Gene interactions and pathways from curated databases and text-mining

◀ Back to HES5

IL1B — IL8

Text-mined interactions from Literome

Hassanain et al., Neuroscience 2003 : In particular, interleukin-1beta in the medial hypothalamus potentiates defensive rage behavior elicited from the periaqueductal gray in the cat, and the potentiating effects of interleukin-1beta on this form of emotional behavior are mediated via a 5-HT2 receptor mechanism
Andoh et al., Ther Apher Dial 2005 (Colitis, Ulcerative...) : IL-1beta induced IL-8 and IL-6 secretion was significantly decreased after granulocyte/monocyte adsorptive apheresis
Takaki et al., Laryngoscope 2003 : The expression of both IL-8 protein and messenger RNA in adenoidal fibroblasts was enhanced by Haemophilus influenzae endotoxin and interleukin-1 beta and was positively correlated with increases in NF-kappa B activity
Nakamura et al., Exp Eye Res 2003 : IL-6 and IL-8 in the culture media of ARPE-19 cells were increased by IL-1beta in a dose dependent manner ... Baicalin did not suppress IL-1beta induced IL-6 and IL-8 production, but dexamethasone, baicalein, and wogonin, significantly suppressed IL-6 and IL-8 production ... The objective of the study was to investigate the effects of baicalin, baicalein, and wogonin ( plant flavonoids ) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production, mRNA expression, and nuclear factor-kappaB (NF-kappaB) binding activities induced by interleukin-1beta (IL-1beta) in human retinal pigment epithelial cell line ( ARPE-19 ) cells
Handa et al., Inflamm Res 2006 (Stomach Neoplasms) : HPE and IL-1beta induced a significant increase in IL-8 production by MKN45 and HUVEC, respectively, along with NFkappaB activation, which was significantly inhibited by PPI
Yoshida et al., Invest Ophthalmol Vis Sci 2001 : IL-4 also enhanced IL-1beta induced HRPE IL-8
Elner et al., Exp Eye Res 1997 : Substantial dose- and time dependent RPE secretion of IL-8 was observed following stimulation with IL-1 beta or TNF-alpha, but cell associated IL-8 was detectable only after high dose ( 20 ng ml-1 ) IL-1 beta stimulation and comprised less than 1 % of the total IL-8 induced
Okuno et al., Scand J Gastroenterol 2002 : IL-1beta and TNF-alpha both induced a dose- and time dependent increase in IL-8 , MCP-1 and MMP-1 secretion, and weakly stimulated MMP-2 secretion
Lotz et al., J Immunol 1992 (Arthritis) : By using a specific RIA, we demonstrate that not only IL-1 beta , but also TNF-alpha and LPS can induce abundant IL-8 secretion from chondrocytes
Berry et al., Int J Gynecol Cancer 2001 (Carcinoma, Papillary...) : Further, the treatment of endometrial carcinoma cells with inflammatory cytokines, IL-1beta and tumor necrosis factor-alpha (TNF-alpha), demonstrated that IL-1beta and TNF-alpha induced IL-8 expression in endometrial cancer cells ... IL-1beta was a more potent inducer of IL-8 expression than TNF-alpha in our studies
Netsch et al., Planta Med 2006 : In this study, we investigated the effects of a defined green tea extract ( GTE ) or EGCG on basal or IL-1beta induced IL-8 expression and secretion in the human gastrointestinal epithelial cell line Caco-2 ... At the highest concentration, GTE inhibited IL-1beta induced IL-8 secretion to a similar extent as found for brefeldin A, an inhibitor of vesicular transport
Choi et al., Scand J Gastroenterol 2008 (Adenocarcinoma...) : Effect of Lactobacillus GG and conditioned media on IL-1beta induced IL-8 production in Caco-2 cells ... We demonstrated that the pretreatment of Caco-2 cells with LGG significantly inhibited IL-1beta induced IL-8 production ... Furthermore, LGG attenuated the IL-1beta induced transcriptional activation of the IL-8 gene and the NF-kappaB-responsive gene, and attenuated the IL-1beta induced IkappaBalpha degradation ... LGG-CM attenuated IL-1beta induced IL-8 production ... LGG inhibited IL-1beta induced IL-8 production in Caco-2 and this effect occurred at the transcriptional level, at least in part, by inhibition of the NF-kappaB signaling pathway ... Both the structural material of LGG and the soluble factor secreted from LGG inhibited the IL-1beta induced IL-8 production, and thus different substances may cause the effects
Mauviel et al., Biochem Biophys Res Commun 1988 : The ability of the two forms of interleukin-1 , IL-1 alpha and IL-1 beta, to induce IL-1 beta gene expression in human skin fibroblasts was studied in vitro, using Northern blot hybridization
Hwang et al., Oncogene 2004 (Stomach Neoplasms) : Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells ... In this study, the effect of IL-1beta on IL-8 expression in human gastric cancer TMK-1 cells and the underlying signal transduction pathways were investigated ... IL-1beta induced the IL-8 expression in a time- and concentration dependent manner ... N-acetyl cysteine (NAC) prevented the IL-1beta induced ROS production and IL-8 expression ... Deletional and site directed mutagenesis studies on the IL-8 promoter revealed that activator protein-1 (AP-1) and nuclear factor (NF)-kappaB sites were required for the IL-1beta induced IL-8 transcription ... The above results suggest that MAPK-AP-1 and ROS-NF-kappaB signaling pathways are involved in the IL-1beta induced IL-8 expression and that these paracrine signaling pathways induce endothelial cell proliferation
Zakharova et al., PloS one 2010 (Inflammation) : For example, E. coli LPS induced IL-1 beta was suppressed by 6 fold and IL-8 by 10 fold in mycoplasma positive THP-1 cells
Neudeck et al., Eur J Pharmacol 2003 : In the present study, we determined that Caco-2 cells express the kappa-opioid receptor and its activation by trans- ( +/- ) -3,4-dichloro-N-methyl-N [ 2- ( 1-pyrolidinyl ) cyclohexyl ] benzeneacetamide methanesulfonate ( U-50488 ) leads to decreased interleukin-8 secretion in the presence of interleukin-1beta
Mathy-Hartert et al., Inflamm Res 2003 (Inflammation...) : LPS and IL-1beta stimulated IL-1beta, IL-6, IL-8 , iNOS and COX-2 gene expression
Maresca et al., Toxicol Appl Pharmacol 2008 (Inflammation) : We found that deoxynivalenol, ochratoxin A and patulin all potentiated the effect of IL-1beta on IL-8 secretion ( ranging from 35 % to 138 % increase ) and increased the transepithelial passage of commensal bacteria ( ranging from 12- to 1544-fold increase )
Pan et al., Respir Med 2006 : However, pyocyanin upregulated the stimulatory effect of IL-1beta or PDBu on the release of IL-8 in a dose dependent manner
Inoue et al., J Immunol 2005 (Arthritis, Rheumatoid...) : Furthermore, IL-1beta induced IL-8 , IL-6, and matrix metalloproteinase-3 protein production was significantly inhibited in DN MKK3/DN MKK6 transfected cells
Bai et al., Inflammation 2005 (Adenocarcinoma...) : Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line ( Caco-2 ) ... IL-1beta promotes IL-8 production, which can be modulated by a number of factors, including oxidative stress ... Thus, we investigated the effect of oxysterols, including 25-hydroxycholesterol and 7beta-hydroxycholesterol, on IL-1beta induced IL-8 production in Caco-2 cells ( a human colon carcinoma cell line ) ... Pre-treatment of Caco-2 cells with 25-hydroxycholesterol significantly enhanced IL-1beta induced IL-8 expression at both mRNA and protein levels ... These results suggest that 25-hydroxycholesterol enhances IL-1beta induced IL-8 production, possibly by enhancing promoter activity
Németh et al., Immunol Lett 2003 : In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate ( PDTC ) on IL-1beta induced IL-8 production by the human intestinal epithelial cell line HT-29
Matsukawa et al., Lab Invest 1997 (Arthritis, Experimental...) : Maximum levels of TNF alpha and IL-8 were detected at 2 hours after LPS-injection, whereas IL-1 beta and IL-1 receptor antagonist (IL-1Ra) were detected at 6 and 9 hours, respectively ... These results provide new evidence that IL-8 as well as TNF alpha are the most proximal cytokines and induce subsequent production of IL-1 beta and IL-1Ra
Zouboulis et al., Proc Natl Acad Sci U S A 2002 : CRH was biologically active on human sebocytes : it induced biphasic increase in synthesis of sebaceous lipids with a maximum stimulation at 10 ( -7 ) M and up-regulated mRNA levels of 3 beta- hydroxysteroid dehydrogenase/Delta ( 5-4 ) isomerase, although it did not affect cell viability, cell proliferation, or IL-1 beta induced IL-8 release
Goebeler et al., J Invest Dermatol 1997 : Upon stimulation with interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), both HDMECs and HMEC-1 expressed high levels of IL-8 , GRO, and monocyte chemoattractant protein-1 ( MCP-1 )
Yang et al., Cell Signal 2008 (MAP Kinase Signaling System) : IL-1beta stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
Sharma et al., Am J Physiol Gastrointest Liver Physiol 2006 : The anti-inflammatory effect extends to both bacterial and host derived proinflammatory stimuli, since prior infection with EPEC suppressed the IL-8 response to tumor necrosis factor-alpha, IL-1beta , and enterohemorrhagic E. coli flagellin
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Wickremasinghe et al., J Immunol 1999 : Recombinant IL-1 beta ( 2 ng/ml ) induced similar levels of IL-8 secretion to CoMTB in both A549 cells and NHBE
