IL-6 and CXCL1 since these cytokines were profoundly reduced in the ischemic hemispheres from IL-1a/ß double KO mice, although injury induced cytokine responses were not abolished
Kloesch et al., Rheumatol Int 2012 : Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1ß induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2
Barsness et al., Pediatr Surg Int 2004 (Respiratory Distress Syndrome, Adult) : Similarly, IL-1beta induced IL-6 production was greater in pediatric PMs compared with adults ( 532+/-3 vs. 444+/-52, P < 0.05 ) ... In conclusion, IL-1beta induced IL-6 and TNFalpha production were greater in pediatric than adult PMs
Vargas et al., J Bone Miner Res 1996 : Receptor deficiency was confirmed by determining the ability of PTH, IL-1 alpha , and TNF-alpha to stimulate IL-6 in the media of primary calvaria derived osteoblastic cell cultures from CD-1 and cytokine receptor-deficient mice ... After 24 h of treatment, IL-1 alpha and TNF-alpha did not stimulate IL-6 production in osteoblasts from IL-1R1-/- and TNFR1-/- mice, respectively
Kawaguchi et al., J Clin Invest 1999 (Scleroderma, Systemic) : Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A ... IL-1alpha induced IL-6 and PDGF-A, which are potent stimulators of collagen production and proliferation in normal fibroblasts ... Inhibition of endogenous IL-1alpha led to decreased levels of IL-6 and PDGF-A expression in SSc fibroblasts
Hültner et al., J Immunol 2000 : Here we report that in primary mouse bone marrow derived mast cells activated by ionomycin or IgE/Ag, the proinflammatory mediator IL-1 ( alpha or beta ) up-regulated production of IL-3, IL-5, IL-6 , and IL-9 as well as TNF, i.e., cytokines implicated in many inflammatory processes including those associated with allergies and helminthic infections
Grimaldi et al., Biochem Biophys Res Commun 1998 : To rule out the possibility that DEX was inhibiting LPS induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1) induced IL-6 release ... DEX slightly inhibited IL-1 induced IL-6 release, while IL-1 releasing action on IL-6 was significantly reduced by IND
Stéphan et al., Mol Cell Endocrinol 1997 : Furthermore, we have also shown that IL-1alpha is able to enhance Sertoli cell IL-6 production by an autocrine action
Topley et al., J Am Soc Nephrol 1996 : Similarly, interleukin (IL)-1 beta induced IL-6 synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF, and this release was stimulated by lipopolysaccharide, interleukin-1 alpha , interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Becker et al., J Immunol 1991 (Respirovirus Infections) : However, TNF, IL-1 , and RSV, but not IL-6, induced IL-8 and IL-6 mRNA expression by the bronchial epithelial cells suggesting that cytokines produced by RSV infected AM may be more important in modulating the inflammatory response in infection than directly interfering with virus infection/replication of airway epithelium
Silfverswärd et al., J Orthop Res 2004 : In conclusion, IL-4/13 synergistically potentiates IL-1 induced secretion of IL-6 in human osteoblast-like cells
Kasahara et al., Rinsho Byori 1990 (Inflammation) : While it has been established that IL 1 has a variety of biological functions in vitro and in vivo, some of these functions are not a direct action of IL 1, but may be ascribed to some other cytokines induced by IL 1, since IL 1 can induce IL 6 ( as an inducer of acute phase protein ), IL 8 ( as a neutrophil chemotactic factor ), or IL 1 itself
Hooper et al., Thromb Res 1996 (Carcinoma, Hepatocellular...) : The results demonstrated that TNF-alpha, and to a lesser degree, IL-1 alpha, could significantly suppress IL-6 upregulation of protein S, whereas the effects of OSM was only suppressed by the combination of IL-1 alpha and TNF-alpha
Panja et al., Clin Exp Immunol 1995 : However, IL-1 beta up-regulated IL-6 synthesis by 6-7-fold
Li et al., J Clin Endocrinol Metab 1992 : Simultaneous stimulation of trophoblasts with rTNF alpha and gamma IL-1 alpha resulted in synergistic enhancement of IL-6 release, subsequently leading to enhanced hCG release ... Collectively, trophoblast derived TNF alpha and IL-1 synergistically regulated the level of IL-6 secreted by trophoblasts, the magnitude of which determined the level of hCG released by activating the IL-6-R system in trophoblasts
McCormack et al., J Immunol 1993 : Although IFN-gamma induced IL-6 gene transcription in both alloAP+ and alloAP- M theta subsets, it induced IL-1 alpha transcripts only in the alloAP+ subset
Akarsu et al., Brain Res 1998 (Fever) : In addition, depending on the experimental condition IL-6 production may or may not require the prior induction of interleukin-1 (IL-1)
Radons et al., Int J Mol Med 2006 : Our results led to the identification of p38MAPK and/or PI3K/JNK as being crucial for IL-1 induced IL-6 secretion by chondrocytes
Taniguchi et al., J Clin Endocrinol Metab 1992 (Choriocarcinoma...) : Interleukin-1 (IL-1) induced IL-6- and IL-6-receptor mediated release of human chorionic gonadotropin by choriocarcinoma cell lines ( Jar and HCCM-5 ) activates adenosine 3',5'-monophosphate independent signal transduction pathway ... The experiments showed that both the Jar and HCCM-5 cell lines possessed a partially intact cytokine mediated cascade, suggesting that IL-1 induced IL-6 release and IL-6-R activation operate in an autocrine manner
Vannier et al., J Biol Chem 1994 : Histamine enhances interleukin (IL)-1 induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells ... Histamine ( 1-100 microM ) enhanced IL-1 alpha induced synthesis of IL-6 ( p < 0.001 ) ... Cimetidine and ranitidine, H2 receptor antagonists structurally unrelated to each other, completely reversed the histamine mediated increase in IL-1 alpha induced IL-6 synthesis ... Prostaglandin E2, an activator of adenylate cyclase, also enhanced IL-1 alpha induced synthesis of IL-6 ... Our results indicate that cAMP increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1 induced IL-6 synthesis
Zhang et al., Mol Cell Biol 1990 (Chromosome Deletion) : On the basis of these and other experiments, we conclude that TNF and IL-1 apparently activate IL-6 gene expression by closely related mechanisms involving activation of a NF-kappa B-like factor, whereas the pathway of IL-6 induction by forskolin is, in part, different
Paik et al., Molecular vision 2012 (Graves Ophthalmopathy...) : The orbital fibroblasts from patients with TAO were Thy-1- positive fibroblasts ( > 90 % ) with the ability to secrete IL-6 , IL-8, monocyte chemotactic protein-1 (MCP-1), and HA in response to IL-1ß
Kinoshita et al., PloS one 2013 (Cell Transformation, Neoplastic...) : IL-6 production from fibroblasts was suppressed by an interleukin-1 (IL-1) receptor antagonist and siRNA inhibition of IL-1a in the fibroblasts
Vellenga et al., Br J Pharmacol 1999 : MK-571 mediated upregulation of IL-6 in the presence of IL-1 was partially attenuated by SB203580 and PD98059
Eda et al., Cell Biol Int 2011 (Arthritis, Rheumatoid) : PI3K inhibitor, LY294002 significantly reduced IL-1ß induced IL-6 production in A549 cells but not in RASF, indicating that IL-1ß induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF ... These results indicate that IL-1ß induced IL-6 production in A549 cells is mediated by both PI3K and IRAK4 and suggest that involvement of PI3K in the IL-1 induced IL-6 production is cell type specific
Neta et al., Lymphokine Res 1988 (Acute-Phase Reaction) : IL 1 and IL 6 share a number of biological activities, including induction of fever, neutrophilia and acute phase response, and IL 1 induces IL 6 production by fibroblasts and macrophages ... IL 1 in doses above 10 ng/mouse induced within 2 to 6 hrs a dose dependent increase in CSF in circulation, but IL 6 did not induce detectable levels of CSF at 2, 6 and 20 hrs after administration
Rokita et al., Cytokine 1993 (Acute-Phase Reaction) : The inhibitory effect of IL-1 is reversed by endogenous IL-1ra and by the direct stimulation of Fg gene expression by IL-6
Musso et al., J Immunol 1992 : These data demonstrate that, in human monocytes, both IL-1 and IL-2 stimulate IL-6 expression by independent mechanisms that can be dissociated by the susceptibility to the inhibitory effect of IFN-gamma
Inoue et al., J Immunol 2005 (Arthritis, Rheumatoid...) : Furthermore, IL-1beta induced IL-8, IL-6 , and matrix metalloproteinase-3 protein production was significantly inhibited in DN MKK3/DN MKK6 transfected cells
Chae et al., Immunopharmacol Immunotoxicol 2005 : When added to HGFs, IL-1beta had a stimulatory effect on the production of IL-6 , and this effect was significantly reduced by SB203580, a specific p38 MAPK inhibitor
Takei et al., J Interferon Cytokine Res 1995 : Untreated IL-1 alpha increased the serum level of IL-6 , but the glycosylated IL-1 alpha did not
Hagood et al., Am J Respir Cell Mol Biol 2002 : However, IL-1beta induced proliferation and expression of IL-6 are significantly higher in Thy-1- fibroblasts
Parikh et al., J Surg Res 1998 : In recent studies, IL-1beta stimulated the production of IL-6 in human enterocytes
De Simoni et al., J Exp Med 1990 : Induction of serum IL-6 by centrally administered IL-1 was also observed in hypophysectomized or adrenalectomized rats, suggesting that activation of the hypothalamus-pituitary-adrenal axis is not essential for this effect of IL-1
Sato et al., Am J Physiol 1994 : Both sweat IL-1 alpha and human recombinant IL-1 alpha at 500 pg/ml strongly stimulated interleukin-6 and interleukin-8 production in cultured fibroblasts
Erwin et al., Arthritis Res Ther 2011 (Intervertebral Disc Degeneration) : Furthermore, NP cells treated with NCCM in the presence of IL-1ß+Fas-L down-regulate the expression of IL-6 by almost 50 %
Li et al., Cancer Res 1992 (Ovarian Neoplasms) : In many systems, IL-1 induces the expression of the IL-6 gene ... To determine whether the basal levels of IL-6 production are dependent on the endogenous IL-1 , neutralization studies were carried out ... These results suggest that multiple cytokines are produced by ovarian cancer cells and that the endogenous IL-1 may not be directly involved in the regulation of IL-6 gene expression in these cells
de Haij et al., J Am Soc Nephrol 2005 : IL-6 production induced by IL-1 , TNF-alpha, and IL-17 was specifically inhibited by the c-jun NH ( 2 ) -terminal kinase ( JNK ) inhibitor SP600125, but not by a selective inhibitor of p38 MAPK, and was moderately increased when the ERK1/2 pathway was inhibited
Moon et al., Spine (Phila Pa 1976) 2012 (Fibrosis...) : Prior macrophage exposure increased the secretion of IL-8 and VEGF in response to TNF-a/IL-1ß stimulation whereas IL-6 production was increased in response to IL-1ß
Katiyar et al., Arthritis Res Ther 2011 (Osteoarthritis) : In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1ß induced inflammatory cytokines, TNFa, IL-6 , granulocyte-macrophage colony stimulating factor and several chemokines from human chondrocytes
Kanakaraj et al., J Exp Med 1998 : In addition, IL-6 production in response to IL-1 was also dramatically reduced in IRAK-deficient embryonic fibroblasts and in skin fibroblasts prepared from IRAK-deficient mice
Bird et al., Cytokine 1992 : Even after 2 hours exposure, the ability of IL-1 to induce IL-6 or PGE2 was still IL-1ra-inhibitable by more than 80 %, suggesting that events downstream of, or parallel to MAP-kinase activation, requiring the continual formation of new IL-1 receptor complexes, are needed to fully elicit these responses
Szabo-Fresnais et al., Mol Cell Endocrinol 2008 : Activation of the cAMP pathway synergistically increases IL-1 induced IL-6 gene expression in FRTL-5 thyroid cells : involvement of AP-1 transcription factors ... In the latter cell type, secretion of IL-6 is stimulated notably by interleukin-1 (IL-1) , thyroid stimulating hormone ( TSH ) or forskolin ( Fk ), a cAMP elevating agent ... We report here that Fk and IL-1 synergistically enhance IL-6 mRNA expression in FRTL-5 thyroid cells by mechanisms involving the cAMP/PKA pathway, and both stabilization of the IL-6 mRNA and activation of the IL-6 promoter
