Gene interactions and pathways from curated databases and text-mining

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IL6 — IL8

Text-mined interactions from Literome

Yasuda et al., Food Funct 2013 : In a co-culture system consisting of differentiated Caco-2 cells and RAW264.7 macrophages, mRNA expression of IL-6 , IL-8, IL-1ß and BAFF cytokines was up-regulated in Caco-2 cells and IL-8 production in basolateral medium was induced after 24 h apical treatment with 5 mg ml(-1) of ESG
Zhang et al., Mol Cell Biol 1990 (Chromosome Deletion) : Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence
Wallace et al., Rheumatology (Oxford) 2001 (Fibromyalgia) : Because IL-8 promotes sympathetic pain and IL-6 induces hyperalgesia, fatigue and depression, it is hypothesized that they may play a role in modulating FM symptoms
Nakamura et al., Eur J Oral Sci 2011 (Gingivitis) : Involvement of angiotensin II type 1 receptors in interleukin-1ß induced interleukin-6 production in human gingival fibroblasts
Ishikawa et al., Jpn J Vet Res 2001 : Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
Utsunomiya et al., Eur J Pharmacol 1994 (Pleurisy) : However, production of tumor necrosis factor (TNF) and interleukin-1 in the pleural exudate was significantly enhanced by the pretreatment with indomethacin, whereas the interleukin-6 level was reduced
Koyama et al., Extremophiles 2002 : PKC dependent IL-6 production and inhibition of IL-8 production by PKC activation in normal human skin fibroblasts under extremely high hydrostatic pressure
Meyer et al., Clin Sci (Lond) 1997 (Endotoxemia...) : 3. Administration of endotoxin induced a greater than fourfold increase in brain interleukin-1 , a greater than threefold increase in interleukin-6 and an increase in mRNA for both cytokines
Lai et al., Int J Gynecol Cancer 2011 (Genital Neoplasms, Female...) : Similar treatment in HeLa cells caused increases in the mRNA levels of CCL2, CXCL2, IL-6 , and IL-8, and in SKOV3 cells, mRNA levels of CCL2, CCL20, CXCL1, CXCL2, IL-6, and IL-8 increased
de Fijter et al., Am J Kidney Dis 1996 : In addition, interleukin-1-beta induced interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Fc receptor- mediated uptake of S epidermidis by PMO in the complete absence of Ca++ was comparable to that by PMO incubated in GHBSS with calcium
Hua et al., Molecular oral microbiology 2010 (Periodontal Diseases) : Furthermore, as little as 2 µg ml(-1) mPE was sufficient to inhibit interleukin-1ß induced secretion of interleukin-8 in both gingival epithelial cells and THP-1 cells
Vittori et al., J Allergy Clin Immunol 1992 : Protective effect of nedocromil sodium on the interleukin-1 induced production of interleukin-8 in human bronchial epithelial cells
Hoffmann et al., J Hepatol 1994 : Furthermore, lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta and phorbol ester induced interleukin-6 production and, at the same time, suppressed the level of interleukin-6 receptor mRNA
Roger et al., Am J Physiol Lung Cell Mol Physiol 2004 (Adenocarcinoma...) : The previously unrecognized phase of reduced IL-8 and IL-6 mRNA degradation and the concurrent amplified epithelial IL-8 and IL-6 responses may play an important role in virus induced potentiation of airway inflammation
Levine et al., Psychoneuroendocrinology 1994 : Pituitary-adrenal and interleukin-6 responses to recombinant interleukin-1 in neonatal rats
Hirota et al., Rheumatol Int 1992 : Production of interleukin 8 by cultured synovial cells in response to interleukin 1 and tumor necrosis factor
Krogh Rasmussen et al., Acta Endocrinol (Copenh) 1991 : In conclusion, it is unlikely that interleukin 6 by itself mediates the biological effects of interleukin 1 on human thyroid cells
Szabo et al., J Clin Immunol 1991 (Burns...) : Furthermore, interleukin-4 dependent downregulation of monocyte interleukin-6 expression is confirmed at both the supernatant and the mRNA levels
