Gene interactions and pathways from curated databases and text-mining

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IL1B — IL6

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: IL6 → IL1B (increases) Newton et al., J Pharmacol Exp Ther 2007*
    Evidence: Similar levels of RANTES and MCP-1 release were induced by IL-1 and TNF treatments. However, the induction of IL-6, IL-8, and GMCSF by TNF was 50 to 80% lower than for IL-1, whereas TNF-induced GRO was some 35- to 40-fold lower than that for IL-1. In all instances, preincubation with PS-1145 or ML120B resulted in a significant attenuation of cytokine release (Fig. 6).
  • OpenBEL Selventa BEL large corpus: IL6 → IL1B (increases) Newton et al., J Pharmacol Exp Ther 2007*
    Evidence: Thus, IL-6 release was substantially increased by both IL-1 and to a lesser extent by TNF. In each case, prior infection with the null adenovirus showed no significant effect, whereas dominant IBN reduced IL-6 release to near-background levels. Likewise, the dominant-negative IKK2 adenovirus prevented IL-6 release
  • OpenBEL Selventa BEL large corpus: IL6 → IL1B (increases) Hai , Curr Drug Discov Technol 2008*
    Evidence: For example, IL-11b stimulates the production of CCL2, eotaxin, IL-6, IL-8, and RANTES in airway smooth muscle cells (Fig. (1)).

Text-mined interactions from Literome

Fan et al., Cytokine 2004 (MAP Kinase Signaling System...) : IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways ... Clearly, both IL-6 and LIF can be very efficiently induced by IL-1beta in articular chondrocytes in vitro
Aloisi et al., J Immunol 1992 : Production of hemolymphopoietic cytokines ( IL-6 , IL-8, colony stimulating factors ) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha
Morales-Montor et al., Int J Parasitol 2003 (Chronic Disease...) : Infection induced interleukin-1beta gene expression in the hypothalamus, while interleukin-6 and migration inhibitory factor mRNAs were induced only in the pituitary and adrenal glands
Wetzler et al., Cancer Res 1990 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : However, granulocyte colony stimulating factor expression could be induced by recombinant human IL-1 beta ; while IL-6 could be induced by both IL-1 beta and tumor necrosis factor-alpha
Gustavsson et al., Retina 2008 (Diabetes Mellitus, Experimental...) : Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Evans et al., J Leukoc Biol 1992 (Rhabdomyosarcoma) : Tumor cell IL-6 gene expression is regulated by IL-1 alpha/beta and TNF alpha : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages
Lozanski et al., J Rheumatol 1992 (Lymphoma, Large B-Cell, Diffuse) : In contrast, flurbiprofen completely abolished IL-6 production by both cell lines and substantially inhibited IL-1 beta and TNF alpha production
Bender et al., FEBS Lett 1990 : Interleukin-1 beta induces synthesis and secretion of interleukin-6 in human chondrocytes ... Here we show that human interleukin-1 beta (IL-1 beta) induces IL-6 synthesis and secretion in differentiated human chondrocytes ... The induction of IL-6 synthesis by IL-1 beta was also shown at the mRNA level
Levine et al., Psychoneuroendocrinology 1994 : Since hyporesponsiveness depends to a large extent on the stimulus, these experiments investigated the ontogeny of the HPA axis and interleukin-6 (IL-6) responses to IL-1 beta
Spangelo et al., Neuroimmunomodulation 2004 (Glioma...) : Somatostatin and gamma-aminobutyric acid inhibit interleukin-1 beta stimulated release of interleukin-6 from rat C6 glioma cells ... We investigated the ability of inhibitory neurotransmitters to alter the interleukin-1 beta (IL-1 beta) stimulated release of interleukin-6 (IL-6) from cultured glial tumor cells ... IL-1 beta promoted the release of IL-6 with a maximally effective concentration of 25 ng/ml ... IL-1 beta and LPC synergistically enhanced release of IL-6 in the presence of the beta-adrenergic receptor agonist isoproterenol ( ISO ) ; these effects were largely reversed by SRIF or GABA ... The pyridinylimidazole inhibitor of p38, SB-203580, completely blocked stimulation of IL-6 release by IL-1 beta or LPC ; conversely, the anthrapyrazolone JNK inhibitor, SP-600125, was ineffective in modifying stimulated IL-6 release ... The effects of IL-1 beta and LPC on IL-6 release from glioma cells are effectively antagonized by the inhibitory neurotransmitters SRIF and GABA
Holmlund et al., Int J Mol Med 2002 : Additive effects of amyloid beta fragment and interleukin-1beta on interleukin-6 secretion in rat primary glial cultures ... In addition, increased secretion of IL-6 was detected by ELISA after 96 h exposure in response to IL-1beta , Abeta ( 1-42 ) or Abeta ( 25-35 )
Kim et al., Spine (Phila Pa 1976) 2008 : In addition, IL-6 secretion from AF cells in response to TNF-alpha was up-regulated by coculture, however, IL-6 secretion in response to IL-1 beta was downregulated in a dose dependent manner
Bouchelouche et al., Urology 2006 : TNF-alpha and IL-1beta ( 0.01 to 100 ng/mL ) induced secretion of IL-8, IL-6 , and RANTES in a dose and time dependent manner
Laulederkind et al., J Exp Med 1995 : Compared with IL-1 beta induced IL-6 production, cells treated with ceramide or exogenous sphingomyelinase induced 82 and 50 % of maximal IL-1 beta induced IL-6 levels by 6 h, respectively ; by 24 h all three treatments induced similar levels of IL-6 production
Chevrel et al., J Neuroimmunol 2003 (Myositis) : Both IL-17 and IL-1 beta induced IL-6 production by normal myoblasts and muscle samples
Rödel et al., J Rheumatol 1998 (Chlamydia Infections) : IL-1beta increased the production of IL-6 and GMCSF by mock infected and infected cells
Blanque et al., Drugs Exp Clin Res 1997 : IL6 release and resorption ( 45Ca release ) were induced by IL 1 beta in neonatal mouse calvaria bones in culture
Nawata et al., Ann N Y Acad Sci 1989 (Arthritis, Rheumatoid) : Connective tissue type cells ( synoviocytes ) cultured from RA synovial tissue produce IL-6 in response to IL-1 beta , and IL-6 formation is increased by TGF-beta
Murakami et al., Int Immunol 2001 : Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine ( 2-CADO ), N ( 6 ) -cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta induced IL-6 and IL-8 production
Lim et al., Biol Reprod 2013 (Inflammation...) : Transfection of primary amnion cells with SIRT6 siRNA was associated with an increase in IL-1beta induced proinflammatory cytokine gene expression and release ( IL6 , IL8, TNF [TNF-alpha ] ), cyclooxygenase ( [ COX]-2 ; official symbol PTGS2 ) expression and subsequent prostaglandin ( PGE ( 2 ) and PGF ( 2alpha ) ) release, and MMP9 gene expression and release of pro-MMP9
Duncan et al., J Invest Dermatol 1991 : Moreover, an anti-rhIL-6 antibody, which effectively neutralized the fibroblast stimulating activities of rhIL-6, only fractionally blocked the fibroblast stimulating actions of rhIL-1 beta, suggesting autocrine IL-6 only partially mediates the effects of IL-1 beta on fibroblasts
Oshima et al., J Med Virol 2001 (Encephalitis, Viral...) : Moreover, recombinant IL-1beta markedly enhanced IL-6 production in glioma cells with a concomitant elevation of its mRNA level ... Taken together, the results suggest that in HSV1-infection of the CNS, enhancement of IL-6 production in glial cells is mediated not by direct infection to glial cells but rather by IL-1beta released from HSV1 stimulated MNC
Isumi et al., Biochem Biophys Res Commun 1998 (Inflammation) : Furthermore, AM remarkably potentiated stimulatory effects of tumor necrosis factor-alpha, IL-1 beta and lipopolysaccharide on IL-6 production
Braquet et al., Int Arch Allergy Appl Immunol 1991 : We compared the effects of platelet activating factor (PAF), interleukin-1 beta (IL-1 beta) and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on IL-6 production by confluent L929 mouse fibroblasts
Becker et al., Am J Respir Crit Care Med 2004 (Cystic Fibrosis...) : Constitutive or interleukin (IL)-1beta induced IL-8 or IL-6 secretion or nuclear factor-kappaB activity was not significantly different between non-CF and CF cells
Stephanou et al., J Endocrinol 1995 : When added to placental cultures during the first 6 days of culture, IL-6 markedly inhibited IL-6, IL-1 alpha and IL-1 beta mRNA expression ... However, when added to the cells during days 6-9 of culture, when most of the cells were syncytiotrophoblast cells, IL-6 stimulated IL-1 alpha and IL-1 beta mRNA expression
Grassl et al., J Am Soc Nephrol 1999 : Stimulation with lipopolysaccharide and IL-1beta resulted in the full induction of IL-6 expression only if the cells were coincubated with cAMP agonists ; this effect was attenuated by protein kinase A inhibitors
Miyazawa et al., J Biochem 1998 (Arthritis, Rheumatoid) : Regulation of interleukin-1beta induced interleukin-6 gene expression in human fibroblast-like synoviocytes by glucocorticoids
Tipton et al., Toxicol In Vitro 2003 (Inflammation) : This study determined myrrh oil ( MO ) cytotoxicity to human gingival fibroblasts and epithelial cells and its effect, measured by ELISA, on interleukin (IL)-1beta stimulated IL-6 and IL-8 production ... There was little or no detectable IL-1beta stimulated production of IL-6 or IL-8 by cells exposed to > /=0.0025 % MO, probably reflective of loss of viability ... At subtoxic MO levels ( 0.00001-0.001 % ), there was a significant reduction of IL-1beta stimulated IL-6 and IL-8 production by fibroblasts, but not by epithelial cells
Riechelmann et al., J Occup Environ Med 2004 : Twenty-four hours after exposure to 500 microg/m3, nasal secretion levels of IL-1beta increased 72.3 % ( 0-150.2 %, P=0.002 ), levels of IL-6 increased 42.2 % ( -28-161.9 %, P=0.01 ), and levels of IL-8 increased 19.7 % ( -20.3-60.5 %, P=0.03 ; median and 95 % confidence interval )
Guo et al., Free Radic Biol Med 2008 : CH3-Avn-c, a synthetically prepared methyl ester derivative of Avn-c with a high biological potency, significantly and dose dependently decreased mRNA expression and secretion of IL-6 , IL-8, and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA, and it inhibited IL-1beta- and TNFalpha stimulated NF-kappaB activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay
Netea et al., Eur J Immunol 2000 (Disease Models, Animal...) : Moreover, the induction of IL-6 was also independent of endogenous IL-1beta , as macrophages isolated from IL-1beta deficient mice produced normal amounts of IL-6 after stimulation with IL-18
Hettmannsperger et al., J Invest Dermatol 1992 (Psoriasis) : Unstimulated HDMEC did not produce significant amounts of IL-6, whereas lipopolysaccharide (LPS), TNF, and IL-1 beta were potent inducers of HDMEC derived IL-6 production ... IL-1 beta stimulation resulted in pronounced IL-6 production after 4 h, followed by complete downregulation at the transcriptional level after 24 h ... The effects of hydrocortisone, dexamethasone, calcitriol, acitretin, and cyclosporin A on TNF- or IL-1 beta induced IL-6 production by HDMEC were determined by ELISA
Henrotin et al., Clin Exp Rheumatol 1999 : Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production
Kauma et al., Endocrinology 1994 : Interleukin-1 beta stimulates interleukin-6 production in placental villous core mesenchymal cells ... Because IL-1 beta is known to induce IL-6 production in nonplacental mesenchymal cells and is locally produced by maternal decidua, this study was designed to determine whether IL-1 beta could regulate IL-6 production by second trimester placental villous core mesenchymal cells ( VCMC ) in vitro ... In dose-response experiments, a specific dose-response induction of IL-6 mRNA expression and IL-6-immunoreactive protein production by IL-1 beta was demonstrated ; this was first seen at 100 pg/ml IL-1 beta [ 455 +/- 191 ng/ml ( +/- SEM ) ; controls, 42 +/- 16 ng/ml ; P < 0.05 ] ... In summary, IL-1 beta stimulates VCMC IL-6 production in a specific dose- and time dependent manner
Hilbert et al., Microbes Infect 2008 : Uropathogenic E. coli prevented interleukin-6 secretion in response to non-pathogenic E. coli and a panel of Toll-like receptor agonists, as well as to interleukin-1beta , but not to tumor necrosis factor alpha
Burger et al., Ann Hematol 1994 (Giant Lymph Node Hyperplasia...) : Cell populations from various sites including peripheral blood, bone marrow, lymph nodes, and osteolytic bone lesions were cultured and tested for spontaneous or IL-1 beta/TNF alpha induced IL-6 production in a sensitive bioassay
Moon et al., Shock 2000 (Acute-Phase Reaction...) : Interleukin-1beta induces complement component C3 and IL-6 production at the basolateral and apical membranes in a human intestinal epithelial cell line ... In previous studies, stimulation of cultured enterocytes with IL-1beta resulted in production of IL-6 and complement component C3 ... We tested the hypothesis that IL-1beta induced C3 and IL-6 production is differentially regulated at the apical and basolateral membranes of the enterocyte ... Stimulation of the Caco-2 cells with IL-1beta resulted in increased mRNA levels for C3 and IL-6 with no major differences noted when the cells were treated at the apical or basolateral membrane
