Hyman et al., Arch Neurol 2000
(Alzheimer Disease) :
In this review, we highlight data that support a role for LRP in A beta metabolism and hypothesize that LRP therefore plays a critical role in Alzheimer disease Pietrzik et al., J Neurosci 2004
:
We have shown previously that LRP mediates beta-amyloid precursor protein (APP) processing and affects amyloid beta-protein and APP secretion and APP-c-terminal fragment generation ... Indeed, FE65 was only able to increase APP secretion in the presence of LRP Postuma et al., FEBS Lett 1998
(Alzheimer Disease) :
As LRP may regulate neurite outgrowth, we examined whether the effects of APP are mediated by LRP ... Thus the effect of substrate bound APP on neurite outgrowth is not mediated by LRP