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INS — TNF

Text-mined interactions from Literome

Bertrand et al., J Biol Chem 1999 : Insulin increased the expression of tumor necrosis factor receptor associated factor 2 ( TRAF2 ) mRNA and protein in Chinese hamster ovary cells overexpressing insulin receptors (IRs)
el-Nawawy et al., Indian J Pediatr 1998 (Diabetes Mellitus, Type 1...) : In vitro TNF-A and interleukin 1-beta (IL-1-beta) inhibit insulin release from islet beta-cells
Del Aguila et al., Am J Physiol Endocrinol Metab 2000 (Pain) : Although more research is needed on the potential role for TNF-alpha inhibition of insulin action, elevated TNF-alpha production after muscle damage may impair insulin signal transduction
Kim et al., Am J Physiol Cell Physiol 2001 : TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells
Ozes et al., Proc Natl Acad Sci U S A 2001 (Insulin Resistance) : A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1 ... These results suggest that TNF impairs insulin signaling through IRS-1 by activation of a PI 3-kinase/Akt/mTOR pathway, which is antagonized by PTEN
Iida et al., J Biol Chem 2001 (MAP Kinase Signaling System) : The results of array analysis showed that insulin stimulated gene expression of tumor necrosis factor-alpha (TNF-alpha) the most among all genes in the analysis ... To determine the signaling pathway involved in this TNF-alpha response to insulin , we pretreated the cells with three distinct protein kinase inhibitors : wortmannin, PD98059, and SB203580 ... These observations indicate that insulin stimulates TNF-alpha production in macrophages by regulating the expression of TNF-alpha mRNA and that the extracellular signal regulated kinase signaling pathway may have a critical role in stimulating the production of TNF-alpha in response to insulin in macrophages
Tsiotra et al., Int J Obes Relat Metab Disord 2001 : TNFalpha and leptin inhibit basal and glucose stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells ... TNFalpha significantly suppressed basal and glucose stimulated insulin secretion and proinsulin mRNA transcription in a dose dependent manner, an effect that was more powerful in the presence of high glucose
Mabley et al., Br J Pharmacol 2001 (Diabetes Mellitus, Experimental) : In vitro the cytokine combination ; interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma inhibited glucose stimulated insulin secretion from isolated rat islets of Langerhans and decreased RIN-5F cell viability
Das et al., Prostaglandins Leukot Essent Fatty Acids 2001 (Inflammation...) : Insulin inhibits TNF alpha and enhances TGF beta production, augments nitric oxide synthesis and blocks superoxide anion generation
Coppack et al., Proc Nutr Soc 2001 (Obesity) : There is conflicting data about whether insulin and cortisol regulate TNF-alpha
Sheu et al., Metabolism 2001 (Hypertension...) : Anthropometric measurements, fasting plasma glucose, insulin, lipoprotein concentrations, glucose, and insulin responses to OGTT, TNFalpha , and leptin concentrations were similar between the genotype at the -308 site both in hypertensive and normotensive groups
Wu et al., J Surg Res 2001 : We tested the in vitro effects of interleukin (IL)-1 beta, tumor necrosis factor (TNF)alpha , and interferon (IFN)gamma on glucose stimulated insulin release in the MIN6 beta-cell line and correlated metabolic dysfunction with NO production and rates of apoptosis
Hemi et al., J Biol Chem 2002 (Insulin Resistance...) : Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins
McTernan et al., Diabetes 2002 : Insulin stimulated TNF-alpha secretion in a dose dependent manner ( P < 0.01 ) ; the addition of RSG ( 10 ( -8 ) mol/l ) reduced TNF-alpha secretion ( P < 0.05 )
Maeda et al., Nat Med 2002 (Insulin Resistance) : Our results indicate that adiponectin/ACRP30 deficiency and high TNF-alpha levels in KO mice reduced muscle FATP-1 mRNA and IRS-1 mediated insulin signaling, resulting in severe diet induced insulin resistance
Medina et al., Metabolism 2002 (Diabetes Mellitus, Experimental...) : In nondiabetic rats, TNF-alpha increased plasma insulin ( P =.016 ) and prevented the fasting induced decrease of circulating leptin ( P =.004 ) over the initial 12 hours compared with vehicle
Jiang et al., J Biol Chem 2003 (Insulin Resistance) : This study investigated the effect of salicylic acid on phorbol 12-myristate 13-acetate ( PMA ) - and TNFalpha induced insulin resistance in a human embryonic kidney 293 (HEK293) cell line stably expressing recombinant human IRS1
