Gene interactions and pathways from curated databases and text-mining

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FOS — JUN

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hidalgo-Estévez et al., J Gen Virol 2006 : Constitutive or transient Tat expression in Jurkat T cells enhanced cooperative NFAT/AP-1- but not AP-1 dependent transcription independent of its ability to transactivate the HIV-1 LTR
Lee et al., Life Sci 2003 : The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells : involvement of AP-1 and NFkappaB ... The roles of AP-1 and NFkappaB in the regulation of inducible nitric oxide synthase (iNOS) mRNA expression induced by the combination of lipopolysaccharide and tumor necrosis factor-alpha ( LT ) in C6 cells were examined in the present study
Conejo et al., J Cell Physiol 2001 : Furthermore, insulin induced nuclear factor-kappaB (NF-kappaB) DNA binding activity and down-regulated activating protein-1 (AP-1) DNA binding activity throughout the differentiation process
Rahman et al., J Biol Chem 1999 : Gel shift and supershift analysis showed that TNF-alpha increased AP-1 DNA binding which was predominantly formed by dimers of c-Jun
Konstantinopoulos et al., Int J Colorectal Dis 2007 (Adenocarcinoma...) : Down-regulation of PPAR gamma and induction of the CBP transcriptional coactivator can augment NF-kappaB and AP-1 transcriptional activities leading to up-regulation of COX-2 expression in colon adenocarcinoma cells
Dhar et al., Oncogene 2004 (Cell Transformation, Neoplastic...) : Previous studies have established that expression of a dominant negative c-Jun ( TAM67 ) inhibits phorbol 12-tetradecanoyl-13-acetate ( TPA ) -induced AP-1 transactivation as well as transformation in mouse epidermal JB6/P+ cells and tumor promotion in mouse skin carcinogenesis ... We show that TPA induction of the architectural transcription factor HMGA1 is inhibited by TAM67, is extracellular-signal regulated kinase ( ERK ) -activation dependent, and is mediated by AP-1
Yao et al., Mol Carcinog 2006 (Urinary Bladder Neoplasms) : Unexpectedly, neither TAM67 or JNK inhibition, nor forced c-jun expression had a significant impact on cyclin D1 induction by PEITC, indicating that c-jun/AP-1 does not play an important role in cyclin D1 induction by PEITC
Haim et al., Neoplasia (New York, N.Y.) 2011 (Breast Neoplasms) : In parallel, in the joint stimulation, EGF acted independently at the transcription level through AP-1 , to upregulate CXCL8 expression
Wu et al., Mol Cell Biol 2007 : Fibroblast growth factor 2 (FGF-2) and cortisol induced AP-1 and GR occupancy, respectively, at a Notch4 promoter composite response element consisting of an imperfect half-glucocorticoid response element and an AP-1 motif, which mediated signal dependent activation
Pierce et al., J Clin Invest 1996 : These data indicate that, in contrast to most LPS effects, AP-1 , but not nuclear factor-kappaB, mediates LPS induction of collagenase transcription in macrophagelike cells
Zhang et al., J Biol Chem 1991 : We show here that the alpha-fetoprotein gene (AFP) promoter can be regulated by AP-1 activity using transient transfection assays
Bergelson et al., Oncogene 1994 (Carcinoma, Embryonal...) : Induction of AP-1 ( Fos/Jun ) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression
Berger et al., Proc Natl Acad Sci U S A 1995 (Niemann-Pick Diseases) : Here we show that SPC increased specific DNA binding activity of transcription activator AP-1 in electrophoretic mobility-shift assays ... Since the increase in AP-1 binding activity preceded the increase in c-fos mRNA, posttranslational modifications may be important in mediating the early SPC induced increases in AP-1 DNA binding activity ... Since the expression of many proteins with diverse functions is known to be regulated by AP-1, SPC induced activation of AP-1 may contribute to the pathophysiology of Niemann-Pick disease
Kim et al., Eur J Immunol 2005 (Bacteroides Infections...) : BFT stimulation also activated AP-1 signals composed of c-Jun/c-Fos heterodimers ... The p38 inhibitor SB203580 and the ERK inhibitor U0126 reduced not only AP-1 activity, but also decreased IL-8 and MCP-1 expression
Zhang et al., Int J Cancer 2009 (Prostatic Neoplasms) : We show that inhibition of NF-kappaB or activation of AP-1 can only partially sensitize resistant prostate cancer cells to proapoptotic effects of TNFalpha or TRAIL ... However, concomitant repression of NF-kappaB and activation of c-Fos/AP-1 significantly enhanced the proapoptotic effects of TNFalpha and TRAIL in resistant prostate cancer cells
Kim et al., Circulation 1998 : In vitro studies show that extracellular signal regulated kinases ( ERKs ) and c-Jun NH2-terminal kinases (JNKs) , belonging to the mitogen activated protein kinase ( MAPK ) family, play a critical role in the activation of transcription factor activator protein-1 (AP-1) and cell proliferation or apoptosis ... JNK and ERK activations were followed by a 3.9-fold increase in arterial AP-1 DNA binding activity, which contained c-Jun and c-Fos proteins
Gertzberg et al., Am J Respir Cell Mol Biol 2000 : We tested the hypothesis that protein kinase ( PK ) G activation in response to nitric oxide ( ( * ) NO ) mediates tumor necrosis factor (TNF)-alpha induced activation of the transcription factor activating protein-1 (AP-1) in pulmonary microvessel endothelial monolayers ( PEM ) ... TNF treatment ( 1,000 U/ml ) for 4 h induced a significant increase in DNA binding of AP-1 ... SOD prevented SIN-1 induced AP-1 activation, a response similar to that of the SOD + TNF Group
Gao et al., Biochem Biophys Res Commun 2008 : These data consistently suggest that SIRT1 directly inhibits the transcriptional activity of AP-1 by targeting c-JUN ... These data consistently suggest that SIRT1 directly inhibits the transcriptional activity of AP-1 by targeting c-JUN
Böhm et al., Exp Dermatol 2004 : Functional studies have shown that alpha-MSH exerts anti-inflammatory actions in human fibroblastic skin cells by suppressing interleukin-1 (IL-1) induced IL-8 production, activation of the transcription factor activator protein-1 (AP-1) and induction of intercellular adhesion molecule-1 by interferon-alpha ... Functional studies have shown that alpha-MSH exerts anti-inflammatory actions in human fibroblastic skin cells by suppressing interleukin-1 (IL-1) induced IL-8 production, activation of the transcription factor activator protein-1 (AP-1) and induction of intercellular adhesion molecule-1 by interferon-alpha ... Functional studies have shown that alpha-MSH exerts anti-inflammatory actions in human fibroblastic skin cells by suppressing interleukin-1 (IL-1) induced IL-8 production, activation of the transcription factor activator protein-1 (AP-1) and induction of intercellular adhesion molecule-1 by interferon-alpha ... Functional studies have shown that alpha-MSH exerts anti-inflammatory actions in human fibroblastic skin cells by suppressing interleukin-1 (IL-1) induced IL-8 production, activation of the transcription factor activator protein-1 (AP-1) and induction of intercellular adhesion molecule-1 by interferon-alpha
Biswas et al., Phytochemistry 1996 : The activity of AP-I was not affected by 1 mM Mg2+ , Mn2+, Ca2+, Co2+ or Pb2+, but severely inhibited by 1 mM Cu2+, Fe3+, Hg2+, Mo6+ or Zn2+ ... The activity of AP-I was not affected by 1 mM Mg2+, Mn2+, Ca2+ , Co2+ or Pb2+, but severely inhibited by 1 mM Cu2+, Fe3+, Hg2+, Mo6+ or Zn2+
Ahn et al., Gene Ther 2004 (Diabetic Nephropathies) : This investigation was undertaken to test the hypothesis that AP-1 plays an important role in ECM gene expression, and to develop a molecular therapeutic strategy based on decoy oligodeoxynucleotides ( ODN )
Chen et al., J Biol Chem 1998 : Taken together, these data demonstrate that nucleotides, especially UTP, can potentiate the LPS induced activation of NF-kappaB and AP-1 and of iNOS induction via a CaMK -dependent pathway and suggest that the UTP dependent up-regulation of iNOS may constitute a novel element in the inflammatory process
Iacobelli et al., J Immunol 1999 : Similarly, IL-2 neither activates JNK nor increases AP-1 binding activity to a consensus o-tetradecanoylphorbol 13-acetate ( TPA ) response element
Zhou et al., Zhonghua Yi Xue Za Zhi 2002 : To clarify whether the activating protein-1 (AP-1) is involved in the transcriptional regulation of expression of oxidized low density lipoprotein ( Ox-LDL ) induced transforming growth factor (TGF)-beta(1) gene and further to investigate the possible signal transduction pathway in the cultured mesangial cells ( MsCs ) ... Pre-treatment with the different specific kinase inhibitors, the activities of AP-1 induced by Ox-LDL were determined by electrophoretic mobility shift assay ( EMSA ) ... The inhibitor of PKC remarkably reduced the activity of AP-1 induced by Ox-LDL
Sun et al., Biochem Biophys Res Commun 2008 : We find that TNF induced oscillations in p65 and p50 recruitment to the CD38 promoter correlated with recruitment of MAPK induced AP-1 recruitment, as analyzed by quantitative ChIP analysis
Mendes et al., Nitric Oxide 2002 : Finally, the p42/44MAPK inhibitor, PD 98059, prevented IL-1 induced AP-1 activation in a concentration that did not inhibit iNOS expression ... Finally, the p42/44MAPK inhibitor, PD 98059, prevented IL-1 induced AP-1 activation in a concentration that did not inhibit iNOS expression ... Finally, the p42/44MAPK inhibitor, PD 98059, prevented IL-1 induced AP-1 activation in a concentration that did not inhibit iNOS expression ... Finally, the p42/44MAPK inhibitor, PD 98059, prevented IL-1 induced AP-1 activation in a concentration that did not inhibit iNOS expression ... In conclusion, this study shows that ( 1 ) PTK are part of the signaling pathway that leads to IL-1 induced NF-kappaB activation and iNOS expression ; ( 2 ) the p38MAPK cascade is required for IL-1 induced iNOS expression ; ( 3 ) the p42/44MAPK and AP-1 are not involved in IL-1 induced iNOS expression ; and ( 4 ) NF-kappaB and the p38MAPK lie on two distinct pathways that seem to be independently required for IL-1 induced iNOS expression
Lee et al., J Biochem Mol Biol 2002 : TAK1 dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB ... TAK1 dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB
Pfeuffer et al., J Immunol 1994 : By contrast, both classes of factors bind simultaneously to the IL-2 promoter, and their tight association with AP-1 enhances the IL-2 promoter activity
Zhang et al., J Ethnopharmacol 2012 : The differences between IL-1RI expression after treatment for 10 and 60 min were significantly higher than the corresponding values in the control ( P < 0.01, P < 0.01, respectively ) ; After pretreatment with YiGanKang Decoction, IL-1RI expression induced by IL-1ß was not decrease obviously ; IL-1ß could activate AP-1 in rat HSCs ( P < 0.01 ) ... Meanwhile YiGanKang Decoction could inhibit activity of AP-1 induced by IL-1ß ( P < 0.01 ), and the inhibition rate was 42.71 % ... YiGanKang Decoction could not decrease IL-1RI expression, but it could inhibit activity of AP-1 in rat HSCs induced by IL-1ß
Thompson et al., J Biol Chem 2008 (Inflammation) : LTC ( 4 ) stimulation induced NF-kappaB and AP-1 DNA binding, which involved the formation of a p50/p65 and a c-JUN.c-FOS complex, respectively ... LTC ( 4 ) stimulation induced NF-kappaB and AP-1 DNA binding, which involved the formation of a p50/p65 and a c-JUN.c-FOS complex, respectively
Deng et al., World J Gastroenterol 2008 (Stomach Neoplasms) : The over-expression of RASSF1A significantly inhibited AP-1 activity in SGC7901 cells ( 0.981+/-0.011 vs 0.354+/-0.053, P < 0.001 )
Chang et al., Mol Pharmacol 2001 : Furthermore, the PMA induced extracellular signal regulated kinase 1/2 and c-Jun amino-terminal kinase activities that contributed to AP-1 activity and MCP-1 gene induction were obviously attenuated after pretreating ECs with Wog
Oukka et al., J Exp Med 2004 : KRC physically associates with the c-Jun transcription factor and serves as a coactivator to augment AP-1 dependent IL-2 gene transcription
Jana et al., Free Radic Biol Med 2005 : All three cytokines alone induced the activation of AP-1 while IL-1beta and TNF-alpha but not IFN-gamma induced the activation of NF-kappaB ... All three cytokines alone induced the activation of AP-1 while IL-1beta and TNF-alpha but not IFN-gamma induced the activation of NF-kappaB ... Although IL-1beta and IFN-gamma alone induced the activation of AP-1 , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1 ... Although IL-1beta and IFN-gamma alone induced the activation of AP-1 , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1 ... Consistently, JNK-I, a specific inhibitor of JNK, inhibited IL-1beta mediated activation of AP-1 and expression of iNOS
Jung et al., Exp Cell Res 2003 (Cell Transformation, Neoplastic...) : DNA binding activity of AP-1 , downstream of ERK1/2, was also inhibited by catalase , N-acetyl-L-cysteine, and the MEK inhibitor PD98059, which significantly blocked arsenite activation of ERK1/2
Quan et al., Am J Pathol 2006 : Furthermore, elevated CYR61 induced transcription factor activator protein-1 (AP-1) , which functions to stimulate MMP-1 expression
Bliziotes et al., J Musculoskelet Neuronal Interact 2002 : 5-HT potentiates the PTH induced increase in AP-1 activity in UMR 106-H5 cells
Schaefer et al., J Biol Chem 2005 : In conclusion, this study demonstrates an important role of AP-1 and a member of the Ets family in the transcriptional regulation of C3aR expression, a prerequisite for the ability of C3a to participate in immunomodulation and inflammation
Guo et al., Inflammation 2000 : IRAK-2 and PI 3-kinase synergistically activate NF-kappaB and AP-1 ... IRAK-2 and PI 3-kinase synergistically activate NF-kappaB and AP-1 ... As a result, antisense IRAK-2 ODN or antisense p110 PI 3-kinase ODN inhibited IL-1 induced NF-kappaB and AP-1 activation in HepG2 cells ... As a result, antisense IRAK-2 ODN or antisense p110 PI 3-kinase ODN inhibited IL-1 induced NF-kappaB and AP-1 activation in HepG2 cells ... The inhibition of NF-kappaB activation by antisense IRAK-2 ODN or antisense p110 PI 3-kinase ODN and the inhibition of AP-1 activation by antisense IRAK-2 ODN were incomplete, whereas AP-1 activation could be inhibited by antisense p110 PI 3-kinase ODN completely ... These results indicate that IRAK-2 is necessary but insufficient to activate NF-kappaB and AP-1 completely and that although PI 3-kinase is not sufficient for NF-kappaB full activation, it is sufficient to activate AP-1 completely ... The effects of IRAK-2 or PI 3-kinase on NF-kappaB and AP-1 activation were confirmed by the results that overexpression of IRAK-2 failed to fully activate NF-kappaB and AP-1 and that overexpression of p110 PI 3-kinase is insufficient for NF-kappaB full activation but sufficient for AP-1 activation ... The effects of IRAK-2 or PI 3-kinase on NF-kappaB and AP-1 activation were confirmed by the results that overexpression of IRAK-2 failed to fully activate NF-kappaB and AP-1 and that overexpression of p110 PI 3-kinase is insufficient for NF-kappaB full activation but sufficient for AP-1 activation ... Cotransfection experiments showed that the combination of antisense IRAK-2 ODN and antisense p110 PI 3-kinase ODN resulted in additive inhibition of NF-kappaB as well as AP-1 activation ... On the other hand, coexpression of IRAK-2 with p110 PI 3-kinase led to a synergistic activation of NF-kappaB and AP-1
Mi et al., Carcinogenesis 2006 (Mammary Neoplasms, Animal...) : Our results indicate that binding of an RGD bearing ligand, such as OPN, to integrin receptors in metastatic 4T1 cells transcriptionally mediates MMP-2, uPA and OPN expression through ILK dependent AP-1 activity and significantly increases in vitro functional correlates of metastasis
Xu et al., Toxicol Lett 2008 : Collectively, these data favor the notion that alpha-ZAL antagonizes oxLDL induced upregulation of ET-1 gene expression and secretion via suppression of oxLDL induced ROS accumulation, ERK phosphorylation, and activation of the endothelial transcriptional factor AP-1
Jang et al., Inflamm Res 2013 (Helicobacter Infections) : The RK-I-123 suppressed the H. pylori induced IL-8 expression and activation of MAPKs, NF-?B, and AP-1 by reducing ROS levels in AGS cells
Tripathi et al., Mol Cell Biochem 2012 (MAP Kinase Signaling System...) : Gel shift assays demonstrated that ANP inhibited VEGF stimulated AP-1 and CREB DNA binding ability by 67 and 62 %, respectively ... The addition of the protein kinase G ( PKG ) inhibitor, KT-5823, restored the VEGF stimulated activation of MAPKs, AP-1 , and CREB, demonstrating the integral role of cGMP/PKG signaling in NPRA mediated effects
Gnanabakthan et al., Birth Defects Res A Clin Mol Teratol 2009 : The exposure of mouse embryos to 5-bromo-2'-deoxyuridine ( BrdU ), a model teratogen, generates oxidative stress, induces c-Fos dependent activator protein-1 (AP-1) DNA binding activity, and causes skeletal malformations ( Sahambi and Hales, 2006 )
Weng et al., J Biomed Sci 2009 (Liver Cirrhosis, Biliary...) : In vitro, Arm ( 1-10 microM ) concentration-dependently attenuated TNF-alpha- and LPS stimulated alpha-SMA protein expression and AP-1 activation by HSC-T6 cells without adverse cytotoxicity
Li et al., Zhonghua Gan Zang Bing Za Zhi 2005 : EMSA showed that stimulation of HSC by Aldo markedly increased AP-1 DNA binding activity ... Stimulation of HSC by Aldo results in activation of AP-1 via ERK1/2 pathway, leading to up-regulation of AP-1 target gene alpha1 ( 1 ) procollagen mRNA expression
Venza et al., Invest Ophthalmol Vis Sci 2007 : Transcriptional regulation of IL-8 by Staphylococcus aureus in human conjunctival cells involves activation of AP-1
Watabe et al., Oncogene 1998 (Leukemia) : Both curcumin ( 1,7-bis [ 4-hydroxy-3-methoxy-phenyl ] -1,6-heptadiene-3,5-dione ), an inhibitor of the biosynthesis of AP-1, and the expression of dominant negative c-Jun inhibited the activation of AP-1 and the induction of apoptosis by bufalin
Lendemans et al., J Endotoxin Res 2006 : LPS induced AP-1 binding to DNA was also enhanced in GM-CSF-pre incubated cells ... In contrast, the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of TNF-alpha release and activation of both NF-kappaB and AP-1 ... In contrast, the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of TNF-alpha release and activation of both NF-kappaB and AP-1 ... It is concluded that a tyrosine kinase of the GM-CSF triggered ERK1/2 pathway augments the LPS induced NF-kappaB and AP-1 activation
Kumar et al., J Immunol 1998 : Overall our results demonstrate that HIV-tat activates JNK and AP-1 , which may contribute to the pathogenesis of AIDS
Okuma et al., Jpn J Pharmacol 2001 : The findings suggest that M1 muscarinic receptors are involved in muscarinic receptor mediated enhancement of IL-2 production in Jurkat cells and that the transcription factor AP-1 and pathways via mitogen activated protein kinase ( MAPK ) /extracellular signal regulated protein kinase and c-Jun N-terminal kinase, but not via p38 MAPK, may be involved in the muscarinic receptor mediated enhancement of IL-2 production
Li et al., Cell Mol Life Sci 1999 (Ovarian Neoplasms) : Phorbol ester exposure activates an AP-1 mediated increase in ERCC-1 messenger RNA expression in human ovarian tumor cells ... These data suggest that AP-1 may contribute to the upregulation of ERCC-1 in response to TPA in human ovarian cancer cells
Lake et al., Biomaterials 2013 : Results from transfection of CAT/a5-promoter plasmids, Western blot and EMSA analyses indicated that ECM/35d significantly increase expression of a5 in HCECs as a result of alteration in the expression and DNA binding of the transcription factors NFI, Sp1, AP-1 and PAX6
Anouar et al., Mol Pharmacol 1999 (Second Messenger Systems) : The involvement of activator protein-1(AP-1) and cAMP response element binding protein ( CREB ) in serine/threonine protein kinase activation of GAL gene transcription was assessed
Gober et al., J Neurovirol 2005 (Herpes Genitalis) : Up-regulation correlated with activator protein (AP)-1 activation , notably c-Jun and c-Fos that bind cognate elements in the ICP10 promoter ... Up-regulation correlated with activator protein (AP)-1 activation , notably c-Jun and c-Fos that bind cognate elements in the ICP10 promoter
Asschert et al., Int J Cancer 1999 (Ovarian Neoplasms) : TNF-alpha stimulation enhanced AP-1 and induced NF-KB but no NF-IL6 DNA binding in these cells
Schenk et al., Proc Natl Acad Sci U S A 1994 : A similar increase of AP-1 activity was also observed with other, structurally unrelated antioxidants such as pyrrolidine dithiocarbamate and butylated hydroxyanisole, indicating that the thioredoxin induced increase of AP-1 activation was indeed based on an antioxidant effect ... These results suggest that thioredoxin plays an important role in the regulation of transcriptional processes and oppositely affects NF-kappa B and AP-1 activation
Peng et al., Diabetes 2008 (Diabetes Mellitus, Experimental...) : Activity of the transcription factor AP-1 , increased in diabetic MCs and kidneys, is important in the profibrotic effects of glucose, and this was dependent on Rho-kinase signaling
Dai et al., Biochem Biophys Res Commun 2010 (Myocarditis) : Myofibrillogenesis regulator-1(MR-1) can aggravate cardiac hypertrophy induced by angiotensin(Ang) II in mice through activation of NF-kappaB signaling pathway, and nuclear transcription factor (NF)-kappaB and activator protein-1(AP-1) regulate inflammatory and immune responses by increasing the expression of specific inflammatory genes in various tissues including heart
Jeon et al., Toxicol Lett 1999 : Treatment of AAF to RAW 264.7 cells induced a dose related inhibition of NF-kappa B/Rel in chloramphenicol acetyltransferase activity, while either AP-1 or NF-IL6 activation was not affected by AAF ... Treatment of AAF to RAW 264.7 cells induced a dose related inhibition of NF-kappa B/Rel in chloramphenicol acetyltransferase activity, while either AP-1 or NF-IL6 activation was not affected by AAF
Fang et al., Anat Rec (Hoboken) 2012 (Carcinoma, Hepatocellular...) : Our results demonstrated that mda-7/IL-24 could restore the drug sensitivity through the downregulation of MDR1, MRP1, and LRP expression, as well as the transcriptional activation of AP-1 and NF-?B and effectively reverse MDR ... Our results demonstrated that mda-7/IL-24 could restore the drug sensitivity through the downregulation of MDR1 , MRP1, and LRP expression, as well as the transcriptional activation of AP-1 and NF-?B and effectively reverse MDR ... Our results demonstrated that mda-7/IL-24 could restore the drug sensitivity through the downregulation of MDR1, MRP1 , and LRP expression, as well as the transcriptional activation of AP-1 and NF-?B and effectively reverse MDR ... Our results demonstrated that mda-7/IL-24 could restore the drug sensitivity through the downregulation of MDR1, MRP1 , and LRP expression, as well as the transcriptional activation of AP-1 and NF-?B and effectively reverse MDR
Chen et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Transcription factor ELISA and chromatin immunoprecipitation assays further showed that HG-MCM increases the NF-?B- and AP-1 DNA binding activities in ECs
Guo et al., Am J Transplant 2004 (Liver Diseases...) : Interestingly, Ref-1 significantly increased DNA binding of Stat3, but not AP-1
Wenk et al., J Biol Chem 1999 : Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1 mediated induction of matrix degrading metalloprotease-1 ... Collectively, we have found that enhanced Mn-SOD activity, via an unbalanced H ( 2 ) O ( 2 ) overproduction and detoxification, induces MMP-1 mRNA levels, and this effect is at least partly mediated by the DNA recognition sequence AP-1 ... Collectively, we have found that enhanced Mn-SOD activity, via an unbalanced H ( 2 ) O ( 2 ) overproduction and detoxification, induces MMP-1 mRNA levels, and this effect is at least partly mediated by the DNA recognition sequence AP-1
Fahmi et al., Arthritis Rheum 2001 : Similarly, in a PPARgamma dependent manner, 15d-PGJ2 inhibited deltaMEKK-1 induced AP-1- and NF-kappaB-luciferase reporter plasmid activation
Palcy et al., J Bone Miner Res 2000 : Protein kinase C ( PKC ) - and protein tyrosine kinase ( PTK ) -dependent pathways have been implicated in both TGF-beta1 signaling and AP-1 gene regulation
Gruber et al., Exp Cell Res 1995 (Melanoma) : These results suggest a hypothesis whereby RA-induced nuclear PKC alpha might lead to increased AP-1 activity and show that RA-induced growth inhibition and differentiation are not always accompanied by an inhibition of AP-1 activity as has been proposed by other investigators
Wei et al., J Biochem 2005 : Expression of adipose differentiation related protein ( ADRP ) is conjointly regulated by PU.1 and AP-1 in macrophages
Kosco et al., Mol Immunol 2008 : In contrast, moderate overexpression of SKAP55 increased TCR dependent AP-1 transcriptional activity, suggesting that high-level SKAP55 overexpression interfered with the assembly of functional signaling complexes required for TCR coupling to the Ras pathway
Sasaki et al., Am J Physiol Regul Integr Comp Physiol 2005 (Dehydration...) : Both hepatic and splenic AP-1 expressions were enhanced by LPS
Merry et al., J Heart Lung Transplant 2010 (Lung Injury...) : Lungs were assessed for vascular permeability, myeloperoxidase content, bronchoalveolar lavage inflammatory cell and cytokine/chemokine content, as well as nuclear translocation of nuclear factor kappaB (NFkappaB) and activator protein-1 (AP-1) , and interleukin-1 receptor associated kinase-1 ( IRAK-1 ) and stress activated protein kinase ( SAPK ) activation
Wu et al., J Biol Chem 2003 : DACH1 repressed TGF-beta induction of AP-1 and Smad signaling in gene reporter assays and repressed endogenous TGF-beta-responsive genes by microarray analyses ... NCoR enhanced DACH1 repression, and the repression of TGF-beta induced AP-1 or Smad signaling by DACH1 required the DACH1 DS domain ... NCoR enhanced DACH1 repression, and the repression of TGF-beta induced AP-1 or Smad signaling by DACH1 required the DACH1 DS domain
Cho et al., Carcinogenesis 2007 (MAP Kinase Signaling System) : Furthermore, as evidenced by MMP-9 promoter and electrophoretic mobility shift assays, ascofuranone specifically inhibited MMP-9 gene expression by blocking PMA stimulated activation of activator protein-1 (AP-1)