Noguchi et al., J Periodontal Res 2002 : Indomethacin, a cyclooxygenase inhibitor, significantly enhanced IL-1beta induced IL-6 production by HGF, although it completely inhibited IL-1beta induced PGE2 production ... Exogenous PGE2 suppressed the IL-1beta induced IL-6 production ... 11-deoxy-PGE1, a selective EP2/EP3/EP4 agonist, and butaprost, a selective EP2 agonist, inhibited IL-1beta induced IL-6 production, although butaprost was less potent than 11-deoxy-PGE1 ... 17-phenyl-omega-trinor PGE2, an EP1 agonist, enhanced IL-1beta induced IL-6 production ... Based on these data, we suggest that PGE2 can up- or downregulate IL-1beta induced IL-6 production via EP1 receptors or via EP2/EP4 receptors in HGF, respectively
Jeevanandam et al., Nutrition 1999 (Wounds and Injuries) : The plasma levels of TNF-alpha and IL-1 beta in trauma patients are not significantly different from those in healthy volunteers, but plasma IL-6 levels are significantly increased ( five times ) in severely injured patients
Sakuta et al., Cell Immunol 1995 : IL-1 beta induced IL-6 production was maintained by CGRP after removal of IL1 beta
Frering et al., J Thorac Cardiovasc Surg 1994 (Heart Diseases) : A local production of these cytokines can not be excluded, because interleukin-6 and interleukin-8 are produced by stimulated macrophages and monocytes in response to tumor necrosis factor-alpha and interleukin-1 beta
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Nasu et al., Arch Pathol Lab Med 1998 (Endometrial Neoplasms...) : Interleukin-1beta , ( 100 pmol/L ), tumor necrosis factor-alpha ( 1 nmol/L ), and lipopolysaccharide ( 1 microg/mL ) each increased the release of IL-6 , IL-8, and monocyte chemoattractant protein-1 by MaMi cells
Nilsen et al., Gut 1998 (Celiac Disease) : Stimulation of HIMEC and HUVEC with recombinant human ( rh ) IL-1 beta or rhTNF-alpha induced cell associated bioactive IL-1 alpha but not IL-1 beta, as well as enhanced secretion of both IL-6 and IL-8
Keelan et al., J Soc Gynecol Investig 2000 (Obstetric Labor, Premature) : U46619 augmented IL-1 beta stimulated IL-6 and IL-8 mRNA expression within 2 hours of treatment
Szeto et al., J Steroid Biochem Mol Biol 2007 : Consistently, induction of IL-6 by TNFalpha or IL-1beta was much more robust in VDR ( -/- ) than in VDR ( +/- ) cells, indicating that VDR ( -/- ) cells are more susceptible to inflammatory stimulation
Simpson et al., J Reprod Fertil 1999 : Production rates of interleukin 6 and prostaglandin E2 were significantly increased by interleukin 1 beta , tumour necrosis factor alpha and lipopolysaccharide in explants from tissues taken during and before labour, while the responsiveness of interleukin 10 production to these treatments was inconsistent
Jung et al., J Biochem 2000 : Moreover, exogenous IL-1beta stimulated IL-6 mRNA expression in hepatocytes
Zhao et al., Int J Mol Med 2000 : Similarly, IL-6 and IFN-gamma potently enhanced IL-1beta- or TNF-alpha induced C3 and factor B secretion, respectively
Nishitai et al., J Biol Chem 2004 : Instead, interleukin-1 beta (IL-1 beta) induced IL-6 gene expression was greatly suppressed in sek1 ( -/- ) mkk7 ( -/- ) fibroblasts
Reyes et al., J Neuroimmunol 1996 : Interleukin-1 beta differentially affects interleukin-6 and soluble interleukin-6 receptor in the blood and central nervous system of the monkey
McGee et al., Clin Exp Immunol 1996 : However, IL-4 did not induce IL-6 secretion by the IEC-6 cells, nor did it alter IL-1 beta induced IL-6 secretion
Son et al., Mol Cells 2005 : It also inhibited NF-IL6- and NF-kappaB induced activation of IL-1beta , with IC50 values of 78 nM and 1.6 microM, respectively, revealing a potent inhibitory effect on NF-IL6
Wang et al., Hua Xi Kou Qiang Yi Xue Za Zhi 2013 : The expression of IL-1beta , IL-6 and TNF-alpha mRNA of group A and group B increased compared with the control group, and the expression of IL-1beta, IL-6 and TNF-alpha mRNA of group B increased more than that of group A ( P < 0.05 )
Lee et al., Infect Immun 2005 (Periodontitis) : Expression of proinflammatory cytokines, such as interleukin-6 (IL-6) and IL-8, was also induced significantly in both cell types by the Msps, as determined by reverse transcription-PCR and an enzyme linked immunosorbent assay, whereas IL-1beta synthesis could be detected only in the THP-1 cells
Wang et al., Brain Res 1999 : The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and interleukin-1 beta
Choi et al., Rheumatol Int 2010 : The level of IL-6 expression was strongly increased in both FLSs and THP-1 macrophages in response to IL-1beta and TNF-alpha, but the level by TNF-alpha was less than that by IL-1beta
Holden et al., Br J Pharmacol 2010 (Asthma) : Pre-incubation with beta(2)-adrenoceptor agonists ( salbutamol, salmeterol, formoterol ) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB dependent transcription was significantly repressed, and AP-1 dependent transcription was unaffected
Zhang et al., Blood 2000 : Interleukin 1beta inhibits interleukin 6-mediated rat gamma fibrinogen gene expression
Leseth et al., Neuroreport 1999 : However, after 1 day of organ culture, fully defined concentration-response curves were obtained in artery segments exposed to sarafotoxin S6c. Organ culture in the presence of either interleukin-1 beta or tumour necrosis factor-alpha, but not interleukin-2 or interleukin-6 , further amplified the maximal contraction to sarafotoxin S6c
Friebe-Hoffmann et al., Am J Reprod Immunol 2001 : IL-1beta significantly induced IL-6 mRNA expression and protein secretion, which did not further enhance IL-1beta induced OT secretion
Sanders et al., J Bone Miner Res 1998 (Bone Resorption) : IL-1beta ( 18 and 180 pM ) stimulated bone resorption and increased IL-6 ... Since bone cultures contain multiple cell types, further experiments were carried out to determine whether alendronate could increase IL-1beta stimulated IL-6 production in an osteoblast cell line, UMR-106
Walker et al., J Immunol 1992 (Mycobacterium Infections) : In particular, IL-1 (-alpha and -beta) , IL-2, TNF (-alpha and -beta), and IFN-gamma mRNA were readily detected , whereas IL-3, IL-4, IL-5, IL-6 , IL-7, and granulocyte-macrophage colony stimulating factor mRNA were not detected, or were detectable only at very low levels
Hines et al., Vet Microbiol 1999 : MIF-A3 does induce secretion of IL-6 , but does not induce secretion of TNFalpha, IL-1beta , and GM-CSF
Murray et al., Circulation 2000 : In myocardium from control animals, neither TNF-alpha nor IL-1beta were detected , whereas IL-6 was present at very low levels
Villiger et al., J Immunol 1991 (HTLV-I Infections) : Furthermore, IL-6 expression in HTLV-1 infected cells was enhanced by stimulation with IL-1 beta or TNF-alpha
Fujiwara et al., Cancer Res 1992 : Specific inhibition of interleukin 1 beta gene expression by an antisense oligonucleotide : obligatory role of interleukin 1 in the generation of lymphokine activated killer cells
Hoffmann et al., J Hepatol 1994 : Furthermore, lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta and phorbol ester induced interleukin-6 production and, at the same time, suppressed the level of interleukin-6 receptor mRNA
Fiebich et al., Neuroreport 1996 (Astrocytoma) : In the present study, the effects of seven non-steroidal anti-inflammatory drugs ( NSAIDs ) on interleukin-1 beta (IL-1 beta) induced IL-6 mRNA expression and protein synthesis in a human astrocytoma cell line were investigated ... Tenidap, naproxen and meloxicam inhibited the IL-1 beta induced synthesis of IL-6 , whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect
Fischer et al., J Immunol 1999 : Since C3a has been shown to induce PGE2 production by monocytes, and PGE2 has been shown to influence cytokine production, we investigated the potential role of PGE2 in C3a mediated enhancement of LPS- and IL-1beta induced IL-6 production
Bruserud et al., Acta Haematol 1996 (Leukemia, Myeloid, Acute) : IL1 beta , granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor and stem cell factor increased IL6 secretion, whereas IL4 caused decreased IL6 secretion together with increased release of IL1 receptor antagonist
Kang et al., Spine (Phila Pa 1976) 1997 (Intervertebral Disc Displacement) : Normal and herniated human intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6 , prostaglandin E2, and matrix metalloproteinases ... Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta ... Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta
Molina-Holgado et al., J Neuroimmunol 2000 : Incubation with human recombinant IL-1beta ( 100 ng/ml ) also stimulated NO and IL-6 release to a similar extent to LPS, but IL-1beta ( 1 or 100 ng/ml ) caused only modest increases ( approximately seven-fold ) in PGE ( 2 ) release ... These results indicate that exogenous IL-1beta induces release of NO, PGE ( 2 ) and IL-6 in mixed glial cultures, and that endogenous IL-1beta mediates inflammatory actions of LPS on NO and to a lesser extent IL-6, but not on PGE ( 2 ) release in mixed glial cultures
Gealy et al., J Gen Virol 2007 (Glioblastoma) : Here, it is reported that both wild-type and mutant IE2p86 can block activation of the IL-6 promoter in response to interleukin-1beta
Shalaby et al., Clin Immunol Immunopathol 1989 (Shock, Septic) : The ability of Escherichia coli derived lipopolysaccharide (LPS), recombinant ( r ) interleukin 1-beta ( rIL-1 beta ), and r murine tumor necrosis factor-alpha ( rMuTNF-alpha ) to induce interleukin 6 (IL-6) production in vivo was investigated ... These data demonstrate the abilities of IL-1 beta and TNF-alpha to induce IL-6 production in vivo and indicate that LPS induction of IL-6 may be mediated, at least partially, through TNF-alpha action
Appel et al., Neuroreport 1997 (Inflammation) : Interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma) induced similar effects on GDNF production, whereas IL-2 and IL-6 had no significant effects
Linkhart et al., J Bone Miner Res 1991 (Bone Resorption) : IL-1 beta increased IL-6 mRNA levels, maximally 40-fold at 12 h. IL-1 beta increased IL-6 secretion to 0.13 nM, more than 80-fold that of untreated controls at 12 h. IL-1 beta also increased IL-1 beta mRNA levels, maximally 9-fold at 12 h, but did not increase cellular levels or secretion of IL-1 beta protein
Pansky et al., Eur J Clin Invest 1997 (Melanoma) : Bombesin dose-dependently increased cytosolic calcium, but did not alter interleukin (IL) 1beta induced reduction of cell viability or IL-6 secretion, both A375-6-specific cell functions
Marquette et al., Int J Radiat Biol 2003 (Encephalitis) : Six hours after irradiation, IL-1beta levels had increased in the hypothalamus, thalamus and hippocampus, and TNFalpha and IL-6 levels had increased significantly in the hypothalamus
Barsness et al., Pediatr Surg Int 2004 (Respiratory Distress Syndrome, Adult) : Similarly, IL-1beta induced IL-6 production was greater in pediatric PMs compared with adults ( 532+/-3 vs. 444+/-52, P < 0.05 ) ... In conclusion, IL-1beta induced IL-6 and TNFalpha production were greater in pediatric than adult PMs
Sonoda et al., Reproduction 2013 : These results suggest that CpG-ODN derived from microbes upregulates the expression of IL1B and IL6 by interaction with TLR21 and then IL1B induces AvBD1 and -3 to prevent infection in the vagina
Topley et al., J Am Soc Nephrol 1996 : Similarly, interleukin (IL)-1 beta induced IL-6 synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF, and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta , a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Soboslay et al., Clin Exp Immunol 1992 (Dermatitis...) : Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta, tumour necrosis factor-alpha (TNF-alpha) and IL-6 in response to mitogenic stimulation with phytohaemagglutinin ( PHA ), only low levels of IL-1 beta , IL-2 and TNF-alpha in response to OvAg, but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals
Zhang et al., Curr Eye Res 2005 : IL-1beta stimulated IL-6 , IL-8, and MCP-1 mRNA expression and protein levels
Thorn et al., Eur J Pharmacol 2005 : The aim of the present study was to investigate the effect of nitric oxide on interleukin-1beta induced interleukin-6 secretion ... The effect of interleukin-1beta and interferon-gamma on interleukin-6 and nitric oxide secretion was investigated in pituicytes cultured for 14 days ... In addition interferon-gamma inhibits interleukin-1beta induced interleukin-6 secretion dose dependently ... Use of the nitric oxide releaser DETA/NO ( 2,2'- ( hydroxynitrosohydrazono ) bis-ethanimine ) demonstrated that nitric oxide does not inhibit interleukin-1beta induced interleukin-6 secretion
Cadman et al., Neurosci Lett 1994 (Astrocytoma) : We also found that, although interleukin 1 beta (IL-1 beta) did not activate phosphatidy-linositol turnover, it induced , a robust release of IL-6 ... Other possible signal transduction mechanisms involved in IL-1 beta induced IL-6 release are discussed
Van Dam et al., Cytokine 1998 : It is concluded that IL-1beta induced ACTH, cort and IL-6 production is mediated by interleukin 1 type I receptors
