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AKT1 — KRAS
Text-mined interactions from Literome
Choi et al., Oncogene 2004
:
Taken together, these findings explain the opposite effects of Ha-Ras and Ki-Ras on modulation of radiosensitivity, and suggest that differential
activation of
PI3K/Akt and Rac/p38 MAPK signaling by Ha-Ras and
Ki-Ras may account for the opposing response to the ionizing radiation
Carón et al., Mol Cancer Ther 2005
(Carcinoma...) :
Activated forms of H-RAS and
K-RAS differentially
regulate membrane association of PI3K, PDK-1, and
AKT and the effect of therapeutic kinase inhibitors on cell survival
Toulany et al., Mol Cancer Res 2007
(Neoplasms) :
Therefore, the
role of
K-Ras activity for a direct ( i.e., through activation of PI3K by K-Ras ) or an indirect stimulation of
PI3K-AKT signaling ( through K-Ras activity dependent EGFR ligand production ) was investigated by means of small interfering RNA and inhibitor approaches as well as ELISA measurements of EGFR ligand production ... Knocking down
K-Ras expression by specific small interfering RNA markedly
affected autocrine production of AREG, but not
PI3K-AKT signaling, after treatment of K-RAS mutated or wild-type cells with EGFR ligands or exposure to ionizing radiation ... These results indicate that PI3K mediated activation of
AKT in K-RASmt human tumor cells as a function of EGFR ligand or radiation stimulus is
independent of a direct function of
K-Ras enzyme activity but depends on a K-Ras mediated enhanced production of EGFR ligands ( i.e., most likely AREG ) through up-regulated extracellular signal regulated kinase-1/2 signaling
Zeng et al., PloS one 2010
(Colonic Neoplasms...) :
This activation of
K-ras did not depend upon EGFR and
resulted in the phosphorylation of
Akt and induction of VEGF expression
Levallet et al., Mol Cancer Ther 2012
(Carcinoma, Non-Small-Cell Lung...) :
siRNA
K-Ras knockdown,
inhibition of RAF/MEK ( MAP-ERK kinase ) and phosphoinositide 3-kinase
(PI3K)/AKT signaling, and hypoxia were shown to downregulate TUBB3 expression in bronchial cells