Quentmeier et al., Leuk Res 1994 : Alternatively, these data support the notion that neither AP-1 nor the c-myc protein are involved in the MDHM induced increase in IL-1 beta , IL-6 or TNF alpha mRNA levels ... Alternatively, these data support the notion that neither AP-1 nor the c-myc protein are involved in the MDHM induced increase in IL-1 beta, IL-6 or TNF alpha mRNA levels
Fan et al., Cancer Res 2001 : KB3-TAM67 cell lines displayed normal growth kinetics and essentially unaltered basal AP-1 activity, but vinblastine induced phosphorylation of c-Jun and activating transcription factor-2 , and AP-1 activation, were strongly inhibited ... KB3-TAM67 cell lines displayed normal growth kinetics and essentially unaltered basal AP-1 activity, but vinblastine induced phosphorylation of c-Jun and activating transcription factor-2, and AP-1 activation, were strongly inhibited ... KB3-TAM67 cell lines displayed normal growth kinetics and essentially unaltered basal AP-1 activity, but vinblastine induced phosphorylation of c-Jun and activating transcription factor-2 , and AP-1 activation, were strongly inhibited
Kasid et al., Mol Cell Biochem 1997 (Carcinoma, Squamous Cell) : HVH1/CL100 , a dual specificity protein phosphatase, may attenuate the AP-1 response by dephosphorylating a key upstream element, mitogen activated protein kinase ( MAPK )
Redhu et al., Am J Physiol Lung Cell Mol Physiol 2011 : Essential role of NF-?B and AP-1 transcription factors in TNF-a induced TSLP expression in human airway smooth muscle cells
Hou et al., Arch Biochem Biophys 2007 : The results demonstrated that PDGG suppressed COX-2 expression via blocking MAPK mediated activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta
Koutsioumpa et al., Eur J Pharmacol 2009 : Aprotinin inhibits pleiotrophin proteolysis and induces expression and secretion of pleiotrophin through an AP-1 dependent transcriptional activation of the pleiotrophin gene, and pleiotrophin seems to mediate the stimulatory effects of aprotinin on cell migration through its receptor protein tyrosine phosphatase beta/zeta
Valente et al., J Mol Cell Cardiol 2012 (Cardiomegaly...) : Since Ang-II is a potent activator of NF-?B and AP-1 , we investigated whether CIKS is critical in Ang-II mediated cardiac hypertrophy ... Here we report that Ang-II induced CIKS mRNA and protein expression, CIKS binding to IKK and JNK perhaps functioning as a scaffold protein, CIKS dependent IKK/NF-?B and JNK/AP-1 activation, p65 and c-Jun phosphorylation and nuclear translocation, NF-?B- and AP-1 dependent IL-18 and MMP-9 induction, and hypertrophy of adult cardiomyocytes isolated from WT, but not CIKS-null mice ... Here we report that Ang-II induced CIKS mRNA and protein expression, CIKS binding to IKK and JNK perhaps functioning as a scaffold protein, CIKS dependent IKK/NF-?B and JNK/AP-1 activation, p65 and c-Jun phosphorylation and nuclear translocation, NF-?B- and AP-1 dependent IL-18 and MMP-9 induction , and hypertrophy of adult cardiomyocytes isolated from WT, but not CIKS-null mice ... Further, Ang-II induced IKK/p65 and JNK/c-Jun phosphorylation, NF-?B and AP-1 activation, and IL-18 and MMP-9 expression were also markedly attenuated in CIKS-null mice
Cho et al., Dig Dis Sci 2010 (Adenocarcinoma...) : Involvement of Ras and AP-1 in Helicobacter pylori induced expression of COX-2 and iNOS in gastric epithelial AGS cells ... Involvement of Ras and AP-1 in Helicobacter pylori induced expression of COX-2 and iNOS in gastric epithelial AGS cells ... We investigated whether H. pylori in a Korean isolate ( HP99 ), a cagA ( + ), vacA ( + ) strain, induces the expression of c-Fos and c-Jun for AP-1 activation to induce COX-2 and iNOS and whether HP99 induced expressions of COX-2 and iNOS are mediated by Ras and AP-1 , determined by the expressions of c-Fos and c-Jun, in gastric epithelial AGS cells, using transfection with mutant genes for Ras ( ras N-17 ) and c-Jun ( TAM-67 ) ... We investigated whether H. pylori in a Korean isolate ( HP99 ), a cagA ( + ), vacA ( + ) strain, induces the expression of c-Fos and c-Jun for AP-1 activation to induce COX-2 and iNOS and whether HP99 induced expressions of COX-2 and iNOS are mediated by Ras and AP-1 , determined by the expressions of c-Fos and c-Jun, in gastric epithelial AGS cells, using transfection with mutant genes for Ras ( ras N-17 ) and c-Jun ( TAM-67 ) ... We investigated whether H. pylori in a Korean isolate ( HP99 ), a cagA ( + ), vacA ( + ) strain, induces the expression of c-Fos and c-Jun for AP-1 activation to induce COX-2 and iNOS and whether HP99 induced expressions of COX-2 and iNOS are mediated by Ras and AP-1 , determined by the expressions of c-Fos and c-Jun, in gastric epithelial AGS cells, using transfection with mutant genes for Ras ( ras N-17 ) and c-Jun ( TAM-67 ) ... We investigated whether H. pylori in a Korean isolate ( HP99 ), a cagA ( + ), vacA ( + ) strain, induces the expression of c-Fos and c-Jun for AP-1 activation to induce COX-2 and iNOS and whether HP99 induced expressions of COX-2 and iNOS are mediated by Ras and AP-1 , determined by the expressions of c-Fos and c-Jun, in gastric epithelial AGS cells, using transfection with mutant genes for Ras ( ras N-17 ) and c-Jun ( TAM-67 )
Awasthi et al., J Steroid Biochem Mol Biol 2007 : Electrophoretic mobility shift assay using uterine nuclear fraction from various treatment groups demonstrated that Orm caused a significant reduction in E2 induced AP-1 DNA binding
Kim et al., Mol Immunol 2007 (Ovarian Neoplasms) : Saxatilin inhibits TNF-alpha induced proliferation by suppressing AP-1 dependent IL-8 expression in the ovarian cancer cell line MDAH 2774 ... TNF-alpha induced IL-8 promoter activation that is inhibited by saxatilin treatment was dependent on activating protein-1 (AP-1) instead of nuclear factor-kappa B (NF-kappaB) ... Experimental evidence clearly indicated that saxatilin inhibits TNF-alpha induced proliferation of the ovarian cancer cells by suppressing IL-8 expression in AP-1 dependent manner
Chuang et al., J Immunol 2001 : These results demonstrate a significant role for AP-1 in the transcriptional regulation of the h2B4 gene
Huang et al., Proc Natl Acad Sci U S A 1997 : The inhibition appears to be specific for UV-induced signal transduction for AP-1 activation, because these inhibitors did not block UV-induced p53 activation nor did they exhibit any significant influence on epidermal growth factor induced AP-1 transactivation
Dawson et al., Int J Cancer 2001 (Neoplasms, Experimental...) : Evaluation of retinoic acid receptor ( RAR ) subtype-selective alpha and gamma agonists and antagonists and a retinoid X receptor ( RXR ) class-selective agonist for efficacy at inhibiting both induction of ornithine decarboxylase (ODC) by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate ( TPA ) in mouse epidermis and rat tracheal epithelial cells and the appearance of papillomas in mouse epidermis treated in the 2-stage tumor initiation-promotion model indicated that ( i ) RXR class-selective transcriptional agonists, such as MM11246, were not involved in ODC inhibition ; ( ii ) RAR-selective agonists that induce gene transcription from RA-responsive elements ( RAREs ) were active at low concentrations ; ( iii ) RAR-selective antagonists that bind RARs and inhibit AP-1 activation on the collagenase promoter but do not activate RAREs to induce gene transcription were less effective inhibitors ; and ( iv ) RARgamma-selective retinoid agonists were more effective inhibitors of TPA induced ODC activity than RARalpha-selective agonists
Chung et al., Arch Pharm Res 2002 (Carcinoma, Hepatocellular) : To elucidate the role of AP-1 in CYP1A2 regulation, we transiently overexpressed c-Jun and c-Fos transcription factors in human hepatoma HepG2 cells, and examined their influence on the CYP1A2 promoter activity by reporter gene assays
Tanguay et al., Cell Immunol 1994 : Activation of AP-1 in primary B lymphocytes by surface immunoglobulin requires de novo Jun-B synthesis
Li et al., J Cell Physiol 2007 (Prostatic Neoplasms) : Electrophoretic mobility-shift assay ( EMSA ) and promoter-reporter activity analyses suggested that p38MAPK activated transcription factor AP-1 is responsible for proteasome inhibitor induced maspin expression
Tanaka et al., Mol Cell Biol 1995 (Cell Transformation, Neoplastic...) : Furthermore, AML1/Evi-1 stimulated c-fos promoter transactivation and increased AP-1 activity, as Evi-1 ( which is not normally expressed in hemopoietic cells ) did ... Furthermore, AML1/Evi-1 stimulated c-fos promoter transactivation and increased AP-1 activity, as Evi-1 ( which is not normally expressed in hemopoietic cells ) did
Lee et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : Moreover, eupatolide significantly suppressed the LPS induced expression of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) reporter genes
Sutcliffe et al., Br J Pharmacol 2009 : Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1
Migita et al., Immunol Lett 2005 (Arthritis, Rheumatoid) : FK506 also prevented IL-1beta stimulated JNK activation and transcriptional activation of AP-1 in these cells
Bataller et al., J Clin Invest 2003 (Liver Cirrhosis, Experimental) : Ang II phosphorylated AKT and MAPKs and increased AP-1 DNA binding in a redox-sensitive manner
Bianchi et al., J Biol Chem 2003 : As a functional consequence of this interaction, expression of huCOP1 in mammalian cells down-regulates c-Jun dependent transcription and the expression of the AP-1 target genes, urokinase and matrix metalloproteinase 1
Auwerx et al., Cell 1991 : IP-1 specifically blocks DNA binding of AP-1 from nuclear extracts and of in vitro synthesized Fos/Jun proteins
Hasegawa et al., J Immunol 2009 : We found that the specific activation of ASC induced AP-1 activity, which was required for optimal IL8 promoter activity ... ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8 targeting small interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor, caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants, FADD- or RICK targeting small interfering RNAs, or a MEK inhibitor, indicating that the ASC induced AP-1 activation is mediated by caspase-8, p38, and JNK, but does not require caspase-1, caspase-9, FADD, RICK, or ERK ... ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8 targeting small interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor, caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants, FADD- or RICK targeting small interfering RNAs, or a MEK inhibitor, indicating that the ASC induced AP-1 activation is mediated by caspase-8, p38, and JNK, but does not require caspase-1, caspase-9, FADD, RICK, or ERK ... This is the first report of ASC mediated AP-1 activation and the repertoire of genes induced downstream of ASC activation ... ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8 targeting small interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor, caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants, FADD- or RICK targeting small interfering RNAs, or a MEK inhibitor, indicating that the ASC induced AP-1 activation is mediated by caspase-8, p38, and JNK, but does not require caspase-1, caspase-9, FADD, RICK, or ERK ... ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8 targeting small interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor, caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants, FADD- or RICK targeting small interfering RNAs, or a MEK inhibitor, indicating that the ASC induced AP-1 activation is mediated by caspase-8, p38, and JNK, but does not require caspase-1, caspase-9, FADD, RICK, or ERK ... ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8 targeting small interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor, caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants, FADD- or RICK targeting small interfering RNAs, or a MEK inhibitor, indicating that the ASC induced AP-1 activation is mediated by caspase-8, p38 , and JNK, but does not require caspase-1, caspase-9, FADD, RICK, or ERK
Park et al., Am J Physiol 1999 : AP-1 mediates stretch induced expression of HB-EGF in bladder smooth muscle cells
Cho et al., Biochem Biophys Res Commun 2002 : The enhanced IL-18 production by UVB irradiation requires ROI and AP-1 signaling in human keratinocyte cell line ( HaCaT ) ... Furthermore, inhibitors of UVB induced AP-1 activity, such as PD98059, blocked enhanced IL-18 production, indicating that AP-1 activation is required for UVB induced IL-18 production
Kogut et al., Innate Immun 2008 : Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2 dependent activation of AP-1 and NF-kappaB signaling pathways ... Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2 dependent activation of AP-1 and NF-kappaB signaling pathways ... Taken together these data demonstrate that FLG and LPS stimulate the up-regulation of expression of IL-6 and CXCLi2 through an ERK1/2 dependent activation of both NF-kappaB and AP-1
Kirch et al., Oncogene 1999 : Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1 , NF-kappaB and Myc/Max
Baskey et al., J Neurochem 2002 : Transfection with an AP-1 luciferase reporter gene revealed that PC12 but not B5P cells expressed nerve growth factor induced functional AP-1 activity ... Using DNA-protein gel shift assays we determined that nerve growth factor stimulates AP-1 binding in both PC12 and B5P cells, and identified c-Fos, FosB, Fra-1, Fra-2, c-Jun, JunB and JunD in AP-1 complexes
De Sarno et al., Brain Res 2001 (Neuroblastoma) : Thus, overexpression of PS1wt reduced muscarinic receptor mediated activation of AP-1 , and PS1m overexpression caused greater inhibition, but stress induced activation of Akt and HSF-1 was unaffected by either PS1wt or PS1m
Cheng et al., Mol Cell Biol 2005 : In particular, Mip1 prevented MEKK2 activation by blocking MEKK2 dimer formation, which in turn blocked JNKK2, c-Jun N-terminal kinase 1 ( JNK1 ), extracellular signal regulated kinase 5, and AP-1 reporter gene activation by MEKK2 ... In contrast, the knockdown of Mip1 expression by siRNA augmented the MEKK2 mediated JNK and AP-1 reporter activation
Irarrazabal et al., J Biol Chem 2008 : Thus, AP-1 is part of the TonEBP/OREBP enhanceosome, and its role in high NaCl induced activation of TonEBP/OREBP may require p38 activity ... Thus, AP-1 is part of the TonEBP/OREBP enhanceosome, and its role in high NaCl induced activation of TonEBP/OREBP may require p38 activity
Joseph et al., Free Radic Biol Med 2008 (Hyperoxia) : The data indicate that activation of JNK1/AP-1 and subsequent IL-8 induction in hyperoxia are mediated by intracellular ROS, with SOD having significant protective effects
Muthumani et al., Blood 2005 : Loss-of-function experiments through dominant negative p38 isoform, p38 siRNA, and chemical inhibitors of p38 activation suggest that p38 is necessary for Nef induced activator protein-1 (AP-1) activation, as inhibition leads to an attenuation of AP-1 dependent transcription
Huang et al., J Biol Chem 1996 : Since UVB is responsible for most of the carcinogenic effects of sun exposure, we investigated the role of EGF receptors and PKC in UVB induced AP-1 activation ... All of this evidence indicated that aPKC, but not EGF receptor, is involved in UVB induced AP-1 activation
de Haij et al., J Am Soc Nephrol 2005 : Although stimulation of TEC induced activation of activator protein-1 (AP-1) , the down-stream target of JNK, reporter assays demonstrated that mutation of the AP-1 binding site in the IL-6 promoter did not affect gene transcription
Xue et al., Placenta 2013 : Our study further proved that miR-155* targeted PTEN 3'-untranslated region ( 3'UTR ) increased IRAKM and NKIRAS1 expression by competing for miR-155* binding, thereby suppressing AP-1/NF-?B activation induced by LPS
Hsieh et al., Biochim Biophys Acta 2008 : Moreover, thrombin stimulated activation of NF-kappaB, AP-1 , and COX-2 promoter activity was blocked by the inhibitors of c-Src , PKC, EGFR, MEK1/2, AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB ... Moreover, thrombin stimulated activation of NF-kappaB, AP-1 , and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR , MEK1/2, AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB ... Moreover, thrombin stimulated activation of NF-kappaB, AP-1 , and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR, MEK1/2 , AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB ... Moreover, thrombin stimulated activation of NF-kappaB, AP-1 , and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR, MEK1/2, AP-1 and NF-kappaB , suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB ... Moreover, thrombin stimulated activation of NF-kappaB, AP-1, and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR, MEK1/2, AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
He et al., Zhonghua Yi Xue Za Zhi 2001 (Pulmonary Disease, Chronic Obstructive) : Enhancement of activity of NF kappa B and AP-1 may positively regulate the production of IL-8 and IL-1 beta in the airflow obstruction ... Enhancement of activity of NF kappa B and AP-1 may positively regulate the production of IL-8 and IL-1 beta in the airflow obstruction
Tachibana et al., J Am Soc Nephrol 2012 (Diabetes Mellitus, Experimental...) : In vitro, LXR activation suppressed osteopontin expression in proximal tubular epithelial cells by inhibiting AP-1 dependent transcriptional activation of the osteopontin promoter
Vanden Bush et al., PloS one 2011 : Additionally, the activity of AP-1 , a ubiquitous transcription factor containing phosphorylated c-Jun as a subunit, was inhibited by abrogating CDK4
Chen et al., J Biol Chem 2006 : The effects of Cybr on nuclear factor of activated T cells and AP-1 are dependent on MAPK activation, and enhanced activation of this cascade results in cooperation between the two transcription factors in the regulation of gene expression ... The effects of Cybr on nuclear factor of activated T cells and AP-1 are dependent on MAPK activation, and enhanced activation of this cascade results in cooperation between the two transcription factors in the regulation of gene expression
Serkkola et al., Eur J Biochem 1993 : We have now examined the role of AP-1 in the regulation of the IL-1 beta gene expression by PKC and cAMP in THP-1 cells
Shimizu et al., Cardiovasc Res 1999 : The c-fos induction, the increased AP-1 binding activity and the acceleration of DNA synthesis were all attenuated by genistein ( 100 microM ) or MAPK kinase inhibitor ( 10 or 50 microM PD98059 )
Seo et al., J Physiol Pharmacol 2009 : Nitric oxide induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells
Olsson et al., J Biol Chem 1999 : CTLA-4 ligation suppresses CD28 induced NF-kappaB and AP-1 activity in mouse T cell blasts ... CTLA-4 ligation suppresses CD28 induced NF-kappaB and AP-1 activity in mouse T cell blasts
Kim et al., Carcinogenesis 2008 (Breast Neoplasms) : 15d-PGJ ( 2 ) -induced COX-2 expression was mediated by activation of Akt and subsequently activator protein-1 (AP-1) ... 15d-PGJ ( 2 ) -induced COX-2 expression was mediated by activation of Akt and subsequently activator protein-1 (AP-1)
Matsumura et al., Life Sci 2001 : However, activation of activator protein-1 (AP-1) , which is also contained in the iNOS promoter, was not enhanced by LPS/IFN or inhibited by DEX
Shrivastava et al., Antioxid Redox Signal 1999 : In this report, we investigated the effect of various superoxide radical quenchers -- pyrrolidine dithiocarbamate ( PDTC ), N-acetyl-L-cysteine (NAC), and glutathione ( GSH ) -- an hydroxyl radical quencher ( mannitol ), and lipid peroxide quenchers -- butylated hydroxytoluene ( BHT ) and butylated hydroxyanisole ( BHA ) -- on TNF induced activation of nuclear transcription factors-kappa B ( NF-kappa B ) and activator protein-1 (AP-1) , c-jun amino-terminal kinase ( JNK ), and apoptosis in human monocytic U937 cells ... In contrast, none of the radical quenchers had any significant effect on TNF induced AP-1 activation ... Overall, these results suggest that hydroxyl radicals mediate TNF induced apoptosis but not activation of NF-kappa B, AP-1 , and JNK ; superoxide radicals mediate NF-kappa B and JNK activation but potentiate apoptosis ; and lipid peroxides are required for all the signals induced by TNF
Abe et al., Am J Respir Cell Mol Biol 2000 : In accord with promoter analyses, an electrophoretic mobility shift assay showed that CAM repressed AP-1 binding in TNF-alpha treated BET-1A cells ; however, TNF-alpha induced both AP-1 and NF-kappaB binding activities in BET-1A cells ... In accord with promoter analyses, an electrophoretic mobility shift assay showed that CAM repressed AP-1 binding in TNF-alpha treated BET-1A cells ; however, TNF-alpha induced both AP-1 and NF-kappaB binding activities in BET-1A cells
Viedt et al., Arterioscler Thromb Vasc Biol 2002 (Inflammation) : MCP-1 stimulated the binding activity of NF-kappaB and of activator protein-1 (AP-1) ... The results clearly demonstrate that MCP-1 induces differential activation of NF-kappaB and AP-1 in VSMCs
Chandrasekar et al., J Biol Chem 2005 : Gel shift, supershift, and chromatin immunoprecipitation assays confirmed AP-1 dependent CXCL16 expression ... Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression ... Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88 , interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression ... Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression ... Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression ... Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression ... Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression
Naumann et al., J Exp Med 1998 : Since it is established that phosphorylation of c-Jun , the central component of AP-1, by the stress activated c-Jun NH2-terminal kinase (JNK) increases the transcriptional activity of AP-1 , we studied whether Ngo could induce stress response pathways involving JNK
Wang et al., Gastroenterology 2009 (Disease Models, Animal...) : Leptin potentiated signal transducer and activator of transcription 3, AKT, and extracellular signal related kinase 1/2 phosphorylation in KCs and increased AP-1 and nuclear factor-kappaB DNA binding
Al-Murrani et al., Biochem J 1999 : Expression of I2PP2A , an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity ... Expression of I2PP2A , an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity
Li et al., EMBO J 2004 : Conversely, a SPAK-specific RNAi or a dominant negative SPAK mutant inhibited PKCtheta- and TCR/CD28 induced AP-1 , but not NF-kappaB, activation
Ruiz-Ortega et al., Kidney Int 2000 : Ang III also activated AP-1 ( 5-fold, after 18 h ), while SP-1 was unchanged
Marrero et al., Brain Res 2009 (Inflammation) : In this study, we investigated the effects of inhibiting the alpha7 nAChR-JAK2 pro-survival cascade on the nicotine induced production of the survival factor Bcl-2 and the transcriptional activation of NF-kappaB, AP-1 , STAT1, STAT3, and STAT5
Humbert et al., Nucleic Acids Res 2003 : When losing the AP-1 dependent hMSH2 promoter activity, either by mutating the AP-1 binding sites of the hMSH2 promoter or by using a dominant negative c-Jun factor, the hMSH2 overexpression induced by TPA is abolished both in vitro and in vivo
Colangelo et al., Brain Res Mol Brain Res 1996 (Glioma) : Correlation between increased AP-1NGF binding activity and induction of nerve growth factor transcription by multiple signal transduction pathways in C6-2B glioma cells ... Gel mobility shift assays using an oligonucleotide homologous to the AP-1 responsive element of the rat NGF gene ( AP-1NGF ) revealed that 12-O-tetradecanoyl phorbol-13-acetate ( TPA ) and, to a lesser extent, isoproterenol ( ISO ) and thapsigargin, a microsomal Ca ( 2+ ) -ATPase inhibitor, stimulated binding to AP-1NGF within 2 h
Chano et al., Eur J Immunol 2002 : Electrophoretic mobility shift assays and luciferase reporter constructs revealed that LPS induced AP-1 transcriptional activity was normal in DN PKC-alpha overexpressing RAW 264.7 cells
Zhang et al., Front Biosci (Elite Ed) 2010 : We previously showed that AC3-33 ( GenBank name : c3orf33, FLJ31139 ), significantly inhibited transcriptional activity of AP-1
Sahambi et al., Birth Defects Res A Clin Mol Teratol 2006 (Abnormalities, Drug-Induced) : We hypothesize that oxidative stress and activation of a redox-sensitive transcription factor , activator protein-1 (AP-1) , are early indicators of embryonic stress in response to a teratogenic insult
Yamanaka et al., J Orthop Res 2008 (MAP Kinase Signaling System...) : We have previously determined that RANKL is an essential cytokine mediator of particle induced osteoclastogenesis, and that PMMA particles activate JNK and c-jun/AP-1 in bone marrow macrophages ( osteoclast precursors )
Yeligar et al., J Biol Chem 2010 : Furthermore, livers of ethanol fed c-Jun ( fl/fl ) mice showed reduced levels of mRNA for HO-1 but not of NQO1 compared with ethanol fed control rats, supporting the role of c-Jun or the AP-1 transcriptional complex in ethanol induced HO-1 expression
Tonetti et al., J Steroid Biochem Mol Biol 2003 (Breast Neoplasms) : Furthermore, ERbeta , at least in the context of the MDA-MB-231 cellular milieu, does not enhance AP-1 activity in the presence of antiestrogens
Sasaki et al., Mol Cell 2006 : Thus, this spatiotemporal regulation of c-Fos by ERK5 and UBR1 is critical for the regulation of c-Fos/AP-1 ... Thus, this spatiotemporal regulation of c-Fos by ERK5 and UBR1 is critical for the regulation of c-Fos/AP-1 ... Thus, this spatiotemporal regulation of c-Fos by ERK5 and UBR1 is critical for the regulation of c-Fos/AP-1
Wang et al., Zhonghua Shao Shang Za Zhi 2010 (Acute Lung Injury) : To explore the role of angiotensin II type 1 (AT1) receptor in activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) in lung of mice with LPS induced acute lung injury ( ALI )
Deppmann et al., Biochem J 2003 : Phosphorylation of BATF regulates DNA binding : a novel mechanism for AP-1 ( activator protein-1 ) regulation
Farombi et al., Life Sci 2009 (Drug-Induced Liver Injury) : Furthermore, kolaviron abrogated DMN induced binding activity of NF-kappaB as well as AP-1
Hamada et al., Toxicology 2000 : However, NF-kappaB was increased at 3 h while AP-1 ( Jun B and Jun D ) and CREB were increased at 15 h. Co-stimulation of 12j cells with rMu-IFN-gamma + Be increased the levels of NF-KB in 12j cell nuclei at 3 h, and the levels of AP-1 and CREB at 15 h, however, only Jun B was increased