Kaur et al., Am J Physiol Lung Cell Mol Physiol 2008 : This finding is consistent with the observation that IL-1beta induced expression of IL-6 , a known NF-kappaB dependent gene in ASM, was also unaffected by beta(2)-adrenoceptor agonists, forskolin, PGE ( 2 ), 8-bromo-cAMP, or rolipram
Panja et al., Clin Exp Immunol 1995 : However, IL-1 beta up-regulated IL-6 synthesis by 6-7-fold
Miyazawa et al., J Biochem 1998 (Arthritis, Rheumatoid) : IL-1beta enhanced the production of IL-6 and stromelysin-1, and the surface expression of ICAM-1, in a manner similar to that in the parental FLSs. SB203580, a specific inhibitor of p38 MAP kinase, significantly inhibited IL-1beta induced IL-6 and stromelysin-1 production by both parental FLSs and MH7A cells ; although PD098059, an inhibitor of the p42/p44 MAP kinase pathway, did not affect it
Kuppner et al., Immunology 1995 : We investigated the effect of transforming growth factor-beta ( TGF-beta ) on interleukin-1 beta (IL-1 beta) induction of IL-6 and IL-8 mRNA levels and protein production by human RPE cells ... Both TGF-beta and IL-1 beta alone induce IL-6 mRNA and IL-6 production in human RPE cells and synergize to enhance IL-6 mRNA levels and IL-6 production over a range of TGF-beta ( 0.1-10 ng/ml ) and IL-1 beta concentrations ( 5-500 U/ml )
Kwak et al., Infect Immun 2000 (Streptococcal Infections) : In contrast to the response to LPS, where TNF-alpha, IL-1beta, IL-6 , and IL-8 appear almost simultaneously, the human monocyte response to GBS results in the production of TNF-alpha but delayed appearance of IL-1beta , IL-6, and IL-8
Jörres et al., Kidney Int 1998 : Interleukin-1 beta stimulated IL-6 release from HPMC and HPFB was used as the cell functional parameter ... While short ( 30 min ) pre-exposure to lactate buffered PDF significantly reduced the IL-1 beta stimulated IL-6 release from HPMC during a subsequent recovery period ( 24 hr ), a significant decrease in HPMC IL-6 secretion with bicarbonate buffered PDF was only observed after prolonged ( > or = 60 min ) exposure
Fiebich et al., Neuropharmacology 1999 (Alzheimer Disease) : We found that tepoxalin markedly inhibits IL-1beta induced IL-6 and ACT synthesis in astrocytes and the synthesis of IL-1beta and IL-6 in lipopolysaccharide (LPS) stimulated microglial cells
Coëffier et al., Clin Nutr 2003 (Inflammatory Bowel Diseases) : IL-1beta stimulation increased IL-6 and IL-8, but did not affect IL-4 and IL-10 production
Hörnquist et al., J Immunol 1997 (Colitis, Ulcerative) : Thus, IFN-gamma and IL-1beta levels were increased 13-fold and 30-fold, respectively, with more modest increases in IL-6 levels ( 5-fold ) and TNF levels ( 2-fold )
Bertolucci et al., Am J Physiol 1997 : Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1 beta with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine
Lakota et al., Mediators Inflamm 2009 (Inflammation) : The IL-1beta induced IL-6 levels were dose dependent with highest responses seen in HCAEC
Harcourt et al., J Virol 1999 (Hemorrhagic Fever, Ebola) : Induction of interleukin-6 (IL-6) and ICAM-1 by IL-1beta was not suppressed by infection with EZ, suggesting that the inhibition of IFN signaling is specific
Hassanain et al., Neuroscience 2003 : In particular, interleukin-1beta in the medial hypothalamus potentiates defensive rage behavior elicited from the periaqueductal gray in the cat, and the potentiating effects of interleukin-1beta on this form of emotional behavior are mediated via a 5-HT2 receptor mechanism
Abbott et al., Mol Pharmacol 2000 : However, trans-dominant NFkappaB inhibitors strongly interfere with IL-6 mRNA induction both by IL-1beta and by UTP, which synergistically evoke IL-6 mRNA expression
Al-Harthi et al., J Infect Dis 1997 : The in vitro efficacy of protease inhibitor to block tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 , IL-1alpha, and IL-1beta induction of HIV-1 was investigated
Weeks et al., DNA Cell Biol 1997 : This increase in CDS activity also leads to increased secretion of tumor necrosis factor-alpha and interleukin-6 from endothelial ECV304 cells upon stimulation with interleukin-1beta , suggesting that CDS overexpression may amplify cellular signaling responses from cytokines
Mathy-Hartert et al., Inflamm Res 2003 (Inflammation...) : LPS and IL-1beta stimulated IL-1beta, IL-6 , IL-8, iNOS and COX-2 gene expression
Musso et al., J Immunol 1992 : By using mAb alpha-IL-1 beta we showed that IL-2 induced IL-6 production is not mediated by the autocrine stimulation of IL-1 beta elicited by IL-2 ... In contrast, IFN-gamma could completely abrogate the induction of IL-6 expression by IL-1 beta but did not affect the levels of mRNA and the secretion of IL-2 elicited IL-6 ... We have previously reported that transforming growth factor-beta inhibits IL-6 production in response to IL-1 beta
Inoue et al., J Immunol 2005 (Arthritis, Rheumatoid...) : Furthermore, IL-1beta induced IL-8, IL-6 , and matrix metalloproteinase-3 protein production was significantly inhibited in DN MKK3/DN MKK6 transfected cells
Chae et al., Immunopharmacol Immunotoxicol 2005 : When added to HGFs, IL-1beta had a stimulatory effect on the production of IL-6 , and this effect was significantly reduced by SB203580, a specific p38 MAPK inhibitor ... These results strongly suggest that both p38 MAPK and NF-kappaB are required in IL-1beta induced IL-6 synthesis and that these two IL-1beta activated pathways can be primarily dissociated
Hagood et al., Am J Respir Cell Mol Biol 2002 : However, IL-1beta induced proliferation and expression of IL-6 are significantly higher in Thy-1- fibroblasts
Kawashima et al., Prostaglandins Leukot Essent Fatty Acids 2008 (Glioma) : In addition, peroxisome proliferator activated receptor ( PPAR) gamma antagonists abolished the inhibitory effect of EPA on IL-1beta induced IL-6 production, whereas PPARalpha antagonist did not block the inhibitory effect of EPA
Parikh et al., J Surg Res 1998 : In recent studies, IL-1beta stimulated the production of IL-6 in human enterocytes ... We tested the hypothesis that heat shock regulates IL-1beta induced IL-6 production in human intestinal epithelial cells ... Heat shock resulted in the production of HSP-70 and potentiated IL-1beta induced IL-6 production ... The results suggest that IL-1beta induced IL-6 production in human enterocytes is increased in association with the heat shock response
Nagy et al., J Bone Miner Res 2001 : In contrast to these findings, the stimulatory effects of PTH, TNF-alpha, and IL-1beta on the IL-6 promoter expression were enhanced by staurosporine
Flower et al., Cytokine 2003 : Stimulation of interleukin-6 release by interleukin-1beta from isolated human adipocytes ... IL-1beta , however, induced a substantial increase in IL-6 release in adipocytes and PBC ( all p < 0.05 )
Plum et al., Am J Kidney Dis 2001 (Necrosis) : Regarding IL-1beta stimulated IL-6 release, there was a small, but not significantly better, response for Bic
Tseng et al., J Clin Endocrinol Metab 1996 (Endometriosis) : Stimulation of the various cultures with IL-1 beta dramatically augmented stromal cell production of IL-6
Chen et al., J Immunol 2005 (Graves Disease...) : IL-1 beta induces IL-6 expression in human orbital fibroblasts : identification of an anatomic-site specific phenotypic attribute relevant to thyroid associated ophthalmopathy ... Dexamethasone completely blocked the effect of IL-1beta on IL-6 expression
Aida et al., Life Sci 2006 (Inflammation) : In the present study, we examined the effect of IL-1beta on the expression of IL-1beta, IL-6 , IL-8, IL-11, tumor necrosis factor-alpha (TNF-alpha), and their receptors in human chondrocytes ... The expression of IL-6 and IL-11 increased greatly in the presence of IL-1beta on day 1 and after day 14 of culture
Kawasaki et al., Clin Exp Rheumatol 2000 (Arthritis, Rheumatoid) : However, E2 increased IL-1 beta induced IL-6 production in a dose dependent manner, with a mean 12.5 % increase with 10 ( -8 ) M of E2 ( p = 0.048 ) and 33.4 % with 10 ( -6 ) M ( p < 0.0001 ) versus the control ... Estrogen up-regulates IL-1 beta induced IL-6 production in cultured fibroblast-like synoviocytes, possibly contributing to the enhancement of rheumatoid inflammation in synovial tissues
Kastelic et al., Cytokine 1996 : If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1 beta but also induced an extremely rapid degradation of IL-1 beta, IL-6 and TNF-alpha mRNA to undetectable levels within 5-8 h
Pinteaux et al., J Neurochem 2002 : In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB, p38, JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures ... Interestingly, a neutralizing antibody to IL-1RII significantly increased the concentration of IL-1beta in the medium of LPS treated microglia and exacerbated the IL-1beta induced IL-6 release in mixed glia, providing the first evidence that microglial IL-1RII regulates IL-1beta actions by binding excess levels of this cytokine during brain inflammation
Miyazawa et al., J Biol Chem 1998 (Arthritis, Rheumatoid) : Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes ... In the present study we investigated how the IL-6 promoter is transcriptionally regulated in rheumatoid FLSs in response to a physiologically relevant mediator of inflammation, IL-1beta ... Site-specific mutagenesis analysis demonstrated that the NF-kappaB and CBF1 binding elements regulated inducible activity of the IL-6 promoter in response to IL-1beta stimulation, whereas the C/EBPbeta binding element mainly regulated basal activity
Puyo et al., Anesthesiology 2008 : Tumor necrosis factor alpha, interleukin 1beta , interleukin 6, and interleukin 8 increased over time, but only interleukin 6 increased significantly ( P < 0.01 )
Jarvis et al., Arthritis Rheum 1997 : However, the secretion of IL-6 , IL-8, and GM-CSF stimulated by the complexes was not completely dependent upon the secretion of IL-1beta
Kirkwood et al., Biochem Pharmacol 2003 : Our previous studies indicated that non-antimicrobial chemically modified tetracyclines ( CMTs ) can dose-dependently inhibit IL-1 beta induced IL-6 secretion in osteoblastic cells ... CMT-8 regulation of IL-1 beta induced IL-6 gene expression was further explored ... These data suggest that CMT-8 can modulate inhibit IL-1 beta induced IL-6 expression in MC3T3-E1 cells at the post-transcriptional level affecting IL-6 mRNA stability
Watanabe et al., J Med Virol 2010 (Respiratory Syncytial Virus Infections) : On day 1 after infection, the secretion of both TNF-alpha and IL-6 decreased significantly in the bronchoalveolar lavage fluid prepared from RSV infected offspring exposed to DBDE perinatally, but IL-1beta increased
Hartwig et al., J Interferon Cytokine Res 2001 : Reduced endogenous IL-1beta levels had no effect on the constitutive production of IL-6 , IL-8, and GM-CSF measured by ELISA
Shen et al., Biochem J 2000 : In related experiments, the protein tyrosine phosphatase inhibitor Na ( 3 ) VO ( 4 ) also antagonized the inhibitory effect of IL-1beta on the activation of STAT1 by IL-6
Boost et al., BMC cancer 2008 (Lung Neoplasms...) : In contrast to IL-8, IL-1beta induced cyclooxygenase-2 expression and release of IL-6 were not affected by IFNgamma indicating that modulation of IL-1beta action by this cytokine displays specificity
Lu et al., Invest Ophthalmol Vis Sci 2006 : Lipopolysaccharide (LPS) induced the release of the proinflammatory cytokine IL-6 and that of the chemokines G-CSF, MCP-1, MIP-1beta, and IL-8 as well as surface expression of ICAM-1 by corneal fibroblasts, whereas IL-1beta , TNF-alpha, and GM-CSF were not detected in the culture supernatants of cells incubated with or without LPS
Tsuji et al., Int Immunopharmacol 2007 : While SA981 partially inhibited IL-1beta induced VEGF production at concentrations of 10 to 100 microM ( 10.1 % and 14.2 % inhibition of total VEGF production under IL-1beta coexistence condition, respectively ), it failed to inhibit IL-1beta induced IL-6 production at the same concentrations
Scheibenbogen et al., J Leukoc Biol 1991 : Upon further cultivation of MAC up to 28 days, LPS induced IL-1 beta levels remained very low, but IL-6 levels increased again reaching that of blood MO, and TNF-alpha continued to rise reaching levels up to 30-fold higher than in blood MO. M-CSF secretion stayed high with LPS even suppressing constitutive secretion
Tsuzaki et al., J Orthop Res 2003 : IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells
Vandermolen et al., Fertil Steril 1996 : Interleukin-1 beta stimulated endometrial IL-6 protein production in time- and dose dependent manners
Huang et al., Am J Physiol 1997 : The role of the central noradrenergic system in systemic interleukin-6 (IL-6) production induced by intravenously administered recombinant human interleukin-1 beta (IL-1 beta) was examined in rats ... A modest inhibition of the IL-1 beta induced plasma IL-6 production was observed following pretreatment with prazosin ( 20 micrograms/rat i.c.v. ) but not after administration of idazoxan or propranolol ... Adrenalectomy produced an augmented plasma IL-6 response to intravenous IL-1 beta, whereas chemical sympathectomy with intraperitoneal injection of 6-OHDA ( 50 or 100 mg/kg ) decreased the IL-1 beta induced plasma IL-6 levels ... These findings suggest that the plasma IL-6 response to intravenous IL-1 beta is partially mediated through the activation of the central noradrenergic system and a consequent increase in the sympathetic outflow to the peripheral tissues and that the NE released from the sympathetic terminals may function as a mediator and/or modulator to facilitate the synthesis/release of IL-6 in the sympathetic nerve innervated organs