Culpitt et al., Am J Respir Crit Care Med 2003 (Pulmonary Disease, Chronic Obstructive) : IL-1beta and CSM increased IL-8 and GM-CSF release by macrophages from both smokers and patients with COPD
Bouchelouche et al., Urology 2006 : TNF-alpha and IL-1beta ( 0.01 to 100 ng/mL ) induced secretion of IL-8 , IL-6, and RANTES in a dose and time dependent manner
Liu et al., Cell Biol Int 2009 (Acute Lung Injury...) : The knockdown of PBEF expression significantly inhibited IL-1beta stimulated IL-8 secretion and mRNA level by 60 % and 70 %, respectively, and the knockdown of PBEF expression also significantly attenuated IL-1beta induced cell permeability by 29 % in epithelial cells and 24 % in endothelial cells
Yagi et al., J Gastroenterol 2007 (Colitis) : Both IL-17A and IL-17F augmented IL-1beta induced secretion of IL-6, IL-8 , LIF, MMP-1, and MMP-3
Fyfe et al., Cytokine 2005 (Inflammation...) : Inhibition of p38 MAPK led to decreased IL-8 following stimulation with IL-1beta and/or activating peptide
Moodie et al., FASEB J 2004 : However, H2O2, tumor necrosis factor-alpha (TNF-alpha), and IL-1beta significantly increased NF-kappaB activation and expression of IL-8 compared with control cells
Hosokawa et al., Clin Exp Immunol 2006 (Periodontitis) : The IL-8 and VEGF production induced by TWEAK was augmented synergistically by simultaneous stimulation with transforming growth factor (TGF)-beta1 or IL-1beta
Reznikov et al., J Interferon Cytokine Res 1998 : A significant suppression ( 75 %, p < 0.001 ) of IL-1beta induced IL-8 production 3 and 6 h after IFN-alpha2b compared with control subjects was observed
Jobin et al., J Immunol 1998 : Induction of inducible nitric-oxide synthase (iNOS), IL-1beta, and IL-8 genes by IL-1beta , TNF-alpha, or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA ... In addition, IL-1beta induced IL-8 secretion was totally inhibited by Ad5 IkappaB in primary colonic IEC
Poleganov et al., J Interferon Cytokine Res 2007 : ZnCl ( 2 ) also amplified IFN-gamma production under the influence of IL-12 or IL-18, whereas IL-1beta induced IL-8 expression was not enhanced by the addition of ZnCl ( 2 ), indicating that the effect observed on cytokine induced IFN-gamma is not of a general and unspecific nature
Murakami et al., Int Immunol 2001 : Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine ( 2-CADO ), N ( 6 ) -cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta induced IL-6 and IL-8 production
Gööz et al., Gut 2003 (Gastrointestinal Neoplasms...) : Comparable IL-8 secretory responses ( approximately 1700 ng/ml ) measured by ELISA were induced by 2.0 ng/ml IL-1beta and by H pylori at a multiplicity of infection ( MOI ) of 50
Nanthakumar et al., Am J Physiol Gastrointest Liver Physiol 2005 (Enterocolitis, Necrotizing...) : Concomitant with accelerated maturation, the IL-8 response to both IL-1 beta and LPS was significantly dampened ( from 6- to 3-fold ) by glucocorticoid pretreatment in the immature but not mature xenografts
Sheth et al., Virology 1996 : Secretion of TNF alpha or IL-1 beta , cytokines which themselves increase IL-8 secretion, was not induced by rotavirus, nor was that of TNF alpha, IFN alpha, IFN gamma, or IL-6
Winkler et al., Obstet Gynecol 1998 : Interleukin-1beta induced a significant increase in interleukin-8 secretion by fibroblasts in vitro, from 0.8 ng/10 ( 6 ) cells to 35.6 ng/10 ( 6 ) cells
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
Aida et al., Life Sci 2006 (Inflammation) : In the present study, we examined the effect of IL-1beta on the expression of IL-1beta, IL-6, IL-8 , IL-11, tumor necrosis factor-alpha (TNF-alpha), and their receptors in human chondrocytes ... The expression of IL-1beta, IL-8 , and TNF-alpha markedly increased in the presence of IL-1beta after day 14 of culture ... The expression of IL-1beta, IL-8 , IL-11, and TNF-alpha receptors significantly decreased in the presence of IL-1beta after day 14 of culture, whereas the expression of IL-6 receptor significantly increased
Maeda et al., J Dent Res 2007 (MAP Kinase Signaling System) : Interestingly, neutralization of IL-1beta abolished IL-8 induction by mechanical stresses, indicating that IL-1beta is essential for IL-8 induction, presumably though autocrine or paracrine mechanisms
Coulter et al., Am J Respir Cell Mol Biol 1999 : Release of IL-1beta in the airway microenvironment induces the production of proinflammatory factors from parenchymal airway cells, including IL-8
Patel et al., Immunology 1998 (Respiratory Syncytial Virus Infections) : IL-1beta and TNF-alpha induced the synthesis of IL-8 at 24 hr, but partially inhibited the synthesis at 48 hr
Shimada et al., Dig Dis Sci 1999 : N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta)
Lim et al., Biol Reprod 2013 : We found that the loss of FOXO3 in myometrial cells was associated with a significant decrease in IL1B induced IL6 and IL8 expression and production, cyclooxygenase ( [ COX]-2, official symbol PTGS2 ) expression and subsequent prostaglandin ( PGE2 and PGF2alpha ) release, and matrix metalloproteinase 9 (MMP9) and mRNA expression and activity
Lockwood et al., Am J Pathol 2006 (Chorioamnionitis) : Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells : implications for the genesis of chorioamnionitis
Tixier et al., Cell Microbiol 2005 (Inflammation) : IL-1 beta also increased IL-8 secretion and IL-8 mRNA expression in human neuronal cell lines ( NT2-N and SH-SY5Y ), through p38 and ERK1/2 MAP kinase dependent pathways
Jarvis et al., Arthritis Rheum 1997 : However, the secretion of IL-6, IL-8 , and GM-CSF stimulated by the complexes was not completely dependent upon the secretion of IL-1beta
Miyamoto et al., Inflamm Res 1997 (Inflammation) : We examined the involvement of IL-8 in TNF alpha and IL-1 beta neutrophil infiltration, using homologous reagents
Hallsworth et al., Br J Pharmacol 2001 : 3. The cyclic AMP elevating agents, dibutyryl cyclic AMP ( approximately EC ( 50 ) 135 microM ), forskolin ( approximately EC ( 50 ) 530 nM ) and cholera toxin ( approximately EC ( 50 ) 575 pg ml(-1) ) abolished IL-1 beta induced release of GM-CSF, RANTES and eotaxin, but not IL-8
Chang et al., J Endod 2009 (MAP Kinase Signaling System...) : IL-1beta and PGF ( 2alpha ) ( 0.5-10 mumol/L ) also induced IL-8 production and mRNA expression in pulp cells ... Aspirin inhibited IL-1beta induced PGF ( 2alpha ), but not IL-8 production ... These results indicate that IL-1beta induced IL-8 production in pulp cells is not mainly via direct activation of cyclooxygenase and PGF ( 2alpha ) generation
Becker et al., Am J Respir Crit Care Med 2004 (Cystic Fibrosis...) : Constitutive or interleukin (IL)-1beta induced IL-8 or IL-6 secretion or nuclear factor-kappaB activity was not significantly different between non-CF and CF cells
Van Zee et al., J Immunol 1996 (Bacteremia...) : TNFR5-1,3 treatments attenuated the hemodynamic disturbances, reduced fluid requirements, and decreased the systemic IL-1 beta , IL-6, and IL-8 responses
Andrew et al., Biochem Pharmacol 1999 : Up-regulation of interleukin-1beta stimulated interleukin-8 in human keratinocytes by nitric oxide ... Despite small variations in the response to NO by the three cell types, these results demonstrate that NO can up-regulate IL-1beta stimulated IL-8 expression in human keratinocytes
Wu et al., J Biol Chem 1997 : Although the nuclear factor-kappaB (NFkappaB) element regulates only inducible activity of the IL-8 promoter in response to stimulation with IL-1beta , the AP-1 and CCAAT/Enhancer binding Protein (C/EBP) elements influence both basal and inducible activities
Tabary et al., Am J Pathol 2003 (Cystic Fibrosis) : Compared to non-CF cells, CF bronchial epithelial cells were characterized by a higher susceptibility to produce elevated IL-8 and RANTES production in an hypertonic NaCl milieu in response to IL-1beta activation
Hartwig et al., J Interferon Cytokine Res 2001 : Reduced endogenous IL-1beta levels had no effect on the constitutive production of IL-6, IL-8 , and GM-CSF measured by ELISA
Cooper et al., Biochem Pharmacol 2000 : We then investigated the effects of transfection of monocytes with these oligonucleotides on interleukin-1beta (IL-1beta) stimulated IL-8 production, IL-8 mRNA expression, and NF-kappaB binding activity
Rougier et al., Cytokine 1998 : IL-1 alpha, IL-1 beta , and IL-3, tumour necrosis factor alpha (TNF-alpha), Stem cell factor (SCF) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) ( at 10 ng/ml ) stimulated IL-6 and IL-8 production in 0 % and 10 % FCS
Tipton et al., Toxicol In Vitro 2003 (Inflammation) : This study determined myrrh oil ( MO ) cytotoxicity to human gingival fibroblasts and epithelial cells and its effect, measured by ELISA, on interleukin (IL)-1beta stimulated IL-6 and IL-8 production ... There was little or no detectable IL-1beta stimulated production of IL-6 or IL-8 by cells exposed to > /=0.0025 % MO, probably reflective of loss of viability ... At subtoxic MO levels ( 0.00001-0.001 % ), there was a significant reduction of IL-1beta stimulated IL-6 and IL-8 production by fibroblasts, but not by epithelial cells
Riechelmann et al., J Occup Environ Med 2004 : Twenty-four hours after exposure to 500 microg/m3, nasal secretion levels of IL-1beta increased 72.3 % ( 0-150.2 %, P=0.002 ), levels of IL-6 increased 42.2 % ( -28-161.9 %, P=0.01 ), and levels of IL-8 increased 19.7 % ( -20.3-60.5 %, P=0.03 ; median and 95 % confidence interval )