Pinteaux et al., J Neurochem 2002 : Bacterial lipopolysaccharide (LPS) caused increased expression of IL-1RI , IL-1RII and IL-1RAcP mRNAs, induced the release of IL-1beta, IL-6 and prostaglandin-E2 ( PGE2 ), and activated nuclear factor kappaB (NF-kappaB) and the mitogen activated protein kinases ( MAPKs ) p38, and extracellular signal regulated protein kinase ( ERK1/2 ), but not c-Jun N-terminal kinase (JNK) in microglial cultures ... In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB, p38, JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures
Benigni et al., Mol Med 1995 : We previously reported that CNTF augments the levels of corticosterone ( CS ) and of IL-6 induced by IL-1 and induces the production of the acute-phase protein serum amyloid A (SAA)
Bertini et al., Cytokine 1992 : Recombinant icIL-1ra inhibited the IL-1 induced production of IL-6 , IL-8 and monocyte chemotactic protein by human endothelial cells ( HEC )
Thota et al., Reprod Sci 2013 : Vitamin D also attenuated IL-1ß induced MCP-1, IL-6 , connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression
Tat et al., J Rheumatol 2010 (Osteoarthritis, Knee) : In the presence of IL-1ss , CS2 at 1000 microg/ml significantly inhibited IL-6 and PGE ( 2 ) production, and CS3 at 200 microg/ml markedly reduced the level of IL-6
Borg et al., J Clin Endocrinol Metab 2003 (Adenoma...) : IL-1alpha and dibutyryl cAMP stimulated and dexamethasone inhibited IL-6 secretion ; however, bacterial lipopolysaccharide, forskolin, and cholera toxin had no effect
Moses et al., Blood 1996 (HIV Infections) : Although HIV infected stromal cultures enriched for MVEC constitutively express normal levels of interleukin (IL)-4, IL-6, granulocyte ( G)-colony stimulating factor (CSF), granulocyte-macrophage (GM)-CSF, tumor necrosis factor (TNF)-alpha, transforming growth factor ( TGF ) -beta, and Steel factor, IL-1 alpha induced release of IL-6 and G-CSF is significantly reduced in these cultures
Boost et al., BMC cancer 2008 (Lung Neoplasms...) : In contrast to IL-8, IL-1beta induced cyclooxygenase-2 expression and release of IL-6 were not affected by IFNgamma indicating that modulation of IL-1beta action by this cytokine displays specificity
Rogler et al., Scand J Gastroenterol 2001 (Colitis, Ulcerative...) : IL-8 and IL-6 secretion could be stimulated by IL-1alpha, IL-1beta , TNF, PMA and LPS within 6 h of incubation
Lockwood et al., Am J Pathol 2010 (Chorioamnionitis...) : In confluent leukocyte-free term DCs, secreted interleukin-6 levels in incubations with estradiol-17ß were increased 2500-fold by IL-1ß ( P < 0.05 )
Burnstine et al., Ophthal Plast Reconstr Surg 1999 : DEX is a potent inhibitor of OF IL-6 mRNA while CSA increases IL-1 induced OF IL-6 gene expression
Luheshi et al., Am J Physiol 1996 (Fever) : These data show that peripheral IL-1 plays a part in the induction of both fever and the rise in plasma IL-6 that precedes it, and that IL-1 within the brain is also important in the induction of fever by LPS
Sharif et al., Invest Ophthalmol Vis Sci 1998 : Histamine ( 100 microM ) and interleukin-1alpha ( IL-1alpha, 10 ng/ml ) significantly stimulated IL-6 and granulocyte macrophage colony stimulating factor release, and histamine, BK, and PAF stimulated the mRNA for MMP-1 in these cells
Kawakami et al., J Trauma 1998 (Burns...) : TNF-alpha, IL-1alpha , and IL-1beta increased IL-6 production in normal skin ( p < 0.05 )
Lacey et al., J Clin Invest 1993 : IL-1 induced murine osteoblast IL-6 production is mediated by the type 1 IL-1 receptor and is increased by 1,25 dihydroxyvitamin D3 ... IL-1 induced osteoblast IL-6 production represents one possible mechanism by which IL-1 augments bone resorption ... IL-1 induces ( IL-1 ED50, 0.1 pM ) IL-6 production through the type 1 IL-1R as 35F5 antibodies block IL-1 stimulated IL-6 production ... These observations imply that IL-1 induced IL-6 production in osteoblasts is mediated by type 1 IL-1Rs and that increased IL-1R expression could play a role in mediating IL-1 induced skeletal responses
Musso et al., Blood 1990 : Transforming growth factor beta downregulates interleukin-1 (IL-1) induced IL-6 production by human monocytes ... In contrast, TGF beta added to the culture inhibited, in a dose dependent manner, the induction of IL-6 by IL-1 at the level of messenger RNA and bioactivity
Rogachev et al., Kidney Int 2006 (Disease Models, Animal...) : Treatment with the A ( 2A ) R agonist reduced IL-1 dependent IL-6 secretion from HPMC
Ulivi et al., Arthritis Res Ther 2011 : We report that MGDG : 1 ) represses the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8) induced by interleukin-1alpha ( IL-1a ) or IL-1a + tumor necrosis factor a (TNFa) interfering with the p38 and NF-kB pathways ; 2 ) is not toxic for the cells and does not affect the cell phenotype ; 3 ) strongly enhances COX-2 expression induced by IL-1a or IL-1a + TNFa ; 4 ) represses mPGES expression induced by IL-1a and the synthesis of PGE ( 2 ) and induces the synthesis of 15-deoxy-d 12,14-prostaglandin J ( 2 ) ( 15dPGJ ( 2 ) ) ... In addition, the COX-2 product 15dPGJ ( 2 ) added to the cells : 1 ) strongly represses IL-6 and IL-8 induced by IL-1a ; 2 ) represses mPGES expression induced by IL-1a and the synthesis of PGE ( 2 )
Ujiie et al., International journal of dentistry 2012 : Secretion of IL-1a and IL-1ß proteins was stimulated in hMO by LPS, and IL-6 protein secretion was highly stimulated in hBMCs and hGF
Gauliard et al., J Med Food 2008 : The effects of the following phenolic compounds on basal and interleukin (IL)-1 stimulated release of IL-8, IL-6 , and reduced glutathione ( GSH ) were examined : resveratrol ; Bouvrage, a commercially available raspberry juice ( Ella Drinks Ltd., Alloa, Clacksmannanshire, UK ) ; and quercetin 3'-sulfate
Hedges et al., Int J Antimicrob Agents 1994 : Uroepithelial cells also respond to stimulation by cytokines ; IL-1alpha and TNFalpha induce the secretion of IL-6 and IL-8 and the upregulation of mRNAs for IL-1alpha, IL-1beta, IL-6 and IL-8
Clockaerts et al., Ann Rheum Dis 2012 (Osteoarthritis, Knee) : IL-1ß increased gene expression of PTGS2, TNFa, IL-1ß, IL-6 and VEGF and increased TNFa release in IPFP
Tsakiri et al., Br J Pharmacol 2008 : IL-1 also modifies physiological functions via actions on neurones, through activation of the neutral sphingomyelinase (nSMase)/Src kinase signalling pathway, although the mechanism of IL-1 induced IL-6 synthesis in neurones remains unknown
Ng et al., J Biol Chem 1994 : IL-1 induces IL-6 gene expression after 30 min of IL-1 treatment, reaching a maximum level by 7 h, and is sustained for up to 14 h. TNF also induces the IL-6 gene expression at 30 min but the induction was low ... These results suggest that the induction of the IL-6 gene expression in primary human fibroblasts by TNF and IL-1 is differentially regulated at the transcriptional as well as at the post-transcriptional level
Ling et al., Am J Physiol 1996 (Body Weight) : IL-1 significantly increased core temperature, plasma levels of IL-6 , and acute-phase protein production and decreased food intake and the circulating zinc level
Sugita et al., Int J Immunopharmacol 1993 (Arthritis, Experimental...) : These results suggest that the elevated IL-6 in sera may be associated with the overproduced IL-6 in response to the increased IL-1 at the arthritic joints
Weissgarten et al., J Nephrol 1998 : IL-6 production by mesangial cells from normal kidneys was significantly enhanced by IL-1 , compared to unstimulated cells ( p < 0.01 ), and the increase was significantly greater in mesangial cells from a single remaining kidney ( p < 0.01 ) ... Mesangial cells from single remaining kidneys in culture maintain an exaggerated capacity to produce IL-6 in response to IL-1
Tang et al., Hepatobiliary Pancreat Dis Int 2005 (Pancreatic Neoplasms) : These findings suggested that the expression of VEGF-A, C and their regulation by IL-1alpha , IL-6 in pancreatic cancer contributes to the lymphatic and distant metastasis and the disease progression
Haynes et al., Agents Actions 1993 : In contrast, DHB stimulated production of interleukin (IL)-1 and tumour necrosis factor (TNF) but inhibited IL-6 production by rat macrophages
Georganas et al., J Immunol 2000 (Arthritis, Rheumatoid) : Inhibition of NF-kappaB activation significantly reduced the spontaneous and IL-1beta induced secretion of IL-6 and IL-8 by RA FLS and the IL-1ss induced production of IL-6 and IL-8 by human dermal fibroblasts ... NF-kappaB was essential for IL-6 expression, because fibroblasts in which both NF-kappaB p50/p65 genes were deleted failed to express IL-6 in response to IL-1
Donnelly et al., J Immunol 1993 : Although peripheral blood monocytes did not constitutively express IL-6 mRNA or protein, stimulation with IL-1 or LPS induced de novo IL-6 expression in these cells
Hojo et al., Cancer Lett 1996 (Lung Neoplasms...) : The IL-6 production was greatly enhanced by IL-1 alpha , but not by IL-6, tumor necrosis factor-alpha or interferon-gamma
van Holten et al., Arthritis Res Ther 2004 (Arthritis, Experimental...) : The IL-1 induced expression of IL-6 , IL-8, and granulocyte/macrophage-colony stimulating factor ( GM-CSF ) was studied by ELISA in supernatant of RA and osteoarthritis fibroblast-like synoviocytes incubated with IFN-beta
Cheng et al., Int Immunopharmacol 2008 : The production of IL-1 was induced by GP at a dose of 10 microg/mL ; but, NO, IL-6 and IL-12 was significantly induced at 100 microg/mL
Noguchi et al., Oral Dis 2005 : Prostaglandin E2 ( PGE2 ) downregulates interleukin (IL)-1alpha induced IL-6 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells ... In the present study, we examined whether PGE2 regulated interleukin (IL)-1alpha induced IL-6 production in human periodontal ligament ( PDL ) cells and if so, which subtypes of PGE2 receptors were involved ... Indomethacin significantly enhanced IL-1alpha induced IL-6 production by PDL cells, although it completely inhibited IL-1alpha induced PGE2 production ... Exogenous PGE2 significantly suppressed IL-1alpha induced IL-6 production ... Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha induced IL-6 production, although 17-phenyl-omega-trinor PGE2, an EP1 agonist, and ONO-AP-324, an EP3 agonist, did not affect it ... We suggest that PGE2 downregulates IL-1alpha induced IL-6 production via EP2/EP4 receptors in human PDL cells
Ridley et al., J Immunol 1997 : SB 203580 significantly inhibited IL-1 stimulated IL-6 , ( 30 to 50 % at 1 microM ) but not IL-8 production from human fibroblasts ( gingival and dermal ) and umbilical vein endothelial cells
Baroni et al., Arch Dermatol Res 2001 : Moreover, we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating IL-1alpha and by inhibiting IL-6 and TNF-alpha and by upregulating IL-10 and TGF-beta1
Lin et al., J Endod 2002 (Pulpitis) : To gain further insight into the molecular pathogenesis of pulpitis, we investigated the effects of IL-1alpha or TNF-alpha and PGE2, either alone or in combination on IL-6 and cyclooxygenase (COX)-2 messenger RNA ( mRNA ) production in cultured human dental pulp ( HDP ) fibroblasts
Yu et al., J Biol Chem 2008 : Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1 mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression ... Reconstitution of TAK1-deficient mouse embryo fibroblast cells with wild-type TAK1 or a TAK1 mutant containing threonine 178 and 184 to alanine mutations revealed the importance of these two sites in IL-1 mediated IKK-NFkappaB and JNK-AP-1 activation as well as IL-1 induced IL-6 gene expression
Numerof et al., Cytokine 1992 : Although IL-1 is an inducer of IL-6 production, the administration of the IL-1RA had no effect on circulating IL-6 levels in IL-2 treated mice
Kitamura et al., Cell Mol Life Sci 1998 : Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis ... The results suggest that brain IL-1 induces peripheral production of IL-6 , but not of TNF, through autonomic nervous system activation