Yang et al., Cell Signal 2008 (MAP Kinase Signaling System) : IL-1beta stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells
Kawakami et al., J Trauma 1998 (Burns...) : TNF-alpha, IL-1alpha, and IL-1beta increased IL-6 production in normal skin ( p < 0.05 )
Sato et al., J Mol Cell Cardiol 1995 (Heart Failure...) : Vesnarinone [ OPC-8212 ; 3,4-dihydro-6- ( 4- ( 3,4-dimethoxybenzoil ) -1-piperazinyl ) -2 ( 1H ) - quinolinone ] at 26 mumol/l significantly suppressed the production of IL-6 , granulocyte macrophage colony stimulating factor ( GM-CSF ) and granulocyte colony stimulating factor ( G-CSF ) induced by IL-1 beta
Musso et al., Blood 1990 : We investigated the effects of transforming growth factor beta ( TGF beta ) on the induction by interleukin-1 beta (IL-1 beta) of IL-6 in human monocytes ... We found that IL-1 beta induced IL-6 messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant
Kimura et al., Blood 1990 (Disease Models, Animal...) : Heated IL-1 beta caused an increase of neither IL-6 nor CSF activities
Van Assche et al., Gastroenterology 1999 : These agents each increased cyclic adenosine monophosphate activity in muscle substance P, and the neurokinin 1 agonist Ac- [ Arg6,Sar9,Met ( O2 ) 11 ] substance P ( 6-11 ) inhibited the IL-1beta induced IL-6 release ... This study shows neuropeptide and sympathetic modulation of IL-1beta induced IL-6 production by intestinal smooth muscle
Lieb et al., J Neurochem 1998 (Astrocytoma) : Whereas the antioxidant pyrrolidinedithiocarbamate was only able to inhibit IL-1beta induced IL-6 expression, inhibition of protein kinase C prevented IL-6 expression induced by all three substances ... Promoter deletion analysis revealed that IL-1beta induced IL-6 expression required the transcription factor nuclear factor-kappaB (NF-kappaB), whereas SP- and histamine induced IL-6 synthesis was essentially controlled by NF-IL-6
Delomenie et al., Exp Cell Res 1993 : IL-6 production by HEC was significantly increased only in the presence of IL-1 beta , TNF alpha, or MECIF activity
Larner-Svensson et al., Respir Res 2010 : We have therefore examined the role of miR-146a during the interleukin (IL)-1beta stimulated IL-6 and IL-8 release and proliferation in primary human airway smooth muscle ( HASM ) cells ... However, inhibition of IL-1beta induced IL-6 and IL-8 release was observed at the super-maximal intracellular miR-146a levels obtained by transfection with miR-146a mimics and indicates that studies using miRNA mimics can produce false positive results
Wang et al., J Surg Res 1998 (Endotoxemia) : Endotoxemia and IL-1 beta stimulate mucosal IL-6 production in different parts of the gastrointestinal tract ... In addition, we examined the effects of TNF alpha and IL-1 beta on mucosal IL-6 production ... Treatment of mice with TNF alpha reduced IL-6 levels in gastric mucosa whereas IL-1 beta increased IL-6 levels in mucosa of small intestine ... Both TNF alpha and IL-1 beta may be involved in the regulation of gastrointestinal IL-6 production during endotoxemia
Agarwal et al., Gynecol Endocrinol 2000 : IL-1 beta significantly stimulated trophoblast release of IL-6 in a dose dependent manner ( 3.3-, 5.5-, 10.3- and 22.4-fold higher compared to the control at 10, 50, 100, 500 U IL-1 beta/ml respectively, p < 0.05 )
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : After 24 h incubation with 10 ( -8 ) M concentration of these compounds, there was no decrease in : a ) the constitutive or IL-1beta induced levels of IL-6 protein released to culture medium ; b ) the constitutive IL-6 mRNA expression after incubation of osteoblasts with 10 ( -8 ) M 17betaestradiol or 10 ( -8 ) M tamoxifen for 1, 3, 6, 24 or 30 h
Harcourt et al., Eur J Biochem 2000 : These studies demonstrate that major differences exist in the induction of IL-6 at both the mRNA and protein levels by dsRNA compared to cytokines and that IFNalpha pretreatment selectively enhances IL-6 induction by dsRNA but not by IL-1beta
Xue et al., Curr Eye Res 2001 : The role of IL-1beta in the regulation of IL-8 and IL-6 in human corneal epithelial cells during Pseudomonas aeruginosa colonization ... The purpose of this study was to investigate whether IL-1beta regulates the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization
Fong et al., J Exp Med 1989 (Sepsis...) : Although bacterial endotoxin/lipopolysaccharide is a potent stimulus for the synthesis and release of IL-1 and IL-6 in vitro, specific neutralization of cachectin/TNF in vivo with mAb pretreatment significantly attenuated both the IL-1 beta and the IL-6 responses despite fulminant overwhelming bacteremia
Georganas et al., J Immunol 2000 (Arthritis, Rheumatoid) : Inhibition of C/EBPbeta modestly reduced constitutive and IL-1beta induced IL-6 by RA FLS, but not by human dermal fibroblasts, and had no effect on IL-8 ... These findings document the importance of NF-kappaB for the regulation of the constitutive and IL-1beta stimulated expression of IL-6 and IL-8 by RA FLS and support the role of inhibition of NF-kappaB as a therapeutic goal in RA
Sanchez et al., Biochem Pharmacol 2003 : IL-1beta increased IL-6 , IL-8, MIP-1beta, NO, PGE ( 2 ) and MMP-3 productions, but inhibited AGG and TIMP-1 synthesis ... Rhein partially reversed the effect of IL-1beta on TIMP-1 and NO production, had no effect on AGG, IL-6 and MIP-1beta production, but up-regulated the IL-1beta stimulated PGE ( 2 ) production
Annunziato et al., Blood 2009 (Autoimmune Diseases) : While murine Th17 cells develop in response to IL-6 , IL-1, and transforming growth factor ( TGF ) -beta, human Th17 cells originate from these CD161 ( + ) precursors in response to IL-1beta and IL-23, the need for TGF-beta being controversial
Tesar et al., Blood Purif 1998 (Kidney Diseases...) : On the other hand, there was no change in serum levels of IL-1beta and IL-8, and the serum levels of IL-1ra and IL-6 even increased at the end of a single PE, in spite of high levels of all cytokines and adhesion molecules in the plasma filtrate
Palma et al., Glia 1997 : Interestingly, however, SP selectively potentiated the inducing effect of IL-1beta on IL-6 and PGE2 secretion by spinal cord astrocytes without affecting the IL-1-beta evoked secretion of other cytokines
Vallés et al., Biomaterials 2008 : Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles induces the release of M-CSF, GM-CSF, IL-6 and PGE2 through up-regulation of IL-1beta and TNF-alpha
Mouihate et al., Endocrinology 2003 (Fever) : IL-1beta induced a moderate increase in plasma levels of IL-6 that was suppressed by ovarian hormone replacement
Shun et al., Infect Immun 2005 (Endocarditis, Bacterial...) : In aortic valves and surrounding tissues, IL-6 was detected by Western blots and immunostaining 24 h after GS-5 infection, was maintained over 72 h, and was followed by production of tumor necrosis factor alpha but not IL-1beta
Spörri et al., Cytokine 1996 : IL-1 beta and possibly other soluble factors increased IL-6 production by fibroblasts
Di Loreto et al., Eur Cytokine Netw 2003 : Whereas the IL-1beta-deprivation signal induced a decrease in IL-6 expression and release of normoxic neurones, it provoked an increase in IL-6 protein in hypoxic neurones
Muraki et al., Nihon Hinyokika Gakkai Zasshi 1993 (Carcinoma, Renal Cell...) : In this report, we demonstrated that Interleukin-6 (IL-6) production could be induced by stimulating renal cell carcinoma cell lines, namely ACHN, Caki-1 and TC-1 cells with Interleukin-1 beta (IL-1 beta)
Kurzrock et al., J Lab Clin Med 1998 (Carcinoma, Renal Cell...) : Our observations suggest that the mechanism by which IL-1alpha or IL-1beta induces IL-6 may be mediated through increases in LYT-10 mRNA and protein levels as well as increases in expression of other transcription factors ( NFkappaB1, p65, and NF-IL6 ), in addition to the known ability of IL-1 to post-translationally activate NF-kappaB
Sparacio et al., J Neuroimmunol 1992 : These results suggest that TNF-alpha and IL-1 beta activate IL-6 gene expression in astrocytes by a mechanism ( s ) involving activation of an NF-kappa B-like protein
Song et al., Mol Immunol 2009 (Inflammation) : Ablation of IRAK-4 expression in human umbilical vein endothelial cells ( HUVEC ) with siRNA suppressed IL-1beta induced IL-6 and IL-8 production whereas IRAK-1 siRNA suppressed TNFalpha induced but not IL-1beta induced cytokine production
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2005 : VSMCs were exposed to 44 degrees C for 15-60 min, and subjected to interleukin-1beta (IL-1beta) or tumor necrosis factor alpha (TNFalpha), which induced interleukin-6 (IL-6) production ... Although treatment with Hsp72 or Hsp60 alone did not significantly affect basal IL-6 release into culture medium statistically, cotreatment with IL-1beta and Hsp72, but not Hsp60 or boiled Hsp72, decreased IL-1beta induced IL-6 production in culture medium ... Introduction of Hsp72, but not Hsp60, into VSMCs decreased IL-1beta induced IL-6 production in culture medium
Spangelo et al., Endocrinology 1991 : IL-1 alpha and IL-1 beta ( 10 ng/ml ), vasoactive intestinal peptide ( VIP, 500 nM ), prostaglandin E2 ( PGE2, 1 microM ), and LPS ( 1 ng/ml ) stimulated IL-6 release to a similar degree ... In the presence of VIP and PGE2, IL-1 alpha and IL-1 beta increased IL-6 release without any apparent further change in extracellular or intracellular cAMP ... The preexposure of anterior pituitary cells to 1 microM PMA caused the apparent down-regulation of protein kinase C activity because 100 nM PMA was no longer effective to stimulate IL-6 release ; however, the ability of IL-1 alpha, IL-1 beta , PGE2, or LPS to stimulate IL-6 release was not altered ... In addition, IL-1 alpha and IL-1 beta stimulated IL-6 release in the presence of maximally stimulative concentrations of PMA ... The synthetic glucocorticoid dexamethasone ( 10 nM ) significantly inhibited IL-6 release induced by IL-1 alpha, IL-1 beta , or LPS
Sodin-Semrl et al., J Immunol 2000 : Lipoxin A4 inhibits IL-1 beta induced IL-6 , IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases ... IL-1 beta induced the synthesis of IL-6 , IL-8, and matrix metalloproteinases (MMP)-1 and -3
Dechanet et al., Cytokine 1995 (Arthritis, Rheumatoid...) : This induction was not due to a passive release of pre synthesized IL-6, since IL-4 increased the level of IL-6 mRNA expression induced by IL-1 beta
Sodin-Semrl et al., Int J Immunopathol Pharmacol 2004 : Lipoxin A4 ( LXA4 ) and transforming growth factor beta 2 ( TGF-beta 2 ), mediators with potential anti-inflammatory activities, were tested to determine how they affect IL-1 beta dependent release of IL-6 and MMPs in human fibroblast like synoviocytes
Carlson et al., J Neurochem 1995 (Astrocytoma) : We have investigated the roles of tyrosine kinase and protein kinase C activity in interleukin-1 beta induced interleukin-6 production, using the U373 human astrocytoma cell line as a model system for astrocytes ... Complete to nearly complete inhibition of interleukin-1 beta induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879
Yoon et al., Acta Otolaryngol 1999 : Effects of TNF-alpha and IL-1 beta on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells ... IL-1beta alone or a combination of TNF-alpha and IL-1beta comparably increased IL-6 and IL-8 mRNA levels slightly
Faggioli et al., Eur J Biochem 1996 (Breast Neoplasms...) : The levels of both secreted IL-6 and IL-6 mRNA are significantly higher in response to IL-1 beta in spite of the fact that stimulation by TNF-alpha alone enhances the half life of IL-6 mRNA
Sugawara et al., J Hepatol 1998 (Reperfusion Injury) : Endotoxin and interleukin-6 levels increased in a similar manner to nitrate levels, but tumor necrosis factor-alpha and interleukin-1 beta levels did not
Tipton et al., J Periodontol 2003 (Periodontitis) : Cyclooxygenase-2 inhibitors decrease interleukin-1beta stimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts ... The selective COX-2 inhibitors, but not indomethacin, caused partial ( generally up to approximately 60 % ), dose dependent decreases in IL-1beta stimulated IL-6 in all cell lines ( P < or = 0.003 )
Loiarro et al., J Leukoc Biol 2007 (Chronic Disease...) : After oral administration, ST2825 dose-dependently inhibited IL-1beta induced production of IL-6 in treated mice
Zhang et al., J Leukoc Biol 2005 : In the present study, incubation of AM with unopsonized Pneumocystis organisms was not associated with release of interleukin (IL)-1beta, IL-6 , or tumor necrosis factor (TNF)-alpha ( important cytokines in the host response to Pneumocystis ) and did not induce IL-1beta , IL-6, or TNF-alpha mRNA transcripts
Call et al., Gen Comp Endocrinol 2000 : The release of IL-6 and TNF from the ZG, ZF, ZR, and medulla was increased by PDB, IL-1alpha, IL-1beta , and LPS
