Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shikhman et al., J Immunol 2001 : IL-1beta regulation of glucose transport in chondrocytes depends on protein kinase C and p38 signal transduction pathways, and does not require phosphoinositide 3-kinase, extracellular signal related kinase, or c-Jun N-terminal kinase activation
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003 : The EMSAs demonstrated that both IL-1beta and TGF-beta1 induced AP-1 activation within 2 h after stimulation, and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression
O'Donnell et al., Eur J Neurosci 2000 : The data described indicate that IL-1beta and H2O2 increase the activity of two stress activated mitogen activated protein kinases, c-Jun NH2-terminal kinase (JNK) and p38 in vitro, while age related increases in both kinases were observed
Kida et al., Cytokine 2005 : Three MAPKs, extracellular signal regulated kinase ( ERK ), p38 MAPK and c-Jun N-terminal kinase (JNK) , which were simultaneously activated by IL-1beta , mediated subsequent c-fos and c-jun mRNA expression and DNA binding of AP-1 at different magnitudes
Masamune et al., J Cell Biochem 2006 : Curcumin inhibited interleukin-1beta- and TNF-alpha induced activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase ), but not of nuclear factor-kappaB (NF-kappaB)
Chuen et al., J Lab Clin Med 2004 : In this study, we investigated the possible direct effects of IL-1beta on the expression of thrombopoietin (TPO) and transcription factors c-Jun , c-Fos, GATA-1, and p45 nuclear factor-E2 (NF-E2) in MK cell lines CHRF and Meg-01
Wu et al., J Neurochem 2004 (Translocation, Genetic) : In accordance with these findings, IL-1beta stimulated phosphorylation of p42/p44 MAPK, p38, and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126, SB202190, or SP600125, respectively
Hungness et al., Shock 2000 : The effect of IL-1beta on AP-1 activity in the enterocyte and the potential role of AP-1 in enterocyte IL-6 production are not known ... Geldanamycin, which has been shown in studies to inhibit AP-1 activation, blocked IL-1beta induced AP-1 luciferase gene activation and IL-6 production ... These results suggest that the AP-1 family of transcription factors is activated by IL-1beta in human enterocytes and that AP-1 may at least in part regulate IL-6 production in these cells
Lucio-Cazana et al., J Am Soc Nephrol 2001 : Experiments that used pharmacologic and genetic inhibitors showed that the IL-1beta-inducible MCP-1 expression was dependent on nuclear factor-kappaB (NF-kappaB) and independent of activator protein 1 (AP-1) ... These data suggested that ( 1 ) constitutive and IL-1beta-inducible expression of MCP-1 was differently regulated by AP-1 and NF-kappaB and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway
Brechter et al., Bone 2008 : EMSA showed that IL-1beta and TNF-alpha activated NF-kappaB and AP-1 in MG-63 cells
Nolan et al., J Neuroimmunol 2004 : Lipopolysaccharide (LPS) has a negative impact on long-term potentiation ( LTP ) in the rat hippocampus, which has been correlated with increased concentration of interleukin-1 beta (IL-1 beta) and activation of p38 and c-Jun N-terminal kinase (JNK)
Sawano et al., Kidney Int 2002 : IL-1beta rapidly activated extracellular signal regulated kinase ( ERK ) and c-Jun NH2-terminal kinase (JNK) , which were involved in the up-regulation of COX-2 induction, but 15d-PGJ2 inhibited the activation of these kinases
Lee et al., J Immunol 2003 : IL-1 beta increased NF-kappa B and AP-1 activity and both transcription factors mediated IL-1 beta induced MCP-1 expression in mesangial cells ... BMP-7 inhibited IL-1 beta induced AP-1 activity in a concentration dependent manner