Böcker et al., Gastroenterology 1998 (Inflammation) : Intracellular IL-1Ra I expression in Caco-2 cells decreased IL-1beta stimulated interleukin 8 secretion
Sandell et al., Osteoarthritis Cartilage 2008 (Arthritis) : In the presence of IL-1beta , FGF-18 increased expression of ADAMTS-4, aggrecan, BMP-2, COL2A1, CCL3, CCL4, CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6, and IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Takemura et al., Endocrinology 2006 : The effects of adiponectin on IL-1beta induced secretion of IL-6, IL-8 , and monocyte chemoattractant protein 1 from cultured ESCs were determined using specific ELISAs ... Adiponectin decreased IL-1beta induced secretion of IL-6, IL-8 , and monocyte chemoattractant protein 1 from ESCs
Guo et al., Free Radic Biol Med 2008 : CH3-Avn-c, a synthetically prepared methyl ester derivative of Avn-c with a high biological potency, significantly and dose dependently decreased mRNA expression and secretion of IL-6, IL-8 , and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA, and it inhibited IL-1beta- and TNFalpha stimulated NF-kappaB activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay
Russo et al., Cell Signal 2004 : Despite similar 125I-IL-1beta binding, HT-29 cells displayed no IRAK degradation, a 75 % reduction of IKK activity, and decreased IkappaBalpha phosphorylation, NF-kappaB DNA binding activity and IL-8 mRNA accumulation in response to IL-1beta compared to Caco-2 cells
Yoza et al., J Biol Chem 1996 : In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene
Shimizu et al., Mol Hum Reprod 2007 : Lipopolysaccharide (LPS) and IL-1beta stimulated IL-8 production by cervical stromal cells in a dose dependent manner ... In contrast, IL-1beta induced IL-8 production was significantly blocked by BAY11-7082, but not by C3 transferase exoenzyme or Y-27632 ... Transfection of the cervical stromal cells with RhoA small interfering RNA ( siRNA ) inhibited LPS stimulated IL-8 production, whereas IL-1beta induced IL-8 production was not significantly inhibited by knockdown of RhoA with siRNA
Long et al., J Dent Res 2001 : TENS inhibits IL-1beta induced synthesis of IL-1beta, IL-6, and IL-8 by inhibiting their mRNA expression, and thus significantly suppresses the amplification of IL-1beta induced inflammatory responses in PDL cells
Jin et al., Ann N Y Acad Sci 2002 (Colonic Neoplasms) : Thalidomide inhibited interleukin (IL) 1beta induced NFkappaB transcriptional activation and IL-8 production in Caco-2 colon cancer cells
Eisenhauer et al., Microb Pathog 2004 (Hemolytic-Uremic Syndrome) : IL-1beta and TNF-alpha mRNA, but not protein, were increased, and IL-8 secretion increased without an observed increase in mRNA
Ehrlich et al., Neuroreport 1998 : Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and IL-1beta stimulated IL-8 expression ... NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta induced IL-8 production
Brunius et al., Regul Pept 2005 : Similar to BK, the calcium ionophore A23187 also upregulated the stimulatory effect of IL-1beta and TNFalpha on IL-8 production ... The protein kinase C ( PKC ) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone ... The specific p38 mitogen activated protein kinase ( MAPK ) inhibitor SB 203580 reduced IL-8 production stimulated by the combination of BK and IL-1beta as well as the IL-1beta stimulated IL-8 production
Djalilian et al., Cornea 2006 : In contrast, Dex treatment inhibited the IL-1beta induced production of GM-CSF, IL-6, IL-8 , MCP-3, and RANTES, but not MCP-1
Wetzler et al., Biochem Biophys Res Commun 2000 : In vitro studies confirmed a regulatory role of NO for keratinocyte derived chemokine expression, as NO attenuated IL-1beta- and TNF-alpha induced MCP-1 mRNA expression, whereas NO augmented IL-1beta induced IL-8 ( functional human homolog to murine MIP-2 ) mRNA expression in the human keratinocyte cell line HaCaT
Tobe et al., J Oral Maxillofac Surg 2002 (Ankylosis...) : Interleukin-1beta stimulates interleukin-8 production and gene expression in synovial cells from human temporomandibular joint ... The aims of the present study were to isolate and characterize cultured synovial cells from human temporomandibular joint ( TMJ ) specimens and to investigate the effect of interleukin (IL)-1beta on IL-8 production and gene expression in those cells ... Furthermore, IL-1beta enhanced IL-8 production in HTS cells in a time- and dose dependent manner and stimulated IL-8 gene expression ... In addition, we found that IL-1beta stimulated IL-8 production through an increase in IL-8 gene expression in HTS cells, which may be associated with the increase of infiltrating inflammatory cells seen in the synovial membrane of TMJ disorders
Dudley et al., J Clin Endocrinol Metab 1993 : Northern blot analysis confirmed that IL-1 beta stimulation of chorion and decidual cells resulted in increased IL-8 messenger RNA expression
Marsh et al., J Immunol 1998 : Consistent with the identification of IL-1beta as the lymphocyte factor, fibroblast or mesangial cell IL-8 release induced by the IgG stimulated lymphocyte supernatants was inhibited by 1 ) the combination of IL-1R antagonist and soluble type II IL-1R, 2 ) an IL-1 converting enzyme inhibitor, or 3 ) anti-IL-1beta but not preimmune Abs ... These data suggest that targeted deposits of IgG can stimulate FcgammaRIII bearing lymphocytes to produce IL-1beta , which induces parenchymal cell IL-8 release
Zouki et al., J Leukoc Biol 2001 : The NO synthase inhibitors aminoguanidine and N ( G ) -nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear ( PMN ) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90 % in response to IL-1beta and TNF-alpha
Kwon et al., Immunology 1994 : We demonstrated that IL-8 was expressed by primary cultured HAEC and that this was enhanced by IL-1 beta and tumour necrosis factor-alpha stimulation, but not by IL-6 or lipopolysaccharide
Xue et al., Clin Experiment Ophthalmol 2001 : Regulatory role of IL-1beta in the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization
Patel et al., J Interferon Cytokine Res 2002 (Melanoma) : Addition of capsaicin ( 8-methyl-N-vanillyl-6-nonenamide ), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta induced and TNF-alpha induced IL-8 expression in melanoma cells
Gesser et al., Proc Natl Acad Sci U S A 1997 : These are : ( i ) inhibition of IL-1beta induced IL-8 production by peripheral blood mononuclear cell, ( ii ) inhibition of spontaneous IL-8 production by cultured human monocytes, ( iii ) induction of IL-1 receptor antagonistic protein production by human monocytes, ( iv ) induction of chemotactic migration of CD8+ human T lymphocytes in vitro, ( v ) desensitization of human CD8+ T cells resulting in an unresponsiveness toward rhIL-10 induced chemotaxis, ( vi ) suppression of the chemotactic response of CD4+ T human lymphocytes toward IL-8, ( vii ) induction of IL-4 production by cultured normal human CD4+ T cells, ( viii ) down-regulation of tumor necrosis factor-alpha production by CD8+ T cells, and ( ix ) inhibition of class II major histocompatibility complex antigen expression on IFN-gamma stimulated human monocytes
Cui et al., Ophthalmic Res 2005 : IL-1beta stimulated IL-8 and MCP-1 mRNA at 6 h. TNF-alpha stimulated IL-8 and MCP-1 mRNA expression at 1.5 and 3 h. alpha-MSH ( 10 ( -14 ) to 10 ( -10 ) M ) inhibited IL-8 and MCP-1 mRNA expression in the cells stimulated with IL-1beta or TNF-alpha
Yoneda et al., Am J Physiol Lung Cell Mol Physiol 2004 : In response to hrHRF, these cells induced IL-8 mRNA expression within 4 h. H2O2, but not IL-1 beta or tumor necrosis factor-alpha, stimulated secretion of HRF p23 by BEAS-2B cells, suggesting that oxidative stress may trigger the release of HRF p23 from bronchial epithelial cells
Ogunwobi et al., Regul Pept 2006 : Globular adiponectin doubled IL-1beta stimulated IL-8 and GM-CSF secretion
Cui et al., Ophthalmic Res 2006 : These findings indicate that berberine dose-dependently inhibited the expression of IL-8 and MCP-1 induced by IL-1beta or TNF-alpha
Park et al., Scand J Immunol 2003 (Heart Failure...) : Interleukin-8 production in tuberculous pleurisy : role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta ... Tumour necrosis factor-alpha (TNF-alpha) and IL-1beta induced mesothelial cell IL-8 mRNA expression, and neutralizing anti-TNF-alpha antibody and IL-1 receptor antagonist nearly completely obliterated CoMTB induced mesothelial cell IL-8 mRNA expression and protein secretion
Hua et al., Inflamm Res 2007 (Arthritis, Rheumatoid) : Glucosamine significantly suppressed the IL-1beta induced IL-8 production as well as its mRNA expression ( p < 0.05 ) at 1 mM. Furthermore, glucosamine ( 1 mM ) inhibited the IL-1beta induced nitric oxide and PGE ( 2 ) production ( p < 0.05 ). Moreover, glucosamine suppressed the IL-1beta induced phosphorylation of p38 MAPK ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM )
Osoata et al., Chest 2009 (Pulmonary Disease, Chronic Obstructive) : FDS ( 0.1 mmol/L ) reduced PN-enhanced interleukin (IL)-1beta induced IL-8 release and restored corticosteroid sensitivity defected by PN more potently than those induced by H ( 2 ) O ( 2 ) in A549 airway epithelial cells