Hammaker et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : Quantitative PCR showed that TAK1 deficiency significantly decreased IL-1beta induced MMP3 gene expression and IL-6 protein expression
Ding et al., Cytokine 2000 : Blocking protein tyrosine kinase ( PTK ) activation by herbimycin A or genistein, or blocking NF-kappaB activation by pyrrolidinedithiocarbamate, reduced the IL-6 expression induced by TNF-alpha, IL-1beta and OSM
Lust et al., Hematol Oncol Clin North Am 1999 (Multiple Myeloma...) : Interleukin-1 beta has potent OAF activity, can increase the expression of adhesion molecules, and can induce paracrine IL-6 production ( see Fig. 1 )
Carter et al., Br J Haematol 1990 (Multiple Myeloma) : This study investigates the capacity of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) to induce interleukin-6 (IL-6) production in freshly isolated myeloma cells ( MC ) and bone marrow derived stromal cells (MSC) ... Recombinant human ( rh ) IL-1 alpha, IL-1 beta and TNF-alpha augmented production of IL-6 in human MC. IL-6 was determined on a factor dependent Cess cell line ... Next we found that IL-1 alpha, IL-1 beta and TNF-alpha induced MSC to produce IL-6
Espevik et al., Cell Immunol 1990 : The effect of recombinant ( r ) interleukin-1 beta ( rIL-1 beta ) and transforming growth factor-beta ( TGF-beta ) on the production of interleukin-2 (IL-2) and interleukin-6 (IL-6) from an antigen-specific ( LBRM-33-1A5 ) and an antigen-nonspecific ( EL-4-NOB-1 ) T-cell line was investigated
Goldberg et al., Mol Immunol 2007 : In contrast, both IL-1beta and TNFalpha highly induced IL-6 secretion in chorion derived cells, demonstrating the overall responsiveness of these cells to these stimuli
Chi et al., BMC immunology 2004 (Arteriosclerosis...) : However, IL-6 , IL-8, and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine
Zoja et al., Am J Pathol 1991 : Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony stimulating factors, and interleukin-6 in human mesangial cells ... Similarly IL-1 beta and TNF-alpha induced the interleukin-6 (IL-6) gene and active secretion of its mature protein
Yoon et al., J Biochem Mol Biol 2007 : An anti-peptide-4 antibody which targets domain III inhibited 70 % of IL-1beta induced productions of IL-6 and PGE ( 2 ) from 3T3-L1 cells
Mastrofrancesco et al., J Immunol 2010 (Melanoma, Experimental) : KdPT potently suppressed IL-1beta induced IL-6 and IL-8 expression
Klir et al., Am J Physiol 1994 (Fever) : Interleukin-1 beta causes the increase in anterior hypothalamic interleukin-6 during LPS induced fever in rats
Lichtor et al., Neurosurgery 1994 (Astrocytoma...) : Interleukin-1 beta has been shown to be synthesized in small amounts by astrocytes and can induce the expression of interleukin-6
Sanchez et al., Osteoarthritis Cartilage 2004 (Osteoarthritis, Knee) : IL-1beta highly stimulated *NO, IL-8, IL-6 , MIP-1beta and PGE ( 2 ) synthesis but decreased AGG and TGF-beta1 production
Vona-Davis et al., J Surg Res 2003 (Endotoxemia) : IL-1beta increased IL-6 when combined with TNF-alpha ( P < 0.05 )
Fu et al., Am J Physiol 1997 (Acute Disease...) : In addition, IL-1 beta , IL-6, and TNF-alpha mRNAs were rapidly ( 7 h ) upregulated in the pancreas, and intrapancreatic IL-1 beta and IL-6 protein levels rapidly increased ( 3-fold and 6.4-fold, respectively ) during acute pancreatitis
Sayah et al., J Neurochem 1999 (Astrocytoma) : Whereas IL-1beta , tumor necrosis factor-alpha, and transforming growth factor-beta mRNA levels remained unchanged, stimulation of astrocytoma cells ( T98G, CB193, U118MG ) by C3a, C5a, and peptidic C3aR and C5aR agonists induced an increase in the IL-6 mRNA level
Shikhman et al., J Immunol 2001 : In addition, N-acetylglucosamine also suppresses the production of IL-1beta induced cyclooxygenase-2 and IL-6
Takaoka et al., J Biochem 1999 : Interleukin-1beta induces interleukin-6 production through the production of prostaglandin E ( 2 ) in human osteoblasts, MG-63 cells ... This study was conducted to investigate the mechanism of interleukin-1beta (IL-1beta) induced IL-6 production in human osteoblasts ( MG-63 cells ) ... Stimulation with IL-1beta resulted in the production of IL-6 and prostaglandin E ( 2 ) ( PGE ( 2 ) ) ... These findings indicate that IL-1beta induced IL-6 production in MG-63 cells involves the following sequence of steps : IL-1beta induced COX-2 activation, PGE ( 2 ) production, and EP-1 receptor signaling prior to IL-6 production
Chen et al., Kaohsiung J Med Sci 1997 (Periodontitis) : A dose dependent stimulatory effect of IL-1 beta on IL-6 production by HGF was noted, wherein 3 strains exhibited higher IL-6 activity than the other 3
Hattori et al., Int J Hematol 2003 (Fever...) : Levels of IL-6 and G-CSF were elevated during the active phase, but the level of IL-1beta did not increase
Hierl et al., Exp Clin Endocrinol Diabetes 1998 : We observed that ( 1 ) IL-1beta and TNFalpha induced IL-6 in a dose and time dependent fashion, ( 2 ) TGFbeta 1 and 2 enhanced basal and IL-1beta and TNFalpha induced IL-6 expression, ( 3 ) ET-1 elicited a dose dependent stimulatory effect on IL-6 expression
Fiebich et al., J Neurochem 1997 (Astrocytoma) : Furthermore, PGE2 potentiated IL-1 beta induced IL-6 mRNA synthesis
Mauviel et al., Biochem Biophys Res Commun 1988 : The ability of the two forms of interleukin-1 , IL-1 alpha and IL-1 beta, to induce IL-1 beta gene expression in human skin fibroblasts was studied in vitro, using Northern blot hybridization
Ogilvie et al., J Immunol 1996 (Melanoma) : IL-1 beta does not cause neutrophil degranulation but does lead to IL-6 , IL-8, and nitrite/nitrate release when used in patients with cancer
de Fijter et al., Am J Kidney Dis 1996 : In addition, interleukin-1-beta induced interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Fc receptor- mediated uptake of S epidermidis by PMO in the complete absence of Ca++ was comparable to that by PMO incubated in GHBSS with calcium
Palmqvist et al., J Dent Res 2008 (MAP Kinase Signaling System...) : IL-6-type cytokine expression and regulation by IL-1beta and tumor necrosis factor-alpha (TNF-alpha) were studied in fibroblasts from the non inflamed gingiva of healthy individuals ... Constitutive mRNA expression of IL-6, IL-11, and leukemia inhibitory factor (LIF), but not of oncostatin M (OSM), was demonstrated, as was concentration dependent stimulation of IL-6 and LIF mRNA and of protein by IL-1beta and TNF-alpha
Lin et al., Mol Pharmacol 2002 : Similar to dexamethasone, A276575 exhibited high affinity for GR and potently repressed interleukin (IL) 1beta stimulated IL-6 production in human skin fibroblasts, prostaglandin ( PG ) E ( 2 ) production in A549 human lung epithelial cells, and concanavalin A-induced monocyte proliferation
Yamaguchi et al., Acta Endocrinol (Copenh) 1990 : Interleukin 1 beta and tumour necrosis factor alpha stimulate the release of gonadotropin releasing hormone and interleukin 6 by primary cultured rat hypothalamic cells ... The abilities of recombinant human interleukin 1 beta and tumour necrosis factor alpha to induce release of GnRH and interleukin 6 from primary culture of rat hypothalamic cells were examined ... The hypothalamic cells secreted interleukin 6 spontaneously, and their secretion over 24 h was stimulated dose-dependently by interleukin 1 beta , tumour necrosis factor alpha and estradiol ... These results suggest that interleukin 1 beta and tumour necrosis factor alpha stimulate the secretions of GnRH and interleukin 6 in the hypothalamus, and that these cytokines may be involved in the mechanism of GnRH secretion in the hypothalamus
Sooranna et al., Mol Hum Reprod 2006 : In primary cultures of uterine myocytes, cPLA(2) mRNA expression was increased by IL-1beta and IL-6 ; PGHS-2 mRNA expression was increased by IL-1beta , PGE ( 2 ) and stretch ; and PGES-1 mRNA expression was increased by IL-1beta only
Christensen et al., Eur J Pharmacol 1999 : In this study, we examined the effect of adrenaline and interleukin-1beta on interleukin-6 secretion from cultured murine neurohypophyseal cells ... Adrenaline and interleukin-1beta increased the release of interleukin-6 from the cells in a concentration dependent manner
Veerhuis et al., Brain Res 2002 (Prion Diseases) : We conclude that, unlike IL-1beta induced IL-6 synthesis in astrocytes, the PrP induced IL-6 synthesis in human adult microglia is not PGE2 mediated
Ogura et al., J Oral Pathol Med 2002 : Interleukin-1 beta induces interleukin-6 mRNA expression and protein production in synovial cells from human temporomandibular joint ... IL-1 beta increased IL-6 production in HTS cells ... IL-1 beta also stimulated IL-6 mRNA expression ... IL-1 beta increased IL-6 production in synovial cells resulting from an increase in IL-6 mRNA expression
Inamura et al., Hepatology research : the official journal of the Japan Society of Hepatology 2005 : Although IL-1beta induces IL-6 production in hepatocytes, our data indicate that the effect of IL-1beta on hepcidin expression is independent from that of IL-6
Ahn et al., J Neurotrauma 2004 (Brain Injuries) : IL-1alpha and IL-1beta mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and TNFa mRNA expression increased significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI
Tosato et al., Blood 1990 : In the present study, we show that IL-1 beta , previously known to be a potent inducer of IL-6 in fibroblasts, endothelial cells, and keratinocytes, but not in monocytes, is also a potent inducer of IL-6 in peripheral blood monocytes ... In addition, monocyte production of IL-6 , induced by IL-1 beta , was specifically neutralized by anti-IL-1 beta antibodies, demonstrating that IL-1, rather than a contaminant in the IL-1 preparation, was responsible for IL-6 induction
Peng et al., Yao Xue Xue Bao 2010 (Glioblastoma) : IL-1 beta could induce the mRNA expression and protein secretion of IL-6 from U251 cells, as well as RANTES
Kim et al., Neurosci Lett 2002 (Alzheimer Disease...) : The production of TNF-alpha and IL-6 was induced by IL-1beta and Abeta [ 25-35 ] and synergistically amplified by the co-stimulation of IL-1beta and Abeta [ 25-35 ]
Dong et al., Clin Exp Immunol 2010 : In the presence of LPS, LcS enhanced IL-1beta production but inhibited LPS induced IL-10 and IL-6 production, and had no further effect on TNF-alpha and IL-12 production
Lin et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006 (Multiple Myeloma) : There were obviously differences of IL-1beta expression between refractory/relapsed group and complete remission ( CR ) group and IL-1beta expression was inhibited more seriously in CR group, whereas there were no significant differences of IL-6 and SCF expression between two groups ; IL-1beta expression of patients treated with PS-341 was not detected ; there were not effects of IL-1beta expression on expressions of IL-6 and SCF
Kirschning et al., Immunobiology 1997 : IL-6 alone induces LBP significantly, whereas IL-1 beta mainly increases the IL-6 effect when applied in combination
Choi et al., Food Chem Toxicol 2010 (Sarcoma) : This study was conducted to evaluate the efficacy of luteolin in regulating interleukin-1beta (IL-1beta) induced production of MMPs ( MMP-1 and -3 ) and cytokines ( tumor necrosis factor (TNF)-alpha and IL-6 ) in human synovial cell line, SW982
Harris et al., Prostate 2000 (Disease Models, Animal...) : After 4 weeks of treatment with E ( 2 ) + DHT, a significant increase in transcript levels of IL-4, IL-5, IL-6 , MIP-2, eotaxin, and iNOS was detected , while IL-1beta and TNF-alpha transcript levels only increased slightly
Benveniste et al., J Neuroimmunol 1990 : IL-6 induction by LPS/Ca2+ ionophore is more sensitive to the suppressive effects of dexamethasone than is IL-6 induction by TNF-alpha/IL-1 beta
Chevrel et al., Ann Rheum Dis 2005 (Translocation, Genetic) : TNFalpha and IL1beta induced IL6 production by normal muscle samples and myoblasts, the action of TNFalpha being more potent on muscle samples
Bosetti et al., J Mater Sci Mater Med 2001 : Mechanical stress evidenced an increase in the release of the examined cytokines both in cemented and uncemented prosthesis tissues ; particularly evident was IL6 trend of increase from cemented prosthesis and IL1beta result from uncemented ones
Fernandes et al., J Neuroimmunol 2004 : UCB leads to an increase of extracellular glutamate and highly enhances the release of TNF-alpha and IL-1beta , while inhibiting the production of IL-6
Krady et al., J Neurosci Res 2008 : We show that CNTF reduces COX-2 levels, whereas IL-6 increases the expression of IL-1beta , TNFalpha, and Cox-2
Xue et al., Clin Experiment Ophthalmol 2001 : Regulatory role of IL-1beta in the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization
Lee et al., Int Immunopharmacol 2010 (Arthritis, Rheumatoid...) : Myricetin significantly decreased IL-1beta induced production of IL-6 and MMP-1 in synovial cells
Khalkhali-Ellis et al., J Rheumatol 2002 (Arthritis, Rheumatoid...) : Androgen receptors in human synoviocytes and androgen regulation of interleukin 1beta (IL-1beta) induced IL-6 production : a link between hypoandrogenicity and rheumatoid arthritis ?