Wu et al., Diabetes 2003 : Globular adiponectin further enhanced insulin stimulated glucose uptake at submaximal insulin concentrations and reversed the inhibitory effect of tumor necrosis factor-alpha on insulin stimulated glucose uptake
Hara et al., Circ J 2003 (Cardiomyopathy, Dilated...) : The mechanism of the change in insulin function remains unclear, but may be related to improvements in left ventricular function or an attenuation of the inhibitory effect of reduction in TNF-alpha on insulin signaling
de Alvaro et al., J Biol Chem 2004 (Insulin Resistance) : In this study we demonstrate that pretreatment with PD169316 or SB203580, inhibitors of p38 MAPK, restored insulin signaling and normalized insulin induced glucose uptake in the presence of TNF-alpha ... Moreover, TNF-alpha produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 MAPK dependent manner, and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling
Borst et al., Endocrine 2004 (Insulin Resistance) : This review will discuss the regulation of insulin responses by TNF-alpha and evidence supporting the hypothesis that over expression of TNF-alpha plays a role in the pathophysiology of insulin resistance
Franch et al., American journal of physiology. Renal physiology 2004 (Acidosis) : We tested the hypothesis that acidosis or TNF-alpha , a cytokine whose production increases in acidosis, regulates proteolysis by inhibiting insulin signaling through phosphoinositide 3-kinase (PI3K)
Sato et al., Adv Exp Med Biol 2003 (Anorexia...) : Tumor Necrosis Factor (TNF) and/or interleukin-1 (IL-1) stimulate leptin release, but not insulin
Gao et al., Zhonghua Shao Shang Za Zhi 2004 (Burns) : The plasma levels of PGE2, TXB2, TNF-alpha and IL-6 significantly decreased and insulin , rhGH and IGF-1 obviously increased when compared with those in group B
Hernandez et al., Diabetologia 2004 (Insulin Resistance) : Pretreatment with PD98059 or PD169316, which inhibit p42/p44MAPK and p38MAPK respectively, restored insulin signalling and insulin induced glucose uptake in the presence of TNF-alpha
Kim et al., Cancer Res 2004 (MAP Kinase Signaling System) : Moreover, insulin decreased the apoptotic level induced by TNF-alpha , whereas the PI3K inhibitor enhanced it
Harte et al., Circulation 2005 (Obesity) : Insulin increased TNF-alpha secretion in a concentration dependent manner ( P < 0.01 ), whereas RSG ( 10 nmol/L ) significantly reduced the insulin mediated rise in TNF-alpha ( P < 0.001 ), as well as angiotensin and angiotensin II
Sun et al., Zhonghua Nei Ke Za Zhi 2005 (Diabetes Mellitus, Type 2...) : The synergistic effect of TNFalpha and leptin may induce insulin secretion, which in turn leads to insulin resistance
Parkash et al., Anat Rec A Discov Mol Cell Evol Biol 2005 (Calcium Signaling) : We used RINr1046-38 ( RIN ) insulin producing beta-cells, which constitutively express calbindin-D(28k), to characterize the effect of TNF-alpha on apoptosis, replication, insulin release, and gene and protein expression
Rosa et al., Coll Antropol 2005 (Insulin Resistance) : Effects of tumor necrosis factor-alpha on insulin stimulated amino acid transport in cultured rat hepatocytes
Gwozdziewiczová et al., Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005 (Hyperlipidemias...) : Multiple regression analysis demonstrated the important role of TNF-alpha in the regulation of both the insulin resistance and in the secretion of insulin in women
Eringa et al., Arterioscler Thromb Vasc Biol 2006 : Although insulin or TNF-alpha alone did not affect arterial diameter, insulin induced dose dependent vasoconstriction of cremaster resistance arteries in the presence of TNF-alpha, ( -12+/-1 % at 272 microU/mL )
Birkás Kováts et al., Neuropsychopharmacol Hung 2005 (Insulin Resistance...) : Role of ghrelin ( RIA ), resistin and TNF-alpha ( ELISA ) in weight gain and insulin resistance ( fasting plasma insulin, HOMA, ELISA ) was studied in Hungarian psychiatryic patients ( n=60 ) treated with SGA ( clozapine, olanzapine, risperidone, quetiapine, 15 each )
Gonzalez-Gay et al., Clin Exp Rheumatol 2006 (Arthritis, Rheumatoid...) : Since insulin resistance can promote endothelial dysfunction and anti-TNF-alpha blockade yield a rapid improvement of endothelial function, we have sought to assess whether TNF-alpha blockade may also result in a reduction of insulin serum levels and improvement of insulin resistance in RA patients who require this therapy because of severe and refractory disease