Betjes et al., J Infect Dis 1993 : In this study, human peritoneal mesothelial cells were shown to produce high levels of interleukin-8 (IL-8) in response to IL-1 beta and tumor necrosis factor-alpha (TNF alpha) but not lipopolysaccharide or S. epidermidis
Bar-Or et al., Shock 2003 (Inflammation) : HUVEC IL-8 induction by copper was higher than by 50 pg/mL tumor necrosis factor-alpha, whereas 50 pg/mL IL-1beta and 1 ng/mL platelet activating factor did not stimulate IL-8 production or release
Chaly et al., Cytokine 2000 : As was seen with MO, antibodies to TNF-alpha, IL-1alpha and IL-1beta did not inhibit the expression of IL-8 in purified LY and non fractionated PBMC stimulated with SAC and LPS
Kang et al., Spine (Phila Pa 1976) 1997 (Intervertebral Disc Displacement) : Normal and herniated human intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6 , prostaglandin E2, and matrix metalloproteinases ... Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta ... Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta
Masood et al., Clin Cancer Res 2001 (Sarcoma, Kaposi) : The inflammatory cytokine IL-1beta up-regulated IL-8 expression in a time- and concentration dependent manner in KS cell lines
Romier et al., Br J Nutr 2008 (Colitis) : Ellagic acid, genistein and epigallocatechin gallate reduced ( 4- to 8-fold ) IL-1beta induced IL-8 secretion, while resveratrol promoted ( 1.7-fold ) the secretion
Loghmani et al., Inflammation 2002 : Our results show that pleural fluid isolated human fibroblasts release IL-8 and MCP-1 upon stimulation with IL-1 beta , TNF-alpha, and LPS in both a concentration- and time dependent manner ... IL-1 beta induced the maximum release of IL-8 ( 800-fold ) and MCP-1 ( 164-fold ), as compared to the controls
Wawszczyk et al., Acta Pol Pharm 2013 : IP6 had suppressive effect on basal and IL-1beta stimulated IL-8 secretion by cells
Frering et al., J Thorac Cardiovasc Surg 1994 (Heart Diseases) : A local production of these cytokines can not be excluded, because interleukin-6 and interleukin-8 are produced by stimulated macrophages and monocytes in response to tumor necrosis factor-alpha and interleukin-1 beta
Kim et al., J Immunol 2010 : Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis ... In this study, we showed that the proinflammatory cytokine IL-1beta induces the synthesis of IL-8 , a potent angiogenic factor, in human mast cells via the leukotriene B(4) receptor (BLT)2 ... For instance, knockdown of BLT2 and Nox1 with specific small interfering RNA, treatment with a specific BLT2 antagonist, LY255283, or treatment with a potential Nox inhibitor, diphenylene iodonium, suppressed IL-1beta induced IL-8 synthesis ... Taken together, our results suggest that BLT2-Nox1-reactive oxygen species dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta , thus contributing to angiogenesis
Rathanaswami et al., Arthritis Rheum 1993 (Arthritis, Rheumatoid) : Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on interleukin-8 gene expression in synovial fibroblasts ... TNF alpha and IL-1 beta induced a time- and dose dependent release of immunoreactive IL-8
Nasu et al., Arch Pathol Lab Med 1998 (Endometrial Neoplasms...) : Interleukin-1beta , ( 100 pmol/L ), tumor necrosis factor-alpha ( 1 nmol/L ), and lipopolysaccharide ( 1 microg/mL ) each increased the release of IL-6, IL-8 , and monocyte chemoattractant protein-1 by MaMi cells
He et al., Gastroenterology 2002 : Toxin A did not increase IL-8 levels in EB-treated cells, whereas IL-8 release in response to IL-1beta was not affected
Meda et al., Cell Immunol 1994 : Addition of anti-TNF and anti-IL-1 beta antibodies to IFN-gamma plus LPS treated PMN indicated that the LPS induced production of endogenous TNF and IL-1 beta , which was further potentiated by IFN-gamma pretreatment, mediated in autocrine fashion the enhanced LPS induced IL-8 accumulation observed at 18 hr
Jobin et al., J Immunol 1997 : IL-1beta stimulated NF-kappaB nuclear translocation and NF-kappaB dependent IL-1beta and IL-8 expression in both Caco-2 and HT-29 cells as assayed by electrophoretic mobility shift assay, immunofluorescence, kappaB-luciferase transfection, reverse transcriptase-PCR analysis and ELISA
Ogilvie et al., J Immunol 1996 (Melanoma) : IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8 , and nitrite/nitrate release when used in patients with cancer
Sun et al., J Steroid Biochem Mol Biol 2008 (Colonic Neoplasms) : LCA significantly decreased IL-8 secretion induced by IL-1beta
Paik et al., Lab Invest 2006 (Fibrosis...) : These findings suggest that TNF-alpha or IL-1beta primed HSCs enhance the production of IL-8 in response to PGN and LTA through augmentation of the TLR2 system
Weisbach et al., Vox Sang 1999 (Hemolysis) : At the end of storage, we detected IL-8 in 1 of 16 units of WB tested, in 10 of 16 standard PAGGS-M RBCs and in 15 of 16 temporarily warmed SAG-M RBCs. Prestorage filtration of RBCs prevented the accumulation of IL-1beta and TNF-alpha
Fusunyan et al., Pediatr Res 1998 : Butyrate enhances interleukin (IL)-8 secretion by intestinal epithelial cells in response to IL-1beta and lipopolysaccharide ... We hypothesized that butyrate may alter the secretion of IL-8 by intestinal epithelial cells in response to stimulation by IL-1beta or lipopolysaccharide
Larner-Svensson et al., Respir Res 2010 : We have therefore examined the role of miR-146a during the interleukin (IL)-1beta stimulated IL-6 and IL-8 release and proliferation in primary human airway smooth muscle ( HASM ) cells ... However, inhibition of IL-1beta induced IL-6 and IL-8 release was observed at the super-maximal intracellular miR-146a levels obtained by transfection with miR-146a mimics and indicates that studies using miRNA mimics can produce false positive results
Andoh et al., J Nutr 2000 : The addition of MCFA ( 5 mmol/L ) induced a 40 % increase in IL-1beta induced IL-8 secretion and a 35 % increase in tumor necrosis factor (TNF)-alpha induced IL-8 secretion, respectively ... The addition of LCFA ( 5 mmol/L ) induced a 140 % increase in IL-1beta induced IL-8 secretion and a 110 % increase in TNF-alpha induced IL-8 secretion, respectively
Peng et al., Exp Cell Res 2007 (Inflammation...) : We have further identified that interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) from PMN-melanoma co-cultures synergistically contribute to IkappaB-alpha degradation and IL-8 synthesis in PMNs. Taken together, these findings show that melanoma cells induce PMNs to secrete IL-8 through activation of NF-kappaB and suggest a model in which this interaction promotes a microenvironment that is favorable for metastasis
Lee et al., Biochem Biophys Res Commun 2005 : It has been reported that the differentiation of colonic epithelial cells is associated with reduced interleukin (IL)-8 responses to IL-1beta
Dudley et al., Am J Reprod Immunol 1996 : Similarly, IL-1 beta also caused chorion cells to produce more IL-8 than MIP-1 alpha
Seitz et al., Br J Rheumatol 1995 (Arthritis, Rheumatoid) : In addition, clinical improvement was associated with decreased synthesis of IL-1 beta, TNF-alpha and IL-8 induced by bacterial lipopolysaccharide, IL-1 alpha and IL-1 beta in PBMC in vitro
Kiriyama et al., J Neuroimmunol 1997 (Glioblastoma) : In human glioblastoma A172 cells, interleukin-6 (IL-6) production was induced by interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP
Keelan et al., J Soc Gynecol Investig 2000 (Obstetric Labor, Premature) : U46619 augmented IL-1 beta stimulated IL-6 and IL-8 mRNA expression within 2 hours of treatment
Cheng et al., J Immunol 2002 : The eotaxin/CCL11-suppressive effect on endothelial cells was not seen on IL-1beta induced IL-8/CXCL8 release
Suzuki et al., J Periodontal Res 2010 (Periodontitis) : Scavenger receptor inhibitors, fucoidan and dextran sulfate, inhibited the OxLDL induced IL-8 and PGE ( 2 ) production in the presence of IL-1 beta
Yoshino et al., J Clin Endocrinol Metab 2003 : Whereas IL-1 beta increased the production of IL-6, IL-8 , and monocyte chemotactic protein-1, and expression of cyclooxygenase-2 mRNA in ESC cultured without treatment, the stimulatory effects of IL-1 beta were reduced in the decidualized cells
Evans et al., Cytokine 2006 (Inflammation) : We investigated whether ATP and/or over-expression of the P2X7 receptor caused icIL-1ra1 inhibition of IL-1beta mediated IL-8 reporter activation, by permitting its release
Grunenberg et al., Infusionsther Transfusionsmed 1995 (Blood Group Incompatibility) : IL-1beta , IL-8 increased steadily in all units and TNF-beta in 3 out of 7 from undetectable levels to concentrations of the lower standard ranges
Hwang et al., Invest Ophthalmol Vis Sci 2009 (Graves Ophthalmopathy) : IL-1beta also induced MCP-1, IL-6, and IL-8 more vigorously in TAO derived fibroblasts
Walsh et al., Shock 2008 : Lastly, inhibition of exportin 1 attenuates monocyte chemoattractant protein, IL-8 , and intercellular adhesion molecule expression in response to IL-1beta stimulation
Fitzgerald et al., Vet Immunol Immunopathol 2007 (Mastitis, Bovine) : High dose interleukin-1beta (IL-1beta) induced IL-8 release, however significantly less potently than TNF-alpha