Long et al., J Dent Res 2001 : TENS inhibits IL-1beta induced synthesis of IL-1beta, IL-6 , and IL-8 by inhibiting their mRNA expression, and thus significantly suppresses the amplification of IL-1beta induced inflammatory responses in PDL cells
Fan et al., Immunology 2007 : LPS induced production of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA induced TNF-alpha, and IL-1beta production ; and GBS induced TNF-alpha, IL-6 , IL-1beta, macrophage inflammatory protein-1alpha ( MIP-1alpha ) and keratinocyte chemoattract ( KC ) production were all decreased ( P < 0.05 ) in Galpha ( i2 ) ( -/- ) or Galpha ( i1/3 ) ( -/- ) mice compared with WT mice
Lee et al., Scand J Rheumatol 2008 (Arthritis, Experimental) : TNFalpha, IL-1beta , and MMP-3 expression decreased, but IL-6 expression in AD-treated joint tissues increased
Hu et al., Invest Ophthalmol Vis Sci 2011 : Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway
Patil et al., Immunol Invest 2004 : p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts ... These results indicate that p38 MAPK regulates IL-1beta stimulated IL-6 at a post transcriptional mechanism and one of the primary targets of IL-6 gene regulation is the 3'UTR of IL-6
Spitzweg et al., Thyroid 1999 : IL-6 did not alter NIS functional activity, but IL-1beta suppressed iodide accumulation by approximately 25 %
Tsukihara et al., Am J Reprod Immunol 2004 : Interleukin-1beta induced expression of IL-6 and production of human chorionic gonadotropin in human trophoblast cells via nuclear factor-kappaB activation ... The purpose of this study was to examine the role of nuclear factor-kappaB (NF-kappaB) during the induction of IL-6 by IL-1beta in human trophoblast cells ... The addition of IL-1Ra neutralized the effects of IL-1beta on IL-6 secretion ... The addition of TPCK reduced the IL-1beta induced IL-6 expression ... IL-1beta may induce the IL-6 expression and hCG production in human BeWo cells via NF-kappaB
Hwang et al., Invest Ophthalmol Vis Sci 2009 (Graves Ophthalmopathy) : IL-1beta also induced MCP-1, IL-6 , and IL-8 more vigorously in TAO derived fibroblasts
Henrotin et al., J Rheumatol 1998 : LPS and IL-1beta stimulated IL-6 , IL-8, and PGE2 production are downregulated by endogenously produced NO, which could limit the inflammatory reaction occurring in arthritis
Lottaz et al., J Invest Dermatol 2001 : In interleukin-1beta transfected human dermal fibroblasts, interleukin-8 was induced through an autocrine activity of interleukin-1beta
Bresser et al., Eur Respir J 1997 (Bronchitis...) : Furthermore, pre-exposure of cells to persisting and nonpersisting isolates did not block subsequent IL-1beta induced IL-6 production
Hungness et al., Shock 2000 : The effect of IL-1beta on AP-1 activity in the enterocyte and the potential role of AP-1 in enterocyte IL-6 production are not known ... Geldanamycin, which has been shown in studies to inhibit AP-1 activation, blocked IL-1beta induced AP-1 luciferase gene activation and IL-6 production ... These results suggest that the AP-1 family of transcription factors is activated by IL-1beta in human enterocytes and that AP-1 may at least in part regulate IL-6 production in these cells
Fleisher et al., Exp Eye Res 2000 : Tumor necrosis factor-alpha, although ineffective alone, increased interleukin-1beta induced interleukin-6 release in a concentration dependent manner when co-incubated with interleukin-1betafor 18 hr ... However, tumor necrosis factor-alphadid not enhance interleukin-1beta induced interleukin-6 release if co-incubated with interleukin-1betafor a shorter time ( 6 hr ) ... However, neither the adenyl cyclase activator, forskolin or the adenosine 3 ', 5'-cyclic monophosphate-mimetic, dibutyryl 3',5'-cyclic monophosphate enhanced interleukin-1beta induced release of interleukin-6 ... Although agents that activate the adenyl cyclase/adenosine 3 ', 5'-cyclic monophosphate system through cell surface G-protein transduced receptors increased interleukin-1beta induced release of interleukin-6 , the ineffectiveness of forskolin and dibutryl 3 ', 5'-cyclic monophosphate suggest that simply increasing intracellular 3',5'-cyclic monophosphate is not sufficient to augment interleukin-1beta induced release of interleukin-6
Yagi et al., J Gastroenterol 2007 (Colitis) : Both IL-17A and IL-17F augmented IL-1beta induced secretion of IL-6 , IL-8, LIF, MMP-1, and MMP-3
Chaudhary et al., Endocrinology 1992 : IL-1 beta in doses from 1-100 U/ml stimulated dose dependent increases in IL-6 ( r = 0.87 ; P less than 0.001 ) and IL-8 ( r = 0.95 ; P less than 0.001 )
Olman et al., J Immunol 2004 (Pulmonary Edema...) : Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta induced IL-6 expression ... These novel findings indicate that soluble IL-1beta bioactivity and autocrine IL-1beta dependent IL-6 up-regulation are critical initiators of fibroblast activation and proliferation and that they likely play a role in the fibroproliferative response seen in human acute lung injury
Takada et al., Infect Immun 1991 : Neutralization assays using antisera to human interleukin-1 alpha ( HuIL-1 alpha ), HuIL-1 beta, and HuIL-6 revealed that cell-free TAF was attributable mainly to IL-1 beta and that IL-6 augmented the TAF activity of IL-1 beta in the culture supernatant
Palma et al., Br J Cancer 1999 (Glioma) : Second, application of SP or neurokinin A ( NKA ) to NK1R+ glioma cell lines increased the secretion of interleukin 6 (IL-6) and potentiated IL-6 secretion induced by IL-1beta
Fuse et al., Lymphokine Cytokine Res 1992 (Cell Transformation, Neoplastic...) : In these cell lines the degree of tumorigenicity was inversely correlated with IL-6 induction by IL-1 beta ... The less transformed cell lines produced lower yields of IL-1 beta induced IL-6 , dependent on their degrees of transformation and tumorigenicity
Perrier d'Hauterive et al., Neuroimmunomodulation 2005 : Only the highest concentration of inhibin B ( 10 ( -8 ) M ) reduced IL-6 secretion by EEC, but did not modulate IL-1beta induced stimulation of IL-6 secretion
Rasmussen et al., Autoimmunity 1994 : Nitric oxide production is not involved in the effects of interleukin-1 beta on cAMP, thyroglobulin and interleukin-6 in TSH stimulated human thyroid cells ... However, the nitrite production was unrelated to the IL-1 beta induced inhibition of thyroglobulin (Tg) and cyclic AMP ( cAMP ) and the IL-1 beta induced IL-6 production
Yoshida et al., J Nutr 2001 : Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta
Marin et al., Toxicology 1996 : In the presence of LPS and CPA, however, IL-1 beta and IL-6 mRNA levels gradually increased up to 24 h reaching 2.5 and 29-fold higher than controls, respectively
Brydon et al., Brain Behav Immun 2005 : IL-1beta activates IL-6 , and both cytokines are produced by peripheral blood mononuclear cells
Todo et al., J Neurosurg 1994 (Meningeal Neoplasms...) : Interleukin-6 secretion was remarkably stimulated by tumor necrosis factor-alpha, IL-1 beta , and IL-4, and was also influenced by a combination of epidermal growth factor and bromocriptine
Hou et al., Fertil Steril 2008 (Endometriosis) : Addition of soluble IL-1RII ( 2.0 microg/mL ) significantly inhibited IL-1 beta induced IL-6 and IL-8 secretion by endometrial cells in vitro
Tsakiri et al., Mol Cell Neurosci 2008 : Here we demonstrate that, whilst IL-1beta induced significant synthesis of IL-6 in neurones, IL-1alpha had no effect ... Whilst IL-1beta induced IL-6 synthesis was dependent on the nSMase/Src kinase signalling cascade, specific inhibitors of nSMase ( 3-OMS ) and Src kinase ( PP2 ) failed to inhibit IL-1alpha- and IL-1beta induced chemokines synthesis, suggesting the existence of alternative signalling pathway ( s ) in neurones
Chen et al., Endocrinology 1999 : Sustained levels of IL-1beta in blood over time contribute to the high peripheral IL-6 response
Luz et al., Neuropeptides 2006 (Dehydration...) : These results suggest that the central activation of interleukin-1 receptors by IL-1beta is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia
Suzuki et al., FEBS Lett 2000 (Arthritis, Rheumatoid) : We examined the role of p38 mitogen activated protein ( MAP ) kinase in the tumor necrosis factor alpha (TNF-alpha)- or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity
Bradley et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : However, Rb overexpression had no effect on spontaneous or IL-1beta induced production of IL-6 or MMP-1 in non-RA synovial fibroblasts
Scamurra et al., J Interferon Cytokine Res 1996 : IL-6 expression in transformed swine testicular (TST) fibroblasts was enhanced by TNF and IL-1 beta and to a lesser extent by poly ( I ). ( C ) and LPS
Henness et al., J Allergy Clin Immunol 2004 : However, IL-17A ( 10 ng/mL ) significantly augmented TNF-alpha induced IL-6 secretion 12-fold ( TNF-alpha, 2.3 +/- 0.4 ng/mL ; IL-17A and TNF-alpha, 27.5 +/- 4.8 ng/mL ; P < .05 ) while having no effect on IL-1beta induced IL-6
Suarez-Cuervo et al., Breast Cancer Res Treat 2003 (Breast Neoplasms) : We show here, that while basal, TGF-beta and IL-1beta induced IL-6 production was similar in parental cells and in pcDNA3 control, ERK1K71R and p38/AF clones, TNF-alpha induced IL-6 production was blunted in the ERK1K71R clones
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Moutabarrik et al., Scand J Immunol 1994 : IL-6 was detected in the culture supernatants of human GEC and its production was enhanced in time and dose dependent manner by lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta) and tumour necrosis alpha ( TNF-alpha )
Szabo et al., J Clin Immunol 1991 (Burns...) : Interleukin-6 induction by FcRI stimulation is not mediated solely by FcRI induced M phi tumor necrosis factor alpha, IL-1 alpha, or IL-1 beta production and is independent of M phi prostaglandin E2 levels
Rambukkana et al., Lab Invest 1996 : After 24 hours, contact allergens not only increased the expression of IL-1 beta but also induced the expression of IL-1 alpha, TNF-alpha, GM-CSF, and IL-6 proteins mainly by suprabasal keratinocytes
Rougier et al., Cytokine 1998 : IL-1 alpha, IL-1 beta , and IL-3, tumour necrosis factor alpha (TNF-alpha), Stem cell factor (SCF) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) ( at 10 ng/ml ) stimulated IL-6 and IL-8 production in 0 % and 10 % FCS
Zumwalt et al., Endocrinology 1999 (Glioma) : Interleukin-1beta and catecholamines synergistically stimulate interleukin-6 release from rat C6 glioma cells in vitro : a potential role for lysophosphatidylcholine ... Forty ng/ml IL-1beta induced a maximal 30-fold stimulation of IL-6 release ( P < 0.01 ) ; higher and lower concentrations of IL-1beta were less effective ... In the presence of ( Bu ) 2cAMP, IL-1beta induced a strongly synergistic response with respect to IL-6 release ; thus, the combination of these two agents resulted in a release of IL-6 that was much larger that the release attributed to either agent alone ( i.e. 30-fold higher ) ... We have demonstrated that IL-1beta stimulates IL-6 release from rat C6 glioma cells via a noncAMP mediated mechanism that may involve LPC
Aronica et al., Neuroscience 2005 : Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1beta stimulated release of IL-6 in cultured human astrocytes ... Activation of mGluR3 with DCG-IV ( but not of mGluR5 with DHPG ) enhanced, in the presence of IL-1beta , the release of IL-6 in a dose dependent manner in astrocytes cultured under conditions ( +EGF ) in which the mGluR expression is known to be upregulated ... The capacity of mGluR3 to modulate the release of IL-6 in the presence of IL-1beta supports the possible involvement of this receptor subtype in the regulation of the inflammatory and immune response under pathological conditions associated with glial cell activation
Koka et al., J Interferon Cytokine Res 1998 : Estrogen inhibits interleukin-1beta induced interleukin-6 production by human osteoblast-like cells ... Using enzyme linked immunosorbent assay ( ELISA ), we demonstrate that IL-1beta significantly enhances IL-6 secretion into culture supernatants in a dose dependent and time dependent manner
Herseth et al., Toxicol In Vitro 2009 : Role of IL-1 beta and COX2 in silica induced IL-6 release and loss of pneumocytes in co-cultures ... In this study we investigated the role of IL-1 beta , TNF-alpha and COX2 in silica induced regulation of IL-6 release and pneumocyte loss in various mono- and co-cultures of monocytes, pneumocytes and endothelial cells
Wu et al., Atherosclerosis 1999 : However, IL-1beta induced productions of both MCP-1 and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E. Vitamin E, at the doses used, did not significantly change the spontaneous production but dose-dependently inhibited the IL-1beta induced production of inflammatory cytokine IL-6
Rodriguez-Cimadevilla et al., Blood 1990 (Leukemia, Myeloid, Acute) : Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia : role of interleukin-1 as an endogenous inducer
Grimaldi et al., J Neurochem 1995 : The involvement of protein kinase C and its interaction with interleukin 1 beta in the control of interleukin 6 release by cortical astrocytes was studied
Fiebich et al., J Neural Transm Suppl 1998 (Alzheimer Disease...) : Furthermore, PGE2 potentiated IL-1 beta induced IL-6 mRNA synthesis
Lieb et al., J Neurochem 1996 (Astrocytoma) : For a better understanding of their pathogenic role, we analyzed signal transduction pathways mediating the interleukin (IL)-1 beta induced synthesis of IL-6 and tumor necrosis factor alpha (TNF alpha) in the human astrocytoma cell line U373 MG ... Whereas activation of protein kinase A was able to induce expression of the IL-6 gene, it did not induce TNF alpha gene expression and was not involved in IL-1 beta induced IL-6 and TNF alpha gene expression
Bertolucci et al., Neuroreport 1996 : Moreover, morphine potentiated the IL-6 response induced by IL-1 beta ( 400 ng, i.p. or i.c.v. )
Rosengren et al., J Allergy Clin Immunol 2007 (Autoimmune Diseases...) : FCAS monocytes respond to mild hypothermia with IL-1beta release, which in turn induces autocrine transcription and secretion of IL-6 and TNF-alpha as well as stimulation of further IL-1beta production
Rifas et al., Endocrinology 1995 : To investigate this hypothesis in a human model, we have examined 12 separate strains of normal human osteoblasts ( HOB ) and 11 separate strains of human bone marrow stromal cells ( HBMSC ) and determined whether ovarian steroids regulate the induction of IL-6 by interleukin-1 beta (IL-1 beta) , tumor necrosis factor-alpha (TNF-alpha) or IL-1 + TNF
Gallucci et al., Int Immunol 1998 (Inflammation) : We found that IL-1beta , tumor necrosis factor (TNF)-alpha and lipopolysaccharide (LPS) stimulated myoblast IL-6 secretion in a dose- and time dependent manner, whereas forskolin and cholera toxin did not