Spangelo et al., Endocrinology 1991 : IL-1 alpha and IL-1 beta ( 10 ng/ml ), vasoactive intestinal peptide ( VIP, 500 nM ), prostaglandin E2 ( PGE2, 1 microM ), and LPS ( 1 ng/ml ) stimulated IL-6 release to a similar degree ... In the presence of VIP and PGE2, IL-1 alpha and IL-1 beta increased IL-6 release without any apparent further change in extracellular or intracellular cAMP ... Conversely, LPS did not increase cAMP concentrations, and IL-1 did not significantly increase IL-6 release in the presence of LPS ... The preexposure of anterior pituitary cells to 1 microM PMA caused the apparent down-regulation of protein kinase C activity because 100 nM PMA was no longer effective to stimulate IL-6 release ; however, the ability of IL-1 alpha , IL-1 beta, PGE2, or LPS to stimulate IL-6 release was not altered ... In addition, IL-1 alpha and IL-1 beta stimulated IL-6 release in the presence of maximally stimulative concentrations of PMA ... The synthetic glucocorticoid dexamethasone ( 10 nM ) significantly inhibited IL-6 release induced by IL-1 alpha , IL-1 beta, or LPS
Fantuzzi et al., Cytokine 1995 (Anorexia...) : A single intravenous injection of CNTF induced hypoglycaemia and SAA and potentiated IL-1 induced CS and IL-6
Van Offel et al., Cytokine 2005 : Stimulation with IL-1 resulted in a dose dependent induction of IL-6 and IL-8, but no production of the other cytokines could be demonstrated
Robinson et al., Cytokine 1998 (Breast Neoplasms) : IL-1alpha upregulates IL-6 production ; therefore, the correlation between IL-1alpha and IL-6 immunoreactivity and OR-positivity in paraffin embedded human breast tumours was further investigated.The results indicate IL-6 immunoreactivity in 40 of 66 paraffin embedded breast tumour specimens, a finding which did not correlate with the clinical evaluation of oestrogen receptor positivity ( P=0.32 by Fisher 's exact test )
Jones et al., J Pathol 1997 (Meningioma) : Dexamethasone decreased the IL-1 stimulated IL-6 release in all cases
El-Osta et al., Mol Cancer Ther 2010 (Giant Lymph Node Hyperplasia) : Because interleukin-1 (IL-1) might promote the production of interleukin-6 (IL-6) , a key pathogenic factor for the disease, we hypothesized that blocking the interleukin-1 receptor would be a useful therapy for CD
Guerne et al., J Clin Invest 1989 (Arthritis, Rheumatoid) : In vitro, synoviocytes spontaneously released IL-6 , which was increased by IL-1 and tumor necrosis factor-alpha
Fuller et al., J Cosmet Dermatol 2006 : Treatment of fibroblasts with 10 microm of CoQ10 suppressed the UVR- or IL-1 induced increase in PGE-2, IL-6 , and MMP-1
Cai et al., Biochem Biophys Res Commun 2012 (Genetic Predisposition to Disease...) : The AluYb8MUTYH genotype was strongly associated with increased IL-1ß levels among controls and increased IL-1ß and IL-6 levels among hemodialysis patients
Kandere-Grzybowska et al., Br J Pharmacol 2006 : Regulation of IL-1 induced selective IL-6 release from human mast cells and inhibition by quercetin ... The p38 inhibitor SB203580 and the PKC inhibitors Calphostin C and Gö6976 completely inhibited IL-1 induced IL-6 production ... Quercetin 1-100 microM inhibited IL-1 induced IL-6 secretion, p38 and PKC-theta phosphorylation in a dose dependent manner
Call et al., Gen Comp Endocrinol 2000 : The release of IL-6 and TNF from the ZG, ZF, ZR, and medulla was increased by PDB, IL-1alpha , IL-1beta, and LPS
Vindeløv et al., Growth Horm IGF Res 2011 (Adenoma...) : IL-1ß dose-dependently stimulated GH, IL-6 and IL-8 secretion
Shahar et al., Clin Immunol Immunopathol 1996 (Lung Diseases, Interstitial...) : Tumor necrosis factor-alpha (TNFalpha) and interleukin-1 (IL-1) enhanced IL-6 secretion and IL-6 mRNA transcription in AFb of SA patients
Jones et al., Acta Endocrinol (Copenh) 1993 (Adenoma...) : Interleukin-1 (IL-1) stimulated IL-6 release after a 24-h incubation period in five of the seven IL-6 secreting adenoma cultures and in all seven after 72 h. Tumour necrosis factor, interferon-gamma and epidermal growth factor did not significantly affect IL-6 secretion ... Prostaglandin E2 did not influence basal IL-6 secretion and indomethacin did not inhibit IL-1 stimulated IL-6 release ... Stimulation of IL-6 release by IL-1 in these tumour cells is probably not mediated by prostaglandins or by a pertussis toxin-sensitive mechanism
Agro et al., J Rheumatol 1996 : Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro
Carter et al., Br J Haematol 1990 (Multiple Myeloma) : This study investigates the capacity of interleukin-1 alpha (IL-1 alpha) , interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) to induce interleukin-6 (IL-6) production in freshly isolated myeloma cells ( MC ) and bone marrow derived stromal cells (MSC) ... Recombinant human ( rh ) IL-1 alpha , IL-1 beta and TNF-alpha augmented production of IL-6 in human MC. IL-6 was determined on a factor dependent Cess cell line ... Next we found that IL-1 alpha , IL-1 beta and TNF-alpha induced MSC to produce IL-6
Nishikawa et al., Blood 1993 : Further, Northern analysis showed that the preadipocyte cell line acquired the ability to produce a significant amount of stem cell factor (SCF), interleukin-6 (IL-6) , leukemia inhibitory factor, and macrophage colony stimulating factor mRNAs in response to IL-1 or lipopolysaccharide stimulation
Balto et al., Infect Immun 2001 (Bacterial Infections...) : In the present study, we determined the role of IL-6 in regulating IL-1 expression and bone resorption
Trautwein et al., Nature 1993 : Also, NF-IL6/LAP is involved in the activation of the IL-6 promoter in response to IL-1 and bacterial lipopolysaccharide ... Under some conditions the NF-IL6/LAP gene is transcriptionally activated by IL-1 and lipopolysaccharide, whereas in other instances, its binding to cognate DNA sequences is enhanced by cytokines
Nguyen et al., Neurosignals 2011 (MAP Kinase Signaling System) : We found that IL-1RAcPb deletion had no effect on IL-1a- and IL-1ß induced activation of the extracellular signal regulated kinase 1/2 or IL-6 release in glial cultures, although IL-6 release in response to high IL-1a concentration ( 30 IU/ml ) was significantly reduced ... We identified the p38 kinase as a key signaling element in IL-1a- and IL-1ß induced IL-6 synthesis and release in neuronal cultures ... IL-1RAcPb deletion had no effect on IL-1a- and IL-1ß induced IL-6 release in neurons, but significantly reduced IL-1a- but not IL-1ß induced p38 phosphorylation
Fida et al., Pediatr Int 2006 (Meningitis, Bacterial...) : In sepsis, levels of IL-1alpha increased in the S2 subgroup ( P < 0.001 ) and IL-6 increased in the S1 and S2 subgroups ( P < 0.05, P < 0.001, respectively ) compared with healthy controls
Everaerdt et al., J Immunol 1994 (Neoplasms, Experimental) : However, the induction of high levels of circulating IL-6 by murine TNF was not affected, although IL-1ra almost completely blocked the induction of IL-6 by exogenously administered IL-1
Fioravanzo et al., Curr Alzheimer Res 2010 (Alzheimer Disease...) : The removal of IL-1ß , TNF-a and/or VEGF, a strong angiogenic inducer highly over expressed in AD brains, by means of specific antibody coated beads in RHA media affects RCEC release of IL-1ß, IL-6 and TNF-a
Dinarello et al., Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001 : This unit describes a bioassay for testing biological fluids based on the ability of IL-1 to induce IL-8 or IL-6 in fibroblasts
Kuroyanagi et al., Biochimie 2013 : EGCG significantly enhanced the IL-1 stimulated IL-6 synthesis in a dose dependent manner in the range between 50 and 100 µM ... We previously reported that interleukin-1 (IL-1), a potent bone resorptive cytokine, stimulates the synthesis of interleukin-6 (IL-6) via activation of p44/p42 mitogen activated protein ( MAP ) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that AMP activated protein kinase (AMPK) negatively regulates the IL-1 induced IL-6 synthesis through the inhibitor of ?B ( I?B ) /nuclear factor-?B ( NF-?B ) pathway
Labow et al., J Immunol 1997 (Acute-Phase Reaction...) : IL-1RI-deficient mice were viable and fertile, but failed to respond to IL-1 in a variety of assays, including IL-1 induced IL-6 and E-selectin expression and IL-1 induced fever
Boxman et al., J Invest Dermatol 1993 : Interleukin-1 alpha secreted by normal human keratinocytes and squamous carcinoma cells-4 cells was mainly responsible for the increased interleukin-6 production in fibroblasts ... Low interleukin-1 activity was most probably not due to inhibition of interleukin-1 alpha production in squamous carcinoma cells-4/3T3 co-cultures because interleukin-1 alpha messenger RNA expression in squamous carcinoma cells-4 cells remained unchanged in the presence of 3T3 cells
Yoon et al., J Biochem Mol Biol 2007 : Anti-peptide-2 or 3 also inhibited IL-1 induced IL-6 production by 30 % ... IL-1 induced IL-6 production was augmented by coincubation with PGE ( 2 ) ... The COX inhibitor ibuprofen blocked IL-1 induced IL-6 and PGE ( 2 ) production
Naora et al., J Immunol 1994 : Furthermore, IL-5, IL-6 , and IL-10 genes were independently induced by IL-1 alpha , the phorbol ester PMA, and by forskolin, an activator of adenylate cyclase
Chávez-Sánchez et al., Lipids in health and disease 2010 : Blocking CD14 in monocytes inhibited secretion of interleukin (IL)-1ß ( 72 % ), IL-6 ( 58 % ) and IL-10 ( 63 % ), and blocking TLR4 inhibited secretion of IL-1ß by 67 %, IL-6 by 63 % and IL-10 by 60 % ... Blocking both receptors inhibited secretion of IL-1ß by 73 %, IL-6 by 69 % and IL-10 by 63 %
Takii , Yakugaku Zasshi 2001 : This up-regulation leads to the increasing susceptibility of IL-1RI to IL-1, as the DNA binding of IL-1 induced NF-kappa B and the production of IL-1 induced IL-6 from the fibroblasts are augmented by pretreatment with IFNs ... On the other hand, the expression of cell surface IL-1RI is inhibited by tyrosine kinase inhibitors, herbimycin and genistein, resulting in reduction of the kinase activity of IRAK ( IL-1 receptor associated kinase ) and IL-1 induced IL-6 production from the fibroblasts
Denizot et al., Biochim Biophys Acta 1999 : By contrast, IL-4 stimulates their serum- and IL-1alpha induced IL-6 synthesis
Cavaillon , Pathol Biol (Paris) 1990 (Inflammation) : IL-1 as well as microbial products induces the production of interleukin-6 and interleukin-8
Kawano et al., Fertil Steril 2004 : Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6 , IL-8, and macrophage colony stimulating factor by endometrial stromal cells ... To measure the level of interleukin 6 (IL-6) , IL-8, and macrophage colony stimulating factor ( M-CSF ) induced by IL-1alpha in endometrial stromal cells ( ESC ) following treatment with ceramide analogues ... The effects of IL-1alpha , IL-1 receptor antagonist (IL-1RA), C2-ceramide, and C6-ceramide on the production of IL-6 , IL-8, and M-CSF by ESC ... Production of IL-6 , IL-8, and M-CSF was not statistically significantly increased by IL-1alpha plus C2-ceramide as compared with IL-1alpha alone ... Production of both IL-8 and M-CSF was statistically significantly increased by IL-1alpha plus C6-ceramide as compared with IL-1alpha alone ; however, IL-6 production was not increased
Neta et al., J Exp Med 1992 (Hypoglycemia...) : Thus, it is difficult to identify the cytokine primarily responsible for a particular biologic effect, since IL-1 and TNF stimulate one another, and both IL-1 and TNF stimulate IL-6
Hedges et al., Scand J Immunol 1993 : Cyclosporin A does not inhibit IL-1 alpha induced epithelial cell IL-6 secretion ... E. coli Hu734, IL-1 alpha and TNF-alpha stimulated an IL-6 response in the two epithelial cell lines ... The IL-1 alpha induced IL-6 response was rapid, and the secreted IL-6 levels were significantly higher than those induced by E. coli Hu734 or TNF-alpha ... The IL-6 response to IL-1 alpha was insensitive to CsA ... IL-1 alpha may play a role in the induction of trauma associated CsA-insensitive IL-6 secretion
Benwell et al., Clin Immunol 2010 : However, in the presence of the physiologically low levels of IL1 such as those produced by DCs, both TGFbeta and IL6 were also essential
Engler , C R Seances Soc Biol Fil 1995 (Inflammation) : IL1 and TNF alpha mediated stimulation of type 1 APP genes is synergistically enhanced by IL6 type cytokines
Chabaud et al., J Immunol 1998 (Arthritis, Rheumatoid) : Enhancing effect of IL-17 on IL-1 induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines
Norioka et al., Autoimmunity 1990 (Vasculitis) : To determine whether IL-1 could contribute to the pathogenesis of vascular diseases, we examined the effect of IL-1 on B cell stimulatory factor-2/interleukin-6 (IL-6) production by cultured human vascular smooth muscle cells ( SMC ) and the proliferation of these cells