Imoto et al., Diabetes 2006 (Carcinoma, Hepatocellular...) : TNF-alpha significantly activated ASK1, increased serine phosphorylation of insulin receptor substrate (IRS)-1 , and decreased insulin stimulated tyrosine phosphorylation of IRS-1 and serine phosphorylation of Akt, and all of these effects were inhibited by overexpression of either UCP-1 or MnSOD ... These results suggest that TNF-alpha increases mitochondrial ROS and activates ASK1 in Huh7 cells and that these TNF-alpha induced phenomena contribute , at least in part, to impaired insulin signaling
Fernández-Veledo et al., Arch Physiol Biochem 2006 (Insulin Resistance) : Ceramide mediates TNF-alpha induced insulin resistance on GLUT4 gene expression in brown adipocytes
Tjokroprawiro et al., Acta Med Indones 2006 (Diabetes Mellitus, Type 2...) : Current evidence suggests a close relationship between activation of PPARgamma and restoration of insulin sensitivity by reductions in TNFalpha and FFAs, and the enhancement of insulin stimulation of PI3-K Pathway and also increase adiponectin & decrease resistin
Ghosh et al., Endocrinology 2007 (Insulin Resistance) : We hypothesized that TNFalpha attenuated insulin signaling by dephosphorylating Akt and its targets via ceramide activated protein phosphatase ... TNFalpha increased serine/threonine phosphatase activity of protein phosphatase 1 (PP1) in response to C6, but not insulin , suggesting a ceramide-specific effect
Lo et al., Horm Metab Res 2007 : Role of tumor suppressor PTEN in tumor necrosis factor alpha induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells
Janjic et al., J Endocrinol 1992 (Diabetes Mellitus, Type 1...) : Whereas TNF and IFN had , respectively, a minor or no effect on insulin production, IL-1 caused a time- and dose dependent decrease in insulin release and lowered the insulin content as well as the preproinsulin mRNA content of INS-1 cells
Ishizuka et al., Endocrinology 2007 (Insulin Resistance) : Chronic TNFalpha may inhibit insulin signaling effectively because it causes both IRS-1 serine phosphorylation and the following SOCS3 induction in 3T3-L1 adipocytes
Sell et al., Horm Metab Res 2007 (Insulin Resistance) : Treatment with GI rapidly induced insulin resistance whereas TNFalpha impaired insulin signaling in a more chronic fashion ( 48-72 h )
Xi et al., Br J Pharmacol 2007 (Insulin Resistance) : Crocetin blocked the impaired insulin stimulated glucose uptake and disordered TNF-alpha and adiponectin expression induced by palmitate in rat adipocytes
Kavanagh et al., Obesity (Silver Spring) 2007 (Diabetes Mellitus, Type 2...) : Postprandial insulin and glucose concentrations, and insulin stimulated serine/threonine protein kinase ( Akt ), insulin receptor activation, and tumor necrosis factor-alpha concentrations in subcutaneous fat and muscle were measured in subsets of animals
Plomgaard et al., Diabetologia 2007 (Diabetes Mellitus, Type 2...) : Clear evidence exists that TNF-alpha inhibits insulin signalling and thereby glucose uptake in myocytes and adipocytes
Guo et al., Biochem Pharmacol 2008 (Insulin Resistance) : Pretreatment of cells with Cy-3-G reduced the intracellular production of reactive oxygen species, the activation of JNK, and attenuated H ( 2 ) O ( 2 ) - or TNF-alpha induced insulin resistance in a dose dependent manner
Qin et al., Am J Physiol Gastrointest Liver Physiol 2008 (Insulin Resistance) : In summary, these data provide direct evidence that TNF-alpha induces whole-body insulin resistance and impairs hepatic insulin signaling accompanied by overproduction of apoB100 containing VLDL particles, an effect likely mediated via TNF receptor 2
Li et al., Crit Care Med 2008 (Reperfusion Injury) : Insulin inhibits tumor necrosis factor-alpha induction in myocardial ischemia/reperfusion : role of Akt and endothelial nitric oxide synthase phosphorylation ... In cultured cardiomyocytes subjected to SI/R, insulin reduced TNF-alpha induction and increased Akt and endothelial nitric oxide synthase (eNOS) phosphorylation and subsequent nitric oxide ( NO ) production ... Our data showed that insulin inhibits ischemia/reperfusion induced TNF-alpha production through the Akt activated and eNOS-NO dependent pathway in cardiomyocytes
Austin et al., Diabetes 2008 (Insulin Resistance) : We determined the role of inhibitor of nuclear factor-kappaB kinase ( IKK)beta in TNF-alpha induced impairments in insulin signaling and glucose metabolism in skeletal muscle