Maruyama et al., J Dermatol 1995 (Carcinoma, Squamous Cell...) : NHKs secreted detectable levels of IL-8, but not of IL-6 , and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate ( PMA )
Hallberg et al., J Affect Disord 2010 : IL-8 , IL-6 and TNF-alpha increased , and IL-4 decreased during the challenge in both groups
Bastian et al., Eur Surg Res 2008 : The acute sterile inflammation after major orthopaedic surgery is principally characterized by significantly increased local and systemic levels of IL-6 and significantly increased local levels of IL-8 and IL-1Ra
Lee et al., J Clin Immunol 2013 (MAP Kinase Signaling System) : These results indicate that MPL induced IL-8 increase is transcriptionally regulated by NF-IL6 more than by NF-?B
Kenney et al., J Allergy Clin Immunol 1994 : Furthermore, IL-6 and IL-8 release from human nasal epithelial cell cultures was enhanced by addition to the cultures of lipopolysaccharide, and IL-6 release was inhibited by polymyxin B
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Galley et al., Crit Care Med 1999 (Shock, Septic) : IL-6 accumulation was decreased ( p < .05 ) and IL-8 accumulation increased ( p < .01 ) with L-NMMA
Adams et al., Neurosurgery 1994 (Neuroma, Acoustic) : Tumor necrosis factor-alpha, interleukin-1-beta , and cholera toxin all stimulated IL-6 secretion
Bunning et al., Biochem Biophys Res Commun 1990 : Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes
Hashmi et al., Coron Artery Dis 2006 (Angina, Unstable) : Role of interleukin-17 and interleukin-17 induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease ... Role of interleukin-17 and interleukin-17 induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease
Puyo et al., Anesthesiology 2008 : Tumor necrosis factor alpha, interleukin 1beta, interleukin 6, and interleukin 8 increased over time, but only interleukin 6 increased significantly ( P < 0.01 )
Braquet et al., Int Arch Allergy Appl Immunol 1991 : We compared the effects of platelet activating factor (PAF), interleukin-1 beta (IL-1 beta) and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on IL-6 production by confluent L929 mouse fibroblasts
Helle et al., Eur J Immunol 1988 : Interleukin 6 is involved in interleukin 1-induced activities
Bresser et al., Eur Respir J 1997 (Bronchitis...) : A suspension of 10 ( 7 ) and 10 ( 8 ) colony forming units ( cfu ) x mL(-1) of H. influenzae, persisting and nonpersisting, induced a dose- and time dependent production of IL-6 and IL-8 by the human pulmonary mucoepidermoid carcinoma derived cell line H292, but levels of IL-6 were lower after exposure to persisting H. influenzae ( p < 0.05 )
Riechelmann et al., J Occup Environ Med 2004 : Twenty-four hours after exposure to 500 microg/m3, nasal secretion levels of IL-1beta increased 72.3 % ( 0-150.2 %, P=0.002 ), levels of IL-6 increased 42.2 % ( -28-161.9 %, P=0.01 ), and levels of IL-8 increased 19.7 % ( -20.3-60.5 %, P=0.03 ; median and 95 % confidence interval )
Kozawa et al., Prostaglandins Leukot Essent Fatty Acids 1998 : However, retinoic acid had little effect on the IL-6 synthesis induced by interleukin-1
Burch et al., Agents Actions 1991 (Wounds and Injuries) : Basal interleukin-1 and 6 release were not affected by sucralfate, but the agent enhanced interleukin-1 stimulated interleukin-6 release from fibroblasts
Fitzgerald et al., PloS one 2012 (Carcinoma, Renal Cell...) : Finally, we have characterized that enhanced levels of IL-6 and IL-8 result in RCC cell invasion and that activation of AMPK reduces Nox4 expression, IL-6 and IL-8 production, and RCC cell invasion
Zimecki et al., Arch Immunol Ther Exp (Warsz) 1994 : Interleukin 6 produced by activated thymocytes induces interleukin 1 production by macrophages
Fujimoto et al., Alcohol Clin Exp Res 2000 (Acute-Phase Reaction...) : In the recovery phase, these cytokine levels in survivors tended to decrease, but in nonsurvivors, IL-6 remained high, and IL-8 and IL-10 further increased