Ulich et al., J Immunol 1991 : IL-6 in turn inhibited TNF and IL-1 expression, suggesting that IL-6 may be part of a negative feedback mechanism in the cytokine cascade
Ishikawa et al., Jpn J Vet Res 2001 : To test possible involvement of brain IL-1 in the stress induced IL-6 production, IL-1 mRNA expression in the hypothalamus, in parallel with blood IL-6 level, was examined in rats subjected to restriction of their movement ( immobilization stress ) ... These results indicate that IL-1 in the hypothalamus plays a pivotal mediating role in the stress induced peripheral IL-6 production
Huang et al., Nat Immunol 2004 : MEKK3 forms a complex with TRAF6 in response to IL-1 and lipopolysaccharide (LPS) but not CpG, and is required for IL-1R- and TLR4 induced IL-6 production
Akash et al., Pharm Res 2012 : When compared directly, IL-1Ra loaded PF127 gel exhibited prolonged in vitro and in vivo release, greater efficacy to induce hypoglycemia and inhibited IL-1ß stimulated production of IL-6 as compared to IL-1Ra aq. solution
Bendtzen et al., Lymphokine Res 1989 (Autoimmune Diseases...) : IL-1 induces IL-6 in isolated islets and in thyrocytes
Richards et al., J Immunol 1996 : In contrast, when IL-6 or leukemia inhibitory factor ( two other cytokines that share gp130 receptor components with OM ) were used in a similar fashion in combination with IL-1 alpha, neither cytokine consistently altered the IL-1 induced levels of IL-8, GM-CSF, or IL-6
Napolitano et al., Thymus 1997 : Addition of RA to lympho-stromal cell co-culture results in the enhancement of IL4 and IL7 expression in thymocytes while in thymic epithelial cells IL1 alpha decreased and IL6 and IL7 increased
Rautava et al., Neonatology 2011 : In addition, TGF-ß2 reduced the IL-1ß induced IL-8 and IL-6 mRNA response in H4 cells
Kurzrock et al., J Lab Clin Med 1998 (Carcinoma, Renal Cell...) : Our observations suggest that the mechanism by which IL-1alpha or IL-1beta induces IL-6 may be mediated through increases in LYT-10 mRNA and protein levels as well as increases in expression of other transcription factors ( NFkappaB1, p65, and NF-IL6 ), in addition to the known ability of IL-1 to post-translationally activate NF-kappaB
Van der Meer et al., Eur J Immunol 1989 (Pseudomonas Infections) : Since IL 1 also induces interleukin 6 (IL 6) , we tested the hypothesis that IL 6 mediates the effect of IL 1 on nonspecific resistance
Ahn et al., J Neurotrauma 2004 (Brain Injuries) : IL-1alpha and IL-1beta mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and TNFa mRNA expression increased significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI
Phillips et al., Clin Exp Immunol 1995 : Similarly, TGF-alpha, interferon-gamma (IFN-gamma), IL-6 , and tumour necrosis factor-alpha (TNF-alpha) substantially increased HaCAT cell IL-1 alpha , but had no effect on the IL-1Ra, with a concomitant reduction in the icIL-1Ra : IL-1 alpha ratio
Spörri et al., FEBS Lett 1998 : In addition, IL-1sR I enhanced expression of IL-6 and IL-8 mRNA
Suzumura et al., Brain Res 1996 : Given that IL-1 and TNF alpha, monokines derived from microglia, induce IL-6 production in astrocytes, but not in microglia, results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines
Tosato et al., Blood 1990 : Size heterogeneity is a reported feature of IL-6 produced in a variety of cell types, and monocyte derived IL-6 induced by either IL-1 or LPS displayed similar size heterogeneity ... In addition, monocyte production of IL-6, induced by IL-1 beta, was specifically neutralized by anti-IL-1 beta antibodies, demonstrating that IL-1 , rather than a contaminant in the IL-1 preparation, was responsible for IL-6 induction ... The finding that IL-1 induced IL-6 in monocytes may help in defining the spectrum of biologic activities of each of these interactive cytokines
Takii et al., J Interferon Cytokine Res 1995 : Pretreatment of the cells with IFNs enhanced IL-1 induced IL-6 production, indicating that IFNs upregulate functional IL-1R
Zoja et al., Ren Physiol Biochem 1993 : Recombinant IL-1 receptor antagonist blocked the IL-1 mRNA as well as interleukin-6 and interleukin-8 gene expression induced by IL-1
Yan et al., J Cell Physiol 2013 (MAP Kinase Signaling System) : Mechanistically, LfcinB attenuated the effects of IL-1ß and FGF-2 on the expression of cartilage degrading enzymes ( MMP-1, MMP-3, and MMP-13 ), destructive cytokines ( IL-1ß and IL-6 ), and inflammatory mediators ( iNOS and TLR2 )
Syed et al., Endocrinology 1995 : The pathway of IL-1 alpha induced release of IL-6 was studied in the presence of agents that influence arachidonic acid release and metabolism ... It is concluded that IL-1 produced by Sertoli cells in response to LPS or residual bodies induces IL-6 through the lipoxygenase pathway
Takemura et al., J Rheumatol 1998 (Scleroderma, Systemic) : However, IL-1 receptor antagonist (IL-1ra), when added in the medium, significantly inhibited the PDGF induced IL-6 production by SSc fibroblasts ... The enhanced IL-6 production in response to PDGF is due in part to autocrine IL-1 of SSc fibroblasts
de Launay et al., Am J Pathol 2010 (Arthritis, Experimental...) : Gene silencing demonstrated that each Ras protein contributed to IL-1ß dependent IL-6 production, while H-Ras and N-Ras supported IL-1ß dependent matrix metalloproteinase-3 and IL-8 production, respectively
Lemke et al., Glia 1999 (Encephalitis) : Following cholinergic lesion neither IL-1 beta nor IL-6 expression could be detected in any of the activated glial cell types, whereas IL-1 alpha was found to be expressed in astroglial cells only
Wilson et al., Mol Cell Biol 1990 : Sequences homologous to the palindrome ACATTGCACAATCT, which mediates the induction of the IL-6 gene by IL-1 ( S. Akira, H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto, EMBO J. 9 : 1897-1906, 1990 ), and the core sequence of the IL-6-responsive element of the rat alpha 2-macroglobulin gene ( CTGGGA ; M. Hattori, L. J. Abraham, W. Northemann, and G. H. Fey, Proc. Natl. Acad. Sci. USA 87 : 2364-2368, 1990 ) are contained within this fragment in immediate juxtaposition and partially overlapping
Lim et al., Mol Hum Reprod 2013 (Inflammation...) : Although naringenin significantly attenuated IL-1ß induced IL-6 and IL-8 mRNA expression and release, there was no effect of curcumin and apigenin
Dinarello , Int J Tissue React 1992 (Inflammation) : IL-1 is also a potent inducer of endothelial cell adhesion molecules, IL-6 , and IL-8, a neutrophil chemotactic and activating factor
Silacci et al., J Biol Chem 1998 : Given the high levels of soluble receptor in synovial fluid and the marked induction of IL-6 by IL-1 or TNF-alpha, it is likely that IL-6 and its soluble receptor are critical in controlling the catabolic effects of pro-inflammatory cytokines
Liu et al., Immunology 1995 (Listeriosis) : IL-1 induced a high level of IL-6 in the serum a short time after its administration, and neutralization of IL-6 totally abolished the protective function of rIL-1
Reyes et al., Am J Physiol 1998 : Specifically, we investigated the effects of elevated GC levels on interleukin (IL)-1 induced release of IL-6 into both blood and cerebrospinal fluid (CSF) ... Contrary to our a priori predictions, none of these treatments attenuated the IL-1 induced release of IL-6 into CSF ... These data indicated that the IL-1 induced IL-6 response is for the most part resistant to corticosteroid influence, such that even when a partial inhibition was sometimes evident in blood, cytokine release in the central nervous system was not affected
Perlmutter et al., J Clin Invest 1989 (Carcinoma, Hepatocellular...) : Accordingly, we have examined the effect of IFN beta 2/IL-6 on expression of the IL-1- and tumor necrosis factor-unresponsive acute phase protein alpha 1-antitrypsin ( alpha 1 AT ) in human hepatoma derived hepatocytes and in human mononuclear phagocytes
Ganguli et al., Am J Physiol Gastrointest Liver Physiol 2013 (Enterocolitis, Necrotizing) : In the immature xenograft, PCM exposure significantly attenuated LPS and IL-1ß induced IL-8 and IL-6 expression, decreased TLR2 mRNA and TLR4 mRNA, and increased mRNA levels of specific negative regulators of inflammation, SIGIRR and Tollip
Helle et al., Eur J Immunol 1988 : Upon stimulation by IL 1 and/or IL 2 D10 cells produce IL 6
Sébire et al., J Immunol 1993 : Finally, IL-1 was the main inducer of IL-6 production because IL-1 alpha, but not LPS, induced a significant increase in IL-6 synthesis in cultures kept in FCS-free medium
Castrilli et al., Br J Cancer 1997 (Uterine Cervical Neoplasms) : IL-1alpha induced or increased IL-6 mRNA levels in the Me-180 and HT-3 lines and in normal cervical cells ... IL-6 induced : ( 1 ) the expression of its own mRNA only in Me-180 cells that constitutively lacked IL-6 mRNA ; ( 2 ) the expression of IL-1alpha mRNA in C-33A and increased IL-1alpha mRNA level in the case of Me180 cells ... A significant IL-1alpha dependent increase of IL-6 secretion was found in Me-1 80, HT-3 and normal cells
Harigai et al., J Clin Lab Immunol 1991 (Arthritis, Rheumatoid) : Both IL-1 and TNF-alpha induced IL-6 production by synovial fibroblasts in a dose dependent manner
Seckinger et al., J Immunol 1987 (Fever) : A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha
Lee et al., Scand J Rheumatol 2008 (Arthritis, Experimental) : TNFalpha, IL-1beta , and MMP-3 expression decreased, but IL-6 expression in AD-treated joint tissues increased
Hu et al., Invest Ophthalmol Vis Sci 2011 : IL-1ß ( 0.1-10 ng/mL ) increased IL-6 transcript and protein levels in a dose- and time dependent manner up to sixfold, accompanied by a significant increase of NF-?B in nuclear extracts and phosphorylated p38 MAPK in cell lysates ... NF-?B and p38 inhibitors alone decreased, whereas a combination of these two inhibitors completely abolished the IL-1ß induced expression of IL-6
Thom et al., J Surg Res 1993 (Lung Neoplasms) : The biologic effectiveness of the dose and administration of IL-1ra was determined by the ability to block IL-1 induced IL-6 production in vivo
Natsuka et al., Blood 1992 (Leukemia, Monocytic, Acute) : NF-IL6 was originally identified as a DNA binding protein regulating interleukin-1 (IL-1) stimulated IL-6 expression
Shimizu et al., Mol Cell Biol 1990 (Chromosome Deletion...) : We demonstrate that a common IL-6 promoter element, termed inflammatory lymphokine-responsive element ( ILRE ), is important for induction of IL-6 gene expression by IL-1 and TNF-alpha despite possible differences in the mechanisms of action of these lymphokines ... In addition, mutations of the ILRE sequence which impair the binding of this nuclear factor abolished the induction of IL-6 gene expression by IL-1 and TNF-alpha in vivo ... These results indicate that a nuclear factor indistinguishable from NF-kappa B is involved in the transcriptional activation of the IL-6 gene by IL-1 and TNF-alpha
Libert et al., Eur J Immunol 1990 : We conclude that IL 1 is a potent inducer of IL 6 in vivo and that no major differences are observed between the four IL 1 preparations, as evaluated at 3 h after the injection
Pang et al., Clin Exp Immunol 1994 : The increased mRNA expression of GM-CSF, IL-1 alpha, IL-1 beta, IL-6 and IL-8 in response to IL-1 alpha and LPS stimulation was time- and dose dependent
Shi et al., Inflamm Res 2004 (Chondrosarcoma...) : IL-1 , but not TNF-alpha, can induce IL-6 , bone morphogenic protein 2 (BMP-2), and cyclooxygenase ( COX-2 ) expression in SW1353 cells
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1 , IL-4, tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations ... Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6) , and IL-8 in response to IL-1 , IL-4, tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Schimke et al., J Clin Immunol 2013 (Ectodermal Dysplasia...) : Patient whole blood cells failed to secrete IL-6 in response to IL-1ß , Pam2CSK4, showed reduced responses to LPS and PMA/Ionomycin, and lacked IL-10 production in response to TNF-a
Kirchmeyer et al., Arthritis Res Ther 2008 (MAP Kinase Signaling System) : Among RAR and RXR agonists, only ATRA inhibited IL-1 induced IL-6 expression in rat synovial fibroblasts by inhibiting ERK1/2 pathway and subsequent activation of AP-1 and NF-IL-6 independently of RAR
