Gene interactions and pathways from curated databases and text-mining

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IL8 — SRC

Text-mined interactions from Literome

Salinthone et al., Am J Physiol Gastrointest Liver Physiol 2004 (Inflammation) : Expression of IL-1beta, IL-6, IL-8 , and COX-2 mRNA was reduced by 30 microM PP1, an Src family tyrosine kinase inhibitor, and by 25 microM SB-203580, a p38 MAPK inhibitor
Yeh et al., J Biol Chem 2004 (Inflammation) : Ox-PAPC mediated IL-8 protein synthesis in HAEC was inhibited by Src family kinase inhibitors, PP1 and PP2, but not by an inactive analog, PP3
Øvrevik et al., Toxicological sciences : an official journal of the Society of Toxicology 2004 : However, IL-8 induction was most efficiently inhibited by the Src family kinase (SFK) inhibitor, PP2, suggesting a crucial role of SFKs in regulating silica induced IL-8 release from A549 cells
Trevino et al., Cancer Res 2005 (Adenocarcinoma...) : Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells : implications for angiogenesis ... The purpose of this study was to determine if c-Src , a protein tyrosine kinase frequently overexpressed in pancreatic cancer, regulated IL-8 expression and to elucidate the Src mediated signaling pathways that contribute to angiogenesis in pancreatic adenocarcinoma cells ... Furthermore, ectopic expression of activated Src in PANC-1 cells with low endogenous Src activity significantly increased IL-8 production ( P < 0.005 )
Xiao et al., Invest Ophthalmol Vis Sci 2005 : Previous studies indicate that adenovirus type 19 ( Ad19 ) infection of human corneal fibroblasts ( HCFs ) induces the expression of several proinflammatory mediators, including IL-8 and monocyte chemoattractant protein-1 ( MCP-1 ), and that the tyrosine kinase c-Src and its downstream target, the mitogen activated protein kinase ERK1/2, mediate IL-8 expression
Eum et al., Toxicological sciences : an official journal of the Society of Toxicology 2006 : Most importantly, pharmacological inhibition of Src kinase activity or overexpression of dominant negative c-src in HMECs resulted in a significant decrease in IL-8 expression and promoter activity ... In contrast, ectopic expression of activated c-Src markedly increased promoter activity of IL-8
Trevino et al., Angiogenesis 2006 (Adenocarcinoma...) : To ascertain whether Src mediated expression of IL-8 was dependent on STAT3, we used stable clones expressing a dominant negative isoform of STAT3 that inhibits endogenous STAT3 phosphorylation and subsequent DNA binding and STAT3 mediated gene expression or a constitutively activated isoform of STAT3 ... Pharmacologic inhibition of NF-kappaB activity significantly reduced basal IL-8 expression and tumor necrosis factor induced IL-8 expression ( P < 0.05 for both ), yet NF-kappaB activity was not dependent on Src
Lin et al., J Immunol 2006 : Thrombin induced increase in IL-8/CXCL8-Luc activity was inhibited by the dominant negative mutant of c-Src and the cells transfected with the kappaB site mutation of the IL-8/CXCL8 construct
Han et al., Cancer Res 2006 (Ovarian Neoplasms) : In addition, Src inhibition alone and in combination with docetaxel significantly down-regulated tumoral production of vascular endothelial growth factor and interleukin 8 , whereas combination therapy decreased the microvessel density ( P = 0.02 ) and significantly affected vascular permeability ( P < 0.05 )