Shun et al., Ann Otol Rhinol Laryngol 2005 (Nasal Polyps) : The electrophoretic mobility shift assay revealed that TNF-alpha triggered AP-1 and DNA binding and again, NS-398 and meloxicam inhibited this reaction via reducing c-Fos synthesis
Collins-Hicok et al., Mol Cell Biol 1994 : Both CRE binding protein ( CREB ) and activator protein 1 (AP-1) can regulate RD, but their effects are in opposite directions ; CREB represses and AP-1 activates RD. CREB induced repression and AP-1 activation require distinct elements within the control region, but their binding and functions overlap at CRE-3 ... Both CRE binding protein ( CREB ) and activator protein 1 (AP-1) can regulate RD, but their effects are in opposite directions ; CREB represses and AP-1 activates RD. CREB induced repression and AP-1 activation require distinct elements within the control region, but their binding and functions overlap at CRE-3 ... CREB repression blocks AP-1 activation in unstimulated cells
Dokter et al., Blood 1993 : Finally, using electrophoretic mobility shift assays, evidence was obtained that IL-4 inhibits LPS induced expression of AP-1 protein ... Finally, using electrophoretic mobility shift assays, evidence was obtained that IL-4 inhibits LPS induced expression of AP-1 protein
Kikkawa et al., Am J Kidney Dis 2003 (Diabetic Nephropathies...) : We also found that inhibition of MAPK by PD98059, an inhibitor of MAPK, or mitogen activated extracellular regulated protein kinase kinase prevented enhancement of activated protein-1 (AP-1) DNA binding activity and fibronectin expression in cultured mesangial cells exposed to mechanical stretch in an in vivo model of glomerular hypertension
Chedid et al., J Immunol 1991 (Thymoma) : Activation of AP-1 by IL-1 and phorbol esters in T cells ... IL-1 and agents that elevate intracellular cAMP levels do not, by themselves, induce AP-1 activation, but they synergize with phorbol esters ... IL-1 and forskolin may enhance AP-1 function by different mechanisms, because forskolin enhanced gene expression without producing an increase in nuclear AP-1 DNA binding, whereas IL-1 increased AP-1 binding activity and gene expression ... These observations, in conjunction with the lack of a demonstrable effect of IL-1 on cAMP production in EL-4 cells, are consistent with the view that IL-1 enhances AP-1 activation by a pathway that does not directly involve cAMP and PKA ... However, the induction of AP-1 activity by IL-1 and phorbol esters is dependent upon the presence of PKA, as evidenced by the loss of AP-1 inducibility in cells transfected with a cDNA encoding protein kinase inhibitor, a specific inhibitor of PKA ... However, the induction of AP-1 activity by IL-1 and phorbol esters is dependent upon the presence of PKA , as evidenced by the loss of AP-1 inducibility in cells transfected with a cDNA encoding protein kinase inhibitor, a specific inhibitor of PKA ... The effect of protein kinase inhibitor on AP-1 activation in response to IL-1 and tetradecanoyl-phorbol-13-acetate was reversed in the presence of the serine/threonine protein phosphatase inhibitor okadaic acid
Li et al., Immunity 2012 (Autoimmune Diseases...) : We discovered that Egr2 and/or Egr3 directly induced expression of suppressor of cytokine signaling-1 ( SOCS1 ) and SOCS3, inhibitors of STAT1 and STAT3, and also blocked the function of Batf , an AP-1 inhibitor , in B and T cells
Dhandapani et al., J Neurosci Res 2007 (Brain Neoplasms...) : Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation
Oh et al., J Pharm Pharmacol 2005 : The effects of these glycosides on activator protein-1 (AP-1) mediated inducible nitric oxide synthase (iNOS) gene expression in the Raw264.7 macrophage cell line have been studied
Georganas et al., J Immunol 2000 (Arthritis, Rheumatoid) : Inhibition of c-Jun/AP-1 had no effect on the production of either IL-6 or IL-8 ... Inhibition of c-Jun/AP-1 had no effect on the production of either IL-6 or IL-8
Lin et al., Atherosclerosis 1996 (Arteriosclerosis) : In contrast, the binding activities of AP-1 and GATA, on the other hand, are increased by LDL
Kane et al., Mol Cell Biol 2002 : However, phosphorylation at this site is not required for Cot kinase activity or AP-1 induction , suggesting it specifically regulates Cot effector function at the level of the NF-kappa B pathway
Chan et al., Cytokine 2006 (Cell Transformation, Viral) : In human bronchial epithelial cells, binding sites for NFkappaB, AP-1 , and NF-IL6 in the 5'-flanking region of the IL-8 promoter are necessary for optimal NaCl induction of IL-8
Lgssiar et al., Experimental biology and medicine (Maywood, N.J.) 2004 (Diabetes Mellitus, Experimental) : Interleukin-11 inhibits NF-kappaB and AP-1 activation in islets and prevents diabetes induced with streptozotocin in mice ... Furthermore, the effect of recombinant human ( rh ) IL-11 on MLD-STZ diabetes, insulitis, cytokines, IKK-alpha, NF-kappaB, and AP-1 was analyzed in islets ... Interleukin-11 prevented diabetes without affecting insulitis ; attenuated TNF-alpha and IFN-gamma response ; and stimulated IL-4 production and inhibited activation of IKK-alpha, NF-kappaB, and AP-1
Allport et al., Mol Hum Reprod 2000 : NF-kappaB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line ( WISH )
Cooper et al., Toxicol Appl Pharmacol 2004 : Arsenite stimulated MAP kinase signal transduction resulted in increased production of matrix metalloproteinase (MMP)-9 , an AP-1 regulated gene product
Foster et al., FASEB J 2000 : Taken together, our studies demonstrate that AP-1 proteins are a central regulatory component used by IL-1beta to modulate expression of CD44 during an inflammatory response in vascular smooth muscle cells and that transcription of CD44 by AP-1 proteins is enhanced by HMG-I(Y)
Lee et al., J Immunol 2010 : Inhibition of MMP-3 or -9 also suppressed the activities of MAPK, NF-kappaB, and AP-1
Jeon et al., Immunopharmacology 2000 : Dexamethasone inhibits IL-1 beta gene expression in LPS stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation ... Treatment of DEX to RAW 264.7 cells induced a dose related inhibition of NF-kappaB/Rel and AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor CREB/ATF activation was affected by DEX ... Treatment of DEX to RAW 264.7 cells induced a dose related inhibition of NF-kappaB/Rel and AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor CREB/ATF activation was affected by DEX ... Treatment of DEX to RAW 264.7 cells induced a dose related inhibition of NF-kappaB/Rel and AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor CREB/ATF activation was affected by DEX ... These results suggest that DEX may inhibit IL-1beta gene expression by a mechanism involving the blocking of LPS induced NF-kappaB/Rel and AP-1 activation ... These results suggest that DEX may inhibit IL-1beta gene expression by a mechanism involving the blocking of LPS induced NF-kappaB/Rel and AP-1 activation
Kaminuma et al., Mol Cell Biol 2001 : On the other hand, Vav induced the activation of Rac1 or Cdc42 and c-Jun N-terminal kinase (JNK), enhanced the transcriptional and DNA binding activities of AP-1 , and induced increased phosphorylation of c-Jun ... On the other hand, Vav induced the activation of Rac1 or Cdc42 and c-Jun N-terminal kinase (JNK), enhanced the transcriptional and DNA binding activities of AP-1 , and induced increased phosphorylation of c-Jun
Cho et al., Ann N Y Acad Sci 2006 (Helicobacter Infections) : In conclusion, H. pylori activates Ras, NF-kappaB, and AP-1 and thus induces the expression of integrin alpha5 and integrin beta1 in gastric epithelial cells ... In conclusion, H. pylori activates Ras, NF-kappaB, and AP-1 and thus induces the expression of integrin alpha5 and integrin beta1 in gastric epithelial cells
Brach et al., Blood 1992 (Leukemia, Myeloid) : Taken together, these findings indicate that : ( 1 ) enhancement of JUN/AP-1 activity in ara-C treated cells involves a posttranslational modification of JUN/AP-1 ; and ( 2 ) binding of activated JUN/AP-1 to the AP-1 site in the c-jun promoter confers ara-C inducibility of this gene
Ishimaru et al., Am J Pathol 2012 (Autoimmune Diseases...) : These results indicate that CCR7 essentially controls the migratory function of T ( reg ) cells through S1P(1) mediated AP-1 signaling, which is regulated through its interaction with Foxp3 in the nucleus
Hoshino et al., J Biochem 2002 : These results suggest that Bach2 regulates AP-1- and Maf dependent gene expression during development of neuronal and lens cells and that its activity may be regulated by nuclear export in these cells
Fan et al., J Cell Physiol 2011 : AP-1 , NF-IL-6, and NF-?B cis-elements are required for gAd induced IL-6 transcription
Miller et al., Biochemistry 1996 : Both insulin stimulated JNK activity and insulin induced AP-1 transcriptional activity were found to be Ras dependent
Harada et al., Mol Endocrinol 1997 : OP-1 rapidly induces nuclear protein interaction with the MEF-2-like sequence but not with the AP-1 like sequence
Colangelo et al., Proc Natl Acad Sci U S A 1998 : Our data suggest that, while AP-1 may regulate basal levels of NGF expression, C/EBPdelta is a critical component determining the area-specific expression of NGF in response to BAR stimulation
Zhao et al., Biochem Biophys Res Commun 2002 (Liver Cirrhosis, Experimental) : In conclusion, downregulation of cyclin -D1 , -E, and -A expression, which may be induced by impaired activities of C/EBP and AP-1 , is responsible for the decreased regenerative capacity of cirrhotic liver after partial hepatectomy
Liu et al., Food Chem Toxicol 2006 (Carcinoma, Hepatocellular...) : By EMSA assay, we further demonstrated that decreased c-Fos resulted in the downregulation of AP-1/DNA binding activity
Shi et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2009 : To investigate the expression of CTGF, CTGF mRNA, NF-kappaB and AP-1 induced by TGF-beta1 in human lung fibroblast ( HLF-02 ), and study the effect and possible mechanism of rosiglitazone on signal pathways of TGF-beta1 in HLF-02 ... The effects of TGF-beta1 , curcumin, PDTC and rosiglitazone on the expression of CTGF, NF-kappaB and AP-1 were evaluated with Western blot
Suri et al., Methods Mol Biol 2008 : AP-1 recruitment is mediated by the GTPase Arf1 , requires specific lipids, and cargo signals
Christiansen et al., J Immunol 2002 (Rhinitis, Allergic, Perennial...) : We demonstrated that Lys-des-Arg-BK activates the transcription factor AP-1
Yuksel et al., Thromb Haemost 2002 (MAP Kinase Signaling System...) : APC also inhibited both the binding of activator protein-1 (AP-1) to target sites and the activation of mitogen activated protein kinase pathways ... These observations strongly suggest that APC inhibited LPS induced TNF-alpha production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity ... These observations strongly suggest that APC inhibited LPS induced TNF-alpha production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity
Fjeldbo et al., Am J Physiol Gastrointest Liver Physiol 2012 (Adenocarcinoma...) : Luciferase reporter assay indicates that the AP-1 transcription factor complex is involved in gastrin mediated activation of the clusterin promoter
Bakken et al., Virology 2010 : We find that vGPCR activity results in phosphorylation of regulatory tyrosines in Shp2 and that in turn, Shp2 is required for vGPCR mediated activation of MEK, NFkappaB, and AP-1
Medicherla et al., Mech Ageing Dev 2001 : The observed decrease in AP-1 binding activity in ageing adrenals is most likely due to decreased expression of the AP-1 activating components ( c-Fos, c-Jun, JunD, etc. ) and increased expression of JunB , resulting in a switch from transcriptionally active AP-1 complexes observed in young rats to less efficient JunB containing complexes in old rats
Huang et al., Oncogene 1997 : Signal transduction through atypical PKCs, but not the EGF receptor, is necessary for UVC induced AP-1 activation in immortal murine cells ... This was found at all UVC irradiation doses and time courses studied, while high levels of EGF induced AP-1 activity were observed in B82L cells but not in B82 cells ... This evidence strongly suggests that atypical PKCs, but not the EGF receptor, is necessary for UVC induced AP-1 activation in JB6 and B82 cells
Krug et al., Biochim Biophys Acta 2012 : Most likely, the stimulation of Ang-2 is in part mediated by increased activation of AP-1 but different signal transduction pathways may also be involved since we found opposite activation of PI3K/Akt/mTOR and MAPK7ERK pathways ( both known to regulate in Ang-2 expression )
Peng et al., Cell Mol Biol Res 1995 (Myocardial Reperfusion Injury) : The levels of c-Fos and c-Jun proteins increased in nuclei as revealed by immunostaining, and DNA binding activity of nuclear AP-1 increased ... The levels of c-Fos and c-Jun proteins increased in nuclei as revealed by immunostaining, and DNA binding activity of nuclear AP-1 increased
Urbich et al., J Clin Invest 2001 : Overexpression of TRAF-3 inhibits endothelial expression of proinflammatory cytokines and tissue factor and blocks DNA binding activity of the transcription factor AP-1 ; it thereby prevents CD40 induced endothelial activation
Iles et al., Free Radic Biol Med 2005 : Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated ERK phosphorylation, c-Fos protein induction , AP-1 binding, and HO-1 protein induction, inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA ... Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated ERK phosphorylation, c-Fos protein induction, AP-1 binding, and HO-1 protein induction , inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA
De-Castro Arce et al., J Biol Chem 2004 : Because AP-1 activity was not irreversibly disturbed, but could be switched on through activation of the Jun N-terminal kinase pathway, a model for the transient activation of AP-1 even in the presence of RARbeta as repressor is suggested
Oh et al., Evidence-based complementary and alternative medicine : eCAM 2012 : Moreover, GE and GSs reduced the expression of NF-?B and AP-1 , the transcription factors of MMP-2 and MMP-9
Neves et al., Can J Physiol Pharmacol 2005 (Fibrosis...) : Ang II significantly increased cardiac AP-1 activity and ED-1 expression, which was prevented by spironolactone only
Yang et al., Lab Invest 2013 (Acute Lung Injury...) : Inhibition of TLR4 expression in the lung tissue by infection with pGCSIL-GFP-lentivirus expressing small hairpin RNAs targeting the TLR4 gene ( TLR4-shRNA lentivirus ) significantly attenuated ALI, lung inflammation, and activity of p38MAPK and AP-1 in the lung tissue
Pertel et al., Nature 2011 : Acting with the heterodimeric, ubiquitin conjugating enzyme UBC13-UEV1A ( also known as UBE2N-UBE2V1 ), TRIM5 catalyses the synthesis of unattached K63 linked ubiquitin chains that activate the TAK1 ( also known as MAP3K7 ) kinase complex and stimulate AP-1 and NF?B signalling
Marusina et al., J Immunol 2008 : Taken together, our data indicate that Ap-1 is an important transcription factor for regulating DAP10 gene expression in human NK and T cells, and that Ap-1 plays a key role in the transactivation of DAP10 promoter following TCR stimulation
Qiao et al., Mol Cell Biol 2003 : DCA induced ERK1/2 activation was responsible for increased DNA binding of C/EBPbeta, CREB, and c-Jun/AP-1
Guo et al., Am J Physiol Gastrointest Liver Physiol 2012 : When signaling pathways were evaluated, CCK stimulation increased c-Jun expression, JNK and ERK activity, and AP-1 activation ... Chemical inhibitors of JNK and ERK pathways, dominant negative JNK and c-Jun , and c-Jun shRNA significantly inhibited CCK induced DNA synthesis, CCK induced AP-1 activation, and cyclin D1 expression ... Chemical inhibitors of JNK and ERK pathways, dominant negative JNK and c-Jun, and c-Jun shRNA significantly inhibited CCK induced DNA synthesis, CCK induced AP-1 activation, and cyclin D1 expression
O'Hara et al., J Immunol 2006 (Helicobacter Infections) : Small interfering RNA mediated silencing of APE-1/Ref-1 inhibited basal and H. pylori induced AP-1 and NF-kappaB DNA binding activity without affecting the nuclear translocation of these transcription factors and also reduced H. pylori induced IL-8 mRNA and protein ... In contrast, overexpression of APE-1/Ref-1 enhanced basal and H. pylori induced IL-8 gene transcription, and the relative involvement of AP-1 in inducible IL-8 promoter activity was greater in APE-1/Ref-1 overexpressing cells than in cells with basal levels of APE-1/Ref-1
Yang et al., Biochem J 2011 (Colonic Neoplasms) : IGF-1 induced MAT2A promoter activity and increased nuclear protein binding to USF ( upstream stimulatory factor ) /c-Myb, YY1 ( Yin and Yang 1 ), E2F, AP-1 ( activator protein 1 ) and NF-?B ( nuclear factor ?B ) consensus elements
Lin et al., Carcinogenesis 2008 (Breast Neoplasms...) : A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal regulated kinase ( ERK ) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor ( PD98059 ) and an AP-1 inhibitor ( curcumin ) ... A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal regulated kinase ( ERK ) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor ( PD98059 ) and an AP-1 inhibitor ( curcumin )
Yang et al., Biochem Biophys Res Commun 2005 : Overexpression of ZNF649 in COS-7 cells inhibits the transcriptional activities of SRE and AP-1
Hautala et al., Pflugers Arch 2002 : These results show that ET-1 and Ang II are required for the stimulation of GATA4 and AP-1 DNA binding activity in response to direct left ventricular wall stretch
Rangaswami et al., J Biol Chem 2005 (Neoplasm Invasiveness) : To our knowledge this is first report that OPN induces NIK/MEKK1 mediated JNK1 dependent/independent AP-1 mediated pro-MMP-9 activation and regulates the negative crosstalk between NIK/ERK1/2 and MEKK1/JNK1 pathways that ultimately controls the cell motility, invasiveness, and tumor growth
Hwang et al., FEBS Lett 2005 : AP-1 activation suppressed the expression of Sox-9 , a major transcription factor regulating type II collagen expression ... AP-1 activation suppressed the expression of Sox-9, a major transcription factor regulating type II collagen expression
Wan et al., Cancer Lett 2000 (Carcinoma, Hepatocellular...) : Furthermore, RA and ( C16 : 0 ) -CoA can regulate AP-1 , which is a key regulator of the TGFbeta gene
Funakoshi-Tago et al., Eur J Biochem 2003 : TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway ... TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway ... We found that IL-1 mediated c-Src activation was required for AP-1 activation, but not for NF-kappa B activation and also revealed that c-Src induced AP-1 activation was enhanced synergistically by the coexpression of TNF receptor associated factor 6 (TRAF6) ... We found that IL-1 mediated c-Src activation was required for AP-1 activation, but not for NF-kappa B activation and also revealed that c-Src induced AP-1 activation was enhanced synergistically by the coexpression of TNF receptor associated factor 6 (TRAF6) ... We found that IL-1 mediated c-Src activation was required for AP-1 activation, but not for NF-kappa B activation and also revealed that c-Src induced AP-1 activation was enhanced synergistically by the coexpression of TNF receptor associated factor 6 (TRAF6) ... During the TRAF6 and c-Src induced AP-1 activation, phosphatidylinositol 3 (PI3)-kinase, its downstream signaling molecule, Akt and c-Jun N-terminal kinase (JNK) were significantly activated and inhibition of these kinase activities down-regulated AP-1 activation through the suppression of c-fos expression ... Taken together, our results demonstrate that c-Src and TRAF6 are key mediators of IL-1 induced AP-1 activation and provide evidence of cross talk between c-Src and TRAF6 molecules through PI3 kinase-Akt-JNK pathways
Rahman , Biochem Pharmacol 2002 (Pneumonia) : Pharmacological inhibition of HDAC leads to the increased HAT activity, AP-1 and NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments
Chen et al., J Biol Chem 2008 : The lack of PLCgamma2 markedly diminished RANKL induced activation of NF-kappaB, AP-1 , and NFATc1 ... The lack of PLCgamma2 markedly diminished RANKL induced activation of NF-kappaB, AP-1 , and NFATc1
Abounader et al., J Neurochem 2001 (Glioblastoma) : These results support a model of c-met induction by SF/HGF in human glioma cells that uniformly involves Ras, MAPK, and AP-1 and additionally involves PI3-kinase and PKC in some cell lines
Karimipour et al., Arch Dermatol 2009 : Coarse-grit microdermabrasion induces a wound healing response characterized by rapid increase in induction of cytokeratin 16 and activation of the AP-1 transcription factor in the epidermis
Park et al., Oncogene 2003 (Prostatic Neoplasms) : TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6 ... TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6 ... It was also found that the Ras-Raf-MEK1 cascade is activated by TGF-beta1 and participates in the TGF-beta1 induction of IL-6 in an AP-1 dependent manner ... It was also found that the Ras-Raf-MEK1 cascade is activated by TGF-beta1 and participates in the TGF-beta1 induction of IL-6 in an AP-1 dependent manner
Wu et al., J Am Soc Nephrol 2009 (Diabetes Mellitus, Experimental...) : PKC is known to mediate glucose induced TGF-beta1 upregulation through the transcription factor AP-1 ; here, inhibitors of phosphoinositide-3-OH kinase, PKC-beta and Akt, and dominant negative Akt all prevented glucose induced activation of AP-1 and upregulation of TGF-beta1 ... PKC is known to mediate glucose induced TGF-beta1 upregulation through the transcription factor AP-1 ; here, inhibitors of phosphoinositide-3-OH kinase, PKC-beta and Akt, and dominant negative Akt all prevented glucose induced activation of AP-1 and upregulation of TGF-beta1 ... Finally, pharmacologic and dominant negative inhibition of EGFR blocked glucose induced activation of PKC-beta1, phosphorylation of AktS473, activation of AP-1 , and upregulation of TGF-beta1
Hattori et al., Diabetes 2007 : gAd also activated AP-1 and enhanced angiotensin II (Ang II) induced AP-1 activity
Andoh et al., Gastroenterology 2005 (Inflammatory Bowel Diseases) : IL-22 induced an activation of nuclear factor (NF)-kappaB and activating protein (AP)-1 within 1 hour, and a blockade of NF-kappaB and AP-1 activation markedly reduced IL-22 induction of IL-6, IL-8, IL-11, and LIF mRNA
Miyoshi et al., Eur J Neurosci 2008 : ANG II application enhanced the LPS induced increases in IL-1 and nitrite concentrations, as well as the LPS induced morphological changes and AP-1 activation, and these enhancements were inhibited by losartan ( 10 ( -5 ) M )
Su et al., J Biol Chem 1994 : Furthermore, an inhibitor of sphingosine kinase , DL-threo-dihydrosphingosine, which inhibits sphingosine induced DNA synthesis and the formation of sphingosine 1-phosphate, also inhibited sphingosine stimulated AP-1 DNA binding activity
Milanovic et al., Neuropharmacology 2006 : In this study, we examined the effects of AMPH ( 5mg/kg ), PCP ( 5mg/kg ) and their combination ( 5mg/kg each ) on rat motor activity as well as on the activation of the AP-1 transcription factor in rat brains ... In this study, we examined the effects of AMPH ( 5mg/kg ), PCP ( 5mg/kg ) and their combination ( 5mg/kg each ) on rat motor activity as well as on the activation of the AP-1 transcription factor in rat brains
Chen et al., Chem Biol Interact 2010 : Nitrosative stress induces osteoblast apoptosis through downregulating MAPK mediated NFkappaB/AP-1 activation and subsequent Bcl-X ( L ) expression
Guiton et al., J Biol Chem 1995 : The kinase inserts blocked the ability of TrkC to mediate neurotrophin-3 stimulated c-myc and c-fos transcription and activation of the AP-1 transcriptional complex
Mittelstadt et al., J Biol Chem 2001 : GILZ also potently inhibited AP-1-driven and IL-2 promoter-driven reporter constructs, and recombinant GILZ specifically interacted with c-Fos and c-Jun in vitro and inhibited the binding of active AP-1 to its target DNA
Zhao et al., Biochem Biophys Res Commun 2006 : ZNF325 , a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE mediated transcriptional activity ... Overexpression of ZNF325 in COS-7 cells inhibits the transcriptional activities of AP-1 and SRE
Wang et al., Int Immunol 2006 (MAP Kinase Signaling System) : AP-1 ( c-Fos/c-Jun ) strongly induced IL-5 transcription and dominant negative AP-1 constructs confirmed that AP-1 plays an important role in regulating IL-5 expression ... AP-1/Ets1 transactivation also stimulated IL-5 mRNA expression
Salomonsson et al., Atherosclerosis 2003 : Together, these data suggest that oxLDL decreases VEGFR-1 expression in macrophages, probably through a PPARgamma dependent reduction in the AP-1 transcriptional activity
Welc et al., Am J Physiol Cell Physiol 2013 (Fever) : These studies demonstrate that IL-6 regulation in hyperthermia is directly controlled by HSF-1 and AP-1 signaling and that the IL-6 response in C2C12 myotubes is sensitive to categories of protein stress that reflect accumulation of damaged or unfolded proteins
Lim et al., Biochem Pharmacol 2011 : By using PP2, a pharmacological inhibitor for SFKs, we showed that Fyn kinase regulates B [ a ] PDE induced COX-2 expression by activating MAPKs, AP-1 and NF-?B
Mattson et al., Int J Hyperthermia 2004 : Heat shock and the activation of AP-1 and inhibition of NF-kappa B DNA binding activity : possible role of intracellular redox status ... Gel electromobility shift assays ( EMSA ) demonstrated that heat shock induced AP-1 DNA binding activity but inhibited IR-induced activation of NF-kappa B
Zhong et al., Biochem Biophys Res Commun 2004 : COBRA1 inhibits AP-1 transcriptional activity in transfected cells
Nagashima et al., J Biol Chem 2011 (Ataxia) : CRMP5 associated GTPase (CRAG) protein protects neuronal cells against cytotoxicity of expanded polyglutamine protein partially via c-Fos dependent activator protein-1 activation ... Here we report that CRAG, but not centaurin-?3, induces transcriptional activation of c-Fos dependent activator protein-1 (AP-1) via serum response factor (SRF) ... Taken together, these results demonstrated that CRAG enhances the cell survival signal against the accumulation of unfolded proteins, including polyQ, through not only proteasome activation, but also the activation of c-Fos dependent AP-1