Waehre et al., Thromb Haemost 2004 (Inflammation) : Our main findings were : ( i ) the gene expression of several chemokines and some cytokines were markedly increased by both activated PRP and supernatants, as also confirmed at the protein level for IL-6, IL-8 and MIP-1alpha; (ii) the selective protein kinase A type I ( PKAI ) antagonist Rp-8-Br-cAMP reduced this platelet induced expression of IL-6 , IL-8 and MIP-1alpha in PBMC, suggesting a role of cAMP/PKAI mediated mechanisms in this interaction ; ( iii ) PGE ( 2 ) dose-dependently increased the release of IL-6, IL-8 and MIP-1alpha from PBMC mimicking the effect of activated platelets
Chen et al., Endocrinology 2008 : LPA enhanced IL-8 expression in a dose- and time dependent manner, whereas vascular endothelial growth factor or IL-6 expression was not affected by LPA treatment
Hu et al., Immunopharmacol Immunotoxicol 2009 : The results revealed that anemonin, aesculin and esculetin inhibited the production of IL-6 , aesculin and esculetin inhibited the secretion of IL-8 , anemoside B4, berberine and jatrorrhizine downregulated E-selectin expression, anemonin, berberine, jatrorrhizine and palmatine decreased the content of TXB ( 2 )
Kaminska et al., Tumour Biol 2005 (Colorectal Neoplasms) : The levels of circulating interleukin (IL)-6, IL-8 , macrophage colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly increased with the clinical stage of CRC, and the levels of IL-6 , soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ), soluble interleukin 2 receptor alpha and TNFalpha with tumor grade, while IL-6, IL-8, M-CSF, IL-1ra and sTNF RI levels significantly rose with bowel wall invasion
Krakauer , J Infect Dis 1998 : Interleukin-8 production by human monocytic cells in response to staphylococcal exotoxins is direct and independent of interleukin-1 and tumor necrosis factor-alpha
Imatani et al., Oral Microbiol Immunol 2001 : Rabbit antisera against either outer-membrane protein or lipopolysaccharide inhibited the IL-6 and IL-8 production derived from human gingival fibroblasts stimulated sonicated supernatants from P. gingivalis
Shear et al., Skin Pharmacol Appl Skin Physiol 1999 : IL-6 increased 1.7 times in both cultures, and IL-8 increased 1.7 times in NHPSC and 2.1 times in A431
Stecenko et al., Inflammation 2001 (Cystic Fibrosis...) : In the second 24 hours of TNFalpha stimulation, IL-6 and IL-8 generation ceased in normal and corrected CF cells but accelerated in CF cells, resulting in marked IL-6 and IL-8 accumulation in CF cells
Timper et al., Am J Physiol Endocrinol Metab 2013 (Insulin Resistance) : GIP induced mRNA expression of IL-6 , IL-1ß, and the IL-1 receptor antagonist IL-1Ra, whereas TNFa, IL-8 , and monocyte chemotactic protein (MCP)-1 remained unchanged
Okamura et al., Anticancer Res 2013 (Carcinoma, Squamous Cell...) : These results indicate that the overexpression of IL-6 increases the invasiveness of KYSE170 esophageal carcinoma cells and IL-6 induced IL-8 plays a predominant role in increasing invasiveness
Wang et al., Arterioscler Thromb 1991 : Tumor necrosis factor and bacterial lipopolysaccharide but not IL-6 also induced MCP and IL-8 gene expression in SMCs. Nuclear runoff analysis revealed that IL-1 augmented transcription of the MCP and IL-8 genes
Xia et al., Int Arch Allergy Immunol 2013 (Asthma...) : hASM cell production of IL-8 induced by HMCa condition media but not IL-6 was, however, attenuated by the Src tyrosine kinase inhibitor PP2
Fukui , Alcohol Clin Exp Res 2005 (Hepatitis, Alcoholic...) : In the recovery phase, these cytokine levels in survivors tended to decrease, but in non-survivors, IL-6 remained high, and IL-8 further increased
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Wuyts et al., J Heart Lung Transplant 2004 : N-acetylcysteine inhibits interleukin-17 induced interleukin-8 production from human airway smooth muscle cells : a possible role for anti-oxidative treatment in chronic lung rejection ?
