Gene interactions and pathways from curated databases and text-mining

◀ Back to CA2

CA2 — INA

Text-mined interactions from Literome

Boccara et al., Circ Res 1999 : In conclusion, I(Na) regulates [ Ca2+ ] i in primary cultured HCMs
Jans et al., Pflugers Arch 2000 (Ion Channel Gating) : At constant osmolality ( 200 mOsm/kg H2O ) 10 mM Mg2+ increased I(Na), leaving C ( T ) unaffected, whereas 10 mM Ca2+ stimulated both I(Na) and CT
Lipp et al., J Physiol 2002 (Calcium Signaling) : In contrast, I(Na) induced Ca2+ responses were still spatially homogeneous and lacked Ca2+ sparks even for small current amplitudes
Fraser et al., J Mol Cell Cardiol 2006 (Myocardial Ischemia...) : Augmentation of late INa with sea anemone toxin-II ( ATX-II, 12 nM ) increased diastolic [Ca2+ ] i ( d [ Ca2+ ] i ), and impaired LV mechanical function, but had no effect on [Ca2+ ] i transient amplitude
Levesque et al., Ann N Y Acad Sci 1991 : This result provides direct evidence that Ca2+ entry via reverse-mode Na(+)-Ca2+ exchange mediates the INa induced SR Ca2+ release ... The INa induced release of Ca2+ from SR may partially account for the positive inotropic effects of cardiac glycosides and the negative inotropic effects of antiarrhythmic drugs that block Na+ channels
Krattenmacher et al., J Comp Physiol B 1990 : Removal of Ca2+ from the mucosal Ringer solution stimulated INa by about 120 %
Lipp et al., J Physiol 1994 : Analysis of INa induced Ca2+ signals at higher temporal resolution revealed a faster upstroke of these transients when compared with those triggered by ICa ... INa also induced a residual Ca2+ transient that was insensitive to 10 microM verapamil and characterized by a rapid upstroke ... This result supports the notion that both the residual Ca2+ transient as well as the INa induced Ca2+ release are mediated by the Na(+)-Ca2+ exchange. ( ABSTRACT TRUNCATED AT 250 WORDS )
Cox et al., J Vasc Res 1998 (Ion Channel Gating) : Lowering external [Ca2+ ] to zero increased the maximum INa , shifted its voltage dependence in the hyperpolarizing direction and increased the rate of INa inactivation