Gene interactions and pathways from curated databases and text-mining

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IL12A — JAK2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sudarshan et al., J Immunol 1999 : We examined this and found that TGF-beta1 did not have any effect on IL-12 induced phosphorylation of JAK2 , TYK2, and STAT4 although TGF-beta1 inhibited IL-2- and IL-12 induced IFN-gamma production
Bright et al., J Immunol 1999 (Encephalomyelitis, Autoimmune, Experimental) : Tyrphostin B42 inhibits IL-12 induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis ... Treatment of activated T cells with tyrphostin B42 inhibited the IL-12 induced tyrosine phosphorylation and activation of Jak-2 without affecting Tyk-2 kinase
Franchimont et al., J Immunol 2000 : This occurred even though the level of expression of IL-12 receptors and IL-12 induced Janus kinase phosphorylation remained unaltered
Natarajan et al., J Immunol 2002 (Demyelinating Diseases...) : In vitro treatment of activated T cells with curcumin inhibited IL-12 induced tyrosine phosphorylation of Janus kinase 2 , tyrosine kinase 2, and STAT3 and STAT4 transcription factors
Sugimoto et al., Eur J Immunol 2003 : IL-12 activates TYK2 and Janus kinase (JAK)-2 to induce the phosphorylation of various signal transducers and activators of transcription ( STAT ) proteins
Muthian et al., J Clin Immunol 2004 (Disease Models, Animal...) : In vitro treatment of activated T cells with quercetin blocks IL-12 induced tyrosine phosphorylation of JAK2 , TYK2, STAT3, and STAT4, resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation
Yu et al., J Immunol 2005 : Interestingly, IL-12 induced activation of Jak2 and STAT4, critical components for IL-12 mediated cellular responses, was shortened or attenuated in mutant T cells
Walker et al., Arch Virol Suppl 2005 (Ehrlichiosis) : Ehrlichiae attach to L-selectin and E-selectin, inhibit phagolysosomal fusion, apoptosis, and JAK/STAT activation, and downregulate IL-12 , IL-15, IL-18, TLR2 and 3, and CD14
Muthian et al., J Neurosci Res 2006 (Disease Models, Animal...) : Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the IL-12 induced tyrosine phosphorylation of JAK2 , TYK2, STAT3, and STAT4 in association with a decrease in T cell proliferation in vitro
Shaw et al., J Immunol 2006 (Genetic Predisposition to Disease...) : The Jak , Tyk2, is activated in response to IL-12 and IFN-alphabeta and promotes IFN-gamma production by Th1-type CD4 cells
Yu et al., Biochem Pharmacol 2008 : Like quercetin inhibits macrophage induced cytokine production, it also blocks IL-12 dependent JAK-STAT signaling in Th cells
Wang et al., Blood 2008 (MAP Kinase Signaling System) : IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was mediated by Janus kinase-signal transducers and activators of transcription ( JAK-STAT ) -dependent signaling without induction of calcium flux
Conzelmann et al., Biochem Pharmacol 2010 : JAK2 mediated enhancing effects on IL-12p70 but did not inhibit IL-10 release, whereas Tyk2 mediated inhibitory effects on IL-12p70 release in this system ... The mechanism by which complementary IFN-?/JAK activities affect IL-12p70 production involves STAT1 activation and de novo induction of interferon-responsive factors (IRF)-1 and IRF-8
Bacon et al., J Exp Med 1995 : Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2 : differential use of Janus family tyrosine kinases by IL-2 and IL-12 ... IL-12 , but not IL-2, stimulates the tyrosine phosphorylation of TYK2 and JAK2 , whereas JAK1 and JAK3, which are phosphorylated in response to IL-2, are not phosphorylated after IL-12 treatment
Yu et al., J Immunol 1996 : Finally, IL-2 induced tyrosine phosphorylation of JAK1 and JAK3, while IL-12 induced phosphorylation of JAK2 and TYK2 in both preactivated primary NK and NK3.3 cells
Gollob et al., Eur J Immunol 1997 : One feature of Th2 differentiation in mice is the loss of IL-12 induced Jak2 and Stat4 activation, which is accompanied by the inability to produce IFN-gamma in response to IL-12
Bright et al., J Immunol 1998 : TGF-beta inhibits IL-12 induced activation of Jak-STAT pathway in T lymphocytes
Ahn et al., J Immunol 1998 : 2D6 ( IL-12 ) and 2D6 ( IL-2 ) similarly proliferating in response to IL-12 induced comparable levels of JAK2 activation and STAT5 phosphorylation