Loppnow et al., Cell Immunol 1989 : Adult human vascular endothelial cells express the IL6 gene differentially in response to LPS or IL1
Nakamura et al., Eur J Oral Sci 2011 (Gingivitis) : Therefore, in the present study the expression of the angiotensin II type 1 receptor (AT1R) was investigated in inflamed human gingival tissue, and the possible involvement of the AT1R in interleukin-1ß (IL-1ß) induced interleukin-6 (IL-6) production by cultured human gingival fibroblasts ( HGFs ) was also studied ... The data suggest that the AT1R may be involved in the regulation of gingival inflammation by modulating IL-1ß induced IL-6 production in HGFs
Beyaert et al., Cytokine 1991 : This study shows the in vitro effect of LiCl on the TNF induced or interleukin 1 (IL-1) induced expression of IL-6 , granulocyte-macrophage colony stimulating factor ( GM-CSF ), IL-3, IL-2, and the IL-2 receptor-alpha ( IL-2R alpha ) ... However, LiCl potentiated the IL-1 induced synthesis of IL-6 , GM-CSF, IL-3, and IL-2 in PC60 murine T-cell hybridoma cells
Palmer et al., Cytokine 2005 (Osteosarcoma) : Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells : Differential inhibitory effect of interleukin-1 receptor antagonist ( icIL-1Ra1 )
Tanabe et al., Journal of neuroinflammation 2011 : We previously reported that interleukin (IL)-1ß stimulates IL-6 synthesis from rat C6 glioma cells and that IL-1ß induces phosphorylation of inhibitory kappa B ( I?B ), p38 mitogen activated protein ( MAP ) kinase, stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase 1/2, and signal transducer and activator of transcription ( STAT ) 3 ... It has been shown that p38 MAP kinase is involved in IL-1ß induced IL-6 release from these cells ... In the present study, we investigated the effect of midazolam on IL-1ß induced IL-6 release from C6 cells, and the mechanisms of this effect ... Midazolam, but not propofol, inhibited IL-1ß stimulated IL-6 release from C6 cells ... These results strongly suggest that midazolam inhibits IL-1ß induced IL-6 release in rat C6 glioma cells via suppression of STAT3 activation
Bruno et al., Blood 1991 : However, the addition of IL-1 alpha to CD34+ DR+ cultures containing IL-6 resulted in the appearance of CFU-MK derived colonies, suggesting that IL-6 requires the presence of IL-1 alpha to exhibit its MK colony stimulating activity ( MK-CSA )
Aikawa , Nihon Geka Gakkai Zasshi 1996 (Multiple Organ Failure...) : In response to surgical insults, macrophages produce and release TNF and IL-1 which subsequently induce the production of other cytokines ( IL-6 , IL-8, etc. ) and other endogenous chemical mediators ( growth factors, adhesion molecules, complement cleavage products, thrombin, eicosanoids, PAF, nitric oxides, oxygen-free radicals, granulocyte elastase, etc. )
Fuse et al., Lymphokine Cytokine Res 1992 (Cell Transformation, Neoplastic...) : The induction of IL-6 and gelatinase B by IL-1 in mouse cell lines transformed with bovine papillomavirus : decreased production in tumorigenic cells
Itoh et al., J Immunol 1999 (Melanoma) : IL-1 induced IL-6 production was also suppressed by SB203580
Yoshida et al., J Biol Chem 2004 : These data argue for a novel transcription factor cross-talk mechanism that may help resolve inconsistencies previously reported regarding the mechanism of IL-1 inhibition of IL-6 activity during the acute-phase response
Kato et al., Cell Signal 2012 : In the present study, we investigated the role of AMPK in the interleukin-1 (IL-1) stimulated IL-6 synthesis in osteoblast-like MC3T3-E1 cells ... Transfection of AMPK siRNA-a also amplified the IL-1 stimulated IL-6 release compared to the control cells ... Wedelolactone, an inhibitor of I?B kinase, which reduced the phosphorylation both of I?B and NF-?B, significantly enhanced the IL-1 stimulated IL-6 synthesis
Neta et al., Blood 1990 : Interleukin-1 (IL-1) is radioprotective and induces both circulating colony stimulating factor ( s ) ( CSF ) and IL-6 in mice ... Similarly, 30 micrograms of 35F5 reduced by 96 % to 98 % the induction of IL-6 by IL-1
Marin et al., Toxicology 1996 : In the presence of LPS and CPA, however, IL-1 beta and IL-6 mRNA levels gradually increased up to 24 h reaching 2.5 and 29-fold higher than controls, respectively
Kent et al., J Periodontol 1999 (Periodontal Diseases) : Taken together, these results indicate heterogeneity among gingival fibroblasts and an additive effect of IL-1 and P. gingivalis LPS on IL-6 production by HGF
Strassmann et al., J Immunol 1993 (Cachexia...) : Both IL-1R antagonist (IL-1RA) and the mAb 35F5 directed against IL-1R type I, prevented binding of radioactive IL-1 , and inhibited IL-1 induced IL-6 synthesis by the C-26 cell line
del Rey et al., Pain 2011 (Chronic Pain...) : In WK rats, only SNI induced sustained upregulation of hippocampal interleukin (IL)-1ß , while IL-6 expression was transiently increased and no significant changes in IL-1ra expression were detected
Miyazawa et al., J Allergy Clin Immunol 1999 (Arthritis, Rheumatoid...) : Enhanced IL-6 production by high producing clones was independent of cytokines from other cell populations or autocrine production of tumor necrosis factor-alpha and IL-1
Araki et al., Int J Cancer 1994 (Melanoma) : Resistant cells appeared to produce constitutively IL-6 more than sensitive cells, and IL-6 production both in sensitive and in resistant cells was augmented by exogenous IL-1 ... These data indicate that the resistance is not the result of loss of functional IL-1R and that IL-1 induces IL-6 in an autocrine manner
Chida et al., Biochem Biophys Res Commun 2007 (Fever) : Only IL-1alpha , but not TNFalpha, induced IL-6 in the IL-1alpha/beta/TNFalpha KO mouse brain, while both cytokines induced cyclooxygenase (Cox)-2
Richards et al., Cytokine 1991 : IL-1 alpha and tumor necrosis factor markedly induced steady state levels of IL-6 at 20 h in serum-free conditions, whereas transforming growth factor-beta ( TGF-beta ), epidermal growth factor, and 10 % fetal calf serum did not
Pied et al., J Immunol 1992 (Malaria) : IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite
Onyia et al., J Cell Biochem 1997 (Osteosarcoma) : These results demonstrate PTH, forskolin, the PTHrP analog RS-66271, and IL-1 alpha stimulate IL-6 expression by stimulating gene transcription
Sinfield et al., Biochem Biophys Res Commun 2013 : Selective p38a siRNA gene silencing reduced IL-1a induced IL-6 and MMP-3 mRNA expression and protein secretion, without affecting IL-1a induced IL-1ß and MMP-9 mRNA expression ... In conclusion, human CF express the a, ? and d subtypes of p38 MAPK, and the a subtype is important for IL-1a induced IL-6 and MMP-3 expression in this cell type
Spangelo et al., Neuroimmunomodulation 1995 : Similarly, IL-1 and TNF alpha affect granulosa cell steroidogenesis and IL-6 production
Tsuyuoka et al., Eur J Cancer 1994 (Lung Neoplasms) : These results indicate that CSF producing tumours can be characterised by their constitutive IL-1 production, IL-1 receptor expression and IL-1 dependent excess production of G-CSF and IL-6
Grosset et al., Blood 1995 : In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells : differential regulation by interleukin-1 alpha and glucocorticoids
Schindler et al., Lymphokine Res 1989 : IL-6 also reduced IL-1 induced IL-1 but was approximately 300-fold less potent than the two interferons
Tashima et al., Chem Pharm Bull (Tokyo) 1997 : Several polyenylidene thiazolidine or 2-thioxo-4-thiazolidinone derivatives were synthesized and their retinoidal activities were examined in terms of the differentiation inducing ability towards human promyelocytic leukemia HL-60 cells and inhibitory effect on interleukin (IL)-1 alpha induced IL-6 production in MC3T3-E1 cells ... All the thiazolidines examined also inhibited IL-1 alpha induced IL-6 production with IC50 values of 10 nM order
Nadlonek et al., Ann Thorac Surg 2013 (Aortic Valve Stenosis...) : The IL-1ß stimulation resulted in significantly increased production of the inflammatory cytokines, IL-6 and IL-8, the chemokine monocyte chemoattractant protein-1, and intercellular adhesion molecule-1
Kagechika et al., Biochem Biophys Res Commun 1997 : Inhibition of IL-1 induced IL-6 production by synthetic retinoids ... None of the synthetic retinoids examined stimulated IL-6 production, but all of them strongly inhibited IL-6 production induced by mouse IL-1 alpha ... Among three retinoid antagonists, two weak antagonists exhibited similar inhibition of mouse IL-1 alpha induced IL-6 production, whereas a potent retinoid antagonist, 4- ( 13H-10,11,12,13-tetrahydro-10,10,13,13,15-pentamethyl-dinaph tho[2,3-b ] [ 1,2-e ] diazepin-7-yl ) benzoic acid ( LE540, 14 ), enhanced IL-6 production under the same conditions
Ostberg et al., FEBS Lett 1995 : Similar fibronectin induced dependence was demonstrated for IL-1 regulation of IL-6 gene expression, supporting the notion of a general effect of fibronectin receptor engagement on IL-1 induced signal transduction
Elias et al., J Immunol 1990 : IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA
Harcourt et al., Virology 1998 : In contrast, induction of IL-6 and ICAM-1 by IL-1 is intact in EZ-infected cells
Szabo et al., J Clin Immunol 1991 (Burns...) : Interleukin-6 induction by FcRI stimulation is not mediated solely by FcRI induced M phi tumor necrosis factor alpha, IL-1 alpha , or IL-1 beta production and is independent of M phi prostaglandin E2 levels
Moreb et al., Exp Hematol 1989 : In view of the recent reports that IL-1 induces interleukin 6 (IL-6) in fibroblasts and macrophages and that IL-6 and interleukin 3 (IL-3) are the main growth factors for B1-CFC, we have examined the ability of these interleukins to protect early human hematopoietic progenitor cells from the cytotoxic effects of 4-HC
Zumwalt et al., Endocrinology 1999 (Glioma) : In the presence of ( Bu ) 2cAMP, IL-1beta induced a strongly synergistic response with respect to IL-6 release ; thus, the combination of these two agents resulted in a release of IL-6 that was much larger that the release attributed to either agent alone ( i.e. 30-fold higher )
Aronica et al., Neuroscience 2005 : Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1beta stimulated release of IL-6 in cultured human astrocytes
Hedges et al., Infect Immun 1994 : IL-1 alpha induced significantly higher levels of IL-6 secretion than did E. coli Hu734 or TNF-alpha
Loppnow et al., J Cell Mol Med 2011 : Recombinant IL-1 , tumour necrosis factor-a and IL-6 mediated the synergistic IL-6 production
Fruchart et al., Curr Opin Lipidol 1999 (Arteriosclerosis...) : It inhibits inducible nitric oxide synthase in macrophages and prevents the IL-1 induced expression of IL-6 and cyclooxygenase-2, as well as thrombin induced endothelin-1 expression, as a result of a negative transcriptional regulation of the nuclear factor-kappa B and activator protein-1 signalling pathways
Takematsu et al., Tohoku J Exp Med 1994 (Blister...) : IL-1 induces IL-6 production in vitro, which in turn stimulates the proliferation of human keratinocytes
Lieb et al., J Neurochem 1996 (Astrocytoma) : For a better understanding of their pathogenic role, we analyzed signal transduction pathways mediating the interleukin (IL)-1 beta induced synthesis of IL-6 and tumor necrosis factor alpha (TNF alpha) in the human astrocytoma cell line U373 MG
Clérigues et al., Clin Sci (Lond) 2012 (Bone Resorption...) : Treatment with the HO-1 inducer CoPP ( cobalt protoporphyrin IX ) counteracted the stimulatory effects of IL-1ß on IL-6 , nitrite, PGE2 ( prostaglandin E2 ), TGF ( transforming growth factor ) ß2, TGFß3 and osteocalcin
Rifas et al., Endocrinology 1995 : To investigate this hypothesis in a human model, we have examined 12 separate strains of normal human osteoblasts ( HOB ) and 11 separate strains of human bone marrow stromal cells ( HBMSC ) and determined whether ovarian steroids regulate the induction of IL-6 by interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) or IL-1 + TNF
Ito et al., Jpn J Cancer Res 1997 (Adenocarcinoma...) : These findings indicate that IL-6 induced by IL-1 alpha is an autocrine growth factor for some gastric carcinomas