Collino et al., Diabetes 2009 (Body Weight...) : At 24 h of reperfusion, TDZD-8 and insulin significantly reduced plasma levels of tumor necrosis factor-alpha ; neutrophil infiltration, measured as myeloperoxidase activity and intercellular-adhesion-molecule-1 expression ; and cyclooxygenase-2 and inducible-NO-synthase expression
Evans et al., Biochim Biophys Acta 1991 : It is concluded that PAF and TNF-alpha can increase hepatic lipogenesis in vivo in the absence of adrenal hormones and in the presence of a low plasma insulin
Vassiliou et al., Lipids in health and disease 2009 (Diabetes Mellitus, Type 1...) : TNF-alpha inhibited insulin production but pre-treatment with oleic acid reversed this inhibitory effect
Bouzakri et al., J Biol Chem 2009 (Diabetes Mellitus, Type 2) : Silencing mitogen activated protein 4 kinase 4 ( MAP4K4 ) protects beta cells from tumor necrosis factor-alpha induced decrease of IRS-2 and inhibition of glucose stimulated insulin secretion ... While TNF-alpha treatment increased MAP4K4 mRNA expression by 33 +/- 5 %, knockdown of MAP4K4 by siRNA protected beta cells against the detrimental effects of TNF-alpha on both insulin secretion and signaling
Rabinovitch et al., Endocrinology 1990 (Necrosis) : Whereas indomethacin and NDGA did not prevent TNF/IFN-gamma induced inhibition of insulin release, this recovered after cytokine removal from cultures protected by the cyclo/lipoxygenase inhibitors
Rabinovitch et al., J Clin Endocrinol Metab 1990 : Interleukin-1 (IL-1), tumor necrosis factor (TNF) , and interferon-gamma (IFN gamma) inhibit insulin release and may be cytotoxic to isolated rodent pancreatic islets
Jahromi et al., Biomarker insights 2011 : The purpose of this study was to evaluate the role of Tumor Necrosis Factor-a (TNF-a) in insulin resistance (IR) during normal pregnancy
Mackesy et al., Journal of inflammation (London, England) 2011 : Insulin augments tumor necrosis factor-alpha stimulated expression of vascular cell adhesion molecule-1 in vascular endothelial cells
Wu et al., Cytokine 2013 (Inflammation) : Increased glucose and insulin had no effect on base-line activin A secretion by BMNPs in culture, but pre-treatment with insulin blocked the TNF-a induced release of activin A
Rabinovitch et al., Reg Immunol 1989 (Diabetes Mellitus, Type 1) : When tested as single agents or added together at very low concentrations, interleukin 1 (IL-1), tumor necrosis factor (TNF), and interferon gamma (IFN-gamma) inhibited insulin release from rat islet cell monolayer cultures during 4 day incubations ; however, this secretory function improved after the cytokines were removed
Feingold et al., J Clin Invest 1989 (Diabetes Mellitus, Experimental) : Thus, TNF stimulation of hepatic lipogenesis is independent of changes in insulin
Campbell et al., J Immunol 1988 : In combination, IFN-gamma and TNF-alpha each at 200 U/ml caused significant inhibition of glucose stimulated insulin release ; at 2000 U/ml glucose stimulated insulin release was abolished
Satomi et al., J Natl Cancer Inst 1985 (Fibrosarcoma...) : Insulin addition to the culture medium caused inhibition of TNF production from PEC, which indicated that insulin may block TNF production from macrophages
Corbett et al., J Exp Med 1995 : Although TNF+LPS induce iNOS expression and inhibit insulin secretion by intact islets, this combination does not induce the expression of iNOS by beta or alpha cells purified by fluorescence activated cell sorting ( Facs ) ... Evidence suggests that TNF+LPS inhibit insulin secretion from islets by stimulating the release of IL-1 which subsequently induces the expression of iNOS by beta cells ... The IL-1 receptor antagonist protein completely prevents TNF+LPS induced inhibition of insulin secretion and attenuates nitrite formation from islets, and neutralization of IL-1 with antisera specific for IL-1 alpha and IL-1 beta attenuates TNF+LPS induced nitrite formation by islets ... Local release of IL-1 within islets appears to be required for TNF+LPS induced inhibition of insulin secretion because TNF+LPS do not stimulate nitrite formation from islets physically separated into individual cells
Petit et al., Am J Physiol 1995 (Insulin Resistance) : Tumor necrosis factor mediates zymosan induced increase in glucose flux and insulin resistance
Vara et al., Pancreas 1994 : Interleukin-1, tumor necrosis factor , and interleukin-6 inhibit insulin release and may be cytotoxic to isolated pancreatic islets