Tuyt et al., Br J Haematol 1996 : Since AP-1 has been suggested as negative regulator of the IL-6 gene expression, it is conceivable that, after priming with IL-3, the reduced DNA binding activity of AP-1 , in conjunction with the increased DNA binding of NF-IL6, might result in a synergistic effect on IL-6 mRNA expression, when compared to stimulation with LPS alone
Zhu et al., Int J Biochem Cell Biol 2012 (Bone Resorption) : The RANKL stimulated mRNA expression of osteoclast related genes and transcription factors were also diminished by ISL. Mechanistically, ISL blocked the RANKL triggered RANK-TRAF6 association, phosphorylation of mitogen activated protein kinases ( MAPKs ), inhibitor of ?Ba ( I?Ba ) phosphorylation and degradation, nuclear factor-?B ( NF-?B ) p65 nuclear translocation, as well as activator protein (AP)-1 activation ... The RANKL stimulated mRNA expression of osteoclast related genes and transcription factors were also diminished by ISL. Mechanistically, ISL blocked the RANKL triggered RANK-TRAF6 association, phosphorylation of mitogen activated protein kinases ( MAPKs ), inhibitor of ?Ba ( I?Ba ) phosphorylation and degradation, nuclear factor-?B ( NF-?B ) p65 nuclear translocation, as well as activator protein (AP)-1 activation
Kiemer et al., Endocrinology 2003 : Cotreatment of the cells with U0126 or SP600125, as well as reporter gene assays revealed the involvement of AP-1/JNK activation in HO-1 induction
Rohrbach et al., Mol Med 2007 (Heart Failure) : Activation of AP-1 contributes to the beta-adrenoceptor mediated myocardial induction of interleukin-6
Chen et al., J Biol Chem 1999 : This AP-1 activation was completely blocked by PD 098059, a specific mitogen activated protein kinase/ERK kinase inhibitor, as well as by a dominant negative JNK or a dominant negative Jun , indicating that the AP-1 activation induced by 1,25 ( OH ) ( 2 ) D ( 3 ) was mediated by ERK and JNK ... This AP-1 activation was completely blocked by PD 098059, a specific mitogen activated protein kinase/ERK kinase inhibitor, as well as by a dominant negative JNK or a dominant negative Jun, indicating that the AP-1 activation induced by 1,25 ( OH ) ( 2 ) D ( 3 ) was mediated by ERK and JNK ... Using a specific inhibitor of the Ca ( 2+ ) -dependent PKC isoforms, Gö6976, and CaCo-2 cells stably transfected with antisense PKC-alpha cDNA, demonstrated that PKC-alpha mediated the AP-1 activation induced by this secosteroid
Stanley et al., Biochem Biophys Res Commun 2005 (Neovascularization, Pathologic...) : These effects are caused by the inhibition of constitutively active AP-1 in prostate cancer cells, resulting in the down-regulation of secretion of VEGF and TGF-beta1 from PC-3 cells ... These effects are caused by the inhibition of constitutively active AP-1 in prostate cancer cells, resulting in the down-regulation of secretion of VEGF and TGF-beta1 from PC-3 cells
Gao et al., J Biol Chem 2009 (Esophageal Neoplasms...) : Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells
Gupta et al., J Biol Chem 1999 : Our results demonstrated that : ( i ) PGN induced phosphorylation of the transcription factors ATF-1 and CREB; (ii) ATF-1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid, which was inhibited by dominant negative CREB and ATF-1 ; ( iii ) PGN induced phosphorylation of c-Jun , protein synthesis of JunB and c-Fos, and transcriptional activation of the AP-1 reporter plasmid, which was inhibited by dominant negative c-Fos ; and ( iv ) PGN induced activation of CREB/ATF and AP-1 was mediated through CD14
Griffiths et al., Biochem J 1998 : The activator protein-1 (AP-1) transcriptional complex is made up of members of the Fos ( c-Fos, FosB, Fra1, Fra2 ) and Jun ( c-Jun, JunB, JunD ) families and is stimulated by insulin in several cell types
Jia et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008 : Furthermore we found expression of dominant negative mutant of ERK and JNK impaired silica induced AP-1 activation, whereas, dominant negative mutant of p38 did not show the effect
Li et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008 : To study the role of activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 ) ... To study the role of activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 )
Kim et al., Biol Chem 2003 : Pyrrolidine dithiocarbamate ( PDTC ) has been shown to have unique reciprocal activities in activating AP-1 and inhibiting NF-kappaB , two oxidative stress-sensitive transcription factors
Abdul-Hafez et al., FASEB J 2009 : TGF-beta1-inducible AGT-LUC was reduced by an AP-1 dominant negative or by mutation of the AP-1 site
Rincón et al., EMBO J 1994 : The transcription factor AP-1 contributes significantly to the regulation of interleukin-2 gene transcription during T-cell activation and may play a role in thymocyte development
Böhm et al., Ann N Y Acad Sci 1999 : By use of electric mobility shift assays, we demonstrate that alpha-MSH ( 10 ( -6 ) to 10 ( -14 ) M ) activates AP-1 in human dermal fibroblasts, whereas coincubation with interleukin-1 beta (IL-1 beta) results in suppression of its activation
El Gazzar , Inflamm Res 2007 : Chromatin immunoprecipitation revealed that GATA, AP-1 and NF-AT binding to IL-5 promoter was induced by LPS stimulation and that TQ inhibited GATA binding at the IL-5 promoter but did not affect AP-1 and NF-AT binding ... Chromatin immunoprecipitation revealed that GATA, AP-1 and NF-AT binding to IL-5 promoter was induced by LPS stimulation and that TQ inhibited GATA binding at the IL-5 promoter but did not affect AP-1 and NF-AT binding
Kalariya et al., Exp Eye Res 2008 : Furthermore, CDA induced the activation of NF-kappaB and AP-1 which was significantly inhibited by NAC
Nicolaou et al., Blood 2003 (Leukemia, Hairy Cell) : Functional inhibition of AP-1 expressed by hairy cells reduced CD11c promoter activity by 80 %
Isono et al., Kidney Int 1998 : These results indicate that ANP is able to inhibit ET-1 induced activation of AP-1 by inhibiting both ERK and JNK, suggesting that ANP might be able to counteract the expression of AP-1 dependent genes induced by ET-1
Mackenzie et al., Free radical research 2006 (Neuroblastoma) : Consistent with this, LA and NAC prevented zinc deficiency induced activation of the early steps of NF- kappaB ( IkappaBalpha phosphorylation ) and AP-1 [ c-Jun-N-terminal kinase (JNK) and p38 phophorylation ] cascades, and the high NF-kappaB- and AP-1-DNA binding activities in total cell extracts
Chen et al., Eur J Pharmacol 2008 (MAP Kinase Signaling System) : We suggested that interfering with JNK mediated c-Jun phosphorylation and thus blocking AP-1 activation might contribute to the suppression effects of 8-prenylkaempferol on iNOS
Wehkamp et al., Infect Immun 2004 : NF-kappaB- and AP-1 mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917 : a novel effect of a probiotic bacterium ... Luciferase gene reporter analyses and site directed mutagenesis experiments demonstrated that functional binding sites for NF-kappaB and AP-1 in the hBD-2 promoter are required for induction of hBD-2 through E. coli Nissle 1917
Lee et al., J Cell Physiol 2013 (MAP Kinase Signaling System) : Site directed mutagenesis of the Smurf1 reporter and chromatin immunoprecipitation analysis demonstrated that the activating protein-1 (AP-1) binding motif at -922 bp on the mouse Smurf1 promoter mediated TNF-a/JNK/AP-1 stimulated Smurf1 transcription
McChesney et al., Cancer Res 2006 (Adenocarcinoma...) : Using several truncated mutants and site mutants of the TFF1 promoter, we have shown that COBRA1 can negatively regulate the activator protein-1 (AP-1) complex at the TFF1 promoter and thus down-regulate TFF1 expression in gastric cancer cell lines ... Using several truncated mutants and site mutants of the TFF1 promoter, we have shown that COBRA1 can negatively regulate the activator protein-1 (AP-1) complex at the TFF1 promoter and thus down-regulate TFF1 expression in gastric cancer cell lines
Toualbi et al., Oncogene 2007 : Promoter studies indicate that overexpression of AP-1 activates the transcription of two beta-catenin target genes, cyclin D1 and c-myc, by a mechanism independent of the AP-1 site, and fully dependent on the TCF binding site
Kim et al., PLoS Biol 2007 : We conclude that an inhibitory effect of AP-1 and STAT on NF-kappaB is required for properly balanced immune responses and appears to be evolutionarily conserved
Peto et al., J Gen Virol 1995 (Disease Progression...) : Mutating either AP-1 site in the complete enhancer decreases the EGF response, whereas a double mutation causes a complete loss of EGF regulation, suggesting that the EGF induction of HPV-16 early transcription requires AP-1 activation
Mukherjee et al., Chem Biol Interact 2008 : We observed that ERK and JNK, but not p38 MAP kinase, are involved in BPDE induced AP-1 activation
Farina et al., FEBS Lett 2012 (Neuroblastoma) : Constitutive autotaxin transcription by Nmyc amplified and non amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin
Yang et al., J Immunol 2010 : Moreover, BAFF activated transcription factor AP-1 for binding to IL-10 promoter
Koe et al., Calcif Tissue Int 1997 (Bone Neoplasms...) : Thus, it appears that the differential temporal stimulation of the AP-1 genes by PTH and PMA, particularly an increase in jun-B at the same time as c-fos and c-jun, explains the difference seen in their ability to induce transcription of collagenase
Yang et al., J Biol Chem 2003 (Carcinoma, Hepatocellular) : Tumor necrosis factor alpha (TNFalpha) , which activates both NF-kappa B and AP-1 , increased MAT2A expression in a dose- and time dependent manner, binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity, with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites ... In conclusion, both NF-kappa B and AP-1 are required for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF alpha treatment
Chen et al., J Biol Chem 2003 : HPO site directed mutants ( Cys/Ser ) at active sites, which lost sulfhydryl oxidase activity, could not increase c-Jun phosphorylation and failed to potentiate JAB1 mediated AP-1 activation
Lee et al., Cancer Res 2009 : Furthermore, inhibition of Tpl2 reduced the arsenite induced promoter activity of NF-kappaB and activator protein-1 (AP-1) , indicating that NF-kappaB and AP-1 are downstream transducers of arsenite triggered Tpl2
Gudi et al., J Environ Pathol Toxicol Oncol 2009 : Additionally, Siva-1 also suppressed the activity of another crucial transcription factor AP-1 , and a common mediator of both these pathways is the adaptor protein TRAF2
Lee et al., Biochem Biophys Res Commun 2011 (Breast Neoplasms...) : DHAvD also suppressed activation of mitogen activated protein kinase ( MAPK ), and MAPK mediated nuclear factor-kappa B ( NF-?B ) and activator protein-1 (AP-1) activations in TPA treated MCF-7 cells
Ramachandiran et al., Chem Res Toxicol 2002 : TGHQ increased AP-1 and NFkappaB DNA binding activity, but whereas pharmacological inhibition of ERK1/2 or p38 MAPKs attenuated AP-1 DNA binding activity, it potentiated TGHQ mediated NFkappaB activation
Hipp et al., Eur J Immunol 2002 : These results show that proteasome inhibitors can not only lead to functional AP-1 induction by enhanced c-Jun phosphorylation, but also transactivate the IL-8 gene in human endothelial cells despite complete suppression of NF-kappaB activity
Lee et al., Cell Growth Differ 1997 (Carcinoma, Non-Small-Cell Lung...) : Furthermore, the inhibitory effect of t-RA on AP-1 transcriptional activity was not restored in tumorigenic 11701 cells by transfection of c-fos, silencing mediator for retinoid and thyroid hormone receptors, Jun activation domain binding protein 1 , or CREB binding protein, suggesting the involvement of other transcriptional coregulators in this retinoid signaling defect ... Furthermore, the inhibitory effect of t-RA on AP-1 transcriptional activity was not restored in tumorigenic 11701 cells by transfection of c-fos, silencing mediator for retinoid and thyroid hormone receptors, Jun activation domain binding protein 1, or CREB binding protein , suggesting the involvement of other transcriptional coregulators in this retinoid signaling defect
Shimada et al., Carcinogenesis 2003 (Prostatic Neoplasms) : The results suggest that not only p53 induction through p38/JNK dependent NFkappaB/AP-1 activation but also JNK dependent Bcl-2 phosphorylation are required for 2-ME induced apoptosis ; moreover, inhibition of these pathways may be involved in androgen mediated resistance to apoptosis
Valente et al., Am J Physiol Heart Circ Physiol 2012 (Hyperplasia) : ANG II-induced superoxide generation, NF-?B and AP-1 activation, and IL-18 and MMP-9 induction were all markedly attenuated by losartan, diphenyleneiodonium chloride ( DPI ), and Nox1 knockdown ... ANG II-induced superoxide generation, NF-?B and AP-1 activation, and IL-18 and MMP-9 induction were all markedly attenuated by losartan, diphenyleneiodonium chloride ( DPI ), and Nox1 knockdown ... Similar to ANG II, addition of IL-18 also induced superoxide generation, activated NF-?B and AP-1 , and stimulated SMC migration and proliferation, in part via Nox1, and both ANG II and IL-18 induced NOX1 transcription in an AP-1 dependent manner ... Similar to ANG II, addition of IL-18 also induced superoxide generation, activated NF-?B and AP-1 , and stimulated SMC migration and proliferation, in part via Nox1, and both ANG II and IL-18 induced NOX1 transcription in an AP-1 dependent manner ... Similar to ANG II, addition of IL-18 also induced superoxide generation, activated NF-?B and AP-1, and stimulated SMC migration and proliferation, in part via Nox1, and both ANG II and IL-18 induced NOX1 transcription in an AP-1 dependent manner
Clarke et al., J Cell Biochem 2003 : Critical role of the transcription factor AP-1 for the constitutive and interferon induced expression of IFI 16
Vallejo et al., J Immunol 2000 (MAP Kinase Signaling System) : These results indicate that both NF-kappaB and AP-1 ( via p38 MAPK ) are involved in the regulation of TNF-alpha production in GBS stimulated neonatal monocytes
Muñoz et al., J Immunol 1996 : Taken together, these results indicate that the antioxidant PDTC induces transcriptional activation of ICAM-1 and that this induction is mediated at least in part by the transcription factor AP-1
Higa et al., PloS one 2012 : Adding bamboo extract ( BEX ) inhibited the effects of PA, reduced MCP-1 production, and inhibited nuclear translocation of NF-?B and AP-1 subunits ... Adding bamboo extract ( BEX ) inhibited the effects of PA, reduced MCP-1 production, and inhibited nuclear translocation of NF-?B and AP-1 subunits
Hornberg et al., Mol Biotechnol 2006 : EGF could not induce AP-1 activity or S-phase entry in density arrested cells, but could do so after pretreatment with retinoic acid, which enhances EGF receptor expression ... Our results support a model in which the EGF receptor regulates density dependent growth control in NRK fibroblasts, which is reflected by EGF induced mitogenic signaling and consequent AP-1 activity
Martin et al., Osteoarthritis Cartilage 2005 : IL-1beta enhanced both AP-1 and NF-kappaB binding, whereas H ( 2 ) O ( 2 ) only activated AP-1 ... IL-1beta enhanced both AP-1 and NF-kappaB binding, whereas H ( 2 ) O ( 2 ) only activated AP-1 ... The different regulation of NF-kappaB and AP-1 by H ( 2 ) O ( 2 ) and IL-1beta underlines the distinct roles played by the two transcription factors in the regulation of gene expression
Murata et al., Int J Mol Med 2005 (Arthritis, Rheumatoid...) : The findings indicate that HSP90 is required for increased AP-1 binding activity of rheumatoid synovial cells under inflammatory stimuli and that AP-1 binding activity is inhibited by functionally inactivating HSP90 with the inhibitors
Cataisson et al., J Immunol 2003 (Inflammation) : Chemokine expression and neutrophil migration are not diminished by inhibiting AP-1
Overman et al., Int J Obes Relat Metab Disord 2010 (Inflammation...) : We investigated the effect of GPE pretreatment on LPS mediated activation of mitogen activated protein kinases ( MAPKs ), nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1) , and induction of inflammatory genes in human MPhis ( that is, differentiated U937 cells ) ... Grape powder extract also attenuated LPS activation of MAPKs, NF-kappaB and AP-1 ( c-Jun ), as evidenced by decreased ( 1 ) phosphorylation of c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 ; ( 2 ) degradation of IkappaBalpha and activation of an NF-kappaB reporter construct ; and ( 3 ) phosphorylation of c-Jun and Elk-1
Luo et al., Chin Med J (Engl) 2002 : A decrease in the expression of c-Fos on the 1st and 4th day after trauma had no significant effect on c-Jun expression ; the increase in expression of JunB was only on the 1st day after injury ... Decreased IL-2 expression is, at least in part, due to a decline in the activation of NFAT and AP-1 in traumatized mice ... The decline in DNA binding activity of NFAT and AP-1 is partly due to a trauma induced block in the expression of c-Fos
Rothenberger et al., Cell Mol Life Sci 2002 : Moreover, Ndelta25 inhibited WT LMP1 mediated induction of the transcription factors NF-kappaB and AP-1
Yang et al., Mol Ther 2003 (Myocardial Reperfusion Injury...) : These findings support the notion that both mitochondrial and cytoplasmic derived SOD induce changes in AP-1 and NF kappa B activity, creating an antiapoptotic microenvironment within cardiomyocytes that affords protection following I/R injury
Ju et al., Ann N Y Acad Sci 2006 : Role of mitogen activated protein kinases, NF-kappaB, and AP-1 on cerulein induced IL-8 expression in pancreatic acinar cells
Kim et al., J Immunol 2000 : EMSA using an AP-1-specific oligonucleotide demonstrated that IFN-gamma or LPS treatment increased the AP-1 binding activity
Parra et al., J Immunol 1998 : The role of Rel and activation protein-1 (AP-1) in IL-2 promoter activity in B7-1- and leukocyte function associated Ag-3 ( LFA. 3 ) -costimulated T cells has been evaluated
Seppänen et al., Acta Obstet Gynecol Scand 2008 (Carcinoma, Endometrioid...) : We were able to show that IFN-gamma, TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 ) ... We were able to show that IFN-gamma, TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 ) ... We were able to show that IFN-gamma , TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 )
Zhang et al., Carcinogenesis 2007 : Further investigation revealed that JNK1 mediated the nickel induced COX-2 expression in a c-Jun/AP-1 dependent manner
Liacini et al., Matrix Biol 2002 (Osteoarthritis, Hip) : These results suggest the involvement of MAPKs, AP-1 and NF-kappa B transcription factors in the IL-1 induction of MMPs in chondrocytes ... Inhibition of interleukin-1 stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
Wiejak et al., Cell Signal 2012 : The PKC inhibitors, GF-109203X, Gö-6983 and Ro-317549, were all found to inhibit AP-1 transcriptional activity, transcriptional activation of this minimal SOCS-3 promoter and SOCS-3 gene induction in HUVECs
Kim et al., Biol Pharm Bull 2007 (Atherosclerosis) : Pre-treatment of VSMCs with NQ304 ( 1-10 microM ) was found to significantly inhibit the 5 % FBS induced phosphorylations of ERK1/2 and Akt, the activation of AP-1 and the expression of c-fos ... Pre-treatment of VSMCs with NQ304 ( 1-10 microM ) was found to significantly inhibit the 5 % FBS induced phosphorylations of ERK1/2 and Akt , the activation of AP-1 and the expression of c-fos
Lee et al., J Immunol 2008 (Encephalitis) : Of interest, the negative effects of 15d-PGJ ( 2 ) on AP-1/specificity protein-1 signaling and the resulting inhibition of MCP-1 expression were mediated by MAPK phosphatase (MKP)-1 activity, which was induced by 15d-PGJ ( 2 ) in a peroxisome proliferator activated receptor independent manner ... Of interest, the negative effects of 15d-PGJ ( 2 ) on AP-1/specificity protein-1 signaling and the resulting inhibition of MCP-1 expression were mediated by MAPK phosphatase (MKP)-1 activity, which was induced by 15d-PGJ ( 2 ) in a peroxisome proliferator activated receptor independent manner
Ait-Ali et al., Mol Endocrinol 2004 : In addition, TNF-alpha increased the binding activity of activator protein-1 (AP-1) and stimulated transcription of a reporter gene containing AP-1-responsive elements in chromaffin cells
Yang et al., Pediatr Res 2002 (Hyperoxia) : These data suggest that the neonatal lung is relatively resistant to AP-1 activation and HO-1 induction by GSH perturbation
Zhao et al., J Biol Chem 2005 (Cell Transformation, Neoplastic) : The AP-1 stimulation appeared to be mediated by ERK but not JNK or p38 kinase ... Interestingly, 2-AG enhanced epidermal growth factor induced AP-1 DNA binding and cell transformation
Rui et al., Cardiovasc Res 2005 (Myocardial Reperfusion Injury) : An AP-1 `` decoy '' oligonucleotide prevented the induction of eNOS by EPO and reversed the beneficial effect of EPO ... An inhibitor of phosphatidylinostol 3 (PI3)-kinase prevented the nuclear translocation of AP-1 induced by EPO ... An inhibitor of phosphatidylinostol 3 (PI3)-kinase prevented the nuclear translocation of AP-1 induced by EPO ... This beneficial effect of EPO is mediated by eNOS derived NO via a PI3-kinase dependent activation of AP-1
Viedt et al., Arterioscler Thromb Vasc Biol 2000 : The study was performed to further characterize the role of ROS in Ang II-mediated MAP kinase activation and the regulation of the transcription factor activator protein-1 (AP-1) ... The results indicate that in VSMCs, Ang II activates MAP kinases and AP-1 through different pathways ; the results further suggest that ROS, generated by p22phox, mediate Ang II-induced JNK and p38 MAPK activation, which may contribute to the pathogenesis of atherosclerosis
Liao et al., Endothelium : journal of endothelial cell research 2000 : We have demonstrated that PDTC not only induced AP-1 binding and ICAM-1 expression by itself, but it also augmented AP-1 activation and ICAM-1 induction in low-dose IL-1alpha treated cells
Fukuchi et al., J Biol Chem 2004 : Stable expression of TAF7 in TAF7-deficient cells restored transport activity ( 55 % of CHO cells ), AP-1 gene transactivation ( 100 % of CHO cells ), and sensitivity to MGBG induced apoptosis
Mukhopadhyay et al., Toxicol Lett 2008 (MAP Kinase Signaling System) : TNF-alpha induces activating protein 1 (AP-1) activation via phosphorylation of mitogen activated protein kinases ( MAPKs )
Shih et al., Growth Factors 2001 : Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression ... The tyrosine kinase inhibitor genistein and AP-1 inhibitor curcumin significantly blocked TGF-beta induction of VEGF expression while SP-1 and MKK1 inhibitors did not
Andersen , Environ Health Perspect 2000 (Leiomyoma...) : However, estrogen did not induce myometrial cx43 gene transcription in vitro ; instead, it inhibited AP-1 induction of cx43 expression ... Results from an examination of pregnancy myometrial tissue support the concept that AP-1 activity is involved in the induction of myometrial cx43 expression at term and that suppression of ER-beta expression is needed for this induction
García et al., Ann Rheum Dis 2008 (Arthritis, Rheumatoid) : PARP inhibition reduced TNF induced JNK phosphorylation and AP-1 and NF kappaB binding activities were partially impaired by treatment with PARP inhibitors or by PARP-1 knockdown
Hsu et al., J Cell Physiol 2012 (Carcinoma, Hepatocellular...) : Inhibition of Sp1 and AP-1 activations by specific siRNAs blocked the uPA induced SDF-1 promoter activity and expression
Yamauchi et al., Fertil Steril 2004 (Endometriosis) : Electrophoretic mobility shift assay revealed that U0126 attenuated activator protein-1 (AP-1) activation induced by TNF-alpha ... These findings demonstrate that NF-kappaB and AP-1 activation is critical for TNF-alpha induced IL-6 expression in endometriotic stromal cells
Wang et al., J Cell Biochem 2009 (Orthostatic Intolerance) : A key role for AP-1 , but not NF-kappaB in the regulation of iNOS was shown ... These findings indicate that clinorotation upregulates iNOS in HUVECs by a mechanism dependent on suppression of AP-1 , but not NF-kappaB
Sylvester et al., Cell Physiol Biochem 2012 : These results suggest partial involvement of ERK-, p38-and JNK-MAPKs as well as AP-1 , ATF-2 and NF-?B transcription factors in IL-1 induced ADAMTS-4 in chondrocytes
Jiang et al., Oncogene 2001 (Stomach Neoplasms) : Functional p53 is required for triptolide induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells
Wang et al., Arterioscler Thromb Vasc Biol 2001 : In the present study, a regulated adenovirus expressing a dominant negative mutant of c-Jun ( TAM-67 ) was used to examine the role of AP-1 in the LDL induced ICAM-1 activation
Chang et al., Mol Cell Biol 1998 : We demonstrate in this report that overexpression of an activated form of Rho enhances AP-1 activity in Jurkat T cells in the presence of phorbol myristate acetate ( PMA ), but activated Rho ( V14Rho ) has little or no effect on NFAT, Oct-1, and NF-kappaB enhancer element activities under similar conditions ... The effect of Rho on AP-1 is independent of the mitogen activated protein kinase pathway, as a dominant negative MEK and a MEK inhibitor ( PD98059 ) did not affect Rho induced AP-1 activity
Wang et al., Cancer Res 2007 (Colonic Neoplasms) : Because of the important role of the activator protein-1 (AP-1) transcription factor in cancer cells, we examined possible effects of HINT1 on AP-1 transcription factor activity in SW480 cells transfected with an AP-1-luciferase reporter ... These results suggest that HINT1 inhibits AP-1 activity by binding to a POSH-JNK2 complex, thus inhibiting the phosphorylation of c-Jun
Dschietzig et al., Regul Pept 2009 : In AP-1-luciferase assays, relaxin and modified relaxin inhibited endotoxin induced activation of AP-1 , a transcription factor essentially involved in endotoxin signaling
Ashida et al., Biochem Pharmacol 2000 : Such effects of Mg2+ and ATP on AP-1 were blocked by heparin, indicating that CKII plays an important role in transducing the signal of TCDD into the nucleus
Hirota et al., Biochem Biophys Res Commun 2000 : Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-kappaB, AP-1 , and CREB activation in HEK293 cells ... Nucleoredoxin , glutaredoxin, and thioredoxin differentially regulate NF-kappaB, AP-1 , and CREB activation in HEK293 cells ... Nucleoredoxin, glutaredoxin , and thioredoxin differentially regulate NF-kappaB, AP-1 , and CREB activation in HEK293 cells ... We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB, AP-1 , and CREB activation induced by TNFalpha , PMA, and forskolin and by expression of signaling intermediate kinases, NIK, MEKK, and PKA in HEK293 cells