Lonnemann et al., Kidney Int 1995 (Fibrosis...) : II. Intrinsic interleukin (IL)-1 synthesis and IL-1 dependent production of IL-6 and IL-8 by cultured kidney fibroblasts ... Spontaneous IL-8 and IL-6 synthesis by renal fibroblasts was dependent on the intrinsic release of IL-1 , since blocking IL-1 receptors with IL-1 receptor antagonist (IL-1Ra) partially inhibited the constitutive production of these cytokines
Yang et al., J Biochem 1995 (Melanoma) : All the transfectant cell lines, but not progenitor A375-5 cells, expressed functional type I IL-1 receptors and could produce IL-6 in response to IL-1 , suggesting that the unresponsiveness of A375-5 melanoma cells is exactly due to an IL-1 receptor deficiency
Nietfeld et al., Arthritis Rheum 1990 (Arthritis, Rheumatoid...) : However, IL-1 induced massive production of IL-6 ( up to 135 ng/ml ) in cartilage from all 3 sources, in a dose dependent manner ( in some cases, a peak value was reached )
Cahill et al., J Biol Chem 2008 : Overexpression of either dominant negative AKT or IkappaB kinase alpha mutant, IKKalphaT23A, containing a mutation in a functional AKT phosphorylation site, shown previously to be important for NFkappaB activation, completely abrogated IL-6 promoter activation in response to IL-1 ... This novel pathway is a parallel pathway to the PI 3-kinase/AKT upstream of NFkappaB and both are involved in IL-6 gene transcription in response to IL-1
Yamaguchi et al., Acta Endocrinol (Copenh) 1990 : These findings suggest that IL-1 induced the release of IL-6 from rat pituitary, and that the released IL-6 stimulated the secretions of FSH, LH and PRL
Lubin et al., Immunology 2003 : Finally, culture of the Caco-2 cells on laminin type 5 ( the major ligand for this integrin ) yielded depressed levels of IL-1 induced IL-6 secretion as compared to cells on laminin type 1
Delerive et al., J Biol Chem 1999 (Phlebitis) : In human aortic SMC, fibrates inhibit IL-1 induced IL-6 gene expression
Fantuzzi et al., Am J Physiol 1997 (Inflammation) : In IL-1 beta +/+ mice, IL-1ra inhibited production of IL-6 after zymosan, without affecting TNF-alpha synthesis ... There was no further inhibitory effect of IL-1ra on IL-6 production in IL-1 beta -/- mice, suggesting no role for IL-1 alpha in zymosan induced IL-6
Wagteveld et al., Leukemia 1992 (Leukemia, Myeloid, Acute) : IL-1 induced the endogenous secretion of GM-CSF, IL-6 , and TNF in most cases ... In contrast, no secretion of growth factors was induced by IL-4, whereas in 2 cases IL-4 suppressed the IL-1 induced secretion of GM-CSF, TNF, and IL-6
Turner et al., Am J Physiol Heart Circ Physiol 2009 (MAP Kinase Signaling System...) : IL-1alpha ( 0.001-10 ng/ml, 0-6 h ) stimulated IL-1beta, TNF-alpha, and IL-6 mRNA expression with distinct temporal and concentration profiles, resulting in increased cytokine secretion ... IL-1alpha induced IL-6 mRNA expression was reduced by p38 MAPK inhibition, but increased by ERK and JNK pathway inhibitors ... IL-10 produced a consistent but modest reduction in IL-1alpha induced IL-6 mRNA levels ( not IL-1beta or TNF-alpha ), but this was not reflected by reduced IL-6 protein secretion
Kita et al., Nat Immun 1992 : CK-M stimulated thioglycollate induced peritoneal macrophages to produce interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) at concentrations of 1-100 ng/ml, and it also induced IL-2 and interferon-gamma (IFN-gamma) as well as IL-6 production by splenocytes
Boxman et al., Arch Dermatol Res 1996 : The present study aimed to examine the role of fibroblasts in the regulation of proinflammatory IL-1, IL-6 and IL-8 levels induced by keratinocyte derived IL-1 ... The IL-1 alpha induced increase in IL-8 and IL-6 production, both on the protein level as well as on the mRNA level, were concentration dependent and occurred almost simultaneously
Roldán et al., J Immunol 1992 : Finally, IL-1 beta plus TNF-alpha induced the production of IL-6 , but not of Ig, by adherent BM cells
Shirakawa et al., Mol Cell Biol 1993 : One of the essential proteins which bound to the enhancer was similar or identical to members of the C/EBP family of transcription factors required for both IL-1- and LPS-specific induction of the IL-6 gene ( i.e., the NF-IL6 proteins )
Lok et al., J Lab Clin Med 2006 (Pre-Eclampsia) : IL-1alpha enhanced the expression of IL-1alpha, IL-2, IL-6 , and IL-8 ; nuclear factor of kappa light chain enhancer in B-cells ( NFkappaB ) -1, NFkappaB-2, and NFkappaB-inhibitor ; cyclin dependent kinase inhibitor and monocyte chemotactic protein-1 ; and transiently increased tissue factor expression
Layé et al., Neuroimmunomodulation 2001 (Inflammation) : In wild-type controls, IL-1 and LPS activated the hypothalamic-pituitary-adrenal axis and increased plasma IL-6
Tsakiri et al., Mol Cell Neurosci 2008 : Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones ... The objective of this study was to test the hypothesis that IL-1alpha and beta differentially regulate the expression of IL-6 and chemokines KC, IP-10 and MCP-1 in primary neurones
Yoshida et al., Int Immunol 1999 (Arthritis, Rheumatoid) : In this study, we examined the effect of one of the monovalent gold compounds, aurothioglucose ( AuTG ), on the IL-1 induced production of IL-6 , IL-8 and granulocyte macrophage colony stimulating factor ( GM-CSF ) from rheumatoid synovial fibroblasts ( RSF ) isolated from three RA patients
Tipton et al., J Periodontal Res 2011 (Necrosis) : BPs generally further increased the production of LPS- or IL-1ß stimulated IL-6 ( p = 0.04 ) and had no effect on, or further increased, the production of LPS- or IL-1ß stimulated OPG ( p = 0.04 )
Nietfeld et al., Arthritis Rheum 1994 : To prevent the negative effects of interleukin-1 (IL-1) and IL-1 induced IL-6 on cartilage proteoglycan ( PG ) synthesis, we used an antisense oligonucleotide ( ASO ) specific for IL-6 messenger RNA ( mRNA ) to inhibit IL-6 production ... The IL-6-ASO prevented IL-1 induced production of IL-6 in the cartilage explants, as well as IL-1 induced inhibition of PG synthesis ... The IL-6-ASO used can penetrate the extracellular matrix of articular cartilage, enter the chondrocytes, and inhibit the IL-1 induced production of IL-6 ... The effect of exogenous IL-6 shows that IL-1 requires IL-6 for inhibition of PG synthesis
Miwa et al., Endocrinology 1999 : Mitogen activated protein ( MAP ) kinases are involved in interleukin-1 (IL-1) induced IL-6 synthesis in osteoblasts : modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1 activated protein kinase C ... We previously reported that interleukin-1alpha (IL-1alpha) induced activation of protein kinase C ( PKC ) via phosphatidylcholine-specific phospholipase C ( PC-PLC ) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells ... In the present study, we further investigated the mechanism behind IL-1alpha induced IL-6 synthesis in MC3T3-E1 cells ... PD98059, a specific inhibitor of the upstream kinase that activates p42/p44 MAP kinase, inhibited the IL-1alpha induced IL-6 synthesis as well as the phosphorylation of p42/p44 MAP kinase induced by IL-1alpha ... 1-Oleoyl-2-acetylglycerol, an activator of PKC, suppressed the IL-1alpha induced IL-6 synthesis ... These results strongly suggest that IL-1alpha induced IL-6 synthesis is mediated via activations of both p42/p44 MAP kinase and p38 MAP kinase in osteoblasts, and that PKC activated by IL-1alpha itself negatively regulates IL-6 synthesis at a point upstream from p42/p44 MAP kinase
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Higgins et al., J Immunol 1999 (Scleroderma, Systemic) : In contrast, IL-1 stimulated levels of MCP-1 and IL-6 were not different in control and preIL-1 alpha transduced fibroblasts
Parker et al., Br J Pharmacol 2002 (MAP Kinase Signaling System) : 4. In wildtype mice, inhibition of p38 or ERK1/2 MAPKs significantly reduced IL-1beta induced IL-6 release, whilst the NFkappaB inhibitor caffeic acid phenethyl ester ( CAPE ) modulated IL-1 induced IL-6 release by action on NFkappaB and MAPKs pathways
McMillan et al., Am J Physiol Lung Cell Mol Physiol 2013 : miR-146a overexpression ablated the effects of RelB downregulation on IL-1ß induced Cox-2, PGE2, and IL-6 production, suggesting that RelB mediates IL-1ß induced inflammatory mediator production in lung fibroblasts through miRNA-146a
Bergamaschi et al., Cell Signal 2006 : Synergistic effects of cAMP dependent signalling pathways and IL-1 on IL-6 production by H19-7/IGF-IR neuronal cells ... In this study, we characterized IL-1 induced IL-6 production in hippocampal cells using H19-7/IGF-IR cells and investigated the effect of changes in intracellular cAMP levels on IL-1 activity ... IL-1 potently induced IL-6 mRNA expression with a corresponding increase in IL-6 release, in a time- and dose dependent manner with a maximal at 24 h and with an EC50 value of 0.11 ng/ml. Cell pre-treatment with the IL-1sR antagonist produced a rightward shift of IL-1 dose-response effect with a corresponding decrease in IL-1 potency ... IL-1 induced IL 6 release was attenuated in the presence of the p38 MAPK inhibitor SB203580 but was not significantly affected by the PKA inhibitor KT 5720 ... However, in the presence of IL-1 , IL-6 production was further potentiated by either dbcAMP and rolipram, reaching 300 % and 500 % IL-1 induced levels
Vézina Audette et al., Osteoarthritis Cartilage 2013 : LPS and IL-1ß significantly increased the expression of pro-inflammatory cytokines ( TNF-a, IL-8 and IL-6 ; and IL-1ß and IL-8 respectively )
Bouchelouche et al., J Urol 2006 : Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF
Francis et al., Melanoma Res 1996 (Melanoma...) : These investigations were designed to test the hypothesis that exogenous and/or endogenous interleukin-1 (IL-1) regulates interleukin-6 (IL-6) production in human melanoma cell lines ... Experiments employing the IL-1 receptor antagonist confirmed an extracellular receptor mediated role of IL-1 in regulation of IL-6 production in such cells ... These results indicate that IL-1 can regulate IL-6 in human melanoma cells ; however, heterogeneity in the constitutive expression as well as variability in response exists with respect to these two cytokines
Makó et al., Cytometry A 2010 : Moreover, expression of E-selectin, IL-6 , and IL-8 was induced most efficiently by IL-1ß , while LPS and TNF-a had less effect, whereas we did not find such a difference in ICAM-1 and MCP-1 expression
Zitnik et al., J Immunol 1994 : Retinoic acid inhibition of IL-1 induced IL-6 production by human lung fibroblasts ... They also did not appear to involve alterations in the early events in IL-1 induced IL-6 production, because RA inhibited IL-6 production even when added 6 h after IL-1 and RA did not inhibit IL-1 binding to cell surface IL-1 receptors ... 13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1 induced IL-6 production ... These studies demonstrate that RA and other retinoid analogs inhibit IL-1 induced IL-6 production and that this effect is analog-specific and, at least partially, transcriptionally mediated
Blom et al., Brain Res 1997 (Astrocytoma) : Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta activated IL-6 release from A157 astrocytes and largely potentiated the IL-1 induced release of IL-6 from all astrocytes/astroglioma cells tested
Nakazato et al., Kidney Int 1998 : Interleukin (IL)-1 and IL-4 synergistically stimulate NF-IL6 activity and IL-6 production in human mesangial cells ... Both IL-1 and IL-4 stimulated NF-IL6 activity as early as 30 minutes after treatment ... These results suggest that simultaneous activation of NF-kappa B and NF-IL6 is essential for IL-6 gene expression and that IL-1 and IL-4 cooperatively stimulate MC IL-6 production through their synergistic activation of NF-IL6
Lu et al., Stem Cells 1995 (Multiple Myeloma) : An interleukin 1 receptor antagonist blocks the IL-1 induced IL-6 paracrine production through a prostaglandin E2-related mechanism in multiple myeloma ... These results show that induction of IL-6 by IL-1 is related to PGE2 in the bone marrow of patients with MM. Inhibition of PGE2 synthesis ( as obtained with indomethacin and the IL-1RA ) might be helpful to inhibit myeloma cell proliferation by reducing IL-1 induced endogenous IL-6 production not only in vitro ( as demonstrated here ) but also in vivo