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : IL-1beta stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses ... IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation , and nuclear factor-kappaB (NF-kappaB) p65 translocation were attenuated by the inhibitors of MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids
Jomphe et al., Basic Clin Pharmacol Toxicol 2008 : Chondroitin sulfate reduced IL-1beta induced NF-kappaB nuclear translocation, but not AP-1 translocation, it decreased IL-1beta induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation, but did not prevent IL-1beta induced increase in nitrite
Nolan et al., J Biol Chem 2005 (Inflammation) : The evidence indicates that IL-4 modulates expression of IL-1beta mRNA and protein and that it attenuates IL-1beta induced impairment of LTP and phosphorylation of JNK and c-Jun
Hwang et al., J Biol Chem 2005 : IL-1beta induced expression and transient phosphorylation of c-Jun in primary cultured chondrocytes ... Consistent with its ability to induce phosphorylation of c-Jun, IL-1beta caused transient activation of AP-1 , which is necessary for IL-1beta induced dedifferentiation
Hammaker et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : In addition, MKK4 and MKK7 kinase activity were significantly decreased in TAK1 deficient FLSs. Electrophoretic mobility shift assays demonstrated a significant decrease in IL-1beta induced AP-1 activation due to TAK1 knockdown
Hwang et al., Oncogene 2004 (Stomach Neoplasms) : Electrophoretic mobility shift assay confirmed that IL-1beta increased the DNA binding activity of AP-1 and NF-kappaB
Karakashian et al., FASEB J 2004 : The effect of NSMase-2 expression on IL-1beta induced activation of c-Jun N-terminal kinase (JNK) was tested
Sabolek et al., Stem Cells 2009 (MAP Kinase Signaling System) : Surprisingly, IL-1beta did not activate the NF-kappaB pathway or the transcription factor activating protein 1 (AP-1) , but inhibition of nuclear translocation of NF-kappaB by SN50 facilitated IL-1beta induced Nurr1 expression and dopaminergic differentiation of mdNPCs
Jana et al., Free Radic Biol Med 2005 : Although IL-1beta and IFN-gamma alone induced the activation of AP-1 , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1 ... Consistently, JNK-I, a specific inhibitor of JNK, inhibited IL-1beta mediated activation of AP-1 and expression of iNOS
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Honsho et al., Circ Res 2009 (Endomyocardial Fibrosis...) : IL-1beta deficiency markedly increased c-Jun N-terminal kinase (JNK) and caspase-3 activities and enhanced myocyte apoptosis and fibrosis, whereas replacement of IGF-1 or JNK inhibitor restored them
Xie et al., Respir Res 2005 : IL-1beta induced MMP-12 activity and gene expression was down-regulated by the corticosteroid dexamethasone but up-regulated by the inflammatory cytokine tumour necrosis factor (TNF)-alpha through enhancing activator protein-1 activation by IL-1beta
Patel et al., J Interferon Cytokine Res 2002 (Melanoma) : Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta induced NF-kappaB, but not AP-1 , leading to inhibition of IL-8 expression
Domagala et al., Biorheology 2006 : Inhibition of interleukin-1beta induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1 : potential mechanism for Diacerein effects in osteoarthritis
Legendre et al., Clin Exp Rheumatol 2007 : The drug reduced IL-1Beta induced NF-kappaB and AP-1 DNA binding, as well as the phosphorylation of ERK and JNK
Mohan et al., Endocrinology 2007 : In contrast, IL-1beta increased both AP-1 and NF-kappaB DNA binding at 1 h only