Albanesi et al., J Invest Dermatol 2000 (Dermatitis, Allergic Contact...) : In addition, interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage colony stimulating factor, and interleukin-6 , with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Suzuki et al., J Perinatol 2013 : Serum levels of IL-6 and IL-8 had been already elevated in his cord blood, and serum levels of granulocyte-macrophage colony stimulating factor and IL-8 were significantly increased on the second day of life
Peng et al., Exp Cell Res 2007 (Inflammation...) : We have further identified that interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) from PMN-melanoma co-cultures synergistically contribute to IkappaB-alpha degradation and IL-8 synthesis in PMNs. Taken together, these findings show that melanoma cells induce PMNs to secrete IL-8 through activation of NF-kappaB and suggest a model in which this interaction promotes a microenvironment that is favorable for metastasis
Ng et al., J Biol Chem 1994 : Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1 ... Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8 , TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Kwon et al., Immunology 1994 : We demonstrated that IL-8 was expressed by primary cultured HAEC and that this was enhanced by IL-1 beta and tumour necrosis factor-alpha stimulation, but not by IL-6 or lipopolysaccharide
Libert et al., Eur J Immunol 1990 : Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
van Milligen de Wit et al., Eur J Gastroenterol Hepatol 1999 (Cholangitis, Sclerosing) : Baseline serum levels of interleukin-6 (IL-6) and soluble IL-2 receptor were normal, and serum IL-8 levels were increased , but none of these variables was significantly affected by UDCA therapy
Waehre et al., J Am Coll Cardiol 2003 (Coronary Artery Disease) : Our main findings were : 1 ) gene expression of several chemokines ( i.e., macrophage inflammatory protein [MIP ] -1alpha, MIP-1beta, and interleukin [ IL]-8 ) and chemokine receptors ( i.e., CC chemokine receptor [ CCR]1, CCR2, CCR4, and CCR5 ) was markedly increased among CAD patients compared with healthy control subjects ; 2 ) treatment with atorvastatin and simvastatin markedly reduced the mRNA levels of some of these chemokines ( i.e., MIP-1alpha, MIP-1beta, IL-8 ) and receptors ( i.e., CCR1 and CCR2 ), with the most pronounced effect in the atorvastatin group ; and 3 ) statin therapy reduced the spontaneous release of IL-8 and MIP-1alpha from PBMCs in CAD patients
Shinoda et al., Cell Signal 1999 : C2-ceramide did not affect the IL-6 synthesis induced by interleukin-1
Kuroyanagi et al., Biochimie 2013 : ( - ) -Epigallocatechin gallate amplifies interleukin-1 stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells
Santos et al., J Rheumatol 2004 (Arthritis, Rheumatoid) : MIF activates RA FLS COX-2 and IL-6 expression via p38 MAP kinase activation and induces IL-8 via p38 and ERK MAP kinase independent pathways
Wullt et al., Eur Urol 2006 (Bacteriuria) : In ileal neobladders, the IL-8 responses were higher, and levels of IL-6 were significantly increased
Ueo et al., J Am Coll Surg 1994 : The IL-6 secretion by skin explants was significantly enhanced either by tumor necrosis factor or interleukin-1 , while it was inhibited by corticosteroids
Grandel et al., Mol Cancer Res 2009 (Carcinoma, Non-Small-Cell Lung...) : The LPS induced a dose dependent and time dependent release of IL-8 from A549 cells, whereas IL-6 could not be detected
Lottaz et al., J Invest Dermatol 2001 : We hypothesize that inhibition of this pathway prevents secretion of interleukin-1, thereby downregulating interleukin-1 dependent autocrine induction of interleukin-8