Beales et al., Cytokine 1997 : Stimulation of IL-8 production in human gastric epithelial cells by Helicobacter pylori, IL-1beta and TNF-alpha requires tyrosine kinase activity, but not protein kinase C ... Helicobacter pylori, tumour necrosis factor alpha and interleukin 1beta produced a dose dependent increase in IL-8 production
Smirnova et al., Acta Otolaryngol 2002 (Otitis Media with Effusion) : IL-1beta and TNF-alpha stimulated the secretion of IL-8 in HT29-MTX goblet cells
Saitoh et al., J Gastroenterol 1997 : CsA ( 1, 5, and 10ng/ml ) significantly reduced IL-1 beta induced IL-8 production ( by 32 %, 41 %, and 48 %, respectively ), and reduced TNF alpha induced IL-8 production ( by 21 %, 42 %, and 50 %, respectively )
Loudon et al., Biol Reprod 2003 : In this study, we examined the effects of IL-1beta and progesterone on IL-8 and prostaglandin E2 ( PGE2 ) synthesis and IL-8 and COX-2 mRNA and promoter activity in amnion cells and lower segment fibroblast ( LSF ) cells ... In LSF cells, IL-1beta significantly increased IL-8 and PGE2 synthesis and COX-2 and IL-8 mRNA expression, but progesterone significantly attenuated these effects ... In prelabor amnion cells, IL-1beta also increased IL-8 and PGE2 synthesis and both COX-2 and IL-8 mRNA and promoter expression ; however, progesterone significantly attenuated these effects on IL-8 and PGE2 synthesis and COX-2 expression ... In postlabor amnion cells, IL-1beta increased IL-8 and PGE2 synthesis and COX-2 expression, but progesterone did not attenuate the effect of IL-1beta upon IL-8 synthesis
Bruun et al., J Clin Endocrinol Metab 2001 : In adipose tissue fragments, IL-1beta ( 3 nM ) and tumor necrosis factor alpha ( 0.6 nM ) were able to stimulate IL-8 production by 12-fold and 5-fold, respectively ( P < 0.001 ), when incubated for 48 h. Incubations with isolated adipocytes were performed up to 6 h, and IL-1beta and tumor necrosis factor alpha significantly increased IL-8 production by 50-60 % ( P < 0.05 )
Lottaz et al., J Invest Dermatol 2001 : In interleukin-1beta transfected human dermal fibroblasts, interleukin-8 was induced through an autocrine activity of interleukin-1beta
Xue et al., Curr Eye Res 2001 : The role of IL-1beta in the regulation of IL-8 and IL-6 in human corneal epithelial cells during Pseudomonas aeruginosa colonization ... The purpose of this study was to investigate whether IL-1beta regulates the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization
King et al., J Pharmacol Exp Ther 2009 (Carcinoma, Non-Small-Cell Lung...) : Knockdown of TTP protein by siRNA elevated IL-1beta induced expression of granulocyte macrophage-colony stimulating factor ( GM-CSF ) and IL-8 , demonstrating a role for TTP in feedback control
Parhar et al., Immunology 2003 : The p38 mitogen activated protein kinase regulates interleukin-1beta induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells
Radomska-Leśniewska et al., J Physiol Pharmacol 2006 : NAC inhibited the TNF-alpha/IL-1 beta stimulated ICAM-1 expression and IL-8 release from both cell lines in a concentration dependent manner
Cromwell et al., Immunology 1992 : Expression and generation of interleukin-8 , IL-6 and granulocyte-macrophage colony stimulating factor by bronchial epithelial cells and enhancement by IL-1 beta and tumour necrosis factor-alpha
Zoja et al., J Am Soc Nephrol 1992 : Recombinant interleukin-1 receptor antagonist blocked the interleukin-1 mRNA as well as interleukin-6 and interleukin-8 mRNA accumulation induced by interleukin-1 beta
Takemura et al., J Clin Endocrinol Metab 2007 (Endometriosis...) : Metformin suppresses interleukin (IL)-1beta induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells ... Metformin dose-dependently suppressed IL-1beta induced IL-8 production, cAMP induced mRNA expression and aromatase activity, and 5-bromo-2'-deoxyuridine incorporation in ESCs
Plum et al., Kidney Blood Press Res 2002 (Kidney Failure, Chronic...) : The IL-1beta induced IL-6/IL-8 release of HPMC from healthy donors and from patients with end-stage renal disease ( ESRD ) were measured before the start of chronic peritoneal dialysis ( PD ) and during PD therapy
Smolka et al., BMC gastroenterology 2004 : Lastly, in human gastric adenocarcinoma ( AGS ) cells, ML 3000 dose-dependently inhibited both baseline and IL-1beta stimulated ( 20 ng/ml ) IL-8 secretion with IC50s of 0.46 microM and 1.1 microM respectively
Morimoto et al., Hum Reprod 2005 (Endometriosis) : Effects of GnRH II on interleukin (IL)-1beta induced expression of cyclooxygenase (COX)-2 and IL-8 were also studied
Chaudhary et al., Endocrinology 1992 : IL-1 beta in doses from 1-100 U/ml stimulated dose dependent increases in IL-6 ( r = 0.87 ; P less than 0.001 ) and IL-8 ( r = 0.95 ; P less than 0.001 )
Viscardi et al., Pediatr Pathol Lab Med 1997 (Enterocolitis, Pseudomembranous) : Analysis of covariance including all subjects showed that the presence of acute inflammation was associated with increased IL-1 beta mRNA levels in mucosa ( P = .035 ) and increased IL-8 in full-thickness sections ( P = .005 ) and mucosa ( P = .01 )
Sfakianakis et al., Eur J Oral Sci 2001 (Periodontitis) : We aimed to : 1 ) characterize the expression of interleukin ( IL ) - Ialpha and IL-Ibeta in human gingiva and cultured GEC : 2 ) demonstrate the ability of A. actinomycetemcomitans extracts to upregulate IL-1alpha, IL-1beta and IL-8 expression in GEC in vitro : and 3 ) characterize the role of IL-1alpha and IL-1beta in the induction of IL-8 expression in GEC in vitro ... although they inhibited IL-8 induced by IL-1alpha or IL-1beta
Konda et al., Arthritis Rheum 2010 (Arthritis, Experimental...) : META060 inhibited osteoclastogenesis, as indicated by decreased transformation of RAW 264.7 cells to osteoclasts and reduced TRAP activity, and inhibited IL-1beta activated prostaglandin E ( 2 ), matrix metalloproteinase 3, IL-6, IL-8 , and monocyte chemotactic protein 1 in RASFs
Decker et al., Am J Physiol Cell Physiol 2009 (Astrocytoma...) : Lipoxin A4 inhibits IL-1beta induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells ... As shown by quantitative RT-PCR, LXA ( 4 ) ( 10 nM ) significantly inhibited ( P < 0.05 ) the IL-1beta induced stimulation of IL-8 and ICAM-1 expression in these cells ... Furthermore, LXA ( 4 ) ( 10 nM ) decreased the expression of IL-1beta induced IL-8 protein levels ( P < 0.05 )
Georganas et al., J Immunol 2000 (Arthritis, Rheumatoid) : These findings document the importance of NF-kappaB for the regulation of the constitutive and IL-1beta stimulated expression of IL-6 and IL-8 by RA FLS and support the role of inhibition of NF-kappaB as a therapeutic goal in RA
Yoshino et al., Am J Reprod Immunol 2004 (Endometriosis) : Effects of PD98059, SB202190 and SP600125 ( inhibitors of ERK, p38 and JNK, respectively ) on IL-1beta induced secretion of IL-6 and IL-8 , and on IL-1beta induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied ... Both SB202190 and SP600125 suppressed IL-1beta induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta induced secretion of IL-8
Lee et al., Infect Immun 2005 (Periodontitis) : Expression of proinflammatory cytokines, such as interleukin-6 (IL-6) and IL-8 , was also induced significantly in both cell types by the Msps, as determined by reverse transcription-PCR and an enzyme linked immunosorbent assay, whereas IL-1beta synthesis could be detected only in the THP-1 cells
Huang et al., Rheumatol Int 2010 (Osteoarthritis) : Effects of ( - ) -epigallocatechin-3-gallate on cyclooxygenase 2, PGE ( 2 ), and IL-8 expression induced by IL-1beta in human synovial fibroblasts ... The objective of this study was to examine the effects of ( - ) -epigallocatechin-3-gallate ( EGCG ) on cyclooxygenase 2 (COX-2), prostaglandin E ( 2 ) ( PGE ( 2 ) ), and interleukin 8 (IL-8) expression induced by IL-1beta in human synovial fibroblasts ... PGE ( 2 ) and IL-8 secretion was also induced by IL-1beta stimulation and significantly suppressed by EGCG
Dauletbaev et al., Respiration 2010 (Cystic Fibrosis) : Both TNF-alpha and IL-1beta activated NF-kappaB and stimulated IL-8 production ... The present data do not support the hypothesis that ibuprofen down-regulates IL-8 production in response to TNF-alpha and IL-1beta in CF respiratory epithelium
Topley et al., Am J Pathol 1993 : Stimulation of HPMC with IL-1 beta or TNF-alpha resulted in a time- and dose dependent IL-8 generation ; after 24 hours the levels induced by IL-1 beta and TNF-alpha ( both at 1000 pg/ml ) were ( mean +/- SEM, n = 5 ) 101 +/- 26.6 ( z = 2.023 ; P < 0.01 ) and 35 +/- 8.09 ( z = 2.023 ; P < 0.01 ) respectively
Bian et al., Curr Eye Res 1999 : It has been shown in this and other laboratories that interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are potent inducers of HRPE IL-8 and MCP-1 secretion ... IL-1beta and TNF-alpha induced dose dependent increases in HRPE IL-8 and MCP-1 secretion with maximal stimulation observed at 2-5 ng/ml. IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion ... HRPE IL-8 and MCP-1 gene expression and protein production are stimulated by IL-1beta or TNF-alpha through pathways differentially modulated by IL-4 and GM-CSF
Charron et al., J Biol Chem 2009 (Inflammation) : Hypoxia enhanced interleukin-1beta induced interleukin-8 ( CXCL8 ) production in A549 cells and decreased the ability of dexamethasone to suppress the CXCL8 production