Hashimoto et al., Inflammation 1992 : Both IL-1 and TNF induced PCA, reduced TM, and induced IL-6 production in a dose dependent manner ... IFN-gamma, however, when added in combination with either IL-1 or TNF, modulated the effects of these cytokines ; INF-gamma inhibited the PCA expression and enhanced the reduction of TM and the production of IL-6 , which were induced by either IL-1 or TNF
Van de Loo et al., Cytokine 1997 : We studied the role of IL-6 and nitric oxide ( NO ) in IL-1 and leukaemia inhibitory factor (LIF) induced suppression of proteoglycan synthesis
Kondo et al., Arch Biochem Biophys 2013 : Inhibition of SAPK/JNK leads to enhanced IL-1 induced IL-6 synthesis in osteoblasts ... We previously reported that interleukin 1 (IL-1) stimulates the synthesis of interleukin 6 (IL-6) through activation of ERK and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that AMP activated protein kinase (AMPK) negatively regulates the IL-1 induced IL-6 synthesis through I?B/NF-?B pathway ... In the present study, we investigated the role of SAPK/JNK in the IL-1 stimulated IL-6 synthesis in these cells ... SP600125, an inhibitor of SAPK/JNK, increased the release and the mRNA expression levels of IL-6 induced by IL-1 ... IL-1 stimulated IL-6 release was significantly up-regulated in SAPK/JNK knocked down cells ... SP600125 enhanced IL-1 stimulated IL-6 release also in normal human osteoblasts
Kawaguchi et al., J Rheumatol 2004 (Fibrosis...) : Inhibition of IL-1alpha expression in SSc affected fibroblasts using antisense constructs resulted in decreased proliferation, IL-6 production, and procollagen synthesis
Chida et al., Endocrinology 2005 : The induction of CRH transcript in the paraventricular nucleus at 6 h and plasma IL-6 levels, in response to IL-1alpha , were reduced in IL-1alpha/beta KO mice ... Because IL-1alpha induced activation of signal transducer and activator of transcription 3 in the AP was also suppressed in IL-6 KO mice, we suggest that plasma IL-6 is first induced by IL-1alpha , and IL-6 activates signal transducer and activator of transcription 3 in the AP, leading to the induction of POMC in concert with CRH
Robson et al., Kidney Int 1995 : In marked contrast cholera toxin ( CT ) caused a dose dependent potentiation of both IL-1 induced IL-6 ( approximately fourfold ) and IL-8 peptide ( approximately twofold ) generation ... Thus our data show that cAMP can potentiate IL-1 induced IL-6 production, while having no effect on IL-8 induction, and PGE2 may operate via a positive feedback loop to up-regulate IL-1 induced IL-6
Sauter et al., Cancer Biol Ther 2011 : Studies with IL-1R-deficient mice demonstrate that IL-1 signaling plays a role in doxorubicin induced increases in IL-6 and GCSF
Suzuki et al., Cytokine 2010 (MAP Kinase Signaling System) : Moreover, IL-6+sIL-6R significantly augmented expression of IL-1RI, but not IL-1RII , in SW982 cells ... Finally, IL-6+sIL-6R induced IL-1RI expression was inhibited by a STAT pathway inhibitor, but not a MAPK pathway inhibitor
Helle et al., Eur J Immunol 1988 : Together with the observation that IL 1 induces IL 6 in a variety of cells including thymocytes, our data suggest that IL 6 is involved in many of the pleiotropic effects of IL 1
Miller et al., Br J Pharmacol 1997 (Fever...) : The results also indicate that IL-1 produced locally may contribute to the production of IL-6 which is released into the circulation, and that IL-1 has important actions in the generation of fever at other sites, including the brain
Coceani et al., Brain Res 1993 (Fever) : In addition, by the same route, IL-1 caused a rise in IL-6
Guerne et al., J Immunol 1990 : The inflammatory cytokines IL-1 , and, to a lesser extent, TNF-alpha and IFN-gamma increased IL-6 production ... Hydrocortisone, at 10 ng/ml, reduced IL-1 induced IL-6 production by more than 50 % ... Metabolic labeling and immunoprecipitation studies showed that IL-1 induced de novo synthesis of IL-6 and that the IL-6 proteins secreted by chondrocytes were similar to those from fibroblasts
Thorn et al., Amyloid 2002 : The Saa1 and Saa2 promoters are strongly induced by IL-6 , with synergistic upregulation of Saa2, but not of Saa1, by IL-1 or TNF
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6 , IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß , a significant potentiation of protein and mRNA expression, as well as MMP activity was observed
Kozawa et al., J Cell Biochem 1997 : Protein kinase C activation by interleukin (IL)-1 limits IL-1 induced IL-6 synthesis in osteoblast-like cells : involvement of phosphatidylcholine-specific phospholipase C ... We investigated the regulatory mechanism of interleukin-6 (IL-6) synthesis induced by interleukin-1 (IL-1) in osteoblast-like MC3T3-E1 cells ... IL-1 stimulated the secretion of IL-6 in a dose dependent manner in the range between 0.1 and 100 ng/ml. Staurosporine and calphostin C, inhibitors of protein kinase C ( PKC ), significantly enhanced the IL-1 induced secretion of IL-6 ... The IL-1 induced IL-6 secretion was significantly enhanced by D-609
Wei et al., Spine (Phila Pa 1976) 2013 : IL-1 induced nitric oxide, prostaglandin E-2, and IL-6 accumulation were also reduced by ERK inhibition
Isshiki et al., Mol Cell Biol 1990 (Glioma) : In this study, we have investigated cis acting regulatory elements and trans acting factors responsible for IL-1 induced IL-6 gene expression
Schoeniger-Skinner et al., Brain Behav Immun 2007 (Pain) : While the literature predominantly documents the cascade of pro-inflammatory cytokines as beginning with TNF, followed by the stimulation of IL-1, and finally TNF plus IL-1 stimulating the release of IL-6 , the present findings indicate that a blockade of IL-6 inhibits the gp120 induced elevations of TNF, IL-1, and IL-6 mRNA in dorsal spinal cord, elevation of IL-1 protein in lumbar dorsal spinal cord, and TNF and IL-1 protein release into the surrounding lumbosacral cerebrospinal fluid
Helle et al., Prog Clin Biol Res 1991 : Whereas PMA induced IL-6 production in endothelial cells and it potentiated the induction of IL-6 by IL-1 in these cells, it inhibited LPS stimulated IL-6 production in monocytes
Sawada et al., Biomed Res 2013 (Inflammation...) : IL-1ß increased significantly both gp130 and IL-6 expression in HGFs. IL-6 increased significantly sIL-6R production in THP-1 macrophages but not HGFs. Co-stimulation with IL-1ß and IL-6/sIL-6R induced dramatically the phosphorylation of Stat3, ERK and JNK in HGFs. Interestingly, expression of various inflammation- related molecules such as MMP-1, MCP-1, IL-1ra, bFGF and VEGF were enhanced by co-stimulation with IL-1ß and IL-6/sIL-6R in HGFs. Gingival inflammation is regulated by HGFs affected by both IL-1ß and IL-6/sIL-6R synergistically through induction of gp130 expression, resulting in progression of periodontitis
Kirnbauer et al., J Invest Dermatol 1991 : Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1 induced IL-6 mRNA expression and production by EC
Busam et al., J Hepatol 1990 : The secretion of IL-6 could also be induced by interleukin (IL)-1 beta and tumor necrosis factor ( TNF-alpha )
Erinjeri et al., J Vasc Interv Radiol 2013 (Neoplasms) : There was a significant increase in the plasma level of IL-6 after ablation compared with before ablation ( 9.6-fold±31-fold, P < .002 ). IL-10 also showed a significant increase after ablation ( 1.9-fold±2.8-fold, P < .02 ). Plasma levels of IL-1a , IL-2, and TNF-a were not significantly changed after ablation. Cryoablation resulted in the largest change in IL-6 level ( > 54-fold ), whereas radiofrequency ablation and microwave ablation showed 3.6-fold and 3.4-fold changes, respectively
Shinmei et al., J Rheumatol Suppl 1991 (Osteoarthritis) : IL-6 production was induced by IL-1 alpha and TNF-alpha
Ebihara et al., Invest Ophthalmol Vis Sci 2011 (Keratitis...) : IL-1 derived from necrotic corneal epithelial cells induced the production of IL-6 by corneal fibroblasts
Louie et al., J Acquir Immune Defic Syndr Hum Retrovirol 1995 (Acquired Immunodeficiency Syndrome...) : As expected, IL-1ra also blocks IL-1 mediated upregulation of IL-6 and bFGF, both of which are autocrine growth factors for KS
Kang et al., Cell Immunol 1996 (Disease Models, Animal...) : When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90 %, but the production of interleukin-6 (IL-6) was not inhibited at all
Radstake et al., PloS one 2009 (Disease Progression...) : In line with these observation, circulating levels of IL-17 inducing cytokines IL-6 , IL-23 and IL-1alpha were increased in all or subsets of SSc patients
Ito et al., J Immunol 1999 : The increased binding of IL-1 was completely inhibited by an Ab against murine IL-1RI, indicating that Dex and IL-6 augmented the expression of cell surface IL-1RI molecule ... These results indicate that GC and IL-6 augment the expression of cell surface IL-1RI in hepatocytes, as well as IL-1 signaling and IL-1R associated kinase activation, through up-regulation of IL-1RI mRNA level, which represents a novel regulatory network between IL-1, GC, and IL-6
Zeyse et al., Biol Reprod 2000 : Induction of interleukin-1alpha production in murine Sertoli cells by interleukin-1
Loppnow , Prog Clin Biol Res 1994 : S-form LPS and IL1 stimulated IL6 production and adhesion differentially
Agrawal et al., Immunology 2003 : Its expression is modestly induced by interleukin (IL)-6 in Hep3B cells while IL-1 , which alone has no effect, synergistically enhances the effects of IL-6
Sadowska et al., Int J Dev Neurosci 2012 (Brain Ischemia...) : In conclusion, IL-1ß and IL-6 exhibit developmental regulation in fetal brain, change during gestation in brains of pregnant ewes, show regional differences in normal brains of fetuses and ewes, demonstrate differential responses after ischemia in CC and WM, and IL-1ß but not IL-6 increases after ischemia in CC
Romero et al., Neuroendocrinology 1993 : Bacterial lipopolysaccharide induction of IL-6 in rat telencephalic cells is mediated in part by IL-1 ... Since LPS is known to induce secretion of interleukin-1 (IL-1) in many cell types including those of the brain, and IL-1 can induce IL-6 in brain tissue it appeared reasonable to postulate that the effects of LPS on IL-6 production were mediated through IL-1 induction ... To test this hypothesis, the effects of IL-1 receptor antagonist (IL-1Ra) on LPS and IL-1 induced IL-6 secretion were tested in a mixed brain cell culture from 17-day fetal rat, after 12-14 days in culture
Chung et al., J Invest Dermatol 1996 : Ultraviolet B irradiation enhanced interleukin (IL)-6 production and mRNA expression are mediated by IL-1 alpha in cultured human keratinocytes ... Because IL-1 is a potent inducer of IL-6 , one may speculate that the release of IL-6 by keratinocytes after UV exposure is mediated via the release of IL-1 in an autocrine or paracrine manner ... These results support the hypothesis that UVB irradiation enhanced IL-6 production and mRNA expression may be mediated by IL-1alpha
Persson et al., Biochem Biophys Res Commun 2005 : Furthermore, IL-1beta stimulated IL-6 promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct, and both VIP, and the related neuropeptide PACAP-38, increased the effect of IL-1beta in a synergistic manner
Amano et al., Mol Pharmacol 1993 : DEX was also found to be a potent inhibitor of IL-1 induced expression of the IL-6 gene in connective tissue-type cells from the synovium of patients with rheumatoid arthritis
Oxholm et al., Acta Derm Venereol 1991 (Dermatitis, Contact) : These results demonstrate that enhancement of keratinocyte bound IL-6 does not induce TNF alpha, IL-1 alpha/beta or IL-6 expression by LC during APR or IPR, and that enhanced keratinocyte expression of IL-6 fails to distinguish between these two reactions
Okazaki et al., Biochem Biophys Res Commun 2003 : Unexpectedly, mutants in the TA domain, including S529A, S536A, and S529A/S536A, completely rescued the defect of p65 ( -/- ) MEFs as assessed by tumor necrosis factor (TNF)- or interleukin-1 (IL-1) induced IL-6 production and protection from TNF induced cell death
Gottschall et al., Brain Res 1994 : Also, the neuropeptides PACAP38 and VIP are potential secretagogues for IL-6 secretion, and both peptides synergize with IL-1 to stimulate IL-6 secretion in rat astrocytes