Xue et al., Curr Eye Res 2001 : Addition of IL-1beta Ab resulted in a significant decrease ( P < 0.05 ) in IL-8 protein expression at 4 h, 8 h and 12 h. Addition of IL-1beta Ab reduced IL-6 protein expression at 8 h and increased IL-6 protein expression at 12 h. Addition of recombinant IL-1beta protein alone strongly stimulated the expression of IL-8 and IL-6
Nishitai et al., J Biol Chem 2004 : Instead, interleukin-1 beta (IL-1 beta) induced IL-6 gene expression was greatly suppressed in sek1 ( -/- ) mkk7 ( -/- ) fibroblasts
Baigrie et al., Lymphokine Cytokine Res 1991 (Aortic Aneurysm...) : A sequential interleukin-1 beta and interleukin-6 response has not been noted before in vivo, and would seem to provide evidence supporting the in vitro observation that interleukin-1 induces interleukin-6 synthesis and release
Tanabe et al., Journal of neuroinflammation 2011 : Midazolam suppresses interleukin-1ß induced interleukin-6 release from rat glial cells
Shimizu et al., Arch Oral Biol 1992 : Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells
Saito et al., Mech Ageing Dev 2003 (Endotoxemia...) : The stress mediated induction of interleukin-1beta, interleukin-6 , and interleukin-10 ( IL-1beta, IL-6, and IL-10 ) in the circulating blood tended to be higher with aging in both CLP and LPS models, and in particular, the induction of IL-6 was significantly augmented with aging
Jones et al., J Pathol 1997 (Meningioma) : Effect of interleukin-1 and dexamethasone on interleukin-6 production and growth in human meningiomas
Tesar et al., Blood Purif 1998 (Kidney Diseases...) : On the other hand, there was no change in serum levels of IL-1beta and IL-8 , and the serum levels of IL-1ra and IL-6 even increased at the end of a single PE, in spite of high levels of all cytokines and adhesion molecules in the plasma filtrate
Matsumoto , Masui 1997 (Esophageal Neoplasms) : Interleukin-6 showed a peak level 24 hours after induction and interleukin-8 was increased significantly 12 hours after induction and maintained the elevated level until 72 hours postoperatively
Chan et al., Cytokine 2006 (Cell Transformation, Viral) : In human bronchial epithelial cells, binding sites for NFkappaB, AP-1, and NF-IL6 in the 5'-flanking region of the IL-8 promoter are necessary for optimal NaCl induction of IL-8
Thorgersen et al., Infect Immun 2013 (Inflammation...) : Interleukin-6 (IL-6) was significantly inhibited in all organs, IL-1ß and IP-10 were significantly inhibited in liver, spleen, and kidneys, and tumor necrosis factor, IL-8 , and PAI-1 were inhibited only in the spleen
Carlson et al., J Neurochem 1995 (Astrocytoma) : Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1 induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C ... We conclude that tyrosine kinase activity is essential for interleukin-1 induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved
Hoffmann et al., Head Neck 2007 (Carcinoma, Adenoid Cystic...) : In patients with ACC, IL-8 serum levels were significantly elevated, and IL-6 serum levels were only increased in a subset of patients
Andoh et al., Biochim Biophys Acta 2002 : In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha induced IL-6 secretion through the induction of IL-6 mRNA stabilization
Huang et al., Infect Immun 1995 (Helicobacter Infections) : Purified IL-6 alone did not stimulate IL-8 production from the cell lines tested, indicating that IL-6 was not an intermediary in IL-8 induction
Ungerstedt et al., Clin Exp Immunol 2003 (Endotoxemia) : At a concentration of 40 mmol/l, the IL-1 beta, IL-6 and TNF alpha responses were reduced by more than 95 % and the IL-8 levels reduced by 85 %
Bersinger et al., Arch Gynecol Obstet 2011 : Interferon-? stimulated IL-6 and inhibited IL-8 production above 20 ng/mL
Zitnik et al., Am J Physiol 1993 : cAMP inhibition of interleukin-1 induced interleukin-6 production by human lung fibroblasts