Li et al., Peptides 2007 : In the present study, we found that IL-1beta stimulation induced c-Jun N-terminal kinase (JNK) activity within 15min in A549 cells ... In investigating whether JNK was involved in IL-1beta induced CGRP secretion, the JNK II inhibitor SP600125 was used and it significantly attenuated IL-1beta induced CGRP secretion and c-Jun activity, which was elevated after IL-1beta stimulation from mRNA to protein level
Lu et al., Invest Ophthalmol Vis Sci 2004 : Dexamethasone also inhibited the IL-1beta induced phosphorylation of the MAPKs extracellular signal regulated kinase ( ERK ) and c-Jun N-terminal kinase (JNK) , but not that of p38
Park et al., Ann N Y Acad Sci 2009 (Inflammation...) : We found that omega-3 fatty acids, such as docosahexaenoic acid ( DHA ) and alpha-linolenic acid ( ALA ), suppressed the expression of inflammatory cytokines ( IL-1beta , IL-6 ) and inhibited the activation of transcription factor activator protein-1 in cerulein stimulated pancreatic acinar cells
Martin et al., Inflammation 2003 (MAP Kinase Signaling System...) : Rhein inhibits interleukin-1 beta induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia : a potential mechanism for its disease modifying effect in osteoarthritis
Choi et al., Food Chem Toxicol 2010 (Sarcoma) : Moreover, IL-1beta induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation were inhibited by luteolin
Shen et al., Curr Eye Res 2009 : The effect of interleukin-1beta on the expression of glutamine synthetase and c-Jun in retinal Müller cells under normal and high glucose conditions was measured by immunocytochemistry, Western blot, and real-time ( RT ) PCR, and was further confirmed by c-Jun siRNA method ... Under high glucose conditions, interleukin-1beta significantly increased expression of c-Jun and decreased the expression of glutamine synthetase
Hattori et al., Am J Physiol 1993 (Acute-Phase Reaction...) : In addition, IL-6, tumor necrosis factor-alpha, and IL-1 beta , cytokine regulators of the acute phase response, stimulated expression of an AP-1 responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture
Liu et al., J Neurosci 2000 : However, pretreatment with oATP downregulated activation of NF-kappaB and AP-1 by IL-1beta or TNFalpha
Jeon et al., Immunopharmacology 2000 : Dexamethasone inhibits IL-1 beta gene expression in LPS stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation
Wehkamp et al., J Invest Dermatol 2006 : Pseudomonas aeruginosa- and IL-1beta mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1
Li et al., Hepatology 2006 : IL-1 beta and CDCA reduced CYP7A1 but induced c-Jun messenger RNA expression in human primary hepatocytes ... In conclusion, IL-1 beta and CDCA inhibit HNF4 alpha but induce c-Jun , which in turn blocks HNF 4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin and results in inhibition of CYP7A1 gene transcription
Martin et al., Arthritis Rheum 2004 (Anoxia) : IL-1beta induced DNA binding of NF-kappaB and AP-1 was significantly higher in hypoxic and reoxygenated cultures than in normoxia
Masamune et al., Biochem Pharmacol 2005 : Ellagic acid inhibited IL-1beta- and TNF-alpha induced activation of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase, c-Jun N-terminal kinase and p38 mitogen activated protein kinase ), but not of nuclear factor-kappaB
Lin et al., Cell Signal 2009 : In addition, the IL-1 beta induced c-Jun phosphorylation was reduced by pretreatment with U0126 or SP600125
Masamune et al., Pancreas 2002 (Acute Disease...) : IL-1 beta and TNF-alpha increased the nuclear factor-kappa B (NF-kappa B)-specific and activator protein-1-specific DNA binding activity, whereas the NF-IL6 activity was not altered
Lieb et al., J Neurochem 1996 (Astrocytoma) : Activation of the transcription factor nuclear factor-kappa B by IL-1 beta involved ROIs, whereas the IL-1 beta induced activation of the transcription factor AP-1 was mediated via protein kinase C
