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AKT3 — KIT
Text-mined interactions from Literome
Duensing et al., Oncogene 2004
(Gastrointestinal Neoplasms) :
Using GIST in vitro models, we showed that activation of MAPK p42/44,
AKT , and S6K was
KIT dependent , whereas STAT1 and STAT3 phosphorylation was only partially dependent on KIT activation
Shaw et al., Gynecol Oncol 2007
(Ovarian Neoplasms) :
AKT mediates the pro-survival effects of
KIT in ovarian cancer cells and is a determinant of sensitivity to imatinib mesylate
Lin et al., J Med Chem 2009
(Lung Neoplasms) :
We further confirmed that
PBT-1 suppressed
Akt activation accelerated RelA degradation via IkappaB kinase-alpha and down-regulated NF-kappaB target gene expression
Phung et al., PloS one 2011
:
Using specific inhibitors we observe and verify that
c-KIT induced activation of Mitf is
dependent on PI3-,
Akt- , Src-, p38- or Mek kinases
Brahimi-Adouane et al., Mol Oncol 2013
:
ER inhibitors also inhibited
KIT activation
dependent phosphorylation of
AKT and ERK1/2