Fukushima et al., J Endod 2010 : IL-1beta and IL-6 simultaneously induced IL-8 and monocyte chemoattractant protein-1 secretion in PDL cells, whereas SOCS-3 overexpression suppressed secretion of these chemokines through inhibition of phosphorylation in downstream signaling
Akagi , Nihon Yakurigaku Zasshi 1998 (Asthma...) : Since IL-8 exerts a chemotactic activity for neutrophils, eosinophils and basophils, and IL-6 is involved in endothelium permeability, the secretion of cytokines may be involved in the late phase reaction
Borger et al., Transplantation 2000 : Low concentrations of prednisolone ( 0.01 and 0.001 microg/ml ) enhanced IL-6 and IL-8 secretion, whereas concentrations > or =0.01 microg/ml significantly diminished IL-6 secretion
Kim et al., Mol Med Report 2013 : Monocyte chemotactic protein-1 (MCP-1)/CCL2, interleukin (IL)-6 and IL-8 increased following DpE treatment and arazyme significantly blocked the increase of MCP-1, IL-6 and IL-8 expression in cell types
Tatad et al., Neonatology 2008 : Intracellular leukocyte production of interleukin (IL)-6 , IL-10, IL-12, and IL-8 responses was assessed by flow cytometry
Prause et al., Eur J Pharmacol 2003 : Pharmacological modulation of interleukin-17 induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells ... We found that interleukin-17 ( 1-1000 ng/ml ) increased the release of GCP-2, GRO-alpha and interleukin-8 in a concentration dependent manner
Darbonne et al., J Clin Invest 1991 : Their binding of IL-8 is rapidly reversible and does not result in receptor internalization, although bound IL-8 is resistant to extraction by pH 3 buffer at 5 degrees C. 125I-IL-8 binding to red cells was not inhibited by epidermal growth factor or interleukin 1, but was inhibited by monocyte chemotactic peptide-1, which is not a neutrophil chemotaxin, but is a member of the same family of polypeptides as IL-8
Planck et al., Invest Ophthalmol Vis Sci 1992 : Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1
Lu et al., Nan Fang Yi Ke Da Xue Xue Bao 2007 (Esophageal Neoplasms...) : IL-6 , IL-8 levels in the plasma and BALF collected at T ( 2 ) -T ( 4 ) increased significantly as compared with those in samples collected at T ( 1 ), and their peak concentration inplasma and BALF samples were similar
Uchiyama et al., Am J Obstet Gynecol 1992 : These results indicate that interleukin-8-like chemotactic factor participates in the cervical ripening at term pregnancy and that the production of this factor is controlled effectively by interleukin-1
Zhang et al., Beijing Da Xue Xue Bao 2010 (Chlamydia Infections...) : [ Early production of interleukin-17 in airway upon Chlamydia trachomatis infection increases the local secretion of IL-6 and MIP-2 ]
Yoon et al., PloS one 2011 (Graves Disease...) : Quercetin significantly attenuated intercellular adhesion molecule-1 ( ICAM-1 ), interleukin (IL) -6, IL-8 , and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1ß induced increases in ICAM-1, IL-6 , and IL-8 mRNA
Shalaby et al., Clin Immunol Immunopathol 1989 (Shock, Septic) : Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo
Attur et al., Proc Assoc Am Physicians 1998 (Osteoarthritis) : Addition of CSAIDs to OA-affected cartilage differentially regulates IL-6 and IL-8 production by inhibiting the spontaneous release of IL-6 but not IL-8 in ex vivo conditions
Soloff et al., Endocrinology 2004 : In situ analysis of interleukin-1 induced transcription of cox-2 and il-8 in cultured human myometrial cells
Strieter et al., Am J Respir Cell Mol Biol 1990 : The induction of AMO derived IL-8 by tumor necrosis factor (TNF), lipopolysaccharide (LPS), and interleukin-1 ( IL-1 beta ) was shown to be both dose and time dependent
Yamamoto et al., Arthritis Rheum 2003 (Arthritis, Experimental...) : The effects of RasDN overexpression on cellular proliferation, interleukin-1 (IL-1) induced activation of mitogen activated protein kinases ( extracellular signal regulated kinase [ ERK ], p38, c-Jun N-terminal kinase [ JNK ] ), and IL-6 production by synovial cells were analyzed