Terzidou et al., J Clin Endocrinol Metab 2006 : OTR promoter contains putative transcription factor binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP), and nuclear factor-kappaB (NF-kappaB), which may be activated by IL-1beta , whose concentrations increase with labor
Masamune et al., World J Gastroenterol 2003 (Cystic Fibrosis) : Interleukin-1beta activated nuclear factor-kappaB, activator protein-1 , and MAP kinases
Noh et al., Rheumatology (Oxford) 2009 (Arthritis, Rheumatoid...) : Moreover, cordycepin significantly inhibited IL-1beta induced p38/JNK and AP-1 activation, but not extracellular signal regulated kinase ( ERK ) and NF-kappaB activation
Clerk et al., J Mol Cell Cardiol 1999 (MAP Kinase Signaling System) : IL-1 beta and TNF alpha stimulated the phosphorylation of c-Jun and ATF2 ... However, IL-1 beta induced a greater increase in c-Jun protein ... Inhibitors of protein kinase C ( PKC ) ( Ro318220, GF109203X ) and the ERK cascade ( PD98059 ) attenuated the increase in c-Jun induced by IL-1 beta , but LY294002 ( an inhibitor of phosphatidylinositol 3 ' kinase ) and SB203580 ( an inhibitor of p38-MAPK, which also inhibits certain JNK isoforms ) had no effect ... These data illustrate that some of the pathological effects of IL-1 beta and TNF alpha may be mediated through the MAPK cascades, and that the ERK cascade, rather than JNKs or p38-MAPKs, are implicated in the upregulation of c-Jun by IL-1 beta
Mendes et al., Cell Biol Toxicol 2003 (Inflammation) : Hydrogen peroxide mediates interleukin-1beta induced AP-1 activation in articular chondrocytes : implications for the regulation of iNOS expression
Moore et al., Am J Physiol 1999 : However, Dex did not inhibit IL-1beta induced nuclear translocation of nuclear factor-kappaB or activator protein-1 in HASM cells
Fahmi et al., Osteoarthritis Cartilage 2002 : Interestingly, 15d-PGJ ( 2 ) reduced both basal and IL-1beta induced AP-1 binding activity
Martin et al., Osteoarthritis Cartilage 2005 : IL-1beta enhanced both AP-1 and NF-kappaB binding, whereas H ( 2 ) O ( 2 ) only activated AP-1 ... The different regulation of NF-kappaB and AP-1 by H ( 2 ) O ( 2 ) and IL-1beta underlines the distinct roles played by the two transcription factors in the regulation of gene expression
Migita et al., Immunol Lett 2005 (Arthritis, Rheumatoid) : FK506 also prevented IL-1beta stimulated JNK activation and transcriptional activation of AP-1 in these cells
He et al., Zhonghua Yi Xue Za Zhi 2001 (Pulmonary Disease, Chronic Obstructive) : Enhancement of activity of NF kappa B and AP-1 may positively regulate the production of IL-8 and IL-1 beta in the airflow obstruction
Bian et al., Invest Ophthalmol Vis Sci 2004 : Blockade of PI3K/Akt abolished IL-1beta induced nuclear translocation of AP-1 , whereas the induction of IkappaB degradation was unchanged
Satoh et al., Tohoku J Exp Med 2002 : Interleukin-1beta (IL-1beta) activated nuclear factor-kappaB, activator protein-1 , and three classes of mitogen activated protein ( MAP ) kinases : extracellular signal regulated kinase1/2, c-Jun N-terminal kinase, and p38 MAP kinase
Quentmeier et al., Leuk Res 1994 : Alternatively, these data support the notion that neither AP-1 nor the c-myc protein are involved in the MDHM induced increase in IL-1 beta , IL-6 or TNF alpha mRNA levels
Shah et al., Int J Cancer 2006 (Colonic Neoplasms) : Ursodeoxycholic acid inhibits interleukin 1 beta [ corrected ] and deoxycholic acid induced activation of NF-kappaB and AP-1 in human colon cancer cells
Yamazaki et al., In Vitro Cell Dev Biol Anim 2005 (Sarcoma, Synovial) : Both NF-kappaB and AP-1 deoxyribonucleic acid binding activities were detectable in SW982 cells by EMSA, and they were induced by interleukin-1beta treatment