Batey et al., Alcohol Clin Exp Res 1998 (Endotoxemia...) : Decreased IL-1alpha and TNF-alpha production in 24-hr culture supernatants of mononuclear cells isolated from liver perfusate was detected while IL-6 remained unchanged over 20 weeks
Zhang et al., J Biol Chem 1988 : Synthesis of IL-6 is stimulated by interleukin 1 (IL-1) , tumor necrosis factor (TNF), or platelet derived growth factor ... IL-1 and TNF too increased IL-6 mRNA levels by a protein kinase C-independent mechanism ... Our results suggest a role for the cAMP dependent pathway ( s ) in IL-6 gene activation by TNF and IL-1
Tokuda et al., J Endod 2002 : IL-10 inhibited IL-8 mRNA expression, which is normally stimulated by PiLPS, IL-1alpha , and tumor necrosis factor-alpha and inhibited IL-6 mRNA expression, which is normally stimulated by IL-1alpha
Erroi et al., Infect Immun 1993 : Whereas IL-6 had no effect, IL-1 alpha or TNF induced partial tolerance to LPS in terms of inhibition of LPS stimulated TNF and IL-6 production
Cubitt et al., Invest Ophthalmol Vis Sci 1995 : These results demonstrate that both IL-1 alpha and TNF-alpha could induce keratocytes to produce nanogram levels of IL-6 but IL-1 alpha was a 30-fold more effective inducer
Wu et al., Journal of neuroinflammation 2013 (Inflammation...) : The secretions of IL-6 and CXCL10 in response to IL-1ß were unaffected by FTY720 treatment ( s )
Zitnik et al., Am J Physiol 1993 : Recombinant ( r ) tumor necrosis factor (TNF) weakly stimulated, recombinant interleukin-1-alpha ( rIL-1 alpha ) strongly stimulated, and rIL-1 alpha and rTNF in combination synergistically augmented fibroblast IL-6 production
Monick et al., Am J Physiol 1994 : Dexamethasone blocks the induction of IL-6 and IL-8 by IL-1 or TNF ... Both IL-1 and TNF increased release of IL-6 and IL-8 from the cells in a dose dependent manner and dexamethasone inhibited this effect ... Dexamethasone also inhibited the induction of IL-6 and IL-8 RNA by IL-1 and TNF
Lim et al., Reprod Sci 2013 : Transfection of primary amnion cells with apelin siRNA was associated with significantly increased interleukin (IL)-1ß induced IL-6 and IL-8 release and cyclooxygenase-2 messenger RNA ( mRNA ) expression and resultant prostaglandin E2 and prostaglandin F2a release
Rautava et al., J Pediatr Gastroenterol Nutr 2012 : Conditioning with TGF-ß2 significantly attenuated subsequent interleukin (IL)-1ß- , TNF-a-, and poly I:C induced IL-8 and IL-6 responses in immature human IECs
Schaafsma et al., Blood 1989 : Neutralization experiments using an anti-IL-6 antiserum showed that IL-1 induced IL-6 did not contribute to the observed synergy
Ludwiczek et al., Scand J Gastroenterol 2008 (Chronic Disease...) : Cultures of human primary hepatocytes showed that IL-1sRII is induced by IL-1beta, but not IL-6
Daffada et al., FEBS Lett 1999 : CP mRNA was also increased after 16 h by IL-1beta, whereas IL-1alpha induced two CP peaks at 8 and 20 h, while IL-6 had little effect
Kahlke et al., Cytokine 2000 (Hemorrhage...) : In contrast, IL-1beta and IL-6 production by Mbeta from young males was suppressed and IL-10 production enhanced following trauma-haemorrhage, whereas Mstraight phi from aged males produced elevated levels of IL-1beta and IL-6 and suppressed levels of IL-10 following trauma-haemorrhage
Yoon et al., PloS one 2011 (Graves Disease...) : Quercetin significantly attenuated intercellular adhesion molecule-1 ( ICAM-1 ), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1ß induced increases in ICAM-1, IL-6 , and IL-8 mRNA
Yan et al., PloS one 2012 : CCAAT/enhancer binding protein ? is a critical regulator of IL-1ß induced IL-6 production in alveolar epithelial cells ... Importantly, we demonstrate for the first time that C/EBP? plays a critical role in regulating IL-1ß induced IL-6 expression in both mouse primary alveolar type II epithelial cells and a lung epithelial cell line, MLE12
Kandere-Grzybowska et al., J Immunol 2003 : IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells
Kim et al., J Endocrinol 1999 : Thyroid hormone stimulates basal and interleukin (IL)-1 induced IL-6 production in human bone marrow stromal cells : a possible mediator of thyroid hormone induced bone loss ... To determine if interleukin-6 (IL-6) or interleukin-11 (IL-11) could be the mediator ( s ) of thyroid hormone induced bone loss, we studied the effects of 3,5,3'-tri-iodothyronine ( T3 ) on basal and interleukin-1 (IL-1) stimulated IL-6/IL-11 production in primary cultured human bone marrow stromal cells ... These results suggest that thyroid hormone may stimulate bone resorption by increasing basal and IL-1 induced IL-6 production from osteoblast-lineage cells, and these effects are independent of estrogen status
Elliott et al., Eur J Pharmacol 1992 : Although human dermal fibroblasts did not secrete interleukin-1 alpha or interleukin-1 beta, human recombinant interleukin-1 alpha stimulated arachidonic acid metabolism and interleukin-6 synthesis
Papadopoulos et al., Neuroimmunomodulation 2000 : Since endotoxin and IL-1 both stimulate IL-6 , the question arises as to whether the sex-steroid induced suppression of the HPA response to endotoxin and IL-1 results solely from decreased IL-6 release, or whether other mediators are involved
Bersinger et al., Arch Gynecol Obstet 2011 : The release of ENA-78, IL-8 and IL-6 by the isolated and monolayer cultured stromal cell fraction in the presence of IL-1ß ( 0.08 to 50 ng/mL ), TNF-a, and interferon-? ( both 20 to 500 ng/mL ) was determined ... IL-1ß stimulated the production of IL-8, IL-6 , and ENA-78 dose dependently from 0.08 to 2.0 ng/mL ( ENA-78 ) or to 10 ng/mL ( IL-8, IL-6 ) ; at 50 ng/mL a decrease in release was observed for IL-8 and IL-6
Clarke et al., Circ Res 2010 (Hyperlipidemias...) : Necrotic human aortic VSMCs release IL-1alpha , which induces IL-6 and MCP-1 production from viable human VSMCs in vitro
Radons et al., Int J Mol Med 2006 (Chondrosarcoma) : Interleukin-10 does not affect IL-1 induced interleukin-6 and metalloproteinase production in human chondrosarcoma cells, SW1353 ... Surprisingly, IL-10 had no effect on IL-1 induced IL-6 , pro-MMP1, and pro-MMP13 secretion
Faber et al., Nutrition & diabetes 2012 : Gene expression analyses showed that TNF-a and IL-1ß stimulate the adipocyte expression of TNF-a, IL-1ß and IL-6
Tokuda et al., Endocrinology 1998 : Moreover, in the case of IL-1 induced IL-6 synthesis in these cells, we showed that protein kinase C activation by IL-1 limits the IL-6 synthesis ... On the other hand, T3 markedly enhanced IL-1 induced IL-6 synthesis
Matsuzaki , Nihon Sanka Fujinka Gakkai Zasshi 1994 (Chorioamnionitis) : IL-1 and tumor necrosis factor-alpha (TNF-alpha) synergistically augmented IL-6 production to stimulate hCG production
Miyazawa et al., J Biol Chem 1998 (Arthritis, Rheumatoid) : Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes ... In the present study we investigated how the IL-6 promoter is transcriptionally regulated in rheumatoid FLSs in response to a physiologically relevant mediator of inflammation, IL-1beta
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : GSPE also attenuated TNF-a and IL-1ß induced IL-6 productions ( p? < ?0.05 )
Reyes et al., Am J Physiol 1998 (Inflammation) : A second study confirmed that the IL-1 induced IL-6 in CSF was brain derived and not a result of diffusion from blood
Jilma et al., J Lab Clin Med 1997 : Based on previous studies we hypothesized that interleukin-6 (IL-6) plasma levels would increase during the menstrual cycle, in analogy to the increase in IL-1 levels seen during the luteal phase
Woods et al., Cancer Res 1998 (Carcinoma, Squamous Cell...) : To elucidate possible cytokine regulatory pathways that may contribute to oral SCC growth and/or progression, we tested the hypotheses that exogenous and/or endogenous IL-1 regulates IL-6 production in vitro ... Our studies revealed that IL-1 strongly up-regulated IL-6 protein secretion in all three cell lines tested
Garat et al., Cytokine 2003 : Intracellular IL-1Ra type 1 inhibits IL-1 induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen activated protein kinase and NF-kappaB pathways ... icIL-1Ra1 inhibited IL-1 induced IL-6 and IL-8 production ... Specific inhibitors of each MAP kinase pathway decreased IL-1 induced IL-6 and IL-8 production ... In conclusion, these data indicate that icIL-1Ra1, acting in the cytoplasm of Caco-2 cells, decreased IL-1 induced IL-6 and IL-8 production
Spangelo et al., Ann N Y Acad Sci 2000 : In the rat C6 glioma cell line, IL-1 beta synergistically stimulates IL-6 release in the presence of increased intracellular cAMP concentrations ... Therefore, IL-1 beta induction of LPC 18 : 0 may lead to increases in IL-6 production via activation of a kinase cascade
You et al., J Exp Med 2001 : Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor ... Production of interleukin (IL)-6 in response to IL-1 alpha or tumor necrosis factor (TNF)-alpha was nearly abolished in homozygous mutant ( Shp-2 ( -/ ) - ) fibroblast cells ... The targeted Shp-2 mutation has no significant effect on the activation of the three types of mitogen activated protein ( MAP ) kinases, extracellular signal regulated kinase ( Erk ), c-Jun NH ( 2 ) -terminal kinase ( Jnk ), and p38, by IL-1/TNF, indicating that Shp-2 does not work through MAP kinase pathways in mediating IL-1/TNF induced IL-6 synthesis
Hedrich et al., Rheumatol Int 2012 (Cryopyrin-Associated Periodic Syndromes) : In response to mild hypothermia, an enhanced IL-1ß expression by patient monocytes resulted in increased IL-6 and TNF-a secretion, as compared to control cells
Costes et al., Br J Haematol 1998 (Multiple Myeloma) : We demonstrated that IL-1 was mainly responsible for IL-6 production in the tumoural environment through a PGE2 loop
Henrotin et al., Clin Rheumatol 1998 (Cadaver) : As anticipated, IL-1beta induced a marked release of collagenase, stromelysin, IL-6 , IL-8 and PGE2
Passeri et al., Bone Miner 1994 : Prompted by this evidence, we have now examined whether TNF and/or IL-1 are produced by murine calvarial cells, and whether these cytokines are involved in IL-6 production and osteoclast formation ... The anti-TNF antibody also inhibited IL-6 production in response to exogenous IL-1 or parathyroid hormone (PTH)
Churchill et al., Brain Res 2006 : Relative to saline administration, IL1beta increased IL1beta, TNFalpha and IL6 mRNAs in the nucleus tractus solitarius (NTS), hypothalamus, hippocampus and somatosensory cortex ( SSctx ), but did not induce any changes in IL10
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) ... This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6) , and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) ... IL-1 , double stranded RNA, or virus are potent inducers of IL-6 and IL-8 on dermal fibroblasts, but they are less efficient on epidermal cells
Gerritsen et al., Am J Pathol 1995 (Inflammation) : Apigenin also inhibited IL-1 alpha induced prostaglandin synthesis and TNF-alpha induced IL-6 and IL-8 production, suggesting that the hydroxyflavones may act as general inhibitors of cytokine induced gene expression
Turnbull et al., Endocrinology 2003 (Inflammation) : Induction of IL-6 and activation of the HPAA are dependent upon prior activation of an IL-1 type I receptor, as both are inhibited in type I IL-1 receptor-deficient mice
Schotanus et al., Endocrinology 1993 : The present study was designed to analyze the role of endogenous interleukin-1 (IL-1) in the ACTH, corticosterone (CORT), and IL-6 responses of rats to bacterial endotoxin ... At a dose of 1 mg/kg, IL-1RA inhibited ACTH and IL-6 responses to rIL-1 beta ( 2.5 micrograms/kg, ip ) by 75 % and 90 %, respectively ... We conclude that 1 ) IL-1 receptors are involved in the ACTH and IL-6 responses to rat IL-1 beta ; 2 ) the ACTH response, but not the IL-6 response, to a low dose dose of endotoxin in rats requires IL-1 receptor activation by endogenous produced IL-1 ; and 3 ) circulating IL-6 is not a prime mediator involved in ACTH and CORT responses to low doses of rIL-1 beta and endotoxin
Fujimoto-Ouchi et al., Int J Cancer 1995 (Cachexia...) : Neither TNF alpha, IL-1 alpha nor IFN gamma was detected in the serum of mice bearing either clone, while IL-6 was detected in mice bearing both clones by ELISA and a bioassay