Simeonova et al., Lab Invest 1999 : Furthermore using cell transfection and mobility shift assays, it was found that transcriptional activation of the IL-8 gene required TNF-alpha induced activation and binding of nuclear factor-kappaB (NF-kappaB)- and NF-IL-6 , nuclear transcription factors to regulatory elements in the IL-8 promoter
Fiedler et al., Am J Physiol 1996 (Respiratory Syncytial Virus Infections) : Mutational analysis of the 200-bp 5'-untranslated region of the IL-8 gene demonstrated that activation of NF-kappa B and NF-IL-6 were required for RSV induced transcriptional activation of the IL-8 gene
Topley et al., J Am Soc Nephrol 1996 : Similarly, interleukin (IL)-1 beta induced IL-6 synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution
Moutabarrik et al., Scand J Immunol 1994 : IL-6 was detected in the culture supernatants of human GEC and its production was enhanced in time and dose dependent manner by lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta) and tumour necrosis alpha ( TNF-alpha )
Vindeløv et al., Growth Horm IGF Res 2011 (Adenoma...) : Interleukin-8 production from human somatotroph adenoma cells is stimulated by interleukin-1ß and inhibited by growth hormone releasing hormone and somatostatin
Rougier et al., Cytokine 1998 : IL-6 ( 10 ng/ml ) stimulated IL-8 production with 0 % and 10 % fetal calf serum ( FCS ) in the culture medium
Takizawa et al., Am J Physiol 1996 : Moreover, exogenously added human recombinant IL-6 had a stimulatory effect on IL-8 release from human bronchial epithelial cells
Leng et al., J Immunol 1997 (Leukemia, Monocytic, Acute) : IL-11 did not similarly regulate monocyte/macrophage production of IL-8 or macrophage inflammatory protein-1alpha ( MIP-1alpha ) and IL-6 did not similarly inhibit IL-12 elaboration
Romero et al., Endocrinology 2006 : IL-6 had no effect on IL-8 secretion
Mastronarde et al., J Infect Dis 1996 : Induction of interleukin (IL)-8 gene expression by respiratory syncytial virus involves activation of nuclear factor (NF)-kappa B and NF-IL-6
Arjamaa et al., J Diabetes Complications 2011 (Diabetic Retinopathy...) : The level of IL-6 increased from 68.9 ± 46.8 pg/ml to 102.7 ± 94.1 pg/ml, and IL-8 increased from 165.1 ± 136.0 pg/ml to 521.0 ± 870.9 pg/ml ( mean ± S.D., nonsignificant change : normality test followed with Mann-Whitney Rank Sum Test )
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF, and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : Grape seed proanthocyanidin extract inhibits interleukin-17 induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells
Wu et al., Atherosclerosis 1999 : However, IL-1beta induced productions of both MCP-1 and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E. Vitamin E, at the doses used, did not significantly change the spontaneous production but dose-dependently inhibited the IL-1beta induced production of inflammatory cytokine IL-6
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2
Cadman et al., Neurosci Lett 1994 (Astrocytoma) : cAMP is not involved in interleukin-1 induced interleukin-6 release from human astrocytoma cells
Galatowicz et al., Clin Exp Allergy 2007 (Conjunctivitis, Allergic...) : For conjunctival biopsy derived cultures ( n=11 ), FcepsilonR1 stimulation increased histamine, TNF-alpha, TNF-beta, IL-5 and IL-8 levels and the production of IL-5, IL-6 ( P < 0.05 ), histamine and IL-8 ( P < 0.01 ) was inhibited by epinastine
Suzuki et al., Rheumatol Int 2010 (Arthritis) : IL-6 and IL-6 + sIL-6R induced production of both MCP-1 and IL-8 in PBMC and synovial cells, respectively ... In HUVEC, IL-6 + sIL-6R induced MCP-1 production, but inhibited IL-8 production
