Gene interactions and pathways from curated databases and text-mining

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LEP — PRKAR1B

Text-mined interactions from Literome

Yamagishi et al., J Biol Chem 2001 : Leptin activated PKA , and the effects of leptin were inhibited by the cAMP antagonist Rp-cAMPS
Ke et al., Biochem Biophys Res Commun 2003 (Body Weight) : Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels
Szkudelski et al., Physiol Res 2005 : Inhibition of protein kinase A (PKA) by H-89 ( 50 micromol/l ) slightly enhanced leptin release stimulated by glucose and leucine but not by alanine ... Moreover, it has also been shown that inhibition of PKA evokes the opposite effect and enhances leptin release
Sirotkin et al., Physiol Res 2008 : The aim of our in vitro studies was to understand the role of leptin in controlling proliferation, apoptosis, and protein kinase A (PKA) in human ovarian cells ... We analyzed the in vitro effects of leptin ( 0, 1, 10 or 100 ng/ml ) on the accumulation of proliferation related peptides ( PCNA, cyclin B1 ), apoptosis associated peptide ( Bax ) and the intracellular signaling molecule PKA in cultured human granulosa cells using immunocytochemistry and Western immunoblotting ... It was observed that leptin stimulated in a dose dependent manner the accumulation of PCNA ( at doses 1-100 ng/ml ), cyclin B1 ( at doses 10 or 100 ng/ml ), Bax ( at doses 10 or 100 ng/ml ) and PKA ( at doses 1-100 ng/ml ) in cultured human ovarian cells
Sirotkin et al., Comp Biochem Physiol A Mol Integr Physiol 2007 : Finally, leptin inhibited expression of MAPK/ERK1,2 and CDK/p34 and stimulated expression of PKA
Yang et al., PloS one 2008 : cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin ... All these effects are mediated by the cAMP/PKA/CREB pathway by suppressing leptin , and may contribute to PKA stimulators induced in vivo bone loss in developing zebrafish
Maeda et al., J Biochem 2009 : Finally, PKA inhibited leptin gene transcription without new protein synthesis
Mehebik-Mojaat et al., J Cell Biochem 2009 (Insulin Resistance) : When leptin signaling was blocked by PKA inhibitors, insulin induced NOS activity and NOS III phosphorylation at Ser ( 1179 ) was observed
Maymó et al., PloS one 2012 (MAP Kinase Signaling System) : We found that specific PKA inhibition by H89 caused a significant increase of hCG leptin induction, suggesting that probably high cAMP levels might inhibit hCG effect ... In this work, we demonstrated that hCG leptin induction through the MAPK signaling pathway is inhibited by PKA