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IL6 — INA

Text-mined interactions from Literome

Chatterjee et al., Blood 2002 (MAP Kinase Signaling System...) : Here we show that treatment of human MM cells ( IL-6 dependent MM cell line INA-6 and primary MM cells ) with the IL-6 receptor antagonist Sant7 or with an anti-gp130 monoclonal antibody ( mAb ) induced apoptosis if the cells were cultured in the absence of bone marrow stromal cells ( BMSCs )
Burger et al., Br J Haematol 2003 (Multiple Myeloma) : In INA-6.Tu11 cells, a subline of the IL-6 dependent human plasma cell line INA-6 expressing gp130 and the receptor for leukaemia inhibitory factor (LIF), stimulation with BSF-3 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 ( STAT3 )
Tassone et al., Clin Cancer Res 2005 (Disease Models, Animal...) : Here, we investigated whether inhibition of the IL-6 signaling pathway by the IL-6 receptor superantagonist Sant7 enhances the in vivo antitumor effects of dexamethasone on the IL-6 dependent multiple myeloma cell line INA-6
Burger et al., Mol Cancer Ther 2009 (Multiple Myeloma) : The IL-6 dependent cell line INA-6 was particularly sensitive to the drug ( IC50 < 1 micromol/L )