Choi et al., Rheumatol Int 2010 : In contrast, the expression of IL-8 in both cell types was strongly stimulated by both IL-1beta and TNF-alpha
Holden et al., Br J Pharmacol 2010 (Asthma) : Pre-incubation with beta(2)-adrenoceptor agonists ( salbutamol, salmeterol, formoterol ) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB dependent transcription was significantly repressed, and AP-1 dependent transcription was unaffected
Parilla et al., Respir Res 2006 : CpG DNA modulates interleukin 1beta induced interleukin-8 expression in human bronchial epithelial ( 16HBE14o- ) cells ... CpC ( a control ODN ) had no effect on IL-1beta induced IL-8 levels ... Silencing TLR9 using siRNA or pretreatment of cells with chloroquine had little effect on IL-1beta induced IL-8 levels, but abolished CpG induced synergy
Edwards et al., Pulm Pharmacol Ther 2005 (Asthma) : IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids
Böcker et al., Clin Exp Immunol 2003 : Pointing to the potentially underlying mechanism of increased IL-1 beta stimulated IL-8 secretion in HT-29 cells, butyrate up-regulated IL-1RI mRNA but not IL-1RII ... Pharmacological inhibition of protein tyrosine phosphatases or treatment with mesalamine or sulphasalazine diminished IL-1 beta stimulated IL-8 secretion by butyrate exposed HT-29 cells substantially
Ungerstedt et al., Clin Exp Immunol 2003 (Endotoxemia) : At a concentration of 40 mmol/l, the IL-1 beta , IL-6 and TNF alpha responses were reduced by more than 95 % and the IL-8 levels reduced by 85 %
Gross et al., Gastroenterology 1995 : TNF-alpha and IL-1 beta dose-dependently induced IL-8 production in HT-29 cells ... However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin ( by 79 % or 89 %, respectively ) and genistein ( by > 95 % ) ... The synthesis of IL-8 is stimulated in HT-29 cells by IL-1 beta or TNF-alpha
Illek et al., Am J Physiol Lung Cell Mol Physiol 2008 : Neither flagellin nor IL-1beta altered transepithelial fluxes of membrane-impermeant dextran ( 10 kDa ) or lucifer yellow ( mol wt = 457 ), but both activated p38, NF-kappaB, and IL-8 secretion ... It is concluded that : 1 ) flagellin and IL-1beta activated p38, NF-kappaB, IL-8 , and CFTR dependent anion secretion without altering tight junction permeability ; 2 ) p38 played a role in regulating I ( Cl ) and IL-8 but not NF-kappaB ; and 3 ) p38 was more important in flagellin- than IL-1beta stimulated responses
Tsai et al., J Cell Biochem 2009 (Prostatic Neoplasms) : Glucosamine inhibits IL-1beta mediated IL-8 production in prostate cancer cells by MAPK attenuation ... Upregulation of inflammatory cytokines, such as IL-1beta and IL-8, has been noted in prostate cancer patients and IL-8 has been shown to promote prostate cancer cell proliferation and migration ; however, it is not clear whether IL-1beta regulates IL-8 expression in prostate cancer cells ... Glucosamine is widely regarded as an anti-inflammatory agent and thus we hypothesized that if IL-1beta activated IL-8 production in prostate cancer cells, then glucosamine ought to blunt such an effect ... Three prostate cancer cell lines, DU-145, PC-3, and LNCaP, were used to evaluate the effects of IL-1beta and glucosamine on IL-8 expression using ELISA and RT-PCR analyses ... Glucosamine significantly inhibited IL-1beta induced IL-8 secretion ... Inhibitors of MAPKs and NFkappaB were used to pinpoint MAPKs but not NFkappaB being involved in IL-1beta mediated IL-8 production
Hou et al., Fertil Steril 2008 (Endometriosis) : Addition of soluble IL-1RII ( 2.0 microg/mL ) significantly inhibited IL-1 beta induced IL-6 and IL-8 secretion by endometrial cells in vitro ... Infection of endometrial cells with rAd-RII significantly decreased IL-1 beta induced IL-8 secretion, compared with the PBS and rAd-LacZ controls but had no significant effect on IL-6 secretion
Bernardino et al., J Neurochem 2008 (Encephalitis...) : Potentiation of AMPA toxicity was prevented when IL-1beta production or its receptor signaling were blocked by an inhibitor of interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP
Takahashi et al., Immunopharmacol Immunotoxicol 2002 : 1 alpha,25-dihydroxyvitamin D3 suppresses interleukin-1beta induced interleukin-8 production in human whole blood : an involvement of erythrocytes in the inhibition ... Although monocytes were found to be mainly responsible for IL-1beta induced IL-8 production in whole blood, 1,25 ( OH ) 2D3 inhibited IL-8 production by isolated mononuclear cells only marginally
Nilsen et al., Gut 1998 (Celiac Disease) : Stimulation of HIMEC and HUVEC with recombinant human ( rh ) IL-1 beta or rhTNF-alpha induced cell associated bioactive IL-1 alpha but not IL-1 beta, as well as enhanced secretion of both IL-6 and IL-8
Chivers et al., Mol Pharmacol 2006 : In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 ( Mol Endocrinol 11 : 1245-1255, 1997 ) repress interleukin (IL)-1beta induced expression of cyclooxygenase (COX)-2 and IL-8
Fukushima et al., J Endod 2010 : IL-1beta and IL-6 simultaneously induced IL-8 and monocyte chemoattractant protein-1 secretion in PDL cells, whereas SOCS-3 overexpression suppressed secretion of these chemokines through inhibition of phosphorylation in downstream signaling
Kwong et al., J Clin Immunol 1998 (Hyaline Membrane Disease) : Differential regulation of IL-8 by IL-1beta and TNFalpha in hyaline membrane disease ... Bronchoalveolar lavage cell cytokine relationships were evaluated and the differential regulation of IL-8 by IL-1beta and TNFalpha was studied in a short-term culture system
Fujiwara et al., Cancer Res 1992 : Specific inhibition of interleukin 1 beta gene expression by an antisense oligonucleotide : obligatory role of interleukin 1 in the generation of lymphokine activated killer cells
Chen et al., J Biol Chem 2006 (Enteritis...) : In this study, we found that Sb culture supernatant ( SbS ) inhibits interleukin-8 production induced by C. difficile toxin A or IL-1beta in human colonocyte NCM460 cells in a dose dependent fashion
Handa et al., Redox Rep 2002 (Inflammation) : After addition of IL-1beta to MKN45 cells, a gastric cancer cell line, or human umbilical vein endothelial cells ( HUVECs ), IL-8 production was detected in supernatants
Pechkovsky et al., Eur Cytokine Netw 2000 : TNF-alpha increased both IL-8 mRNA expression and protein production, whereas IL-1 beta slightly increased IL-8 release but did not change mRNA expression in AEC-II
Pantschenko et al., Oncol Rep 2003 (Breast Neoplasms) : Conversely, IL-1alpha and IL-1beta , induced a 5- to 104-fold stimulation of BEC and a 330 to 1,138-fold increase in IL-8 expression in estrogen independent BCC
Reznikov et al., Proc Natl Acad Sci U S A 2000 : Although IL-1beta induced IL-8 synthesis was augmented 3-fold by IL-18, IL-18 suppressed IL-1beta induced PGE ( 2 ) production by 40 %
Song et al., Mol Immunol 2009 (Inflammation) : Ablation of IRAK-4 expression in human umbilical vein endothelial cells ( HUVEC ) with siRNA suppressed IL-1beta induced IL-6 and IL-8 production whereas IRAK-1 siRNA suppressed TNFalpha induced but not IL-1beta induced cytokine production
Matsukawa et al., Lab Invest 1998 (Arthritis) : These results provide evidence that IL-8 and TNFalpha were responsible for the production of IL-1beta and IL-1Ra, and that IL-1beta was responsible for the second phase of IL-1beta and IL-8 production
Maas-Szabowski et al., J Invest Dermatol 1996 : By semiquantitative reverse transcriptase PCR, we demonstrated that IL-1alpha and IL-1beta stimulated the expression of KGF, HGF, IL-1alpha, IL-1beta, IL-1RI, and IL-8 in fibroblasts regardless of their physiologic condition, whereas that of TGF-beta remained unaffected
Takei et al., J Pharmacol Sci 2008 : GL, as well as dexamethasone ( DEX ) inhibited both tumor necrosis factor (TNF)-alpha- and IL-1beta induced IL-8 production, mRNA expression, and promoter activity in A549 cells
Culpitt et al., Thorax 2003 (Pulmonary Disease, Chronic Obstructive) : Resveratrol reduced IL-1beta stimulated IL-8 and GM-CSF release in both smokers and COPD patients to below basal levels
Luz et al., Neuropeptides 2006 (Dehydration...) : These results suggest that the central activation of interleukin-1 receptors by IL-1beta is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia
Nozawa et al., J Gastroenterol Hepatol 2004 : Both TNF-alpha and IL-1beta induced IL-8 releases, conversely, were little affected by lafutidine up to a concentration of 10 ( -5 ) M
Suzuki et al., FEBS Lett 2000 (Arthritis, Rheumatoid) : We examined the role of p38 mitogen activated protein ( MAP ) kinase in the tumor necrosis factor alpha (TNF-alpha)- or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity
Chen et al., Zhonghua Yi Xue Za Zhi 1996 : The effects of IL-1 beta and TNF alpha on the production of IL-8 by glomerular endothelial cells were also observed
Sodin-Semrl et al., J Immunol 2000 : Lipoxin A4 inhibits IL-1 beta induced IL-6, IL-8 , and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases ... IL-1 beta induced the synthesis of IL-6, IL-8 , and matrix metalloproteinases (MMP)-1 and -3