Vendrov et al., J Biol Chem 2010 (Atherosclerosis) : Thrombin induced CD44 expression is mediated by transcription factor AP-1 in a NADPH oxidase dependent manner ... Thrombin induced CD44 expression is mediated by transcription factor AP-1 in a NADPH oxidase dependent manner
Chen et al., Regul Toxicol Pharmacol 2011 : Taken together, CDP inhibits UVB induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production ... Taken together, CDP inhibits UVB induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production
Finch et al., J Cancer Res Clin Oncol 2002 (Cell Transformation, Neoplastic...) : JunB negatively regulates AP-1 activity and cell proliferation of malignant mouse keratinocytes
González et al., J Cell Biol 2000 : Our results show that glucocorticoids antagonize the TNF-alpha induced activation of AP-1 by causing the accumulation of inactive JNK without affecting its subcellular distribution
Heo et al., Toxicol In Vitro 2004 (Breast Neoplasms) : To test the effect of SNL glycoprotein on the DNA binding activities of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) , and nitric oxide ( NO ) production, these experiments were carried out using electrophoretic mobility shift assays ( EMSA ), western blot analysis, and the Griess method ... Results in this experiment showed that SNL glycoprotein inhibits 12-O-Tetra decanoylphorbol-13-acetate ( TPA ; 100 nM ) -induced DNA binding activities of NF-kappaB and AP-1 , and enhances NO production in MCF-7 cells
Langlet et al., Eur J Immunol 2010 : Similarly, dominant negative PKC-alpha repressed Pam ( 3 ) CSK ( 4 ) induced NF-kappaB- and AP-1-driven promoter activities in TLR2 expressing human embryonic kidney 293 T cells ... Similarly, dominant negative PKC-alpha repressed Pam ( 3 ) CSK ( 4 ) induced NF-kappaB- and AP-1-driven promoter activities in TLR2 expressing human embryonic kidney 293 T cells
Henrotin et al., Osteoarthritis Cartilage 2010 (Inflammation...) : Curcumin blocks IL-1beta induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3
Finnegan et al., J Immunol 1996 (Lymphoma, Large B-Cell, Diffuse) : In combination with TNF-alpha, IL-10 stimulated activating protein-1 (AP-1) and nuclear factor (NF)-kappa B binding activities and cooperated to increase HIV-1 steady-state mRNA levels and enhance long terminal repeat directed transcription through activation of the NF-kappa B binding sites, suggesting the IL-10 effect occurs at least in part at the transcriptional level
Dahan et al., Infect Immun 2002 (Escherichia coli Infections) : These findings demonstrate that ( i ) EHEC can induce in vitro a potent proinflammatory response by secretion of IL-8 and ( ii ) the secretion of IL-8 is due to the involvement of MAPK, AP-1 , and NF-kappaB signaling pathways
You et al., FEMS Immunol Med Microbiol 2008 : The DNA binding activity of NF-kappaB and AP-1 was also assessed by an electrophoretic mobility gel shift assay, and an NF-kappaB specific inhibitor, pyrrolidine dithiocarbamate, profoundly inhibited the synthesis and production of the proinflammatory cytokines
Takada et al., J Biol Chem 2004 : PTD-p65-P1 had no effect on TNF induced AP-1 activation ... PTD-p65-P1 had no effect on TNF induced AP-1 activation
O'Neill et al., Arch Biochem Biophys 2011 : Taken together, our findings suggest that c-Jun/AP-1 signaling may, in part, regulate serum induced human nCDase gene transcription
Tseng et al., PloS one 2013 : On the other hand, IL-1ß induced c-Jun and c-Fos mRNA expression, c-Jun phosphorylation, and AP-1 promoter activity ... Pretreatment with U0126 or SP600125 inhibited IL-1ß induced AP-1 and NF-?B promoter activity, but not NF-?B translocation from the cytosol into the nucleus ... These results suggested that NF-?B and AP-1 activated by JNK1/2 and p42/p44 MAPK cascade are involved in IL-1ß induced MMP-9 expression in SIRCs
Yang et al., Oncogene 2001 (Cell Transformation, Neoplastic) : A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation ... A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation
Shyu et al., J Biomed Sci 2009 : The gel shift and promoter activity assay showed that TNF-alpha increased AP-1 binding activity and resistin promoter activity, while SP600125 and atorvastatin inhibited the AP-1 binding activity and resistin promoter activity induced by TNF-alpha
Li et al., Toxicol Mech Methods 2009 (Silicosis) : Dominant negative mutant c-Jun ( TAM67 ) inhibited silica induced AP-1 DNA binding activity and downregulated the TNF-alpha and TGF-beta1 expression
Tsou et al., Toxicol Appl Pharmacol 2007 : We also demonstrated that intracellular glutathione does not modulate the activation of MAPKs and/or their downstream AP-1 induced by lower TNF-alpha ... Although AP-1 activation by the lower TNF-alpha was not detected in our systems, we could not rule out the possible involvement of transiently activated MAPKs/AP-1 in the regulation of TNF-alpha induced adhesion molecule expression
Nadori et al., Hepatology 1997 : We therefore compared in primary and transformed rat hepatocytes ( 1 ) the composition of AP-1 dimers under basal conditions and ( 2 ) AP-1 induction by epidermal growth factor (EGF) ... In both cell types, activation of AP-1 DNA binding activity by EGF was accompanied by the recruitment of Fra-1 into AP-1, detected earlier in 7777 cells than in hepatocytes, and with the transient appearance of c-Fos in 7777 cells only
Theuer et al., Kidney Int 2005 : EPA treatment reduced activator protein-1 (AP-1) activation and partially inhibited nuclear factor-kappaB (NF-kappaB) activity in kidneys of dTGR
Chapman et al., J Biol Chem 1999 : Moreover, phorbol esters were a much more potent inducer of collagenase-CAT gene transcription than insulin, a difference that may be explained by selective effects of insulin and phorbol esters on AP-1 expression
Rao et al., J Biol Chem 2004 (Breast Neoplasms...) : hCG treatment prevented the tumor necrosis factor dependent NF-kappaB and AP-1 activation, which paralleled a decrease in the phosphorylation and degradation of IkappaBalpha
Ye et al., Eur J Biochem 2000 (Choriocarcinoma...) : Taken together, it is concluded that okadaic acid induces the expression of p100 RasGAP protein in JEG-3 cells preceded by activation of ERK and AP-1 cascade, and that this okadaic acid induced p100 RasGAP expression is independent of protein kinase C-mediated pathway but requires c-Jun/AP-1 function ... Taken together, it is concluded that okadaic acid induces the expression of p100 RasGAP protein in JEG-3 cells preceded by activation of ERK and AP-1 cascade, and that this okadaic acid induced p100 RasGAP expression is independent of protein kinase C-mediated pathway but requires c-Jun/AP-1 function
Yan et al., J Biol Chem 2001 (Neoplasm Invasiveness) : Although MMP-9 expression is regulated by AP-1 , Sp1, and Ets transcription factors, KiSS-1 did not alter the binding of these factors to the MMP-9 promoter
Kagami et al., J Cell Physiol 2004 (Glomerulonephritis) : PDGF-BB enhanced not only gel contraction but ERK phosphorylation and AP-1 activity by MCs ... Marked inhibitory effects on PDGF-BB induced gel contraction and ERK/AP-1 activity were observed in the presence of either function blocking anti-alpha1- or anti-beta1-integrin antibody or U0126
Ma et al., Cancer Res 2007 (Carcinoma, Basal Cell...) : Inhibition of GSK3beta activation significantly stimulated activator protein-1 (AP-1) activity
Chen et al., Oncogene 2006 (Multiple Myeloma) : We found that siRNA targeting the TRAF6 C-terminal ( siTRAF6C ) receptor interaction domain specifically reduced only TRAF6 protein expression, without affecting TRAF2 or 5 levels, and substantially interfered with IL-1 induced NF-kappaB and c-Jun/AP-1 activation
Yoshizaki , Histol Histopathol 2002 (Carcinoma...) : LMP-1 down-regulates expression of E-cadherin, induces matrix metalloproteinase-9 and urokinase type-plasminogen activator through activation of NF-kappaB and AP-1 , and enhances cell motility via ets-1 activation ... LMP-1 down-regulates expression of E-cadherin, induces matrix metalloproteinase-9 and urokinase type-plasminogen activator through activation of NF-kappaB and AP-1 , and enhances cell motility via ets-1 activation
Seppänen et al., Eur J Endocrinol 2000 (Cystadenocarcinoma...) : The binding activity of AP-1 was found to be stimulated by the growth inhibitory cytokines, TGF-beta1 and TNF-alpha, and the binding of NF-kappaB was stimulated by TNF-alpha
Yang et al., Biochem Pharmacol 2013 : c-Src dependent MAPKs/AP-1 activation is involved in TNF-a induced matrix metalloproteinase-9 expression in rat heart derived H9c2 cells ... Finally, we showed that, in H9c2 cells, TNF-a stimulated AP-1 promoter activity, c-Jun mRNA expression, and c-Jun phosphorylation were attenuated by PP1 , AG1478, AG1296, LY294002, SB202190, SP600125, or U0126 ... Finally, we showed that, in H9c2 cells, TNF-a stimulated AP-1 promoter activity, c-Jun mRNA expression, and c-Jun phosphorylation were attenuated by PP1, AG1478, AG1296, LY294002, SB202190, SP600125, or U0126
Tili et al., Carcinogenesis 2010 : We further establish that the downregulation of AP-1 activity by resveratrol is miR-663 dependent and that the effects of resveratrol on both AP-1 activity and JunB levels are dose dependent
Das et al., Am J Physiol 1995 : AP-1 activation was inhibited by catalase ( 500 U/ml ) plus SOD plus ethanol ( 1 mM ) ... AP-1 activation was inhibited by catalase ( 500 U/ml ) plus SOD plus ethanol ( 1 mM )
Park et al., Phytother Res 2010 : Further study demonstrated that glabridin inhibited LPS induced DNA binding activity of NF-kappaB and AP-1 in BV-2 cells
Fu et al., Cell 2005 : Partially antagonizing this inhibitory loop, leptin also upregulates AP-1 gene expression, which promotes cyclin D1 expression, osteoblast proliferation, and bone formation
García-Lora et al., Cancer Immunol Immunother 2001 : Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5 ... Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5 ... Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE , IRF-1 and STAT5 ... Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5 ... Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5 ... Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5
Yoshida et al., J Pharmacol Sci 2008 (Gastroenteritis...) : PAR(2) activation in human esophageal epithelial cells by trypsin induces NFkappaB- and AP-1 dependent IL-8 production in association with activation of p38 MAPK and ERK1/2, suggesting that esophageal inflammation may be induced by PAR(2) activation via reflux of trypsin
Chen et al., J Biol Chem 2001 (Cell Transformation, Neoplastic) : Egfr gene deficiency blocked TPA induced ERK activity and AP-1 binding activity
Lee et al., Dev Biol 2001 : In 10.5 day limb cells, gas1 overexpression had little effect on Ap-1 , NFkappaB, and c-myc activities ... In contrast, gas1 overexpression in 12.5 day limb cells enhanced AP-1 response while it inhibited NFkappaB and c-myc activities ... In contrast, gas1 overexpression in 12.5 day limb cells enhanced AP-1 response while it inhibited NFkappaB and c-myc activities
Gough et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Herein we have shown that IFNgamma rapidly activated AP-1 DNA binding that required c-Jun but was independent of JAK1 and STAT1 ... Herein we have shown that IFNgamma rapidly activated AP-1 DNA binding that required c-Jun but was independent of JAK1 and STAT1 ... IFNgamma induced c-Jun phosphorylation and AP-1 DNA binding required the MEK1/2 and ERK1/2 signaling pathways, whereas the JNK1/2 and p38 mitogen activated protein kinase pathways were dispensable ... Thus, IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun, and activation of AP-1 DNA binding, which are important for the induction of a subset of ISGs ... Thus, IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun, and activation of AP-1 DNA binding, which are important for the induction of a subset of ISGs ... Thus, IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun, and activation of AP-1 DNA binding, which are important for the induction of a subset of ISGs ... Thus, IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun , and activation of AP-1 DNA binding, which are important for the induction of a subset of ISGs ... Thus, IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun, and activation of AP-1 DNA binding, which are important for the induction of a subset of ISGs
Los et al., Biochem J 1994 : Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells
Meldrum et al., J Biol Chem 2012 (Fibrosis...) : TLR4 promotor activity, as well as AP-1 activation and the effect of AP-1 knockdown on TLR4 expression, was evaluated in HK-2 cells in response to IL-18 stimulation
Choi et al., J Cell Biochem 2007 : In summary, our results indicate that iron chelator induced IL-8 generation in IECs involves activation of ERK1/2 and p38 kinase and downstream activation of AP-1 ... In summary, our results indicate that iron chelator induced IL-8 generation in IECs involves activation of ERK1/2 and p38 kinase and downstream activation of AP-1
Shah et al., Int J Cancer 2006 (Colonic Neoplasms) : Ursodeoxycholic acid inhibits interleukin 1 beta [ corrected ] and deoxycholic acid induced activation of NF-kappaB and AP-1 in human colon cancer cells ... UDCA did not increase DNA binding of NF-kappaB and AP-1 and UDCA pretreatment inhibited DCA induced NF-kappaB and AP-1 DNA binding
Galdiero et al., Infect Immun 2002 (MAP Kinase Signaling System) : PD-098059 pretreatment of cells decreases AP-1 and NF-kappaB activation by lipopolysaccharide (LPS) but not by porins, and SB203580 pretreatment of cells decreases mainly AP-1 and NF-kappaB activation by porins ; in contrast, forskolin pretreatment of cells does not affect AP-1 and NF-kappaB activation following either porin or LPS stimulation
Fürst et al., J Pharmacol Exp Ther 2006 (MAP Kinase Signaling System) : By applying activator protein-1 (AP-1) decoys, it was shown that the transcription factor AP-1 is crucially involved in the up-regulation of HO-1 downstream of JNK
Okada et al., Int Immunol 2003 : Since introduction of a double mutation into the two AP-1 binding sites in the iNOS promoter region reduced the promoter activity to 25 % of the authentic one in activated RAW264 cells, the induced c-Fos/AP-1 may promote iNOS expression in activated macrophages
Cripe et al., New Biol 1990 : Each AP-1 site as well as a third AP-1 site near the promoter bound c-Jun and Jun/Fos in vitro, and was activated by c-Jun and c-Fos in transfections
Oliver et al., J Rheumatol 2007 (Arthritis, Experimental...) : We evaluated whether a vanadium AP-1 inhibitor could reduce MMP expression and subsequent joint damage in CIA
Da Costa et al., Mol Cell Biol 2010 (MAP Kinase Signaling System...) : Chromatin immunoprecipitation experiments revealed binding of Bag1-L to the promoters of proapoptotic AP-1 target genes, and overexpression of Bag1-L augmented cell death in primary neurons
Lauricella et al., Apoptosis 2006 (Liver Neoplasms) : Interestingly, siRNA silencing of c-Jun or JNK1 reduced HepG2 cell susceptibility to apoptosis and prevented the increase in AP-1 activity
Park et al., Arch Pharm Res 2009 : In contrast, SnPP treatment did not reverse YL-I-108 mediated suppression of AP-1 activation, suggesting that AP-1 inhibition by YL-I-108 is independent of HO-1 induction
Faubert Kaplan et al., Int Immunopharmacol 2003 : This decrease in IL-2 was due to inhibition of activator protein-1 (AP-1) and nuclear factor of activated T cells ( NF-AT ) transcription factors, both of which depend on proteins that are regulated by the extracellular signal regulated kinase subgroup of the mitogen activated protein kinases ( ERK MAPK )
Zeigler et al., J Cell Physiol 1999 : This evidence suggests that while ERK and JNK activity are necessary for AP-1 activation, ERK but not JNK is sufficient in stimulating cell motility
Shi et al., J Interferon Cytokine Res 1999 (Adenocarcinoma...) : Deletion and point mutation analyses of the IL-8 promoter revealed that both AP-1 and NF-kappaB binding sites were necessary for IL-8 induction by hypoxia
Unlap et al., Biol Psychiatry 1997 : Lithium attenuates nerve growth factor induced activation of AP-1 DNA binding activity in PC12 cells ... NGF induced large, time dependent increases in AP-1 DNA binding activity ... Pretreatment with 5 mmol/L lithium for 24 h reduced AP-1 induction by NGF by 42 % ; shorter treatments and lower concentrations of lithium had smaller inhibitory effects on AP-1
Lee et al., J Ethnopharmacol 2009 : Moreover, inhibition of LPS induced iNOS expression by BV was dependent on transcriptional activities of AP-1/NF-kappaB through MEK/ERK pathway
Di Simone et al., Haematologica 1997 (Multiple Myeloma...) : Our results seem to confirm a possible role of the transcriptional complex AP-1 in activating GST-pi promoter in human plasma cells
Abdel-Malak et al., Blood 2008 : Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1 dependent autocrine production of interleukin-8
West et al., J Cell Biol 1997 : Surprisingly, however, neither PLD nor neomycin has any effect on the recruitment of AP-1 adaptors onto the TGN, even though AP-1 recruitment is ARF mediated
Feinberg et al., Circ Res 2004 (Hyperplasia...) : We demonstrate that the inhibitory effect of Smad3 occurs via a novel antagonistic effect of Smad3 on AP-1 DNA-protein binding and activity
Cuevas et al., Oncogene 2005 : Both FGF-2 and phorbol ester-inducible urokinase-type plasminogen activator ( uPA ) expression requires AP-1 binding to an enhancer element in the uPA promoter, and we have previously shown that FGF-2 or PMA induction of uPA expression is strongly dependent on MEKK1 ... Both FGF-2 and phorbol ester-inducible urokinase-type plasminogen activator ( uPA ) expression requires AP-1 binding to an enhancer element in the uPA promoter, and we have previously shown that FGF-2 or PMA induction of uPA expression is strongly dependent on MEKK1
Onyeagucha et al., Exp Cell Res 2013 (Colonic Neoplasms) : Altogether, these data demonstrate that the expression of miR-155 is regulated by S100P and is dependent on RAGE activation and stimulation of AP-1 ... Altogether, these data demonstrate that the expression of miR-155 is regulated by S100P and is dependent on RAGE activation and stimulation of AP-1
Oda et al., J Immunol 2002 : While AP-1 is involved in regulating the IL-1alpha induced expression of IL-8, but not MCP-1 , alprazolam potentiated the binding of c-Jun/c-Fos to the AP-1 oligonucleotide probe ... While AP-1 is involved in regulating the IL-1alpha induced expression of IL-8 , but not MCP-1, alprazolam potentiated the binding of c-Jun/c-Fos to the AP-1 oligonucleotide probe ... These results show that the inhibition of IL-1alpha mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha mediated activation of NF-kappaB ( p50/p65 ) or AP-1 ( c-Jun/c-Fos ) binding to the IL-8 promoter region
Singh et al., Arterioscler Thromb Vasc Biol 2006 : These studies reveal a novel role for JNK, p38 kinase, CK2, and c-Jun/AP-1 in the TGF-beta induced expression of apoE
Legendre et al., Clin Exp Rheumatol 2007 : The drug reduced IL-1Beta induced NF-kappaB and AP-1 DNA binding, as well as the phosphorylation of ERK and JNK
Lin et al., Cell Signal 2009 : These results suggested that in A549 cells, the activation of p42/p44 MAPK, p38 MAPK, JNK1/2, NF-kappaB, and AP-1 are essential for the IL-1 beta induced MMP-9 gene expression and cell migration
Tsou et al., Toxicol Appl Pharmacol 2005 : On the other hand, the TNF-alpha induced VCAM-1 expression could be completely abolished by inhibition of AP-1 or NF-kappaB activity, suggesting that activation of both AP-1 and NF-kappaB was necessary for VCAM-1 expression
Fahmi et al., Osteoarthritis Cartilage 2002 : Interestingly, 15d-PGJ ( 2 ) reduced both basal and IL-1beta induced AP-1 binding activity
Wu et al., Ann N Y Acad Sci 2004 (Inflammation) : Induction of serine racemase by inflammatory stimuli is dependent on AP-1
Waetzig et al., Glia 2005 (Encephalitis...) : The function of JNKs in LPS triggered cellular reactions was investigated using SP600125 ( 0.5-5 microM ), a direct inhibitor of JNKs. Inhibition of JNKs reduced the LPS induced metabolic activity and induction of the AP-1 target genes cyclooxygenase-2 (Cox-2), TNF-alpha, monocyte chemoattractant protein-1 ( MCP-1 ), and interleukin-6 (IL-6) in response to LPS , while ERK1/2 and p38 alpha had a more pronounced effect on LPS induced cellular enlargement than JNKs
Nishita et al., Mol Cell Biol 2010 : Ror2/Frizzled complex mediates Wnt5a induced AP-1 activation by regulating Dishevelled polymerization ... Ror2 can associate with Frizzled7 (Fz7) via its extracellular cysteine-rich domain to form a receptor complex that is required for the regulation of Dvl and activation of the AP-1 promoter after Wnt5a stimulation ... We further show that polymerized Dvl is colocalized with Rac1 and that suppressed expression of Rac1 inhibits Wnt5a induced AP-1 activation ... We further show that polymerized Dvl is colocalized with Rac1 and that suppressed expression of Rac1 inhibits Wnt5a induced AP-1 activation
Ludwig et al., J Biol Chem 2001 (Influenza, Human) : Blockade of JNK signaling at several levels of the cascade by transient expression of dominant negative kinase mutants and inhibitory proteins resulted in inhibition of virus induced JNK activation, reduced AP-1 activity, and impaired transactivation of the IFN-beta promoter
Mou et al., J Biol Chem 2013 (Brain Neoplasms...) : Reporter gene assays indicated hHK-1 enhanced both AP-1 and NF-?B activity ; inhibition of ERK, JNK, and Akt dose-dependently suppressed the NF-?B activity ; only the inhibition of ERK significantly suppressed the AP-1 activity
Kim et al., Oncogene 1996 : In the absence of hormone, TAM-67ER produced complete inhibition of c-Jun induced AP-I transactivation
Wang et al., Kidney Int 2000 : These studies prove that NF-kappaB is critical for LPS induced MCP-1 transcription, and AP-1 and Sp1 are essential for basal expression of MCP-1 in rat tubule cells
Ediger et al., Eur Respir J 2003 (Cell Transformation, Neoplastic...) : LPA and EGF both activated activator protein (AP)-1 , cyclic adenosine monophosphate response element binding protein, nuclear factor of activated T-cells and the serum response element ; however, only AP-1 activation exhibited synergism ... LPA and EGF both activated activator protein (AP)-1 , cyclic adenosine monophosphate response element binding protein, nuclear factor of activated T-cells and the serum response element ; however, only AP-1 activation exhibited synergism
Wu et al., Cancer Lett 2007 (MAP Kinase Signaling System) : 1alpha,25-Dihydroxyvitamin D ( 3 ) antiproliferative actions involve vitamin D receptor mediated activation of MAPK pathways and AP-1/p21 ( waf1 ) upregulation in human osteosarcoma ... Specific blockade of MEK1/MEK2 cascade upstream from ERK1/2 abrogated 1,25D activation of AP-1 and p21, and subsequent antiproliferative effects, even in the presence of a nuclear VDR
Higuchi et al., Antioxid Redox Signal 2002 (Leukemia, Myeloid, Acute) : Additionally, tumor necrosis factor (TNF) induced activation of NF-kappaB and AP-1 observed in ML-1a was greatly reduced in clone 19
Ahmed-Choudhury et al., Mol Biol Cell 2003 : In hepatocytes, CD40 ligation led to sustained up-regulation of AP-1 activity > 24 h associated with increased protein levels of RelA ( p65 ), c-Jun, and c-Fos, whereas no induction of AP-1 activity was observed in IHECs
Romero-Prado et al., J Cell Biochem 2006 : In the absence of FBS and in the presence of insulin or prolactin, cells show cytoskeletal organization and an AP-1 transcription site activity resembling proliferative osteochondrocytes while cells in the presence of dexamethasone and added prolactin or TGF-beta resembled differentiated osteoblasts ... In the absence of FBS and in the presence of insulin or prolactin , cells show cytoskeletal organization and an AP-1 transcription site activity resembling proliferative osteochondrocytes while cells in the presence of dexamethasone and added prolactin or TGF-beta resembled differentiated osteoblasts
Higashi et al., Genes Cells 2004 (MAP Kinase Signaling System) : In contrast, concomitant stimulation of the STAT3 signal and a MEK/Erk-signal markedly increased AP-1 activity with enhanced c-Fos expression ... In contrast, concomitant stimulation of the STAT3 signal and a MEK/Erk-signal markedly increased AP-1 activity with enhanced c-Fos expression ... In contrast, concomitant stimulation of the STAT3 signal and a MEK/Erk-signal markedly increased AP-1 activity with enhanced c-Fos expression
Ziouzenkova et al., J Biol Chem 2003 (Inflammation) : Here we demonstrate that LDL ( - ) increases tumor necrosis factor alpha (TNFalpha) induced inflammatory responses through NF kappa B and AP-1 activation with corresponding increases in vascular cell adhesion molecule-1 ( VCAM1 ) expression ... LPL treated LDL ( - ) suppressed NF kappa B and AP-1 activation, increasing expression of the PPAR alpha target gene I kappa B alpha, although only in the genetic presence of PPAR alpha and with intact LPL hydrolysis
Tomita et al., Leuk Res 2006 (Leukemia-Lymphoma, Adult T-Cell) : Curcumin also inhibited HTLV-1 Tax induced AP-1 transcriptional activity
Kempiak et al., J Immunol 1999 : Dominant negative versions of JNK kinase, c-Jun, and IKK beta interfered In CD3- plus CD28 induced CD28RE/AP-1 luciferase activity in Jurkat cells
Freiss et al., J Steroid Biochem Mol Biol 2005 (Breast Neoplasms) : We have tested the effects of two Eli-Lilly compounds, LY 117, 018 and raloxifene, on E2-regulated and IGF-I induced proliferation or AP-1 activity in human breast cancer cells ... Moreover, raloxifene was the most efficient molecule to prevent IGF-I induced AP-1 activity, with a significant effect observed with a concentration as low as 5 x 10 ( -11 ) M in the presence of IGF-I alone
Ortiz et al., Am J Physiol Lung Cell Mol Physiol 2002 (Body Weight...) : Enalapril protects mice from pulmonary hypertension by inhibiting TNF mediated activation of NF-kappaB and AP-1
Tu et al., Cardiovasc Toxicol 2003 : Distinct roles of p42/p44 ( ERK ) and p38 MAPK in oxidant induced AP-1 activation and cardiomyocyte hypertrophy ... Distinct roles of p42/p44 ( ERK ) and p38 MAPK in oxidant induced AP-1 activation and cardiomyocyte hypertrophy ... Distinct roles of p42/p44 ( ERK ) and p38 MAPK in oxidant induced AP-1 activation and cardiomyocyte hypertrophy