Hashizume et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid) : On the other hand, TNF-alpha and IL-17 did not induce RANKL expression, although TNF-alpha, IL-17 or IL-1beta stimulated cell growth and IL-6 production
Yamaguchi et al., Acta Endocrinol (Copenh) 1990 : Interleukin 6 possibly induced by interleukin 1 beta in the pituitary gland stimulates the release of gonadotropins and prolactin ... Rat anterior pituitary cells released IL-6 spontaneously, and its release was enhanced by IL-1 beta
Edwards et al., J Biol Chem 2007 (Asthma...) : Salmeterol and salbutamol enhanced rhinovirus- and IL-1beta induced IL-6 production ; however, fluticasone treatment caused a reduction of IL-6 protein and mRNA ... Combined activity of salmeterol and fluticasone at equimolar concentrations had no effect on rhinovirus or IL-1beta induction of IL-6
García-Criado et al., J Interferon Cytokine Res 2009 (Reperfusion Injury) : Administration of LA-803, LA-807 and, in a lower proportion, LA-810 prevented from the enhanced production of tumor necrosis factor (TNF), interferon-gamma (IFN-gamma), and interleukin-1beta (IL-1beta), the decrease in interleukin-6 (IL-6) and interleukin-10 (IL-10), the increase in tissue level of superoxide anion ( SOA ) and superoxide dismutase ( SOD ), and the increase in neutrophil infiltration induced by warm I/R. Treatment with LA-803 in animals with renal transplantation after cold ischemia was also associated with reduced plasma levels of TNF, IFN-gamma, and IL-1beta , increased plasma levels of IL-6 and IL-10, reduced renal levels of SOA and SOD, and reduced neutrophil infiltration
Andoh et al., Ther Apher Dial 2005 (Colitis, Ulcerative...) : IL-1beta induced IL-8 and IL-6 secretion was significantly decreased after granulocyte/monocyte adsorptive apheresis
Nakamura et al., Exp Eye Res 2003 : IL-6 and IL-8 in the culture media of ARPE-19 cells were increased by IL-1beta in a dose dependent manner ... Baicalin did not suppress IL-1beta induced IL-6 and IL-8 production, but dexamethasone, baicalein, and wogonin, significantly suppressed IL-6 and IL-8 production ... Wogonin and baicalein inhibited IL-1beta induced IL-6 and IL-8 mRNA and protein production in ARPE-19 cells ... The objective of the study was to investigate the effects of baicalin, baicalein, and wogonin ( plant flavonoids ) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production, mRNA expression, and nuclear factor-kappaB (NF-kappaB) binding activities induced by interleukin-1beta (IL-1beta) in human retinal pigment epithelial cell line ( ARPE-19 ) cells
Kolkhof et al., Biochem Biophys Res Commun 2010 : Qualified specificity of oubain for hepatocellular APP synthesis inhibition is demonstrated by lack of effectivity on IL-1beta induced IL-6 release from primary human coronary artery smooth muscle cells
Zhang et al., Biochem J 1995 : All constructs responded in the same way ; IL-6 , but not IL-1 beta, induced significant chloramphenicol acetyltransferase (CAT) expression which was synergistically enhanced 2- to 3-fold by IL-1 beta
Roldán et al., J Immunol 1992 : Finally, IL-1 beta plus TNF-alpha induced the production of IL-6 , but not of Ig, by adherent BM cells ... These results suggest that IL-1 beta and TNF-alpha produced by adherent BM cells synergistically induce early IL-6 generation, which, in turn, drives BM B cell producers into the high rate Ig-secreting state
Norris et al., J Immunol 1994 (Second Messenger Systems) : Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha ... We have focused on signal transduction related to the stimulation of IL-6 gene expression by IL-1 beta and TNF-alpha ... Our results indicate that stimuli related to protein kinase C ( PKC ), such as PMA and calcium ionophore A23187, increase IL-6 expression, whereas pharmacologic inhibitors of PKC inhibit IL-6 induction by IL-1 beta and TNF-alpha ... However, inhibition of the cAMP pathway effector, protein kinase A, did not reduce the induction of astrocyte IL-6 gene expression in response to IL-1 beta or TNF-alpha, and an ELISA for cAMP detected only very small increases in cAMP synthesis in response to these cytokines ... These data suggest that although cAMP does activate astrocyte IL-6 gene expression, it is the PKC pathway that plays a primary role in the stimulation of astrocyte IL-6 gene expression by IL-1 beta and TNF-alpha
Dovio et al., Cytokine 2001 : We examined the effects of physiological and supraphysiological concentrations of 17beta-estradiol ( E2 ) and cortisol on basal and IL-1beta induced IL-6 release in the medium ... In MG-63 cells, cortisol treatment for 20 h decreased both basal and IL-1beta induced IL-6 release in a dose dependent manner ; in Saos-2 cells the same effect was apparent for IL-1beta induced release
Luo et al., Am J Physiol Regul Integr Comp Physiol 2003 (MAP Kinase Signaling System) : We tested the hypothesis that IL-6 production in muscle cells is regulated by IL-1beta and that mitogen activated protein ( MAP ) kinase signaling and NF-kappaB activation are involved in IL-1beta induced IL-6 production
Nagai et al., Pharmacology 1999 (Arthritis) : Moreover Am-80 inhibited IL-1beta induced IL-6 production and IL-6 mRNA expression in human osteoblast-like cells ( MG-63 )
Liu et al., J Neurosci 2000 : Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP ( oATP ), resulted in a significant downregulation of IL-1beta stimulated expression of nitric oxide, tumor necrosis factor ( TNFalpha ), and IL-6 at both the protein and mRNA levels, without affecting cell viability
Bouchelouche et al., J Urol 2006 : We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha ... Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF
Inoue et al., Inflamm Res 2001 (Arthritis, Rheumatoid...) : NS-398 exhibited an inhibition of IL-1beta induced IL-6 production as well as PGE2 production
Parikh et al., J Surg Res 1997 : PDTC, TLCK, and genistein each inhibited IL-1 beta induced IL-6 production by the Caco-2 cells in a dose dependent fashion ... The results suggest that IL-1 beta induced IL-6 production in the enterocyte is associated with activation of NF-kappa B
Blom et al., Brain Res 1997 (Astrocytoma) : NSAIDS inhibit the IL-1 beta induced IL-6 release from human post-mortem astrocytes : the involvement of prostaglandin E2 ... The glucocorticoid dexamethasone inhibited the IL-1beta activated release of IL-6 from the postmortem astrocyte cultures A157 and A295 and from the astroglioma cell lines ... Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta activated IL-6 release from A157 astrocytes and largely potentiated the IL-1 induced release of IL-6 from all astrocytes/astroglioma cells tested ... Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta activated IL-6 release could not be prevented by the addition of PGE2
Shimada et al., J Immunol 2002 : IL-6 secretion was rapidly induced by IL-17, IL-1beta , and TNF-alpha ... Furthermore, IL-17, IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors ( SB203580, PD98059, and U0216 ) significantly reduced IL-17-, IL-1beta-, or TNF-alpha induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6
Liu et al., Atherosclerosis 2004 (Arteriosclerosis) : Pre-incubation of HAEC with AEM at 20 and 40 microg/ml, but not at 4 microg/ml, for 24h significantly suppressed IL-1beta stimulated expressions of intracellular adhesion molecule-1 ( ICAM-1 ), vascular cell adhesion molecule-1 ( VCAM-1 ), and E-selectin and the secretion of proinflammatory cytokines IL-6 , chemokines IL-8 and monocyte chemoattractant protein (MCP)-1
Fujisawa et al., Placenta 2000 (Choriocarcinoma...) : IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta , tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate ( TPA )
Dong et al., Hypertens Res 2003 (Acute-Phase Reaction...) : IL-1beta ( 1 ng/ml ) and IL-6 ( 1 ng/ml ) increased the accumulation of PAI-1 in the conditioned media over 24 h ( IL-1beta : 2.1 +/- 0.2 ( mean +/- SD ) fold over the control ; IL-6 : 1.4 +/- 0.2 fold ; Western blot, p < 0.05 )
Adams et al., Neurosurgery 1994 (Neuroma, Acoustic) : Tumor necrosis factor-alpha, interleukin-1-beta , and cholera toxin all stimulated IL-6 secretion
Shimetani et al., Nihon Rinsho Meneki Gakkai Kaishi 1997 (Liver Neoplasms, Experimental) : A cytokine IL-6 induced the CRP production in the presence of IL-1 beta , but did not affect the constitutive production of SAA
Sandell et al., Osteoarthritis Cartilage 2008 (Arthritis) : In the presence of IL-1beta , FGF-18 increased expression of ADAMTS-4, aggrecan, BMP-2, COL2A1, CCL3, CCL4, CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6 , and IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Lim et al., Biol Reprod 2013 : We found that the loss of FOXO3 in myometrial cells was associated with a significant decrease in IL1B induced IL6 and IL8 expression and production, cyclooxygenase ( [ COX]-2, official symbol PTGS2 ) expression and subsequent prostaglandin ( PGE2 and PGF2alpha ) release, and matrix metalloproteinase 9 (MMP9) and mRNA expression and activity
Robb et al., Surgery 2002 : IL-10 potentiated IL-1 beta induced IL-6 promoter activity
Saito et al., Mech Ageing Dev 2003 (Endotoxemia...) : The stress mediated induction of interleukin-1beta , interleukin-6, and interleukin-10 ( IL-1beta, IL-6, and IL-10 ) in the circulating blood tended to be higher with aging in both CLP and LPS models, and in particular, the induction of IL-6 was significantly augmented with aging
Suzuki et al., Cytokine 2010 (MAP Kinase Signaling System) : IL-1beta as well as IL-6+sIL-6R induced IL-6 production
Hellstrom et al., Hippocampus 2005 (Encephalitis...) : Finally, we confirmed that LPS dramatically increased IL-1beta, and IL-1beta dependent IL-6 levels in the culture medium for 2 days before returning to baseline
Yoza et al., J Biol Chem 1996 : In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene
Pobanz et al., J Periodontal Res 2000 (Alveolar Bone Loss) : C5a modulation of interleukin-1 beta induced interleukin-6 production by human osteoblast-like cells ... These results indicate that while MG-63 cells express functional C5aRs, the synergistic effect of C5a and IL-1beta on osteoblast IL-6 production is probably controlled by post-receptor signaling events
Nold-Petry et al., J Biol Chem 2009 (MAP Kinase Signaling System) : Unexpectedly, we observed a paradoxical 10-fold increase in IL-1beta induced IL-6 production in MEF cells from mice deficient in the IL-18R alpha-chain ( IL-18Ralpha ) compared with wild type MEF ... Stable lines of IL-18Ralpha depleted human A549 cells were generated using shRNA, resulting in an increase of IL-1beta induced IL-1alpha, IL-6 , and IL-8 compared to scrambled small hairpin RNA
Mastorakos et al., J Clin Endocrinol Metab 1994 (Inappropriate ADH Syndrome) : Plasma IL-1 beta and tumor necrosis factor-alpha concentrations, assayed by specific enzyme linked immunosorbent assays during the 4 h after the first IL-6 injection, were either within the normal range or undetectable, confirming in vitro observations that IL-6 does not stimulate IL-1 beta or tumor necrosis factor-alpha secretion and suggesting that it exerts its effect on the HPA axis and AVP secretion independently of them
Liu et al., Cytokine 2005 : The mechanism by which IL-1beta promoted IL-6 expression in CB-MSCs was studied
Cowland et al., J Immunol 2003 : IL-1beta induces a > 10-fold up-regulation of NGAL expression in the type II pneumocyte derived cell line A549 cells, whereas TNF-alpha, IL-6 , and LPS had no effect
Djalilian et al., Cornea 2006 : In contrast, Dex treatment inhibited the IL-1beta induced production of GM-CSF, IL-6 , IL-8, MCP-3, and RANTES, but not MCP-1
Ghazizadeh et al., J Invest Dermatol 2007 (Keloid) : Induction of IL-6 by IL-1beta peptide and stimulation by IL-6 peptide in NFs, or inhibition of IL-6 or IL-6R alpha in KFs cultures demonstrated a dose dependent increase or decrease in procollagen I synthesis, respectively
Rao et al., Mol Cell Biol 2005 (Inflammation) : Overexpression of IRAK1c suppressed NF-kappaB activation and blocked IL-1beta induced IL-6 as well as lipopolysaccharide- and CpG induced tumor necrosis factor alpha production in multiple cellular systems
Lu et al., Journal of neuroinflammation 2010 (Inflammation) : Resveratrol inhibited LPS induced expression and release of TNF-alpha, IL-6 , MCP-1, and iNOS/NO in both cell types with more potency in microglia, and inhibited LPS induced expression of IL-1beta in microglia but not astrocytes
Busam et al., J Hepatol 1990 : The secretion of IL-6 could also be induced by interleukin (IL)-1 beta and tumor necrosis factor ( TNF-alpha )
Laban-Guceva et al., Med Arh 2007 (Graves Disease) : No stimulatory effect of IL-1beta on IL-6 was observed : IL-1beta was unchanged while IL-6 levels were increased after treatment
Hofbauer et al., J Bone Miner Res 1999 : Treatment with 5alpha-dihydrotestosterone ( DHT ) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80 % at 10-7 M ... In addition, testosterone also suppressed TNF-alpha/IL-1beta stimulated IL-6 mRNA levels by 57 %, while the adrenal androgen dehydroepiandrosterone had no effect
Beauchemin et al., J Cell Physiol 1991 (Blast Crisis...) : In the present study, we show that IL-6 production by AML blasts is up-regulated by endogenously produced IL-1 beta
Linker-Israeli et al., Clin Immunol 1999 (Lupus Erythematosus, Systemic) : We found that ( 1 ) exogenous rIL-10 and rIL-4 mediated reduction of constitutive and lectin induced IL-6 in monocytes of SLE patients as effectively as that of controls ; ( 2 ) IL-6 mRNA decay was significantly delayed in SLE with active disease ( P < 0.001 ) ; ( 3 ) adding rIL-10 or neutralizing endogenous IL-1 beta and TNF-alpha down-regulated IL-6 mainly by destabilizing IL-6 transcripts, whereas exogenous IL-4 and TGF beta 1 down-regulated IL-6 transcriptionally ; ( 4 ) time kinetics and levels of IL-10 were lower than those of IL-6 and IL-1 beta
Yoshino et al., J Clin Endocrinol Metab 2003 : Whereas IL-1 beta increased the production of IL-6 , IL-8, and monocyte chemotactic protein-1, and expression of cyclooxygenase-2 mRNA in ESC cultured without treatment, the stimulatory effects of IL-1 beta were reduced in the decidualized cells
Agarwal et al., J Periodontal Res 1995 : IL-1 beta activation of GF cells showed that IL-1 beta non only induces the expression of IL-6 , IL-8 and TNF-alpha, but also acts in an autocrine manner of GF cells and induces IL-1 beta expression
Strle et al., Am J Physiol Endocrinol Metab 2008 (MAP Kinase Signaling System) : This action of IL-10 is not caused by impairment of IL-1beta induced synthesis of IL-6 or the ability of IL-1beta to activate two members of the MAPK family, ERK1/2 and p38
Takata et al., Circ Res 2002 (Inflammation) : On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) inhibited IL-1beta induced IL-6 expression at a transcriptional revel in VSMCs. Functional promoter analysis revealed that PPAR-gamma ligands inhibited IL-1beta induced transactivation of IL-6 gene via suppression of not only nuclear factor-kappaB but also C/EBP-DNA binding