Pusztai et al., Cytokine 1993 (Breast Neoplasms) : The effect of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and insulin-like growth factor-1 (IGF-1) on the cytostatic activity of tumour necrosis factor-alpha (TNF-alpha) was studied on the breast cancer cell line, T47D
Zhang et al., FEBS Lett 1995 : TNF-alpha inhibits glucose induced insulin secretion in a pancreatic beta-cell line ( INS-1 ) ... The possibility that TNF-alpha might directly reduce glucose stimulated insulin secretion in pancreatic beta-cells was examined by using an established pancreatic beta-cell line ( INS-1 ) ... TNF-alpha did not affect glucose induced acute insulin secretion ( 30 min )
Dunger et al., Diabetes 1996 : Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets ... The aim of this study was to define the effects of tumor necrosis factor-alpha (TNF) and interferon-gamma (IFN) on nitric oxide production, insulin secretion, and DNA damage in islets from unweaned rats
Peraldi et al., J Biol Chem 1996 : Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase ... These data strongly suggest that TNF-alpha inhibits insulin signaling via stimulation of p55 TNFR and sphingomyelinase activity, which results in the production of an inhibitory form of IRS-1
Vara et al., Pancreas 1996 : Tumor necrosis factor ( TNF alpha ) has been shown to inhibit insulin release and it has been postulated to-be an important effector in islet rejection ... Cryopreservation did not significantly modify the hormone response to glucose but it partially reversed the TNF alpha induced inhibitory effect on insulin release in the presence of 20 mM glucose
Atlan-Gepner et al., Diabetes Care 1996 (Atrophy...) : The production of TNF-alpha and IL-6 by the macrophages of the patient in presence of insulin were dramatically increased in comparison with control subjects
de-Mello et al., Biochem Pharmacol 1996 (Insulinoma...) : However, ebselen failed to prevent the increase in nitrite production and the decrease in glucose oxidation and insulin release by rat islets exposed to IL-1 beta for 24 hr. Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines ( IL-1 beta, tumor necrosis factor-alpha and interferon-gamma )
Kellerer et al., Horm Metab Res 1996 (Body Weight...) : TNF-alpha and leptin, which are overproduced in fat tissue of obese insulin resistant animal models and in obese humans, might mediate such an inhibitory effect on insulin signalling in skeletal muscle
Zhou et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1996 : ( 3 ) Insulin released from cultured islet cells was enhanced by IFN-r and TNF-alpha either alone or combined at different concentrations
Leeper-Woodford et al., Am J Physiol 1997 : In the conditioned medium, glucose decreased ( P < 0.05 ), insulin increased ( P < 0.05 ), and exposure to LPS did not alter these levels [ P = not significant ( NS ) ] but did increase TNF activity by 400 % ( P < 0.05 )
Peraldi et al., J Clin Invest 1997 : Thiazolidinediones block tumor necrosis factor-alpha induced inhibition of insulin signaling
Paz et al., J Biol Chem 1997 (Insulin Resistance) : Tumor necrosis factor alpha (TNFalpha) or chronic hyperinsulinemia that induce insulin resistance trigger increased Ser/Thr phosphorylation of the insulin receptor (IR) and of its major insulin receptor substrates, IRS-1 and IRS-2
Kellerer et al., FEBS Lett 1997 : Now we have investigated whether a distinct PKC isoform might be involved in the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells
Wang et al., Diabetes 1998 : Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes
Arnush et al., J Immunol 1998 (Diabetes Mellitus, Type 1) : Resident macrophages appear to be the source of IL-1, as a 7-day culture of rat islets at 24 degrees C ( conditions known to deplete islets of lymphoid cells ) prevents TNF + LPS induced iNOS expression, nitrite production, and the inhibitory effects on insulin secretion
Liu et al., Diabetes 1998 : Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes : implication of the p80 tumor necrosis factor receptor
Spicer et al., Endocrine 1998 : Moreover, TNF-alpha significantly attenuated insulin- and LH-induced androstenedione production by thecal cells from large follicles ... Thus, it appears that TNF-alpha inhibits insulin- and IGF-I induced estradiol production by granulosa cells and androstenedione production by thecal cells via TNF-alpha binding to its own receptor
Park et al., Arch Biochem Biophys 1999 : IL-1beta and TNF-alpha inhibited insulin release and glucose utilization and oxidation