Song et al., Sci China C Life Sci 2005 (Carcinoma...) : Epstein-Barr virus ( EBV ) encoded latent membrane protein 1 (LMP1) may trigger the transcription factor AP-1 including c-Jun and c-fos
Kajanne et al., J Cell Physiol 2007 : Here we provide genetic and biochemical evidence that EGF-R- and AP-1 mediated signals are required for MMP expression and collagen contraction in fibroblasts
Monick et al., J Biol Chem 1999 : There was, however, a significant difference in the amounts of the nuclear protein, REF-1 ( which regulates AP-1 DNA binding by altering the redox status of FOS and JUN proteins ), in alveolar macrophages compared with monocytes
Sakoda et al., J Dent Res 2006 : Dominant negative Rac1 severely inhibited interleukin-1alpha induced NF-kappaB and AP-1 promoter activity ... Dominant negative Rac1 severely inhibited interleukin-1alpha induced NF-kappaB and AP-1 promoter activity
Varghese et al., Endocrinology 2000 : bFGF stimulated the binding of nuclear factors to the collagenase AP-1 site by 3- to 4-fold, as determined by electrophoretic mobility shift assays
Malliri et al., J Cell Biol 1998 : Our data establish a novel link between AP-1 activity and EGFR activation of Rac and Rho , which in turn mediate the actin cytoskeletal rearrangements required for cell motility and invasion ... Our data establish a novel link between AP-1 activity and EGFR activation of Rac and Rho, which in turn mediate the actin cytoskeletal rearrangements required for cell motility and invasion
Rahman et al., FEBS Lett 1998 : Gel mobility shift and mutation analysis of the sequence ( -269 to -263 bp ), showed binding of AP-1 is involved in the oxidant mediated regulation of gamma-GCS-HS promoter activity
Bhanoori et al., Oncogene 2003 : Thiol alkylation inhibited PDGF-BB induced expression of the Fos and Jun family proteins and AP-1 activity in VSMC
Yeung et al., Nature 1999 (Cell Transformation, Neoplastic) : Downregulation of endogenous RKIP by expression of antisense RNA or antibody microinjection induces the activation of MEK-, ERK- and AP-1 dependent transcription
Lee et al., J Immunol 2006 : Our results suggest that IL-1beta stimulated transcription of TGF-beta1 is temporally regulated by NF-kappaB and AP-1 and involves histone hyperacetylation at distinct promoter sites
Liu et al., Molecular cancer 2009 (Nasopharyngeal Neoplasms) : These results suggest that human iE kappa is active in Ig kappa expressing NPC cells and LMP1 stimulated NF-kappaB and AP-1 activation results in an augmenting activation of the iE kappa
Cuschieri et al., Cell Immunol 2004 : Subsequently, LPS induced the degradation of IkappaB, and the nuclear activation of NF-kappaB and AP-1 ... Proteasome inhibition, also, led to increased LPS induced AP-1 activation, and attenuated LPS induced IkappaB degradation resulting in abolished NF-kappaB activation
Zheng et al., Leukemia 2004 (Leukemia, Erythroblastic, Acute...) : HQ also induces ERK dependent AP-1 activation with concomitant increased transcriptional activity of AP-1 reporter gene
Thiel et al., Endocrinology 2012 : The expression of a dominant negative mutant of Elk-1 reduced c-Fos expression and prevented the up-regulation of AP-1 activity as a result of calcium sensing receptor stimulation, indicating that ternary complex factors control both Egr-1- and AP-1 regulated transcription ... The expression of a dominant negative mutant of Elk-1 reduced c-Fos expression and prevented the up-regulation of AP-1 activity as a result of calcium sensing receptor stimulation, indicating that ternary complex factors control both Egr-1- and AP-1 regulated transcription
Butler et al., J Biol Chem 2006 : Elafin prevents lipopolysaccharide induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway ... In this report we have shown that elafin inhibits the lipopolysaccharide induced production of monocyte chemoattractant protein-1 in monocytes by inhibiting AP-1 and NF-kappaB activation ... Elafin prevented lipopolysaccharide induced phosphorylation of AP-1 , c-Jun, and JNK but had no effect on phosphorylation of p38
Raychaudhuri et al., Cytokine 2000 : AP-1 was not affected by IL-10
Paletzki et al., Neuroscience 2008 (Cocaine-Related Disorders) : We have expressed A-FOS , an inhibitor of activator protein-1 (AP-1) DNA binding, in adult mouse striatal neurons
Lv et al., PloS one 2011 : In this study, the role of p38 MAPK in AP-1 activation and in the EMT in the human proximal tubular epithelial cell line ( HK-2 ) under high glucose concentration conditions is investigated ... This study suggests that p38 MAPK may play an important role in the high glucose induced EMT by activating AP-1 in tubular epithelial cells
Fanjul et al., Cancer Res 1996 (Breast Neoplasms) : RAR-beta/gamma and anti-AP-1-selective retinoids, but not RAR-alpha-selective compounds, induced increased RAR-gamma mRNA levels
Kawakita et al., Biol Pharm Bull 2003 : The effect of inhibitors of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB) on the radiation induced gamma-GCS gene expression was then examined
Pérez-Sala et al., J Biol Chem 2003 : Here we show that 15d-PGJ2 covalently modifies c-Jun and directly inhibits the DNA binding activity of AP-1
Kida et al., Immunology 2002 : We previously reported that inducible granulysin gene expression in a human monocytic cell line, THP-1 is dominantly dependent on transcription factor activator protein-1 (AP-1)
Lee et al., Cancer Lett 2007 (Colonic Neoplasms) : The results obtained from electrophoretic mobility shift assay ( EMSA ) and Western blot analysis showed that UDN glycoprotein blocks the DNA binding activities of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) , and attenuates the activities of NF-kappaB subunits ( p50 and p65 ), and AP-1 subunits ( c-Jun and c-Fos ), respectively
Cuschieri et al., J Surg Res 2004 : Subsequently, LPS induced the activation of NF-kappaB and AP-1
Budagian et al., J Biol Chem 2003 : ATP failed to stimulate the phosphorylation of ERK and c-Jun N-terminal kinase and activation of AP-1 in the p56 ( lck ) -deficient isogenic T cell line JCaM1, suggesting a critical role for p56 ( lck ) kinase in downstream signaling
Morel et al., J Biol Chem 2002 (Arthritis, Rheumatoid...) : Electrophoretic mobility shift assay showed that activator protein-1 (AP-1) is activated by IL-18 through ERK and Src but not through PI3-kinase
Feng et al., Mol Cell Biol 2002 (Neuroblastoma) : Our results show that c-Jun/AP-1 , through up-regulation of NCAM140, plays an important role in both NGF induced neuronal differentiation and resistance to apoptosis induced by NO in neuroblastoma cells
Jin et al., Dev Biol 2013 : Second, MAP3K1 potentiated AP-2a expression and SRF and AP-1 activity, but its target genes were enriched for binding motifs of AP-2a and SRF, and not AP-1, suggesting the existence of novel MAP3K1-AP-2a/SRF modules in gene regulation ... Second, MAP3K1 potentiated AP-2a expression and SRF and AP-1 activity, but its target genes were enriched for binding motifs of AP-2a and SRF, and not AP-1, suggesting the existence of novel MAP3K1-AP-2a/SRF modules in gene regulation
Abreu-Martin et al., Am J Physiol 1999 : Signaling via Fas receptor, as determined by induction of c-Jun NH2-terminal kinase (JNK) activity and transcriptional activation of AP-1 , is enhanced in IFN-gamma primed cells ... Signaling through Fas results in activation of JNK and AP-1 binding activity that is increased in the presence of IFN-gamma
Jansen et al., Oncogene 1999 (Cell Transformation, Neoplastic) : By utilizing the JB6 mouse epidermal cell system, the present study determined whether TPA induced ODC gene expression and activity is independent of AP-1 transactivation ... Taken together, the results presented indicate that TPA induced ODC gene expression and activity are independent of AP-1 transactivation
Yoshizaki et al., Proc Natl Acad Sci U S A 1998 (Cell Transformation, Neoplastic...) : Here we report that binding sites for NF-kappaB, SP-1, and AP-1 also contribute to induction of the MMP9 promoter by the viral protein, LMP1, mainly through the NF-kappaB and, to a lesser extent, the SP-1 and AP-1 sites
Jung et al., Int Immunopharmacol 2010 : Inhibition of these inflammatory mediators appears to be at the transcriptional level, since diosgenin decreased LPS/IFN-gamma induced NF-kappaB and AP-1 activity ... Inhibition of these inflammatory mediators appears to be at the transcriptional level, since diosgenin decreased LPS/IFN-gamma induced NF-kappaB and AP-1 activity
Camandola et al., J Neurosci Res 2000 : Par-4 overexpression or functional blockade had no effect on AP-1 DNA binding activity
Coudronniere et al., Proc Natl Acad Sci U S A 2000 : Fourth, CD3/CD28 induced CD28RE/AP-1 activation and NF-kappaB nuclear translocation were blocked by a selective PKCtheta inhibitor
Samson et al., Surgery 2002 : Dual adenoviral infection with Ad5aTGF-beta1 and a dominant negative c-Jun ( Ad5TAM67 ) decreased AP-1 induced Ad5Luc activity but not hepatocyte apoptosis ( 46 % with dominant negative c-Jun and 47 % without )
Suda et al., Oral Microbiol Immunol 2009 : Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha stimulated periodontal ligament cells ... The purpose of this study was to examine the roles of beta-catenin and AP-1 in interleukin-1alpha (IL-1alpha) -induced OPG production in human gingival fibroblasts ( hGFs ) and periodontal ligament ( PDL ) cells ... The effect of the Wnt canonical pathway on OPG production was evaluated using small interfering ( si ) RNA for beta-catenin and the effect of AP-1 on OPG production was evaluated using the AP-1 inhibitor curcumin
Reddy et al., Proc Soc Exp Biol Med 1998 : These data reveal that collagenase gene expression can be regulated by the impairment of IL-1 stimulated NF-kappaB, STAT3, and AP-1 activities, and can highlight a possible molecular mechanism for the anti-inflammatory effects of glucocorticoids
Soh et al., J Biol Chem 2003 : A dominant negative mutant of c-Jun inhibited activation of the cyclin D1 promoter in a concentration dependent manner, providing further evidence that AP-1 activity is required for activation of the cyclin D1 promoter by PKC-alpha and PKC-epsilon ... A dominant negative mutant of c-Jun inhibited activation of the cyclin D1 promoter in a concentration dependent manner, providing further evidence that AP-1 activity is required for activation of the cyclin D1 promoter by PKC-alpha and PKC-epsilon
Rensing et al., Crit Care Med 2001 (Disease Models, Animal...) : Thus, AP-1 dependent HO-1 induction under oxidative stress conditions may subserve a similar function as a stress-inducible vasodilator system as does NF-kappaB dependent iNOS expression in liver inflammation
Shau et al., Biochem Biophys Res Commun 1998 : Tumor necrosis factor-alpha (TNF) activates the expression of activator protein-1 (AP-1) responsive genes ... We show here that over-expression of TxP-1 blocks TNF induced AP-1 activation in endothelial ECV304 cells, which was demonstrated by three independent experimental protocols : electromobility shift assay with AP-1 oligonucleotide probe ; reporter gene expression with AP-1 binding site, and interleukin-8 production, which is dependent on AP-1
Furukawa et al., J Neurosci Res 1998 : Induction of DNA binding activity of the transcription factor AP-1 by NGF was markedly suppressed in cells expressing mutant PS-1
Hu et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2007 : To investigate the role of AP-1 in the secretion of Type I collagen in TGF-beta1 stimulated human lung fibroblasts
Marban et al., Retrovirology 2012 : In addition, when Tax2 and APH-2 are co-expressed, they physically interact in vivo and in vitro and APH-2 acts as an inhibitor of Tax2 mediated activation of AP-1 transcription ... Altogether our results reveal that, in contrast with HBZ, APH-2 regulates AP-1 activity in a Tax2-dependant manner
Oiry et al., Mol Pharmacol 1997 : To confirm that CCK ( B ) receptors are involved in AP-1 response, we investigated the CCK-8 effect on interleukin-2 expression, a natural endogenous gene regulated by several factors, including AP-1
Wang et al., FEBS Lett 2004 : Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity
Das et al., J Biol Chem 2004 (Breast Neoplasms...) : However, the role ( s ) of OPN on AP-1 mediated uPA secretion and cell motility and the involvement of c-Src/epidermal growth factor receptor (EGFR) in these processes in breast cancer cells are not well defined ... Furthermore, OPN induces alpha(v)beta(3) integrin/EGFR mediated ERK1/2 phosphorylation and AP-1 activation ... Furthermore, OPN induces alpha(v)beta(3) integrin/EGFR mediated ERK1/2 phosphorylation and AP-1 activation ... Furthermore, OPN induces alpha(v)beta(3) integrin/EGFR mediated ERK1/2 phosphorylation and AP-1 activation ... OPN induced ERK phosphorylation, AP-1 activation, uPA secretion, and cell motility were suppressed when cells were transfected with dn c-Src or pretreated with alpha(v)beta(3) integrin antibody, c-Src kinase inhibitor ( pp2 ), EGFR tyrosine kinase inhibitor ( PD153035 ), and MEK-1 inhibitor ( PD98059 ) ... To our knowledge, this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and ERK/AP-1 mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells ... To our knowledge, this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and ERK/AP-1 mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells ... To our knowledge, this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and ERK/AP-1 mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells
Orlichenko et al., Am J Physiol Gastrointest Liver Physiol 2010 (Inflammation) : Complete suppression of MIP-2 upregulation required dual inhibition of NF-?B and AP-1 ... MIP-2 upregulation requires both NF-?B and AP-1 in these cells
Jijon et al., Am J Physiol Cell Physiol 2002 : Furthermore, AP-1 and NF-kappaB DNA binding was not affected by ERK and p38 inhibition ... Furthermore, AP-1 and NF-kappaB DNA binding was not affected by ERK and p38 inhibition
Park et al., Toxicol Appl Pharmacol 2006 (Lymphoma) : In contrast, the enhanced AP-1 DNA binding activities and p38 MAPK phosphorylation were significantly suppressed by specific inhibitors for PKC and p38 MAPK, but not by PI3-K inhibitors
Geh et al., Proc Natl Acad Sci U S A 2011 (MAP Kinase Signaling System) : The second network is initiated by the enzymatic activity of MAP3K1, which phosphorylates and activates a JNK-c-Jun module, leading to AP-1 transactivation and induction of its downstream genes, such as Pai-1
Pufe et al., J Pathol 2004 (Osteoarthritis) : VEGF stimulation induced receptor phosphorylation, activation of the mitogen activated protein kinases ERK 1/2, and long lasting activation of the transcription factor AP-1 ( activator protein-1 ) ... VEGF stimulation induced receptor phosphorylation, activation of the mitogen activated protein kinases ERK 1/2 , and long lasting activation of the transcription factor AP-1 ( activator protein-1 ) ... VEGF stimulation induced receptor phosphorylation, activation of the mitogen activated protein kinases ERK 1/2 , and long lasting activation of the transcription factor AP-1 ( activator protein-1 )
Yip et al., J Bone Miner Res 2005 (Calcium Signaling) : In this study, we showed a biphasic effect of TG on osteoclast formation and apoptosis through the regulation of ROS production, caspase-3 activity, cytosolic Ca2+, and RANKL induced activation of NF-kappaB and AP-1 activities ... In this study, we showed a biphasic effect of TG on osteoclast formation and apoptosis through the regulation of ROS production, caspase-3 activity, cytosolic Ca2+, and RANKL induced activation of NF-kappaB and AP-1 activities ... At these lower concentrations, TG potentiated ROS production and RANKL induced NF-kappaB activity, but suppressed RANKL induced AP-1 activity and had little effect on ERK phosphorylation
Chang et al., Exp Cell Res 2002 : This suggests that IL-8 induction by LTbetaR is via TRAFs elicited signaling pathways, including NIK/IKK dependent NF-kappaB activation and ASK/MKK/JNK dependent AP-1 activation ... This suggests that IL-8 induction by LTbetaR is via TRAFs elicited signaling pathways, including NIK/IKK dependent NF-kappaB activation and ASK/MKK/JNK dependent AP-1 activation
Kajanne et al., Int J Oncol 2009 (Prostatic Neoplasms) : Here, we show that constitutive AP-1 activity in prostate cancer cells is dependent on the activities of EGF-R and PI3K ... Here, we show that constitutive AP-1 activity in prostate cancer cells is dependent on the activities of EGF-R and PI3K ... Together, the findings show that AP-1 activity in prostate cancer cells mediates EGF-R and PI3K signalling, is essential for their proliferation, and confers protection against radiation induced cell death ... Together, the findings show that AP-1 activity in prostate cancer cells mediates EGF-R and PI3K signalling, is essential for their proliferation, and confers protection against radiation induced cell death
Blanchette et al., Immunology 2009 (MAP Kinase Signaling System...) : The activation of AP-1 , and not nuclear factor-kappaB (NF-kappaB) or signal transducer and activator of transcription-1 alpha ( STAT-1 alpha ), may explain the enhanced NO generation in SHP-1-deficient cells
Lee et al., Biochem Biophys Res Commun 2005 (Fibrosarcoma) : We also found that SM-7368 strongly inhibits TNF-alpha induced NF-kappaB activity but not AP-1 activity
Kim et al., Biochem J 1997 : The deletion construct containing about 500 nt 5 ' to the transcriptional start, but no AP-1 sites, showed lower but significant activity, suggesting both AP-1 dependent and -independent regulation of the mouse TIMP-3 promoter
Hossain et al., J Biol Chem 2000 : Transfection of cells with a c-jun dominant negative effectively inhibited both AP-1 activation and VEGF mRNA induction by lead
Sabuda-Widemann et al., Nephrol Dial Transplant 2009 : MPA was tested on the expression of platelet derived growth factor-B ( PDGF-B ) and its receptor beta ( PDGFR-beta ), the immediate early gene ( IEG ) c-fos and the early growth response gene-1 (Egr-1) , and AP-1 activation ... MPA treatment did not affect PDGF-BB induced AP-1 activity determined after 1 h and 2 h
Mann et al., J Biol Chem 2002 : CD40 induces interleukin-6 gene transcription in dendritic cells : regulation by TRAF2, AP-1 , NF-kappa B, AND CBF1 ... CD40 induces interleukin-6 gene transcription in dendritic cells : regulation by TRAF2, AP-1 , NF-kappa B, AND CBF1
Mori et al., Cancer Res 1998 : Furthermore, using several deletion and mutated plasmids of the 5'-flanking regulatory region of the IL-8 gene linked to the luciferase gene as a reporter and mutant tax gene expression vectors, we have established that both AP-1 at -126 to -120 and nuclear factor (NF)-kappaB-like cis-element at -80 to -71 are essential and sufficient for the induction of the IL-8 gene by HTLV-I Tax
Ortiz-Lazareno et al., Immunology 2008 : Proteasome inhibition also led to an increase in LPS+PMA induced AP-1 activation and the attenuation of LPS+PMA induced IkappaB degradation, resulting in the abolition of NF-kappaB activation
Talotta et al., Oncogene 2009 (Cell Transformation, Neoplastic) : Here, we show that the miRNA miR-21 , which represents the most frequently upregulated oncomir in solid tumors, is induced by AP-1 in response to RAS ... We further show that, given the role of PDCD4 as negative regulator of AP-1, the miR-21 mediated downregulation of PDCD4 is essential for the maximal induction of AP-1 activity in response to RAS
Guo et al., Diabetes 2004 : PPAR-gamma overexpression inhibited TGF-beta 1-induced fibronectin expression as well as the activation of AP-1 ... PPAR-gamma overexpression inhibited TGF-beta 1-induced fibronectin expression as well as the activation of AP-1 ... 15-Deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ ( 2 ) ), a natural PPAR-gamma ligand, also inhibited TGF-beta1 induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1 ... In conclusion, pioglitazone inhibits TGF-beta 1-induced fibronectin expression by inhibiting AP-1 activation dependent on PPAR-gamma, while 15d-PGJ ( 2 ) acts through a dual mechanism independent of and dependent on PPAR-gamma activation in mouse mesangial cells ... In conclusion, pioglitazone inhibits TGF-beta 1-induced fibronectin expression by inhibiting AP-1 activation dependent on PPAR-gamma , while 15d-PGJ ( 2 ) acts through a dual mechanism independent of and dependent on PPAR-gamma activation in mouse mesangial cells
Zhao et al., J Biol Chem 2001 (Colonic Neoplasms...) : By using reporter gene constructs containing targeted substitutions in the IL-8 promoter, we show that the NF-kappaB, AP-1 , and to a lesser degree the C/EBP sites in the IL-8 promoter region are required for IL-8 gene expression induced by NT
Moon et al., J Cell Physiol 2004 : Furthermore, the transactivation of TNF-alpha stimulated NF-kappaB and AP-1 was inhibited by U0126 treatment ... Overexpression of RasN17 also abolished the TNF-alpha stimulated NF-kappaB and AP-1 activity
Trocmé et al., J Neurosci Res 1997 : AP-1 mediates trans-synaptic induction of tyrosine hydroxylase gene expression in adrenal medulla but not in superior cervical ganglia
von Knethen et al., Mol Biol Cell 1999 : Whereas cytokine mediated Cox-2 induction relies on NF-kappaB activation, a low-level NO-elicited Cox-2 response required activation of both NF-kappaB and AP-1
Son et al., Mol Cells 2009 (Lymphoma...) : Mitogen activated protein kinases ( MAPK ) affect the activation of activator protein-1 (AP-1) , which plays an important role in regulating a range of cellular processes
Fan et al., J Biol Chem 2010 : Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta induced IKK/NF-kappaB and JNK/AP-1 activation
Ponti et al., Eur J Immunol 2002 : Our results show that IL-2 activates CREB in human NK cells and that CREB activation hasa prominent regulatory role on the IL-2 induced expression of functional c-fos and AP-1 in NK cells
Toops et al., Communicative & integrative biology 2013 : Our data show that the polarity of syntaxin 4 ( which is regulated by the clathrin adaptor protein AP-1 ) dictates whether lysosomes parachute down to the basolateral membrane or take a ladder up to the apical membrane
Bai et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2007 (Inflammation) : Overexpression of GILZ inhibits NF-KappaB and AP-1 activities, suggesting that GILZ possesses anti-inflammatory function
Wu et al., Am J Respir Cell Mol Biol 2002 (MAP Kinase Signaling System) : In addition, activations of the IL-8 gene and AP-1 by MG132 and lactacystin were inhibited by GSH and NAC
Huang et al., Arthritis Rheum 2012 : Thrombin mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cd ( PKCd ) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA
Li et al., J Am Soc Nephrol 2004 : Fyn also significantly augmented the activation of the AP-1 promoter induced by nephrin and podocin
Silvers et al., Neoplasia (New York, N.Y.) 2003 (Skin Neoplasms) : The role of JNK and p38 MAPK activities in UVA induced signaling pathways leading to AP-1 activation and c-Fos expression ... The role of JNK and p38 MAPK activities in UVA induced signaling pathways leading to AP-1 activation and c-Fos expression ... To examine the role of p38 and JNK MAPKs in UVA induced AP-1 and c-fos transactivations, the selective pharmacologic MAPK inhibitors, SB202190 ( p38 inhibitor ) and SP600125 ( JNK inhibitor ), were used to independently treat stably transfected HaCaT cells in luciferase reporter assays ... These results demonstrated that activation of both JNK and p38 play critical role in UVA mediated AP-1 transactivation and c-Fos expression in these human keratinocyte cells
Amato et al., Cancer Res 1998 : Consistent with these biochemical events, paclitaxel stimulated AP-1 dependent chloramphenicol acetyltransferase (CAT) reporter gene transcription in vivo, as directed from a tetradecanoyl phorbol acetate-inducible promoter
Liu et al., Proc Natl Acad Sci U S A 2001 : Proteinase inhibitors I and II from potatoes block UVB induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells
Ogasawara et al., J Biol Chem 2001 : These data suggest that C/EBP beta, AP-1 , and CREB play crucial roles in the shear stress induced cox-2 expression in osteoblasts
Kremer et al., J Immunol 2007 : IL-10 promoter activity was ablated by mutating two nonpolymorphic binding sites for the AP-1 transcription factor, and chromatin immunoprecipitation assays of primary human T cells revealed that SDF-1 costimulation enhances AP-1 binding to both of these sites
Jang et al., Proc Natl Acad Sci U S A 2008 (Encephalitis) : Taken together, these data suggest luteolin inhibits LPS induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia
Cheng et al., Cancer Res 2010 (Neoplasms, Multiple Primary) : We further found that ZNF382 inhibited NF-kappaB and AP-1 signaling and downregulated the expression of multiple oncogenes including MYC, MITF, HMGA2, and CDK6, as well as the NF-kappaB upstream factors STAT3, STAT5B, ID1, and IKBKE, most likely through heterochromatin silencing
Domenzain-Reyna et al., J Biol Chem 2009 (MAP Kinase Signaling System...) : Structure and regulation of the versican promoter : the versican promoter is regulated by AP-1 and TCF transcription factors in invasive human melanoma cells
Fujii et al., J Immunol 1999 (Arthritis, Rheumatoid) : Briefly, we found that 1 ) rheumatoid synovial cells highly expressed CD44 ; 2 ) cross linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha ; 3 ) hyaluronan, especially when fragmented, also up-regulated VCAM-1 ; 4 ) CD44 activated the transcription factor AP-1 ; and 5 ) the integrin dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross linking
Subbaramaiah et al., Cancer Res 2002 : The induction of COX-2 transcription by PMA was mediated by increased binding of AP-1 to the cyclic AMP response element ( CRE ) of the COX-2 promoter ... Thus, RA acted by a receptor dependent mechanism to limit the amount of CBP/p300 that was available for AP-1 mediated induction of COX-2 ... By contrast, carnosol inhibited the induction of COX-2 by blocking PKC signaling and thereby the binding of AP-1 to the CRE of the COX-2 promoter