Lee et al., Mol Genet Metab 1998 : Bcl-2 regulates nonapoptotic signal transduction : inhibition of c-Jun N-terminal kinase (JNK) activation by IL-1 beta and hydrogen peroxide
Tominaga et al., Aliment Pharmacol Ther 2000 (Inflammation) : To investigate whether IL-1beta activates MAP kinases [ extracellular signal regulated kinases ( ERKs ), c-Jun NH2-terminal kinases (JNKs) and p38 MAP kinase (p38 MAPK) ] and nuclear factor (NF)-kappaB
Masamune et al., J Pharmacol Exp Ther 2004 : SP600125 inhibited interleukin-1beta induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular regulated kinase, p38 mitogen activated protein kinase, and nuclear factor-kappaB
Hamid et al., Cytokine 2000 : The IL-1beta stimulated the collagenase-CAT and AP-1-CAT activities in a dose dependent manner with respect to the amount of DNA used in transfections
Shen et al., Zhonghua Yan Ke Za Zhi 2007 : After being treated with different doses of IL-1 beta for 24 hours, the effect of IL-1 beta on the expressions of GS and c-Jun in retinal Müller cells in the control and experimental groups was measured by western blot analysis and indirect immunofluorescence
Lin et al., Rheumatol Int 2008 (Chondrosarcoma...) : A slightly synergistic effect on the activation of AP-1 induced by IL-1beta was shown in the presence of GLN
Pinteaux et al., J Neurochem 2002 : Bacterial lipopolysaccharide (LPS) caused increased expression of IL-1RI, IL-1RII and IL-1RAcP mRNAs, induced the release of IL-1beta , IL-6 and prostaglandin-E2 ( PGE2 ), and activated nuclear factor kappaB (NF-kappaB) and the mitogen activated protein kinases ( MAPKs ) p38, and extracellular signal regulated protein kinase ( ERK1/2 ), but not c-Jun N-terminal kinase (JNK) in microglial cultures
Migita et al., Rheumatology (Oxford) 2005 : A77 1726 inhibited IL-1beta induced p38 and c-Jun N-terminal kinase 1/2 ( JNK1/2 ) activation, whereas A77 1726 did not affect IL-1beta induced NF-kappaB activation in hepatocytes
Serkkola et al., Eur J Biochem 1993 : We have now examined the role of AP-1 in the regulation of the IL-1 beta gene expression by PKC and cAMP in THP-1 cells
Larsen et al., Diabetologia 2006 (Insulinoma...) : IL-1beta activates beta cell c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( ERK ) and p38, all of which are members of the mitogen activated protein kinase ( MAPK ) family
Fan et al., J Biol Chem 2010 : Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta induced IKK/NF-kappaB and JNK/AP-1 activation
Benderdour et al., J Rheumatol 2002 (Osteoarthritis) : Of note, in OA chondrocytes, IL-17 and IL-1beta induced collagenase-3 production through AP-1 occurred with differential protein complexes : IL-17 stimulation resulted in FosB activation, while IL-1beta stimulated c-Fos ... We demonstrated that IL-17 and IL-1beta induced collagenase-3 production in OA chondrocytes mainly through AP-1 mediated transcriptional activity but with differential protein complexes, suggesting that some AP-1 proteins play a pivotal role in the different cytokine responses in terms of collagenase-3 production
Liang et al., Mol Hum Reprod 2008 : Since IL-1beta activates NFkappaB, AP-1 and C/EBP, we over expressed these transcription factors alone and in combination and found that only NFkappaB alone increased FP mRNA expression
Cullen et al., J Vasc Res 2007 : While resveratrol had no effect on MCP-1 mRNA degradation, it inhibited MCP-1 promoter activity and reduced nuclear factor kappaB and activator protein-1 binding activity induced by IL-1beta
Wang et al., Cytokine 2009 (Acute Lung Injury) : ZD 7155 also reduced the mRNA expression of TNF-alpha and IL-1 beta , inhibited the activation of NF-kappaB and AP-1 , and improved lung histopathology