Khan et al., Gastroenterology 1995 : Interleukin 1 beta induces the expression of interleukin 6 in rat intestinal smooth muscle cells
Cromwell et al., Immunology 1992 : Expression and generation of interleukin-8, IL-6 and granulocyte-macrophage colony stimulating factor by bronchial epithelial cells and enhancement by IL-1 beta and tumour necrosis factor-alpha
Zoja et al., J Am Soc Nephrol 1992 : Recombinant interleukin-1 receptor antagonist blocked the interleukin-1 mRNA as well as interleukin-6 and interleukin-8 mRNA accumulation induced by interleukin-1 beta
Yang et al., J Immunol 1994 (HIV Infections...) : Both IL-1 beta and the synthetic dsRNA, poly ( I:C ), induced high levels of IL-6 mRNA and protein expression, whereas LPS and TNF-alpha led to only modest increases in IL-6 protein and mRNA
Kiriyama et al., J Neuroimmunol 1997 (Glioblastoma) : In human glioblastoma A172 cells, interleukin-6 (IL-6) production was induced by interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP
Plum et al., Kidney Blood Press Res 2002 (Kidney Failure, Chronic...) : The IL-1beta induced IL-6/IL-8 release of HPMC from healthy donors and from patients with end-stage renal disease ( ESRD ) were measured before the start of chronic peritoneal dialysis ( PD ) and during PD therapy
Shimizu et al., Arch Oral Biol 1992 : IL-1 beta stimulated IL-6 production by these cells in a dose- and time dependent manner ; this increase in IL-6 production was much higher than that in human gingival fibroblasts ... The finding that IL-6 is produced by PDL cells and is regulated by IL-1 beta has revealed a potentially important mechanism for controlling alveolar bone resorption
Haynes et al., J Bone Joint Surg Br 1997 (Bone Resorption) : Both IL-1beta and TNFalpha stimulated IL-6 and PGE2 release from the osteoblast-like cells
Noguchi et al., J Periodontal Res 2001 (Periodontal Diseases) : IL-1beta and tumor necrosis factor alpha (TNFalpha), proinflammatory cytokines, induced IL-6 production in a time dependent manner, and PGF2alpha synergistically enhanced IL-6 production induced by IL-1beta and TNFalpha ... IL-6 mRNA was expressed in PGF2alpha stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha
Romero et al., Neuroendocrinology 1993 : IL-6 secretion was induced by IL-1 beta in a concentration as low as 1 x 10 ( -10 ) M ( p = 0.0008 ) ; addition of IL-1Ra was shown to inhibit IL-1 induced changes by 87 % ( p = 0.0012 ) at a molar ratio of 100 : 1, and by 100 % at a molar ratio of 1,000 : 1, LPS stimulated IL-6 secretion progressively over the concentration of 1-100 ng/ml ( p = 0.0001 )
Konda et al., Arthritis Rheum 2010 (Arthritis, Experimental...) : META060 inhibited osteoclastogenesis, as indicated by decreased transformation of RAW 264.7 cells to osteoclasts and reduced TRAP activity, and inhibited IL-1beta activated prostaglandin E ( 2 ), matrix metalloproteinase 3, IL-6 , IL-8, and monocyte chemotactic protein 1 in RASFs
Persson et al., Biochem Biophys Res Commun 2005 : By using calvarial osteoblasts, we showed that IL-1beta increased IL-6 production time- and concentration-dependently, and that these effects were potentiated by VIP ... Furthermore, IL-1beta stimulated IL-6 promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct, and both VIP, and the related neuropeptide PACAP-38, increased the effect of IL-1beta in a synergistic manner
Ahmed et al., Proc Natl Acad Sci U S A 2008 (Arthritis, Rheumatoid...) : We found that epigallocatechin-3-gallate ( EGCG ), an anti-inflammatory compound found in green tea, inhibits IL-1beta induced IL-6 production and transsignaling in RA synovial fibroblasts by inducing alternative splicing of gp130 mRNA, resulting in enhanced sgp130 production
Yoshino et al., Am J Reprod Immunol 2004 (Endometriosis) : Effects of PD98059, SB202190 and SP600125 ( inhibitors of ERK, p38 and JNK, respectively ) on IL-1beta induced secretion of IL-6 and IL-8, and on IL-1beta induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied
Legrand-Poels et al., Biochem J 2000 (Adenocarcinoma...) : Analyses of secreted IL-6 by ELISA and of IL-6 mRNA by reverse transcription-PCR revealed that, whereas HeLa cells produced high levels of IL-6 in response to tumour necrosis factor-alpha (TNF-alpha) and IL-1beta , the HTM-29 cell line failed to produce both IL-6 protein and mRNA
Yu et al., J Immunol 2007 (Inflammation) : In this study, it was demonstrated that LL-37 synergistically enhanced the IL-1beta induced production of cytokines ( IL-6 , IL-10 ) and chemokines such as macrophage chemoattractant proteins ( MCP-1, MCP-3 ) in human PBMC, indicating a role in enhancing certain innate immune responses
Oxholm et al., Acta Derm Venereol 1991 (Dermatitis, Contact) : These results demonstrate that enhancement of keratinocyte bound IL-6 does not induce TNF alpha, IL-1 alpha/beta or IL-6 expression by LC during APR or IPR, and that enhanced keratinocyte expression of IL-6 fails to distinguish between these two reactions
Tsakiri et al., Br J Pharmacol 2008 : We show here that IL-1beta induces the synthesis of IL-6 in primary mouse neuronal cultures, and this is dependent on the activation of IL-1R1, nSMase and Src kinase ... We also show that NR2B, CamKII and CREB are essential signalling elements involved in IL-1beta induced IL-6 synthesis in neurones ... The mechanism by which IL-1beta induces IL-6 synthesis in neurones could be critical in both physiological and pathophysiological actions of IL-1beta, and may provide a new therapeutic target for the treatment of acute CNS injury
Gottschall et al., Brain Res 1994 : Co-addition of the specific IL-1 receptor antagonist (IL-1ra) completely inhibited IL-1 beta induced IL-6 secretion but did not affect LPS stimulated IL-6 production during a 6 h incubation period
Pousset et al., Glia 1999 : In this report, we describe the sequential effects of IL-4 and IL-10 on the production of interleukin-6 (IL-6) induced by IL-1beta in mouse primary astrocytes and compare these effects to those of the synthetic glucocorticoid agonist, dexamethasone ... Incubation of mouse astrocytes in primary culture simultaneously with IL-1beta ( 10 ng/ml ) + IL-10 ( 10 ng/ml ) or IL-1beta + dexamethasone ( 10 ( -6 ) M ) markedly reduced IL-1beta induced IL-6 secretion and IL-6 mRNA expression, respectively, whereas simultaneous addition of IL-4 ( 10 ng/ml ) did not alter the induction of IL-6 by IL-1beta
Radeff et al., Exp Cell Res 2001 (Bone Resorption) : Involvement of PKC-beta in PTH, TNF-alpha, and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH stimulated bone resorption ... These results indicate that PKC-beta ( I ) is a component of the signaling pathway that mediates PTH-, TNF-alpha-, and IL-1 beta stimulated IL-6 expression and PTH stimulated bone resorption
Takemura et al., Endocrinology 2006 : The effects of adiponectin on IL-1beta induced secretion of IL-6 , IL-8, and monocyte chemoattractant protein 1 from cultured ESCs were determined using specific ELISAs ... Adiponectin decreased IL-1beta induced secretion of IL-6 , IL-8, and monocyte chemoattractant protein 1 from ESCs
Schindler et al., Blood 1990 : IL-6 did not stimulate IL-1 beta or TNF production, but suppressed IL-1 beta and TNF production induced by LPS or PHA by 30 % ( P less than .01 )
Tipton et al., J Periodontol 2007 (Periodontitis) : PGE ( 2 ) and the transcription factor nuclear factor-kappa B (NF-kappaB) regulate IL-1beta stimulated IL-6 production
Kahlke et al., Cytokine 2000 (Hemorrhage...) : In contrast, IL-1beta and IL-6 production by Mbeta from young males was suppressed and IL-10 production enhanced following trauma-haemorrhage, whereas Mstraight phi from aged males produced elevated levels of IL-1beta and IL-6 and suppressed levels of IL-10 following trauma-haemorrhage
Kawada et al., Jpn J Cancer Res 1999 (Prostatic Neoplasms) : In the conditioned medium, marked IL-6 secretion was induced from WI-38 cells by IL-1beta or TNF-alpha
Kida et al., Cytokine 2005 : We comprehensively investigated the involvement of mitogen activated protein kinases ( MAPKs ) /activator protein-1 (AP-1) and IkappaB kinases ( IKKs ) /IkappaBs/nuclear factor-kappaB (NF-kappaB) in IL-1beta stimulated IL-6 , IL-8, prostaglandin E ( 2 ) ( PGE ( 2 ) ) and matrix metalloproteinase-1 (MMP-1) production by human gingival fibroblasts (HGF)
Hildebrand et al., Unfallchirurg 2005 (Inflammation...) : TNF-alpha and IL-1beta are early regulators of the immune response and both induce the release of secondary cytokines, such as IL-6 and IL-8
Sun et al., Am J Physiol Endocrinol Metab 2006 : Consequently, these alterations combined led to a marked increase in nuclear p65 DNA binding and NF-kappaB transcriptional activity ; consistently, induction of IL-6 by TNF-alpha or IL-1beta was much more robust in VDR-/- than in VDR+/- cells, indicating that VDR-/- cells are more susceptible to inflammatory stimulation
Faffe et al., Am J Physiol Lung Cell Mol Physiol 2005 : Consistent with the increase in IL-1R1 expression, OSM markedly augmented IL-1beta induced VEGF, MCP-1, and IL-6 release
Kawasaki et al., J Neurosci 2008 (Hyperalgesia...) : Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine induced currents
Rogler et al., Scand J Gastroenterol 2001 (Colitis, Ulcerative...) : IL-8 and IL-6 secretion could be stimulated by IL-1alpha, IL-1beta , TNF, PMA and LPS within 6 h of incubation
Modéer et al., J Oral Pathol Med 2000 : The stimulatory effect of PHT on IL-1beta induced IL-6 production was strongly reduced by the specific cyclooxygenase-2 inhibitor NS-398 ( 1 microM ) ... The anti-inflammatory drug, dexamethasone ( 1 microM ), abolished the production of both IL-6 and IL-8 in gingival fibroblasts challenged with PHT in the presence or absence of IL-1beta
Gottschall et al., Mol Cell Neurosci 1992 : During short-term incubations of U87MG cells ( 6 h ) in the presence of IL 1beta and dexamethasone ( DEX ), DEX inhibited IL 1beta stimulated IL 6 production over the entire range of the dose-response curve ... In fact, the ED ( 50 ) for IL 1beta stimulated IL 6 production was about 1.3 pM in cells not preincubated with DEX, but was reduced to 0.25 pM in cells that were preincubated with DEX
Hershko et al., Clin Sci (Lond) 2002 : IL-1beta increased NF-kappaB DNA binding activity, IL-6 mRNA levels and IL-6 production
Furuhashi et al., J Pharm Pharmacol 2005 : Licochalcone A ( IC50 15.0 nM ) inhibited PGE2 production, but not IL-6 and IL-8 production, in response to IL-1beta
Ho et al., J Leukoc Biol 2007 : We found that IL-33, but not IL-1beta or IL-18, induced IL-13 and IL-6 production by mouse bone marrow derived, cultured mast cells ( BMCMCs ) independently of IgE ... In BMCMCs incubated with the potently cytokinergic SPE-7 IgE without specific antigen, IL-33, IL-1beta , and IL-18 each promoted IL-13 and IL-6 production, but the effects of IL-33 were more potent than those of IL-1beta or IL-18
Parikh et al., Shock 1997 : Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells ... The results suggest that enterocyte IL-6 production is stimulated by IL-1 beta and that this effect is potentiated by IFN-gamma
Motoyama et al., Virchows Arch 1994 (Carcinoma, Non-Small-Cell Lung...) : Interleukin 1 beta (IL-1 beta) had a stimulatory effect on IL-6 production by HAT.MC8 cells, but no influence on the morphology of the cells
Lee et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010 : IFNgamma and IL-1beta cause an increase of released IL-6 protein level in a time dependent manner
Spangelo et al., Ann N Y Acad Sci 2000 : In the rat C6 glioma cell line, IL-1 beta synergistically stimulates IL-6 release in the presence of increased intracellular cAMP concentrations ... The catecholamines and serotonin also synergistically stimulate IL-6 release in the presence of IL-1 beta ... LPC 18 : 0 synergistically increases IL-6 release in the presence of norepinephrine, and IL-1 beta transiently increases LPC 18 : 0 formation in C6 cells ... Therefore, IL-1 beta induction of LPC 18 : 0 may lead to increases in IL-6 production via activation of a kinase cascade
Bernardino et al., J Neurochem 2008 (Encephalitis...) : Potentiation of AMPA toxicity was prevented when IL-1beta production or its receptor signaling were blocked by an inhibitor of interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
McGee et al., J Immunol 1993 : RT-PCR analysis of IL-1 beta treated cells showed an enhanced level of IL-6 mRNA at 4 h, suggesting that IL-1 beta enhanced IL-6 gene expression
Osawa et al., Nephrol Dial Transplant 1995 : Secretion of IL-6 by GECs was increased by transforming growth factor beta but not by IL-1 beta
Henrotin et al., Clin Rheumatol 1998 (Cadaver) : As anticipated, IL-1beta induced a marked release of collagenase, stromelysin, IL-6 , IL-8 and PGE2
Krakauer et al., Immunol Lett 1998 : The biological activities of IL-1 receptor antagonist (IL-1ra) or IL-1ra-like molecule were measured by its ability to suppress the IL-1beta mediated induction of adhesion molecules ( ICAM and ELAM ) on EC and of IL-6 secretion by these cells
Spangelo et al., Endocrinology 1996 : We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2) mediated hydrolysis of phosphatidylcholine ( PC ) in AP cells ... In addition, H7 ( 20 microM ) abolished the stimulation of IL-6 release by IL-1 beta ( 0.16-100 ng/mL )
Wei et al., Biochimie 2006 : Promutoxin is also able to stimulate the release of IL-12, TNFalpha, IL-6 and IL-1beta from human monocytes, and induce IL-2, TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Vitkus et al., In Vitro Cell Dev Biol Anim 1998 : We have determined that the human colonic carcinoma cell line Caco-2 is capable of secreting IL-6 when stimulated by the inflammatory cytokines IL-1beta or tumor necrosis factor-alpha (TNF-alpha), and stimulation of these cells with IL-1beta plus TNF-alpha induced a synergistic enhancement of IL-6 secretion
Churchill et al., Brain Res 2006 : Relative to saline administration, IL1beta increased IL1beta, TNFalpha and IL6 mRNAs in the nucleus tractus solitarius (NTS), hypothalamus, hippocampus and somatosensory cortex ( SSctx ), but did not induce any changes in IL10
Bradford et al., Mol Cell Biol Res Commun 2000 : Acute IL-6 secretion from osteosarcoma cells induced by the PI-linked hormones PTH ( 1-34 ) and endothelin-1 is potentiated by IL-1 beta
Schotanus et al., Endocrinology 1993 : We conclude that 1 ) IL-1 receptors are involved in the ACTH and IL-6 responses to rat IL-1 beta ; 2 ) the ACTH response, but not the IL-6 response, to a low dose dose of endotoxin in rats requires IL-1 receptor activation by endogenous produced IL-1 ; and 3 ) circulating IL-6 is not a prime mediator involved in ACTH and CORT responses to low doses of rIL-1 beta and endotoxin