Hsu et al., Cancer Res 2001 (Cell Transformation, Neoplastic) : Expression of a transactivation-deficient mutant of Jun or dominant negative extracellular signal regulated kinase suppressed both AP-1 activation and p65-specific transactivation in JB6 cells, suggesting that AP-1 activity is needed for p65 transactivation and consequently for NF-kappaB activation ... Expression of a transactivation-deficient mutant of Jun or dominant negative extracellular signal regulated kinase suppressed both AP-1 activation and p65-specific transactivation in JB6 cells, suggesting that AP-1 activity is needed for p65 transactivation and consequently for NF-kappaB activation
Nold-Petry et al., Proc Natl Acad Sci U S A 2009 : Increasing evidence demonstrates that interleukin (IL)-32 is a pro-inflammatory cytokine, inducing IL-1alpha, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and chemokines via nuclear factor (NF)-kappaB, p38 mitogen activated protein kinase ( MAPK ), and activating protein (AP)-1 activation ... Increasing evidence demonstrates that interleukin (IL)-32 is a pro-inflammatory cytokine, inducing IL-1alpha, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and chemokines via nuclear factor (NF)-kappaB , p38 mitogen activated protein kinase ( MAPK ), and activating protein (AP)-1 activation
Kalra et al., Circulation 2002 : Stimulation with Ang II led to the activation of nuclear factor-kappaB and activator protein-1 (AP-1) , two transcription factors that are important for TNF gene expression
Kim et al., Proc Natl Acad Sci U S A 2009 (Tetanus) : In Drosophila motor neurons, induction of AP-1 , a heterodimer of Fos and Jun, induces cAMP- and CREB dependent forms of presynaptic enhancement
Mann et al., Proc Natl Acad Sci U S A 1999 (Adenocarcinoma...) : There are four genes affected by beta-catenin overexpression ; three overexpressed genes code for two components of the AP-1 transcription complex, c-jun and fra-1, and for the urokinase-type plasminogen activator receptor ( uPAR ), whose transcription is activated by AP-1
Sweeney et al., J Immunol 2010 (Arthritis, Rheumatoid) : Transcription factor activation studies demonstrated a role for IRF3 in regulation of c-Jun phosphorylation and AP-1 binding
Hahm et al., Biochem Biophys Res Commun 2004 (Neoplasm Invasiveness...) : These curcumin analogs have been observed to repress the AP-1 transcription in AP-1 transfected cells and they also inhibited the increased expression of Jun/AP-1 protein by 12-O-tetradecanoylphorbol-13-acetate ( TPA ) in the same cells
Jeon et al., Immunopharmacology 2000 : Third, angelan induced strong NF-kappaB/Rel and slight AP-1 DNA binding, whereas LPS potently activated both NF-kappaB/Rel and AP-1
Guo et al., Immunopharmacology 2000 : Antisense IRAK-1 oligonucleotide blocks activation of NF-kappa B and AP-1 induced by IL-18 ... Antisense IRAK-1 oligonucleotide blocks activation of NF-kappa B and AP-1 induced by IL-18 ... Interleukin-1 receptor associated kinase-1 ( IRAK-1 ) has recently been shown to be involved in IL-18 stimulated activation of NF-kappaB and AP-1 ... The purpose of this study is to investigate the effects of preventing IRAK-1 expression by antisense IRAK-1 oligodeoxynucleotide ( ODN ) on IL-18 stimulated activation of NF-kappaB and AP-1 ... As a result, antisense IRAK-1 ODN attenuated IL-18 induced activation of NF-kappaB and AP-1 as measured by sandwich ELISA in a concentration ( 1-8 microg ml(-1) ) - and time ( 5-24 h ) -dependent fashion
Hua et al., J Neuroimmunol 2002 : Electrophoretic mobility shift assay ( EMSA ) showed that IL-1 induced NF-kappaB and AP-1 DNA complex formation in astrocytes, and that SB203580 inhibited AP-1 complex formation ... Electrophoretic mobility shift assay ( EMSA ) showed that IL-1 induced NF-kappaB and AP-1 DNA complex formation in astrocytes, and that SB203580 inhibited AP-1 complex formation
Hattori et al., Am J Physiol 1993 (Acute-Phase Reaction...) : In addition, IL-6, tumor necrosis factor-alpha , and IL-1 beta, cytokine regulators of the acute phase response, stimulated expression of an AP-1 responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture ... In addition, IL-6, tumor necrosis factor-alpha, and IL-1 beta , cytokine regulators of the acute phase response, stimulated expression of an AP-1 responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture ... In addition, IL-6 , tumor necrosis factor-alpha, and IL-1 beta, cytokine regulators of the acute phase response, stimulated expression of an AP-1 responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture ... These findings demonstrate the complexity of AP-1 hepatic transcription factor responses to humoral regulators with direct hepatocellular effects
Boucher et al., Viral Immunol 2010 (HIV Infections...) : In primary monocytes, ERK and p38 inhibition increased binding of AP-1 and Sp1, respectively, to the IL-12p40 promoter, while JNK inhibition increased NF-kappaB, AP-1, and Sp1 binding ... In primary monocytes, ERK and p38 inhibition increased binding of AP-1 and Sp1, respectively, to the IL-12p40 promoter, while JNK inhibition increased NF-kappaB, AP-1, and Sp1 binding
Ben-Ari et al., Mol Carcinog 1992 (Cell Transformation, Neoplastic) : The activity of AP-1 , a trans acting transcription factor, is stimulated by 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and epidermal growth factor (EGF) in promotion-sensitive ( P+ ) but not in promotion-resistant ( P- ) JB6 mouse epidermal cell lines
Mishra et al., J Biol Chem 2005 (Calcium Signaling) : Differential involvement of calmodulin dependent protein kinase II-activated AP-1 and c-Jun N-terminal kinase activated EGR-1 signaling pathways in tumor necrosis factor-alpha and lipopolysaccharide induced CD44 expression in human monocytic cells ... Differential involvement of calmodulin dependent protein kinase II-activated AP-1 and c-Jun N-terminal kinase activated EGR-1 signaling pathways in tumor necrosis factor-alpha and lipopolysaccharide induced CD44 expression in human monocytic cells ... Furthermore, TNF-alpha induced CD44 expression was regulated by AP-1 through the activation of the CaMK-II pathway, whereas LPS induced CD44 transcription was regulated specifically by Egr-1 through JNK activation
Stone et al., Differentiation 1990 : Given the previously demonstrated role of transcription factor AP-1 in ALBP gene expression, our results suggest that the initiation of expression of this and other adipocyte-specific genes during adipose conversion is regulated by the relative composition of transcription factor AP-1
Zhao et al., Methods Mol Biol 2003 (Disease Models, Animal...) : We have used a well established multistage skin carcinogenesis model to study the effect of manganese superoxide dismutase on the activity of AP-1 during an early stage of mouse skin carcinogenesis
Kim et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid...) : Blocking of PI3 kinase, p38 MAP kinase, JAK-2, NF-?B, and AP-1 also led to a marked reduction in RANKL expression and osteoclastogenesis
Liu et al., J Biol Chem 2009 (Autoimmune Diseases...) : AP-1 activated by toll-like receptors regulates expression of IL-23 p19
Dokter et al., Leukemia 1996 : In electrophoretic mobility shift assays ( EMSAs ) we showed that IL-10 and IL-4 inhibited LPS induced AP-1 binding activity ... In electrophoretic mobility shift assays ( EMSAs ) we showed that IL-10 and IL-4 inhibited LPS induced AP-1 binding activity ... In electrophoretic mobility shift assays ( EMSAs ) we showed that IL-10 and IL-4 inhibited LPS induced AP-1 binding activity ... Downregulation of LPS induced AP-1 was accompanied, and thus possibly explained, by a reduced expression at mRNA level of the two major components of the AP-1 complex, namely c-fos and c-jun as determined by Northern experiments ... However, for IL-4 this was accompanied with a reduction of AP-1 and NF-IL6 binding activity whereas IL-10 only inhibited AP-1 binding activity
Wang et al., Planta Med 2007 (Leukemia...) : Deerberry fruit extracts also blocked TPA- or UVB induced phosphorylation of ERKs and MEK 1/2 , two upstream regulators of AP-1 and inhibited proliferation of human leukemia HL-60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells ... Deerberry fruit extracts also blocked TPA- or UVB induced phosphorylation of ERKs and MEK 1/2 , two upstream regulators of AP-1 and inhibited proliferation of human leukemia HL-60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells
Brzóska et al., Redox Rep 2011 : Based on literature data, we propose the involvement of Nrf2, AP-1 , and NF-?B transcription factors in Pir up-regulation in Sod1 ( -/- ) mice
Thomas et al., Toxicol Appl Pharmacol 1998 (Drug-Induced Liver Injury, Chronic...) : Due to the role of Activator Protein-1 (AP-1) in rGSTP1-1 expression and CYP 1A2 in the pathogenesis of porphyria cutanea tarda, immunohistochemical localization of c-jun, c-fos, and CYP 1A2 was also performed
Navarro-Antolín et al., Kidney Int Suppl 1998 : The potential participation of ROS and the transcription factor AP-1 in the regulation of eNOS gene expression is suggested
Granet et al., Cell Signal 2002 : Downregulation of protein kinase C ( PKC ) and COX1/2 or inhibition of ERK1/2, p38 ( MAPK ) or src kinases had no major effect on AP-1 mRNA expression in the Flexcell ... Downregulation of protein kinase C ( PKC ) and COX1/2 or inhibition of ERK1/2, p38 ( MAPK ) or src kinases had no major effect on AP-1 mRNA expression in the Flexcell ... Downregulation of protein kinase C ( PKC ) and COX1/2 or inhibition of ERK1/2 , p38 ( MAPK ) or src kinases had no major effect on AP-1 mRNA expression in the Flexcell ... Downregulation of protein kinase C ( PKC ) and COX1/2 or inhibition of ERK1/2, p38 ( MAPK ) or src kinases had no major effect on AP-1 mRNA expression in the Flexcell
Ares et al., BMC immunology 2002 : In contrast, oxidized LDL stimulated AP-1 and PPARgamma but inhibited NF-kappaB , indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids ... In contrast, oxidized LDL stimulated AP-1 and PPARgamma but inhibited NF-kappaB, indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids
Rangaswami et al., Oncol Rep 2007 (Lung Neoplasms...) : OPN triggers NIK- and MEKK1 dependent AP-1 activation whereas NIK dependent AP-1 activation is independent of JNK1 that leads to pro-MMP-9 activation ... OPN triggers NIK- and MEKK1 dependent AP-1 activation whereas NIK dependent AP-1 activation is independent of JNK1 that leads to pro-MMP-9 activation
Rooney et al., Immunity 1995 : Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
O'Hara et al., Cytokine 2009 : Silencing of Ref-1 in AGS cells inhibited basal and TNF-alpha induced AP-1 and NF-kappaB DNA binding activity, but not their nuclear accumulation ... Silencing of Ref-1 in AGS cells inhibited basal and TNF-alpha induced AP-1 and NF-kappaB DNA binding activity, but not their nuclear accumulation
Huang et al., Toxicol Appl Pharmacol 2013 (Inflammation) : Moreover, LTA induced increases of ?B-DNA and AP-1-DNA binding activity were inhibited by p38 , JNK, and PI3-kinase inhibitors ... Moreover, LTA induced increases of ?B-DNA and AP-1-DNA binding activity were inhibited by p38, JNK, and PI3-kinase inhibitors ... Moreover, LTA induced increases of ?B-DNA and AP-1-DNA binding activity were inhibited by p38, JNK, and PI3-kinase inhibitors
Zhang et al., Zhonghua Jie He He Hu Xi Za Zhi 2010 (Ventilator-Induced Lung Injury) : To study the expression of intercellular cell adhesion molecule-1 ( ICAM-1 ), Interleukin-10 (IL-10) and the activation of transcription factor activator protein-1 (AP-1) in a rabbit model of ventilator induced lung injury ( VILI ) and therefore to explore their possible role in VILI ... To study the expression of intercellular cell adhesion molecule-1 ( ICAM-1 ), Interleukin-10 (IL-10) and the activation of transcription factor activator protein-1 (AP-1) in a rabbit model of ventilator induced lung injury ( VILI ) and therefore to explore their possible role in VILI ... To study the expression of intercellular cell adhesion molecule-1 ( ICAM-1 ), Interleukin-10 (IL-10) and the activation of transcription factor activator protein-1 (AP-1) in a rabbit model of ventilator induced lung injury ( VILI ) and therefore to explore their possible role in VILI
Kamata et al., Arch Biochem Biophys 2005 : Conversely, incubation of the cells with a reductant, N-acetyl-L-cysteine (NAC), inhibited NGF induced neuronal differentiation and AP-1 activation
Teruel et al., J Cell Physiol 1998 : In addition, insulin induced AP-1 DNA binding activity, this effect being totally prevented in the presence of MEK-1 inhibitor
Cho et al., J Nutr 2008 (Inflammation) : Furthermore, DIM decreased LPS induced transcriptional activity of activator protein (AP)-1, AP-1 DNA binding activity, and phosphorylation of stress activated protein kinase/Jun-N-terminal kinase and c-Jun
Bumrungpert et al., J Nutr 2009 (Inflammation...) : alpha- and gamma-MG also attenuated LPS activation of c-Jun and activator protein (AP)-1 activity
Dai et al., Hum Reprod 2011 (Pre-Eclampsia) : DNA precipitation assays and luciferase reporter analysis were used to evaluate the regulation of miR-155 by AP-1 and NF-?B
Sugimoto et al., Eur J Immunol 2003 : IL-18, but not IL-12 , induced activator protein-1 (AP-1) responsible for high levels of IFN-gamma promoter activation ... IL-18 , but not IL-12, induced activator protein-1 (AP-1) responsible for high levels of IFN-gamma promoter activation
Hong et al., J Leukoc Biol 2011 : AP-1 protein induction during monopoiesis favors C/EBP : AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcription ... C/EBPa : AP-1 heterodimers bound either site preferentially in a gel-shift assay, C/EBPa : c-Fos ER fusion proteins induced endogenous Fosb mRNA but not in the presence of CHX, C/EBP and AP-1 proteins bound the endogenous Fosb promoter, mutation of the -56 cis element reduced reporter activity fivefold, and endogenous FosB protein was expressed preferentially during monopoiesis versus granulopoiesis
Gao et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2006 : ERK and JNK, but not p38 , mediated benzo ( a ) pyrene induced cell cycle changes by AP-1 transactivation in HELF ... ERK and JNK, but not p38, mediated benzo ( a ) pyrene induced cell cycle changes by AP-1 transactivation in HELF
Liu et al., Proc Natl Acad Sci U S A 2001 (Cell Transformation, Neoplastic) : AA treatment had no effect on either TPA- or EGF induced AP-1 transactivation or transformation, but did abrogate the inhibitory effects of DHA on TPA- or EGF induced AP-1 transactivation and cell transformation in a dose dependent manner
Yasumoto et al., J Biol Chem 1992 (Stomach Neoplasms) : Moreover, gel retardation analyses revealed that TNF alpha and IFN gamma synergistically induced the binding of NF-kB like as well as AP-1 like proteins bound to these sites ... Moreover, gel retardation analyses revealed that TNF alpha and IFN gamma synergistically induced the binding of NF-kB like as well as AP-1 like proteins bound to these sites
Higai et al., Biochim Biophys Acta 2009 : The prolonged culture in high glucose increased inducible cAMP early repressor (ICER) II mRNA and protein levels, and overexpression of ICER II dose-dependently suppressed promoter activities of IL-2, NFAT, and AP-1
Park et al., Carcinogenesis 2009 (Breast Neoplasms...) : KPS-A decreased PMA induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA induced phosphorylation of ERK1/2 and Akt ... KPS-A decreased PMA induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA induced phosphorylation of ERK1/2 and Akt
Nemoto et al., Brain Res Mol Brain Res 1999 : The present findings suggest that TPA induced AP-1 de novo synthesis causes the downregulation of NT-3 gene expression in VSMCs
Chen et al., Hum Immunol 2008 : L-selectin ligation induced CSF-1 gene transcription is regulated by AP-1 in a c-Abl kinase dependent manner ... L-selectin ligation induced CSF-1 gene transcription is regulated by AP-1 in a c-Abl kinase dependent manner
De Croos et al., Matrix Biol 2006 : Mechanical stimulation in the presence of the JNK inhibitor, SP600125, blocked AP-1 binding preventing the increased gene expression of MMP-3 and -13 at 2 h and type II collagen and aggrecan at 12 h as well as the increased matrix synthesis and accumulation
Baier-Bitterlich et al., Mol Cell Biol 1996 : Importantly, the critical AP-1 enhancer element was differentially modulated by these two distinct PKC isoenzymes, since only PKC-theta but not PKC-alpha overexpression resulted in an approximately 2.8-fold increase in AP-1-collagenase promoter CAT expression in comparison with the vector control
Rizzi et al., J Immunol 2006 : In contrast, PTX-B inhibited AP-1 binding to target DNA and modified its composition with a proportional increases in FosB, Fra2, and ATF2
Lengyel et al., Biochim Biophys Acta 1995 : Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors
Wang et al., J Mol Neurosci 2000 (MAP Kinase Signaling System) : Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities
Polytarchou et al., Int J Cancer 2009 (Prostatic Neoplasms) : Inhibition of eNOS or the downstream effector soluble guanylate cyclase ( sGC ) completely suppressed HP-induced AP-1 activities that lead to PTN expression and cell migration
Jibiki et al., Am J Respir Crit Care Med 2003 (Asthma...) : In the present study, to clarify this issue we examined the effect of NO in inducing activator protein-1 (AP-1) activation in human bronchial epithelial cells ( BEC ) and a role of apoptosis signal regulating kinase1 ( ASK1 ), an upstream kinase kinase of c-Jun-NH2-terminal kinase (JNK) and p38 mitogen activated protein kinase ( MAPK ) in NO-mediated AP-1 activation
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase ... Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase ... Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Autelitano , J Neuroendocrinol 1994 (Pituitary Neoplasms) : Although DEX treatment of AtT-20 cells did not affect AP-1 DNA binding capacity of nuclear extracts, DEX pretreatment blunted the stimulation of AP-1 binding in response to CRF ... High levels of DEX treated extracts led to a relative repression of CRF induced AP-1 binding, suggesting that ligand activated GR may lower available AP-1 levels by direct protein : protein interaction ... These data suggest that in the corticotrope cell relatively high levels of activated GR may influence CRF induced AP-1 DNA binding via transient genomic actions on basal c-jun and stimulated c-fos and/or via direct protein : protein interactions
Han et al., J Korean Med Sci 2009 (MAP Kinase Signaling System) : We examined the role of extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ), c-Jun N-terminal kinase (JNK) and activator protein-1 (AP-1) in the aldosterone induced TGF-beta(1) expression in rat mesangial cells
Jalvy et al., Circ Res 2007 (MAP Kinase Signaling System) : We previously demonstrated that osteopontin (OPN) expression is a key step for UTP mediated migration of arterial SMCs and that activator protein (AP)-1 , nuclear factor kappaB, and upstream stimulatory transcription factors are involved in this OPN expression
Kong et al., J Biol Chem 2012 (Breast Neoplasms...) : Our findings reveal an important role for AP-1 activation in promoting LY6K gene expression that regulates cell mobility of breast cancer cells, whereas the SNP242 C allele or methylation of the CpG site may reduce the risk of invasion or metastasis by interfering AP-1 activation
Schreiber et al., Oncogene 1997 (Osteosclerosis) : Absence of c-Fos leads to significantly reduced serum stimulation of fra-1 expression in gene targeted mouse fibroblasts, demonstrating that mitogen induction of fra-1 is partially mediated by c-Fos/AP-1
Baek et al., Oncol Rep 2008 (Carcinoma...) : Suppression of the EGF induced uPAR promoter activity by the AP-1 decoy oligonuclotide, as well as expression vectors encoding mutated-type NF-kappaB inducting kinase and I-kappaB, confirmed that the activation of AP-1 and NF-kappaB are essential for the EGF induced uPAR upregulation
Camalier et al., J Cell Physiol 2013 : The mechanism of activation requires FGF receptor signaling followed by stimulation of N-Ras and activation of AP-1 and serum response elements
Simon et al., Int Immunol 1996 : Second, antigen induced a different pattern of transcription factor binding activities than PMA/lonomycin in DP thymocytes, AP-1 activity being selectively induced by antigen and NF-kappa B by PMA/lonomycin
Murthy et al., J Biol Chem 2010 (MAP Kinase Signaling System...) : Deletion and mutational analysis of the MMP-9 promoter revealed that both SP-1 and AP-1 are essential for MMP-9 transcription
Yi et al., Int Immunol 2001 : In addition, CpG DNA showed little or no enhancement of LPS mediated AP-1 activation
Choi et al., Mol Cell Biol 2002 (Astrocytoma...) : These findings collectively indicate that DR5 ligation on human glioma cells leads to apoptosis and that the activation of AP-1 and NF-kappaB leads to the induction of IL-8 expression ; these responses are dependent on caspase activation
Cheng et al., Free Radic Biol Med 2009 : Induction of cPLA2 by CSE was attenuated by selective inhibitors of NF-kappaB ( helenalin ) and AP-1 ( curcumin )
Hamid et al., Cytokine 2000 : The IL-1beta stimulated the collagenase-CAT and AP-1-CAT activities in a dose dependent manner with respect to the amount of DNA used in transfections
Wang et al., Allergy 2007 (Inflammation) : Dominant negative AP-1 inhibited IL-5 transcription
Vayalil et al., Am J Physiol Lung Cell Mol Physiol 2007 : Decoy oligonucleotides ( ODN ) studies further demonstrate that AP-1 , SP-1, and Smad ODNs abrogate the inhibitory effect of GSH on TGF-beta induced PAI-1 promoter activity and inhibit TGF-beta induced expression of endogenous PAI-1
Seol et al., Oncogene 2000 (Carcinoma, Hepatocellular) : Stimulation of Hepa 1-6 cells with HGF resulted in a rapid and dramatic enhancement of the AP-1 binding activity as well as an overall increase in the level of AP-1 protein
Allison et al., J Immunol 2009 : Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1 dependent mechanism
Young et al., Mol Cell Biol 2002 (Cell Transformation, Neoplastic) : These observations suggest that ERK dependent activation of Fra-1 is required for AP-1 transactivation in JB6 cells ... These observations suggest that ERK dependent activation of Fra-1 is required for AP-1 transactivation in JB6 cells
Yasui et al., Digestion 2004 : FGF-2 induced AP-1-DNA binding activity, and the c-Jun/AP-1 inhibitor curcumin attenuated the FGF-2 induced MMP-1, -3 and TIMP-1 mRNA expression
Ren et al., FEBS Lett 2013 : In the present work, luciferase analyses showed that RHBDD1 enhanced the AP-1 activity in a dose- and activity dependent manner
Jaster et al., Biochim Biophys Acta 1999 : Gel shift assays indicated that IL-3 activates the binding of an AP-1 complex containing JunD to the AP-1 sites and the binding of another protein complex to the Ets motif
Wilmer et al., Kidney Int 2001 : This current study investigated the mechanisms of HG-mediated activation of p38 MAPK in cultured human mesangial cells ( HMCs ) and the effects of p38 MAPK activation on the transcription factor activator protein-1 (AP-1) ... This current study investigated the mechanisms of HG-mediated activation of p38 MAPK in cultured human mesangial cells ( HMCs ) and the effects of p38 MAPK activation on the transcription factor activator protein-1 (AP-1)
Quinones et al., Biochem J 1994 (Carcinoma, Hepatocellular...) : Protein binding to this region and to the AP-1 site was modestly induced by IL-1 treatment
Cui et al., Zhonghua Jie He He Hu Xi Za Zhi 2002 (Asthma...) : NF-kappa B and AP-1 may play important roles in the regulation of VCAM-1 and eotaxin
Camandola et al., J Neurochem 2000 : The broad-spectrum caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone and the caspase-3 inhibitor N-acetyl-Asp-Glu-Val-Asp-aldehyde blocked HNE induced increases in AP-1 DNA binding activity, demonstrating a requirement for caspase activation in the activation of AP-1
Ryoo et al., Cardiovasc Res 2004 : These data demonstrated that LDL stimulates SMCs to induce IL-8 production in dose- and time dependent manners at the transcription level and that the LDL signaling in hAoSMCs is conveyed via the generation of H2O2, the phosphorylation of p38 MAPK , the activation of AP-1 , and the participation of NF-kappaB ... These data demonstrated that LDL stimulates SMCs to induce IL-8 production in dose- and time dependent manners at the transcription level and that the LDL signaling in hAoSMCs is conveyed via the generation of H2O2, the phosphorylation of p38 MAPK, the activation of AP-1 , and the participation of NF-kappaB
Herbein et al., Curr HIV Res 2008 : Since tumor necrosis factor alpha (TNFalpha) activates NF-kappaB and AP-1 , we investigated the role of exogenous Nef protein in TNFalpha stimulated U937 cells and primary macrophages ... We observed that exogenous Nef and TNFalpha synergistically activate NF-kappaB and AP-1 in U937 cells and primary macrophages resulting in enhanced stimulation of the HIV-1 long terminal repeat ( LTR ), and subsequently in enhanced viral replication in both chronically infected promonocytic U1 cells and acutely HIV-1 infected primary macrophages
Matsui , Biochem Biophys Res Commun 1996 : RAR alpha , ROR alpha and AP-1 activated the transcription of the murine laminin B1 gene promoter, which consists of three core elements
Galter et al., Eur J Biochem 1994 : In vitro, GSSG inhibited the DNA binding activity of NF kappa B more effectively than that of AP-1, while AP-1 was inhibited more effectively by oxidized thioredoxin
Pang et al., Invest Ophthalmol Vis Sci 2003 (Glaucoma, Open-Angle) : These effects were blocked by sequestering AP-1, suggesting that activation of AP-1 can lead to increased MMP-3 production in the TM, which in turn improves outflow facility
Trauzold et al., FASEB J 2005 (Adenocarcinoma...) : Stimulation of TRAF2 overexpressing cells with CD95 ligand led to induction of NF-kappaB and AP-1 , enhanced IL-8- and uPA-secretion, and a further increased invasiveness
Sun et al., J Cell Biochem 2004 : We also demonstrate that both p300 and TATA box binding proteins cooperated with the transcription factor AP-1 to induce the promoter of MMP1 ; however, p53 only inhibited the p300 mediated induction of the MMP1 promoter and the inhibition was -72AP-1 dependent