Becker et al., J Immunol 1991 (Respirovirus Infections) : However, TNF, IL-1, and RSV, but not IL-6 , induced IL-8 and IL-6 mRNA expression by the bronchial epithelial cells suggesting that cytokines produced by RSV infected AM may be more important in modulating the inflammatory response in infection than directly interfering with virus infection/replication of airway epithelium
Lee et al., Clin Exp Allergy 2007 (Asthma) : IL-8 promoter deletion analysis indicated that position -132 to +41 was essential for GCE induced IL-8 transcription, and mutants with substitutions in activator protein (AP)-1, nuclear factor (NF)-IL6 and NF-kappaB binding sites revealed a requirement for NF-kappaB and NF-IL6 , but not AP-1, in GCE induced activation of the IL-8 promoter
Silfverswärd et al., J Orthop Res 2004 : Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells
Lee et al., Cytokine 2008 : We found that MCP-1 and IL-6 expression due to DpE was related to Src, protein kinase C delta (PKC delta), extracellular-signal regulated kinase ( ERK ) and p38 mitogen activated protein kinase ( MAPK ) and IL-8 expression was involved in Src family tyrosine kinase, PKC delta, ERK
Jacobs et al., Skin Pharmacol Physiol 2004 (Warts) : Analysis of imiquimod treated warts demonstrated that imiquimod enhanced IL-6 expression and induced IL-8 , GM-CSF, MRP-8 and MRP-14
Nesbitt et al., Mol Biol Cell 1992 (Inflammation) : We employed ribonuclease protection assays to measure the expression of IL-6-R and gp130 mRNA in primary rat hepatocytes in response to IL-6, interleukin-1 , dexamethasone, and combinations thereof
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6 , transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Larsen et al., Biochem Biophys Res Commun 1991 : 1,25 ( OH ) 2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production
Zhang et al., J Ethnopharmacol 2013 (Arthritis, Experimental...) : The results also found that there was significant reduction levels of IL-6, IL-8 and TNF-a in serum of CIA rats treated with ATW and ATW inhibited the expression of IL-6 , IL-8, NF-?B, TNF-a in synovial tissue
Wu et al., J Gen Virol 2010 (Adenoviridae Infections...) : The results showed that IL-8 and IL-6 were induced 8 h after infection and, by 24 h, levels of IL-8 , IL-6, MIP-1alpha/beta and MCP-1 were all increased
Gras et al., Int Arch Allergy Immunol 2010 : IL-8 ( 50 ng/ml, 12 h ) induced the release of IL-6 and had no effect on ICAM-1 ... The present study illustrated the fact that IL-8 mediated by CXCR-1 increased IL-6
Boxman et al., J Invest Dermatol 1993 : The remaining interleukin-1 activity, however, was sufficient for maximal induction of interleukin-6 production in fibroblasts
Kunsch et al., J Immunol 1994 : Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 ( RelA ) and NF-IL-6
Lin et al., Nutrition 1997 (Colorectal Neoplasms) : This study was designed to investigate whether preoperative total parental nutrition (TPN) influences systemic interleukin-6 (IL-6) and interleukin-8 (IL-8) responses in patients following surgery for colorectal cancer
Porro et al., J Pharmacol Exp Ther 1998 (Shock, Septic) : In vitro experiments showed that ITF1779 inhibited not only huTNFalpha induced cytotoxicity on LM cells but also another response of the same cells, interleukin-1 induced interleukin-6 production
Tsuchiya et al., Laryngoscope 2007 : However, the PGPS induced IL-8 promoter activation in rodent middle ear epithelial cells required NF-kappaB and NF-IL6 but not AP-1
Zeng et al., Zhonghua Xue Ye Xue Za Zhi 1998 (Leukemia, Promyelocytic, Acute) : Serum IL-6 and IL-8 levels significantly increased when the patients suffered infection, and IL-8 increased even before fever
Chen et al., Cytokine 1996 : In contrast, pretreatment with IL-4 amplified the production of IL-6 in TNF-alpha-, IL-1 beta- or LPS activated ECs, but inhibited IL-8 expression