◀ Back to SRC
IL8 — SRC
Text-mined interactions from Literome
Salinthone et al., Am J Physiol Gastrointest Liver Physiol 2004
(Inflammation) :
Expression of IL-1beta, IL-6,
IL-8 , and COX-2 mRNA was
reduced by 30 microM PP1, an
Src family tyrosine kinase inhibitor, and by 25 microM SB-203580, a p38 MAPK inhibitor
Yeh et al., J Biol Chem 2004
(Inflammation) :
Ox-PAPC mediated
IL-8 protein synthesis in HAEC was
inhibited by
Src family kinase inhibitors, PP1 and PP2, but not by an inactive analog, PP3
Øvrevik et al., Toxicological sciences : an official journal of the Society of Toxicology 2004
:
However,
IL-8 induction was most efficiently
inhibited by the
Src family kinase (SFK) inhibitor, PP2, suggesting a crucial role of SFKs in regulating silica induced IL-8 release from A549 cells
Trevino et al., Cancer Res 2005
(Adenocarcinoma...) :
Expression and activity of
SRC regulate
interleukin-8 expression in pancreatic adenocarcinoma cells : implications for angiogenesis ... The purpose of this study was to determine if
c-Src , a protein tyrosine kinase frequently overexpressed in pancreatic cancer,
regulated IL-8 expression and to elucidate the Src mediated signaling pathways that contribute to angiogenesis in pancreatic adenocarcinoma cells ... Furthermore, ectopic expression of activated
Src in PANC-1 cells with low endogenous Src activity significantly
increased IL-8 production ( P < 0.005 )
Xiao et al., Invest Ophthalmol Vis Sci 2005
:
Previous studies indicate that adenovirus type 19 ( Ad19 ) infection of human corneal fibroblasts ( HCFs ) induces the expression of several proinflammatory mediators, including IL-8 and monocyte chemoattractant protein-1 ( MCP-1 ), and that the tyrosine kinase
c-Src and its downstream target, the mitogen activated protein kinase ERK1/2,
mediate IL-8 expression
Eum et al., Toxicological sciences : an official journal of the Society of Toxicology 2006
:
Most importantly, pharmacological inhibition of
Src kinase activity or overexpression of dominant negative c-src in HMECs
resulted in a significant decrease in
IL-8 expression and promoter activity ... In contrast, ectopic expression of activated
c-Src markedly
increased promoter activity of
IL-8
Trevino et al., Angiogenesis 2006
(Adenocarcinoma...) :
To ascertain whether
Src mediated expression of
IL-8 was dependent on STAT3, we used stable clones expressing a dominant negative isoform of STAT3 that inhibits endogenous STAT3 phosphorylation and subsequent DNA binding and STAT3 mediated gene expression or a constitutively activated isoform of STAT3 ... Pharmacologic inhibition of NF-kappaB activity significantly reduced basal
IL-8 expression and tumor necrosis factor induced IL-8 expression ( P < 0.05 for both ), yet NF-kappaB activity was not
dependent on
Src
Lin et al., J Immunol 2006
:
Thrombin induced increase in
IL-8/CXCL8-Luc activity was
inhibited by the dominant negative mutant of
c-Src and the cells transfected with the kappaB site mutation of the IL-8/CXCL8 construct
Han et al., Cancer Res 2006
(Ovarian Neoplasms) :
In addition,
Src inhibition alone and in combination with docetaxel significantly
down-regulated tumoral production of vascular endothelial growth factor and
interleukin 8 , whereas combination therapy decreased the microvessel density ( P = 0.02 ) and significantly affected vascular permeability ( P < 0.05 )