Kida et al., Cytokine 2005 : We comprehensively investigated the involvement of mitogen activated protein kinases ( MAPKs ) /activator protein-1 (AP-1) and IkappaB kinases ( IKKs ) /IkappaBs/nuclear factor-kappaB (NF-kappaB) in IL-1beta stimulated IL-6, IL-8 , prostaglandin E ( 2 ) ( PGE ( 2 ) ) and matrix metalloproteinase-1 (MMP-1) production by human gingival fibroblasts (HGF)
Sadowsky et al., Am J Obstet Gynecol 2003 : Dexamethasone and interleukin-10 treatment significantly reduced interleukin-1beta induced uterine contractility ( P < .05 ) and amniotic fluid prostaglandins ( P < .05 ) but not interleukin-8 or interleukin-1 receptor antagonist
Satsu et al., J Nutr Sci Vitaminol (Tokyo) 2009 : The IL-8 secretion induced by hydrogen peroxide and by IL-1beta was not suppressed by IFF, suggesting that the inhibitory effect of isoflavone was specific for the TNF-alpha induced regulation of IL-8
Hildebrand et al., Unfallchirurg 2005 (Inflammation...) : TNF-alpha and IL-1beta are early regulators of the immune response and both induce the release of secondary cytokines, such as IL-6 and IL-8
Agarwal et al., J Periodontal Res 1995 : IL-1 beta activation of GF cells showed that IL-1 beta non only induces the expression of IL-6, IL-8 and TNF-alpha, but also acts in an autocrine manner of GF cells and induces IL-1 beta expression
Ahmad et al., Am J Respir Cell Mol Biol 2003 (Lung Diseases...) : Tumor necrosis factor-alpha, IL-1beta , and lipopolysaccharide stimulated IL-8 production from epithelial cells in a dose- and time dependent manner, and these effects were abrogated by specific antibodies or inhibitors
Yoon et al., Acta Otolaryngol 1999 : Effects of TNF-alpha and IL-1 beta on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells ... IL-1beta alone or a combination of TNF-alpha and IL-1beta comparably increased IL-6 and IL-8 mRNA levels slightly
Perez et al., Am J Physiol Lung Cell Mol Physiol 2008 (Cystic Fibrosis...) : In vitro, PPARgamma agonists reduced IL-8 and MMP-9 release from airway epithelial cells in response to PAO1 or TNFalpha/IL-1beta stimulation
Wang et al., Inflamm Res 2001 : TGF-beta did not significantly affect constitutive interleukin (IL)-8 secretion or IL-1beta induced IL-8 secretion from suspended cells ... In contrast, TGF-beta stimulated IL-8 secretion as well as augmented IL-1beta induced IL-8 secretion from adherent cells
Song et al., Am J Physiol Lung Cell Mol Physiol 2000 : However, the LPS effects on TNF-alpha and IL-8 are inhibited by < 20 % and the effect on IL-1beta by < 50 %. Third, at Survanta levels of 1 mg/ml, SP-A induced responses are reduced by > 90 %, and although the inhibitory effects on LPS action increase, they still do not reach those seen with SP-A
Shibata et al., J Photochem Photobiol B 2009 (Arthritis, Rheumatoid...) : We also found that IL-1beta induced release of IL-8 from MH7A cells was completely blocked by pretreatment with the ( IL-8 ) inhibitor Bay11-7085, indicating that activation of NF-kappaB signaling plays an important role in the secretion of IL-8
Nam et al., Particle and fibre toxicology 2006 : IL-1beta markedly up-regulated the hBD-2 promoter activity, and the subsequent DEP exposure increased dose-dependently the expression of hBD-2 and inflammatory cytokine IL-8 at the transcriptional level
Fulcher et al., Am J Physiol Lung Cell Mol Physiol 2009 (Cystic Fibrosis) : CF and non-CF cell lines produced similar levels of IL-8 at baseline and equally increased IL-8 secretion in response to IL-1beta , TNF-alpha, and the Toll-like receptor 2 agonist Pam3Cys
Modéer et al., J Oral Pathol Med 2000 : The anti-inflammatory drug, dexamethasone ( 1 microM ), abolished the production of both IL-6 and IL-8 in gingival fibroblasts challenged with PHT in the presence or absence of IL-1beta
Krakauer , Immunopharmacology 2000 : Both IL-1alpha and IL-1beta induced ICAM-1 expression and IL-8 and MCP-1 production at lower doses than TNF alpha or TNF beta
Sun et al., World J Gastroenterol 2006 : VacA alone induced expression of TNF-alpha, IL-8 and IL-1beta, while NaCl alone induced expression of TNF-alpha and IL-1beta
Jung et al., Cytokine 2002 : Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta induced IL-8 expression in human vascular smooth muscle cells
Iikura et al., Lab Invest 2007 : IL-33 or IL-1beta also induced IL-8 and IL-13 production in naïve HUCBMCs, and enhanced production of these cytokines in IgE/anti-IgE stimulated HUCBMCs, without enhancing secretion of either PGD ( 2 ) or histamine
Imaizumi et al., Prostaglandins Leukot Essent Fatty Acids 2003 : 15d-PGJ ( 2 ) inhibited the IL-1beta induced expression of ENA-78, but not the expression of IL-8 or GRO-alpha in response to IL-1
Fredriksson et al., Inflammation 2003 : IL-8 release from fibroblasts was significantly increased when cultured with RBC or RBC-CM and both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) further stimulated this IL-8 secretion
Bruun et al., Am J Physiol Endocrinol Metab 2004 (Obesity, Morbid) : Dexamethasone ( 50 nM ) attenuated IL-8 production by 50 % ( P < 0.05 ), and IL-1beta ( 2 microg/l ) increased IL-8 production up to 15-fold ( P < 0.001 )
Sanchez et al., Osteoarthritis Cartilage 2004 (Osteoarthritis, Knee) : IL-1beta highly stimulated *NO, IL-8 , IL-6, MIP-1beta and PGE ( 2 ) synthesis but decreased AGG and TGF-beta1 production ... At 1-10ng/ml, OSM significantly decreased IL-1beta stimulated IL-8 , MIP-1beta, PGE ( 2 ) and *NO production but amplified IL-1beta stimulating effect on IL-6 production
Barsness et al., Pediatr Surg Int 2004 (Respiratory Distress Syndrome, Adult) : There was no difference in IL-1beta induced IL-8 production in children compared with adults
Furuhashi et al., J Pharm Pharmacol 2005 : Licochalcone A ( IC50 15.0 nM ) inhibited PGE2 production, but not IL-6 and IL-8 production, in response to IL-1beta
Mizuno et al., Oncology 1994 (Lung Neoplasms) : TNF-alpha and IL-1 beta significantly augmented the levels of mRNA expression for IL-8 and its production
Lee et al., The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2005 : Induction of interleukin-8 (IL-8) expression by tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) , or lipopolysaccharide (LPS) was assessed by RT-PCR
Zhang et al., Clin Exp Immunol 2002 (Genital Diseases, Female) : IL-6 and IL-8 production was stimulated by recombinant human interleukin-1beta ( hIL-1beta ) or human tumour necrosis factor-alpha ( hTNF-alpha ) alone in a dose dependent manner
Sanchez et al., J Rheumatol 2002 (Cadaver...) : No NSAID showed significant effects on basal and IL-1beta stimulated IL-8 production, except CELE and IBUP, which slightly increased basal IL-8 production
Hastings et al., Arterioscler Thromb Vasc Biol 2009 (Atherosclerosis) : Additionally, IL-8 reduced p38 activation and NF-kappaB activity induced by IL-1beta alone
Hattar et al., Crit Care Med 2006 (Sepsis...) : In contrast, IL1-beta was not involved in LTA induced IL-8 generation
Fujiwara et al., Lab Invest 2002 (Arthritis, Experimental) : GROalpha does not seem to initiate TNFalpha, IL-1beta , and IL-8 in an early phase, but induces IL-1beta and IL-8 in a late phase
Fujita et al., Eur Arch Otorhinolaryngol 2000 (Chronic Disease...) : When cells were preincubated with 10 ( -4 ) M CAM for 7 days, the IL-1 beta induced secretion of IL-8 decreased significantly
van der Velden et al., Eur Cytokine Netw 1998 : Interleukin-1beta and interferon-gamma differentially regulate release of monocyte chemotactic protein-1 and interleukin-8 by human bronchial epithelial cells ... IL-1beta increased both MCP-1 and IL-8 release, and increased the expression of ICAM-1 and CD40, but not HLA class II molecules ... Our results indicate that IFN-gamma and IL-1beta differentially regulate the MCP-1 and IL-8 release by human bronchial epithelial cells
Shapiro et al., Proc Natl Acad Sci U S A 1998 : In the presence of a specific p38 MAPK inhibitor (p38 inh), IL-1beta induced HIV production was suppressed by more than 90 % and IL-1beta induced IL-8 production was suppressed completely, both with IC50 of 0.01 microM
Nold-Petry et al., J Biol Chem 2009 (MAP Kinase Signaling System) : Stable lines of IL-18Ralpha depleted human A549 cells were generated using shRNA, resulting in an increase of IL-1beta induced IL-1alpha, IL-6, and IL-8 compared to scrambled small hairpin RNA
Zhang et al., Curr Eye Res 2005 : IL-1beta stimulated IL-6, IL-8 , and MCP-1 mRNA expression and protein levels
Wu et al., Atherosclerosis 1999 : However, IL-1beta induced productions of both MCP-1 and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E. Vitamin E, at the doses used, did not significantly change the spontaneous production but dose-dependently inhibited the IL-1beta induced production of inflammatory cytokine IL-6
Rodriguez-Cimadevilla et al., Blood 1990 (Leukemia, Myeloid, Acute) : Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia : role of interleukin-1 as an endogenous inducer
Khanjani et al., Mediators Inflamm 2012 : In this study we investigated the roles of these transcription factors in IL1B regulation of the IL8 gene in human myometrium ... Small interfering RNA ( siRNA ) silencing of NF?B abolished the IL8 response to IL1B significantly ; siRNA against AP-1 reduced it to a lesser extent whilst knockdown of CEBP enhanced the response
Jobin et al., J Immunol 1999 (Cell Transformation, Viral) : Surprisingly, IL-1 beta mediated IL-8 gene expression was also inhibited in HT-29 cells as measured by Northern blot and ELISA