Frost et al., Mol Cell Biol 1994 : We found that coexpression of small t and either ERK1 , MEK1, or BXB resulted in an increase in AP-1 activity, whereas expression of either small t or any of the kinases alone did not have any effect ... We found that coexpression of small t and either ERK1, MEK1 , or BXB resulted in an increase in AP-1 activity, whereas expression of either small t or any of the kinases alone did not have any effect ... In contrast to REF52 cells, we observed that overexpression of either small or ERK1 alone in CV-1 cells was sufficient to stimulate AP-1 activity and that this stimulation was not enhanced by expression of small t and ERK1 together
Adcock et al., Life Sci 1994 : The interaction of the transcription factors, activator protein 1 (AP-1) and nuclear factor kappa from B cells ( NF kappa B ) with DNA and glucocorticoid receptors was analysed by gel mobility shift assays following stimulation by tumour necrosis factor alpha (TNF alpha) and a phorbol ester ( PMA ) that activates protein kinase C. PMA and TNF alpha both caused significant ( 180-340 % ) increases in AP-1 and NF kappa B DNA binding which peaked at 15 minutes and decreased to a constant elevated level at between 1-3 hrs and was sustained for 24hrs
Zhu et al., Arterioscler Thromb Vasc Biol 2001 : We previously reported that LDL activates c-Jun and AP-1 in ECs
Lee et al., J Mol Med (Berl) 2007 (Disease Models, Animal...) : Although C. difficile toxin A is known to induce nuclear factor-kappaB mediated chemokine expression in intestinal epithelial cells, little is known about its effect on the regulation of activator protein-1 (AP-1) by mitogen activated protein kinase ( MAPK )
Famulski et al., Cell Death Differ 1999 : We propose that ( i ) the up-regulation of an acidic nuclease activity is governed by a regulatory pathway different from that responsible for AP-1 factor induction, caspases activation and intracellular acidification, and ( ii ) activation of an acidic nuclease does not cause any deleterious effects when AP-1 transcription factor induction , caspases activation and intracellular acidification are down-regulated
Qian et al., Mol Cell Endocrinol 2007 : Transcriptional regulation of endothelial nitric oxide synthase expression in uterine artery endothelial cells by c-Jun/AP-1 ... We developed a c-Jun adenoviral expression system to overexpress c-Jun protein into UAEC to investigate the effects of c-Jun/AP-1 on NOS3 expression ... Lastly, the pharmacological AP-1 activator phorbol myristate acetate increased AP-1 binding, trans activated the wild-type but not the AP-1 mutant NOS3 promoter and dose-dependently stimulated UAEC NOS3 and c-Jun protein expression ... Lastly, the pharmacological AP-1 activator phorbol myristate acetate increased AP-1 binding, trans activated the wild-type but not the AP-1 mutant NOS3 promoter and dose-dependently stimulated UAEC NOS3 and c-Jun protein expression ... Hence, our data show that c-Jun/AP-1 regulates NOS3 transcription involving the proximal AP-1 site in the 5'-regulatory region of the sheep NOS3 gene
Dragomir et al., Vascul Pharmacol 2006 : Together, the findings indicate that in endothelial cells aspirin and PPAR-alpha activators reduce the high glucose increased expression of MCP-1 by a mechanism that includes the inhibition of reactive oxygen species, and decrease of AP-1 and NF-kB activation
Deng et al., Int J Biochem Cell Biol 2013 (Pulmonary Fibrosis) : Collectively, these findings strongly suggest that the increased binding of transcription factors to NF-?B and AP-1 elements in the CCL2 promoter is responsible for the active transcription expression of CCL2 in pulmonary fibrosis
Yamashita et al., J Biol Chem 2001 : The results support essential roles for AP-1 , GATA-2, and NF-1 in stabilizing the binding of HIF-1 and promoting recruitment of p300/CBP to the ET-1 hypoxia response complex
Hong et al., Mol Cell Biochem 2010 : Further, ERK inhibitor inhibited significantly OPN expression, Elk1 phosphorylation, and activator protein-1 (AP-1)-DNA binding activation, but not FAK phosphorylation, in the force applied cells
Mollinedo et al., J Immunol 1994 : Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells ... We have examined the possibility that stimulation of phospholipase D ( PLD ) may regulate activation of transcription factor AP-1 in human T cells by transfecting human T lymphocyte Jurkat cells with a plasmid containing an AP-1 enhancer element and a chloramphenicol acetyltransferase reporter gene ... We found a good correlation in the transfected cells between PLD activation and induction of AP-1 enhancer activity under different experimental conditions ... These data indicate that PLD stimulation can activate the transcription factor AP-1 in T lymphocytes, and suggest that the induction of AP-1 enhancer factor activity by PA is mediated via PKC stimulation, either through a direct activating effect of PA or through PA-derived diacylglycerol formation
Afford et al., FASEB J 2001 (Liver Cirrhosis, Biliary) : CD40 activation induced , Fas dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells ... CD40 activation induced, Fas dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells
Kustikova et al., Mol Cell Biol 1998 (Adenocarcinoma...) : We found that the enhanced level of AP-1 in CSML100 cells was due to high expression of Fra-1 and Fra-2 proteins, which were undetectable in CSML0 nuclear extracts ... We found that the enhanced level of AP-1 in CSML100 cells was due to high expression of Fra-1 and Fra-2 proteins, which were undetectable in CSML0 nuclear extracts
Liang et al., Mol Hum Reprod 2008 : Since IL-1beta activates NFkappaB, AP-1 and C/EBP, we over expressed these transcription factors alone and in combination and found that only NFkappaB alone increased FP mRNA expression
Yamazaki et al., J Dermatol Sci 2002 (Dermatitis, Atopic...) : Together, our present study indicates that AP-1 is over activated by IL-4 in PBMC of the atopic patients with the higher IgE level, thereby implying that IL-4 induced over-activation of AP-1 might be one of pathogenic factors in atopic dermatitis
Koul et al., Mol Cell Biochem 2007 (Glioma) : PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway
Ding et al., J Biol Chem 2001 : Catalase inhibited phosphorylation of ERKs and p38 kinase, as well as AP-1 activation induced by FFSi, suggesting the involvement of H ( 2 ) O ( 2 ) in the mechanism of silica induced AP-1 activation
Kizaki et al., Biochem Biophys Res Commun 2001 : Negative regulation of LPS stimulated expression of inducible nitric oxide synthase by AP-1 in macrophage cell line J774A.1
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003 : The EMSAs demonstrated that both IL-1beta and TGF-beta1 induced AP-1 activation within 2 h after stimulation, and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression ... The EMSAs demonstrated that both IL-1beta and TGF-beta1 induced AP-1 activation within 2 h after stimulation, and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression
Hu et al., Mol Cell Biol 1994 : We conclude that the activity of the albumin enhancer is subject to regulation by ras signaling pathways and that the effect of ras on the albumin enhancer activity may be mediated by AP-1
Bergers et al., Mol Cell Biol 1995 (Cell Transformation, Neoplastic) : Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron ... Using the posttranslational FosER induction system, we demonstrate that this AP-1 dependent stimulation of fra-1 expression is rapid, depends on a functional DNA binding domain of FosER, and is a general phenomenon observed in different cell types ... In vitro mutagenesis and functional analysis of the rat fra-1 gene in stably transfected Rat-1A-FosER fibroblasts indicated that basal and AP-1 regulated expression of the fra-1 gene depends on regulatory sequences in the first intron which comprise a consensus AP-1 site and two AP-1-like elements
Conrad et al., Mol Cell Biol 1994 : In contrast, we show that intact c-Jun expression inhibited the Ras induced activation of the prolactin promoter, defining it as a negative regulator of this pathway, whereas c-Jun was able to enhance the Ras activation of an AP-1-driven promoter in GH4 cells
Werman et al., Proc Natl Acad Sci U S A 2004 (Inflammation) : Under conditions of IL-1 receptor blockade, intracellular overexpression of the precursor and propiece forms of IL-1alpha were sufficient to activate NF-kappaB and AP-1
Li et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : Furthermore, overexpression of ZNF322 in COS-7 cells activates the transcriptional activity of SRE and AP-1
Ren et al., Laryngoscope 2004 (Carcinoma...) : LMP1 induces IL-8 mainly through the activation of NF-kappa B and partly through AP-1 in NPC model cell lines, NPC-KT, and this suggests that LMP1 plays an important role in the angiogenesis of NPC ... LMP1 induces IL-8 mainly through the activation of NF-kappa B and partly through AP-1 in NPC model cell lines, NPC-KT, and this suggests that LMP1 plays an important role in the angiogenesis of NPC
Koh et al., J Pharmacol Exp Ther 2010 (Acute Disease...) : Furthermore, we found that specific ERK1/2 and JNK inhibitors reduce NF-kappaB and AP-1 activity
Salvat et al., Oncogene 1998 : Taken together, these observations show that in vivo during a G0-to-S phase transition ( i ) the precise mechanisms triggering c-Fos and c-Jun directing to the proteasome are not identical, ( ii ) the presence of c-Fos is not an absolute prerequisite for the degradation of c-Jun and ( iii ) the degradation of c-Jun is not required for that of c-Fos
Hammaker et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : In addition, MKK4 and MKK7 kinase activity were significantly decreased in TAK1 deficient FLSs. Electrophoretic mobility shift assays demonstrated a significant decrease in IL-1beta induced AP-1 activation due to TAK1 knockdown
Deng et al., Proc Natl Acad Sci U S A 1992 : Construction and expression of a monomeric c-Jun protein that binds and activates transcription of AP-1-responsive genes
Shyu et al., Clin Sci (Lond) 2012 : The gel shift and promoter activity assay showed that Ang II increased AP-1 ( activator protein-1 ) -binding activity and leptin promoter activity, while SP600125, NAC and atorvastatin inhibited the AP-1 binding activity and leptin promoter activity induced by Ang II
Tomita et al., Respirology 2002 : Using a human airway cell line ( LC-2/ad ), lipopolysaccharide (LPS) induced gene expression of hBD-2 was studied in the absence or the presence of ( i ) dexamethasone, ( ii ) inhibition of NF-kappaB and AP-1 , ( iii ) intracellular calcium chelator, and ( iv ) cyclooxygenase (COX) inhibitors ... Lipopolysaccharide induced gene expression of hBD-2 was down-regulated by ( i ) dexamethasone, ( ii ) inhibition of NF-kappaB and AP-1 , and ( iii ) intracellular calcium chelator ... These findings suggest that glucocorticoids ( GC ), but not COX inhibitors, reduce hBD-2 gene expression, while NF-kappaB, AP-1 and intracellular calcium are essential for hBD-2 expression ... These findings suggest that glucocorticoids ( GC ), but not COX inhibitors, reduce hBD-2 gene expression, while NF-kappaB, AP-1 and intracellular calcium are essential for hBD-2 expression
Hirai et al., Osaka City Med J 2006 : AP-1 DNA binding activities in the FW and SW of group R significantly increased at POD 5, and NF-kappaB DNA binding activities of group R significantly increased at PODs 3 and 5
Guo et al., J Immunol 2005 : This study illustrates the crucial roles for AP-1 , IRF-1, IRF-2, and STAT1 in the regulation of murine TLR9 expression
Kawauchi et al., Biol Pharm Bull 2007 : cPrG.HCl potently suppressed AP-1 activity induced by tumor necrosis factor (TNF) alpha and phorbol myristate acetate ( PMA ) ... cPrG.HCl potently suppressed AP-1 activity induced by tumor necrosis factor (TNF) alpha and phorbol myristate acetate ( PMA )
Erdem et al., J Appl Physiol 2002 (Body Weight) : We conclude that 1 ) SET elicits a pretranslational stimulatory effect on adrenomedullary CA biosynthetic enzymes, 2 ) another immediate early mRNA product, rather than FRA-2 , may contribute to the increase in AP-1 binding activity in response to SET, and 3 ) SET increases NPY mRNA expression
Terzidou et al., J Clin Endocrinol Metab 2006 : OTR promoter contains putative transcription factor binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP), and nuclear factor-kappaB (NF-kappaB), which may be activated by IL-1beta , whose concentrations increase with labor ... In transient transfection studies, OTR promoter activity was increased by C/EBPbeta and NF-kappaB, but not by AP-1
Sun et al., Proc Natl Acad Sci U S A 1997 : Here we have used mutational analysis to study the role of the NFAT RIR in binding to DNA and AP-1
Zhang et al., Zhonghua Bing Li Xue Za Zhi 2004 (Glomerulonephritis) : Angiotensin II enhanced the expression of MCP-1 and activation of JNK and AP-1 in cultured human mesangial cells in a dose dependent manner, with maximal stimulation seen at 100 nmol/L ( 20.99 +/- 4.71 ) folds, ( 6.91 +/- 1.65 ) folds and ( 7.82 +/- 1.32 ) folds respectively
Hohensinner et al., Journal of thrombosis and haemostasis : JTH 2007 : To determine a possible role of nuclear factor kappaB (NF-kappaB) and activating protein 1 (AP-1) in M-CSF regulation, blockers to both pathways and an adenovirus overexpressing a dominant negative ( dn ) form of IkappaB kinase 2 (IKK2) were used
Nakahira et al., J Immunol 2002 : These results show that STAT4 up-regulates AP-1 mediated IFN-gamma promoter activation without directly binding to the promoter sequence, providing a mechanistic explanation for IL-12/IL-18 induced synergistic enhancement of IFN-gamma gene expression
Chen et al., Mol Carcinog 2000 : In the present study, we further examined the role of p38 in UVB induced AP-1 activation ... These results suggested, for the first time, that activation of p38 is required for UVB induced AP-1 activation in human keratinocytes
Burroughs et al., Mol Cancer Res 2003 (MAP Kinase Signaling System) : The expression of an activator protein (AP)-1 dominant negative in an immortalized prostate epithelial cell line PZ-HPV-7 suppressed the IGF-I induced increase in VEGF promoter activity
Li et al., Phytochemistry 2010 : Compounds 1, 5-7, 9-10, and 13 showed anti-inflammatory potency to suppress expression of NF-?B and AP-1 targeted genes including TNF-a and IL-6 induced by lipopolysaccharide (LPS) in mouse macrophages Raw 264.7 cells
Shibata et al., Biochem Biophys Res Commun 2012 : It has been reported that overexpression of TRIM45 , one of the TRIM family ubiquitin ligases, suppresses transcriptional activities of Elk-1 and AP-1 , which are targets of the MAPK signaling pathway
Tsuchiya et al., Laryngoscope 2007 : However, the PGPS induced IL-8 promoter activation in rodent middle ear epithelial cells required NF-kappaB and NF-IL6 but not AP-1
Liu et al., Biochim Biophys Acta 2013 (Osteoarthritis) : CCN4 induced VCAM-1 expression was attenuated by avß5 or a6ß1 integrin antibody, Syk inhibitor, PKCd inhibitor ( rottlerin ), JNK inhibitor ( SP600125 ), and AP-1 inhibitors ( curcumin and tanshinone )
Cha et al., Immunol Invest 2009 (Inflammation) : In addition, the essential oil suppressed the LPS stimulated activation of mitogen activated protein kinases ( MAPKs ) as well as the AP-1 DNA binding activity
Fisher et al., J Investig Dermatol Symp Proc 1998 : In the dermis and epidermis, AP-1 induces expression of matrix metalloproteinases collagenase, 92 kDa gelatinase , and stromelysin, which degrade collagen and other proteins that comprise the dermal extracellular matrix
Ko et al., Toxicol In Vitro 2005 : We also demonstrated that RVS glycoprotein inhibits activities of the nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) induced by G/GO, and prevents from G/GO induced apoptosis in the NIH/3T3 cells
Park et al., Int Immunol 2004 : IL-12 stimulation greatly enhanced the promoter binding activity of c-Jun/AP-1 , a critical transcription factor for IFN-gamma gene expression in wild-type T cells, but not in STAT4-deficient ( STAT4 ( -/- ) ) T cells
Joo et al., J Immunol 2007 (Atherosclerosis...) : Chromatin immunoprecipitation assays show that L-PGDS induction was regulated positively by AP-1 , but negatively by p53
Ikeo et al., Endocr J 2004 (Multiple Endocrine Neoplasia Type 1) : JunD-menin interaction regulates c-Jun mediated AP-1 transactivation ... JunD-menin interaction regulates c-Jun mediated AP-1 transactivation
Hayashi et al., J Immunol 2006 : Depletion of FLNa by RNA interference did not affect TCR induced early tyrosine phosphorylation or actin polymerization but, nevertheless, resulted in impaired IL-2 expression by human primary T cells and reduced activation of NF-kappaB, AP-1 , and NFAT reporter genes in transfected T cells ... Depletion of FLNa by RNA interference did not affect TCR induced early tyrosine phosphorylation or actin polymerization but, nevertheless, resulted in impaired IL-2 expression by human primary T cells and reduced activation of NF-kappaB, AP-1 , and NFAT reporter genes in transfected T cells
Miraoui et al., Hum Mol Genet 2010 (Acrocephalosyndactylia) : Investigation of the underlying molecular mechanisms revealed that activated FGFR2 enhances EGFR and PDGFRalpha mRNA expression via activation of PKCalpha dependent AP-1 transcriptional activity
Lin et al., Inflamm Bowel Dis 2008 (Crohn Disease) : Probiotic L. reuteri suppressed TNF transcription by inhibiting activation of MAP kinase regulated c-Jun and the transcription factor , AP-1 ... Probiotic L. reuteri suppressed TNF transcription by inhibiting activation of MAP kinase regulated c-Jun and the transcription factor, AP-1
Hong et al., Toxicology 1998 : The combination of ciprofibrate and PGF2alpha blocked the inhibitory effect of transforming growth factor ( TGF ) -beta on the DNA binding activity of AP-1 induced by EGF
Chuang et al., Chem Biol Interact 2010 : Thus, the present results indicate that R in combination with VE attenuates VEGF expression in HL-60 cells and that this effect is mediated by a decreased binding activity of AP-1 through down-regulation of protein expression of insulin-like growth factor 1 receptor ( IGF1-R ) /IRS-1, while the antioxidant activity of R+VE appears to play a minor role
Chun et al., Carcinogenesis 2004 : Celecoxib inhibits phorbol ester induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin ... In order to clarify the roles of p38 and ERK in TPA induced AP-1 activation, we utilized the pharmacologic inhibitors of these enzymes ... In order to clarify the roles of p38 and ERK in TPA induced AP-1 activation, we utilized the pharmacologic inhibitors of these enzymes
Wang et al., Nephrology (Carlton) 2013 (Kidney Diseases...) : IMD/ADM2 also increased cyclin D1 promoter activity and AP-1 DNA binding activity
Bae et al., Development 2006 : PKD-2 is directed to moving dendritic particles by the UNC-101/adaptor protein 1 (AP-1) complex
Ma et al., Molecular cancer 2012 (Carcinoma, Ductal, Breast) : Individually, epidermal growth factor (EGF), and interleukin (IL)-1ß activated ERK1/2 , increased cell migration and invasion, MMP-9 expression and activity, AP-1 activation in vitro and the expression of p-ERK1/2 was positively correlated with EGF expression levels, as well as IL-1ß, MMP-9 and c-fos in IBDC tissue samples ... Individually, epidermal growth factor (EGF), and interleukin (IL)-1ß activated ERK1/2, increased cell migration and invasion, MMP-9 expression and activity, AP-1 activation in vitro and the expression of p-ERK1/2 was positively correlated with EGF expression levels, as well as IL-1ß, MMP-9 and c-fos in IBDC tissue samples
Jung et al., Biofactors 2008 : Matrine inhibited PMA induced activation of the AP-1 promoter, an important nuclear transcription factor in MMP-1 expression
Balmanno et al., Oncogene 1999 : This suggests that both early and late AP-1 gene expression is regulated by the same Gi-mediated, MEK dependent MAPK signalling pathway but that expression of late AP-1 genes and cyclin D1 requires that this pathway be persistently activated
Zhou et al., Proc Natl Acad Sci U S A 2011 (Inflammation) : Overexpression of PPARa significantly attenuated the AP-1 mediated miR-21 expression ... These results demonstrate a unique mechanism by which OSS induces AP-1 dependent miR-21 expression, which directly targets PPARa to inhibit its expression, thereby allowing activation of AP-1 and the promotion of monocyte adhesion
Hu et al., BMB Rep 2010 : KBTBD7 , a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1 ... Overexpression of KBTBD7 in MCF-7 cells activates the transcriptional activities of activator protein-1 (AP-1) and serum response element ( SRE ), which can be relieved by siRNA
Wang et al., J Biol Chem 2002 (Inflammation) : Furthermore, constitutive activation of PPAR-gamma resulted in simultaneous repression of AP-1 and NF-kappaB activity, which suggests that PPAR-gamma may reduce pro-inflammatory phenotypes via, at least in part, suppression of the AP-1 and NF-kappaB pathways
Hu et al., Lung 2006 : AP-1 inhibitor curcumin also inhibited TGF-beta1 induced alpha-SMA expression ... In addition, dominant negative mutant c-Jun ( TAM67 ) downregulated TGF-beta1 induced AP-1 transactivation and alpha-SMA expression ... In additional, PD98059 but not SB203580 inhibited the AP-1 DNA binding activity induced by TGF-beta1 ... Based on these findings, we conclude that p38 kinase, Erk, and AP-1 are responsible for the alpha-SMA expression induced by TGF-beta1 in human fetal lung fibroblasts
Liou et al., Immunity 2000 (MAP Kinase Signaling System) : HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1
Hsu et al., J Immunol 2001 : The nuclear translocation and DNA binding study revealed that ceramide can inhibit LPS induced NF-kappaB and AP-1 activation ... In conclusion, we suggest that ceramide inhibition of LPS mediated induction of inducible NO synthase and cyclooxygenase-2 is due to reduction of the activation of NF-kappaB and AP-1 , which might result from ceramide 's inhibition of LPS stimulated IkappaB kinase, p38 mitogen activated protein kinase, and protein kinase C ... In conclusion, we suggest that ceramide inhibition of LPS mediated induction of inducible NO synthase and cyclooxygenase-2 is due to reduction of the activation of NF-kappaB and AP-1 , which might result from ceramide 's inhibition of LPS stimulated IkappaB kinase, p38 mitogen activated protein kinase, and protein kinase C
Gutzman et al., Mol Endocrinol 2005 (Breast Neoplasms...) : Here we demonstrate that PRL and E2 cooperatively enhance the activity of AP-1 in MCF-7 derived cells
Kumasawa et al., Eur J Pharmacol 2005 : We examined the effect LTD ( 4 ) on AP-1 activation in human airway smooth muscle cells and analyzed a role of apoptosis signal regulating kinase1 ( ASK1 ), an upstream kinase kinase of c-Jun-NH ( 2 ) -terminal kinase ( JNK ) and p38 mitogen activated protein kinase ( MAPK ) in LTD ( 4 ) -induced AP-1 activation to clarify the signaling molecule regulating AP-1 activation ... We examined the effect LTD ( 4 ) on AP-1 activation in human airway smooth muscle cells and analyzed a role of apoptosis signal regulating kinase1 ( ASK1 ), an upstream kinase kinase of c-Jun-NH ( 2 ) -terminal kinase ( JNK ) and p38 mitogen activated protein kinase ( MAPK ) in LTD ( 4 ) -induced AP-1 activation to clarify the signaling molecule regulating AP-1 activation ... The results showed that LTD ( 4 ) induced AP-1 activation determined by AP-1 dependent luciferase gene activity and ASK1 phosphorylation ... These results indicate that LTD ( 4 ) is capable of inducing AP-1 activation and ASK1 regulates AP-1 activation in LTD ( 4 ) -stimulated airway smooth muscle cells
Bianchi et al., Arch Biochem Biophys 2002 (Melanoma, Experimental) : Since in B16-F1 cells HGF increased AP-1 activity and the mRNA expression of various AP-1 subunits, we may conclude that HGF induced transcription of mouse ODC was largely due to triggering of AP-1 pathway
Roger et al., Biochem J 2005 : Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression
Lee et al., J Biomed Sci 2008 (Colitis...) : In addition, consumption of UDN glycoprotein attenuated the activities of proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) , and inhibited the DNA binding activities of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in the mice colonic tissue ... In addition, consumption of UDN glycoprotein attenuated the activities of proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS) , and cyclooxygenase-2 (COX-2), and inhibited the DNA binding activities of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in the mice colonic tissue ... In addition, consumption of UDN glycoprotein attenuated the activities of proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), and inhibited the DNA binding activities of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in the mice colonic tissue
Iles et al., Free Radic Biol Med 2005 : Downstream, MAPK activation leads to increased AP-1 binding, which mediates GCL induction
Huo et al., Oncol Rep 2013 : The results showed that MDA-7/IL-24 overexpression decreased the expression of CD44, ICAM-1, MMP-2/-9, CyclinB, Twist, survivin, TGF-ß and p-Akt, transcriptional activity of NF-?B, and increased the expression of E-cadherin and p-ERK and transcriptional activity of AP-1 in HepG2 and BEL-7402 cells
Henderson et al., J Virol 2000 : HMG I binding to this composite site inhibits the binding of recombinant AP-1
Maldonado et al., Immunology 2003 : The mutation study further indicated that the activator protein-1 (AP-1) ( -3471 ) or Ets ( -3836 ) motifs in this distal region were essential for the LDL-IC stimulated MMP-1 expression ... In conclusion, the present study shows that both the distal and proximal AP-1 and Ets motifs are required for LDL-IC stimulated MMP-1 expression in U937 histiocytes
Klampfer et al., Mol Cell Biol 1994 : Consistent with this possibility, IL-1 and TNF-alpha markedly increase the binding of Fos and Jun to the AP-1 site, and NF-IL6 activates the native TSG-6 promoter ... Consistent with this possibility, IL-1 and TNF-alpha markedly increase the binding of Fos and Jun to the AP-1 site, and NF-IL6 activates the native TSG-6 promoter ... Consistent with this possibility, IL-1 and TNF-alpha markedly increase the binding of Fos and Jun to the AP-1 site, and NF-IL6 activates the native TSG-6 promoter
Yogesha et al., J Immunol 2009 (Arthritis, Experimental...) : We found that IL-3 prevented TNF-alpha induced c-fos nuclear translocation and AP-1 DNA binding activity ... We found that IL-3 prevented TNF-alpha induced