Henrotin et al., Clin Rheumatol 1998 (Cadaver) : As anticipated, IL-1beta induced a marked release of collagenase, stromelysin, IL-6, IL-8 and PGE2
Chi et al., BMC immunology 2004 (Arteriosclerosis...) : However, IL-6, IL-8 , and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine
Sooranna et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : IL-1beta and stretch increase uterine smooth muscle cell ( USMC ) prostaglandin H synthase 2 (PGHS-2) and interleukin (IL)-8 mRNA expression in a mitogen activated protein kinase ( MAPK ) dependent mechanism
Andoh et al., Pancreas 2000 (Pancreatic Neoplasms) : IL-1beta and tumor necrosis factor (TNF)-alpha both induced a marked increase in C3 and IL-8 secretion
Olaru et al., J Invest Dermatol 2010 (Staphylococcal Skin Infections) : IL-1alpha and IL-1beta increased mRNA production and protein secretion of the neutrophil chemotactic CXCL1, CXCL2, and IL-8 in keratinocytes
Kaur et al., Am J Physiol Lung Cell Mol Physiol 2008 : IL-1beta induced IL-8 release was also repressed by PGE ( 2 ) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective
Coulter et al., Pharmacotherapy 2000 (Cystic Fibrosis) : Induction of interleukin-8 release by lung epithelium with cystic fibrosis epithelial lining fluid is marginally affected by inhibitors of interleukin-1beta ... Both IL-1beta and NE led to a significant increase in IL-8 : 12.8 +/- 2.8 ng/ml and 0.8 +/- 0.3 ng/ml, respectively
Kurtz et al., Invest Ophthalmol Vis Sci 1997 : Although DEX ( 10 ( -8 ) to 10 ( -6 ) M ) inhibited IL-1 beta stimulated MCP-1 and IL-8 production, it did not inhibit TNF-alpha stimulated chemokine secretion
Suswam et al., Int J Cancer 2005 (Breast Neoplasms) : Here, we show that activation of IL-1beta receptors on malignant HS578t and MDA-MB-231 breast cancer cells strongly induces IL-8 expression and that RNA stabilization is persistently activated at least 12-24 hr after stimulation
Fiedler et al., Am J Physiol 1995 (Lung Neoplasms...) : We hypothesized that RSV directly induces interleukin (IL)-8 gene expression in airway epithelial cells, independent of IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) production
Muselet-Charlier et al., Biochem Biophys Res Commun 2007 (Cystic Fibrosis) : Enhanced IL-1beta induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen activated protein kinases and NF-kappaB signaling ... To test whether other signaling pathways such as that of mitogen activated protein kinases ( MAPKs ) could be involved in IL-1beta induced IL-8 production of CF cells, we investigated ERK1/2, JNK, and p38MAP signaling compared to NF-kappaB ... However, when used together, these inhibitors caused a blockade in IL-1beta induced IL-8 production in CF cells
Zhang et al., J Neuroimmunol 1999 (Brain Ischemia) : However, 100 u/ml IL-1beta induced greater stimulation of both IL-8 and MCP-1 secretion in HCEC ( 50 and 20 times above controls, respectively ) than in FHAS ( three and two times above controls, respectively )
Kuppner et al., Immunology 1995 : TGF-beta was also found to enhance IL-1 beta induction of IL-8 mRNA levels at lower IL-1 beta concentrations ( 50 U/ml ) but had no effect at higher IL-1 beta concentrations ( 500 U/ml ) ... However, TGF-beta had no synergistic effect on IL-1 beta induction of IL-8 secretion
Hirota et al., Endocrinology 2009 : We previously reported that IL-1beta induced IL-8 production in human endometrial stromal cells ( ESCs ) and that induction was regulated by substances implicated in implantation ... Both basal and IL-1beta induced IL-8 levels of cell supernatants were much higher in EECs than ESCs ... In the present study using human primary cells in culture, we measured IL-1beta induced production of IL-8 from endometrial epithelial cells ( EECs ) and ESCs and examined effects of the endometrium derived IL-8 on migration and number of first-trimester villous cytotrophoblast cells ( vCTs )
Chaudhary et al., J Biol Chem 1996 : Regulation of interleukin-8 gene expression by interleukin-1beta , osteotropic hormones, and protein kinase inhibitors in normal human bone marrow stromal cells ... Interleukin-8 (IL-8) , a potent neutrophil chemotactic peptide that elicits pleiotropic biological effects is secreted in large amounts by normal human osteoblastic and bone marrow osteoprogenitor stromal ( HBMS ) cells in response to IL-1beta and tumor necrosis factor-alpha ... Both synthetic and natural glucocorticoids dexamethasone ( 10 ( -7 ) -10 ( -10 ) M ) and hydrocortisone ( 10 ( -6 ) -10 ( -8 ) M ) inhibited IL-1beta stimulated IL-8 mRNA expression ... Furthermore, as determined by nuclear run-on analysis, IL-1beta increased the rate of transcription of IL-8 gene and dexamethasone did not affect the IL-1beta induced transcription of IL-8 ... 1- ( 5-Isoquinolinesulfonyl ) -2-methylpiperazine, HCl ( 50 microM ) and staurosporine ( 1 microM ), potent inhibitors of protein kinase C, and genistein ( 100 microM ), a specific protein tyrosine kinase inhibitor blocked IL-1beta induced IL-8 gene expression ... Because curcumin ( 20 microM ), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase dependent signal transduction pathways
Ruef et al., Eur Respir J 1993 (Cystic Fibrosis) : Local production of IL-8 in response to elastase and IL-1 beta , together with the inactivation of the anti-inflammatory protein IL-6, may result in a significant upregulation of airway inflammation in cystic fibrosis
Enesa et al., J Biol Chem 2008 : Quantitative reverse transcription-PCR and enzyme linked immunosorbent assay revealed that H ( 2 ) O ( 2 ) enhanced the induction of IL-8 by TNFalpha or IL-1beta
Rasmussen et al., Inflamm Res 2008 (Inflammation) : IL-1beta induced both the IL-8 and p53 mRNA expression and protein production of IL-8, but not p53
Kwak et al., Infect Immun 2000 (Streptococcal Infections) : In contrast to the response to LPS, where TNF-alpha, IL-1beta, IL-6, and IL-8 appear almost simultaneously, the human monocyte response to GBS results in the production of TNF-alpha but delayed appearance of IL-1beta , IL-6, and IL-8
Mastrofrancesco et al., J Immunol 2010 (Melanoma, Experimental) : KdPT potently suppressed IL-1beta induced IL-6 and IL-8 expression
Li et al., Acta Pharmacol Sin 2006 (Lung Neoplasms) : Calcitonin gene related peptide inhibits interleukin-1beta induced interleukin-8 secretion in human type II alveolar epithelial cells ... In the present study, we investigated the effect of endogenous and exogenous CGRP on IL-1beta induced chemokine interleukin-8 (IL-8) secretion ... CGRP-1 receptor antagonist hCGRP8-37 ( 0.1-1 nmol/L ) greatly amplified IL-1beta induced IL-8 production ... However, cell clones stably transfected with CGRP showed significantly inhibited mRNA and protein levels of IL-8 induced by IL-1beta ... These data imply that AEII cell derived CGRP suppress IL-1beta induced IL-8 secretion in an autocrine/paracrine mode
Inoue et al., Am J Respir Crit Care Med 2000 (Bronchial Hyperreactivity...) : In addition, tumor necrosis factor-alpha (TNF-alpha) plus IL-1beta plus interferon-gamma (IFN-gamma) increased IL-8 in culture supernatant of epithelial cells ; the combination of NO synthase (NOS) inhibitors, aminoguanidine ( AG ) plus N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) attenuated the cytokine induced IL-8 production in epithelial cells
Coëffier et al., Clin Nutr 2003 (Inflammatory Bowel Diseases) : IL-1beta stimulation increased IL-6 and IL-8 , but did not affect IL-4 and IL-10 production
Huang et al., Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital 1999 : Stimulation of epithelial cells with IFN-gamma +TNF-alpha +IL-1 beta significantly increased IL-8 release and neutrophil adherence ... The spontaneous or IFN-gamma +TNF-alpha +IL-1 beta induced IL-8 release was significantly augmented after the addition of neutrophils
Yamada et al., Biochem Pharmacol 2001 : The additive effect of H. pylori and IL-1beta on IL-8 production was inhibited by treatment with a p38 MAPK inhibitor
Ehrlich et al., J Immunol 1998 : We found that IL-8 protein levels increased in response to LPS or IL-1 beta , or to TNF-alpha, which also corresponded to elevated IL-8 mRNA levels by RT-PCR
Bian et al., Lab Invest 1998 : In the present study, we further examined the effects of GHSA on TNF-alpha- and IL-1 beta induced HRPE IL-8 and monocyte chemoattractant protein (MCP)-1 gene expression and protein secretion in HRPE ... Moreover, potentiation of HRPE IL-8 generation by GHSA appeared to be selective for TNF-alpha because, under similar conditions, GHSA was unable to enhance the IL-1 beta stimulated IL-8 gene expression and protein secretion
Sakamoto et al., Clin Exp Immunol 2004 : Levels of IL-8 and IL-1beta , a regulator of IL-8 expression, were determined by enzyme linked immunosorbent assay ( ELISA )
Marotte et al., Rheumatology (Oxford) 2010 (Arthritis, Experimental...) : GTE ( 2.5-40 microg/ml ) inhibited IL-1beta induced MCP-1/CCL2 ( 10 ng/ml ), RANTES/CCL5, GROalpha/CXCL1 and IL-8/CXCL8 production in human RA synovial fibroblasts ( P < 0.05 )
Lisignoli et al., Cytokine 2002 (Arthritis) : Moreover, IFN-gamma reduced IL-1beta stimulated IL-8 production but significantly increased both MCP-1 and RANTES