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IL6 — LTB

Text-mined interactions from Literome

Zhong et al., Yao Xue Xue Bao 1998 : The results showed that LTB4 , LTC4 and LTD4 can enhance the production of IL-6 from cultured peritoneal macrophages of mice
Rola-Pleszczynski et al., Blood 1992 : Pretreatment of cells with cyclohexamide before exposure to LTB4 superinduced IL-6 message expression, but partially inhibited the effect of LTB4 on IL-6 mRNA accumulation, suggesting that newly synthesized proteins may be involved in the transcriptional activation of the IL-6 gene by LTB4
Brach et al., Eur J Immunol 1992 : Activation of the IL-6 promoter by LTB4 was not only associated with accumulation of the respective transcripts but resulted in synthesis of functional IL-6 protein as well
Subrata et al., Liver Int 2005 (Carcinoma, Hepatocellular...) : Hepatic expression of the tumor necrosis factor family member lymphotoxin-beta is regulated by interleukin (IL)-6 and IL-1beta : transcriptional control mechanisms in oval cells and hepatoma cell lines ... Key regulatory cis acting elements of the LT-beta promoter that mediate IL-6 responsiveness ( Sp/BKLF, Ets, NF-kappaB and Egr-1/Sp1 ) and IL-1beta responsiveness ( NF-kappaB and Ets ) of hepatic LT-beta expression were identified
Poubelle et al., Agents Actions 1991 : Leukotriene B4 (LTB4) preferentially induced IL-6 mRNA accumulation and IL-6 protein release as assessed by ELISA and the B9 cell bioassay ... Our results now help clarify that LTB4 stimulated preferentially IL-6 production and that the observed LTB4 induced augmentation in thymocyte responses to monocyte supernatants is due to augmented IL-6 contents in the presence of baseline minimal IL-1 production
Stanke-Labesque et al., J Lipid Res 2012 (Atherosclerosis...) : LTB ( 4 ) ( 10 ng/ml ) increased IL-6 ( P=0.006 ) and MCP-1 ( P=0.002 ) production in OSA patient monocytes
Rola-Pleszczynski et al., Union Med Can 1989 : In particular, LTB4 can induce suppressor cells, activate the synthesis and production of lymphokines such as interleukin 2 or interferon-gamma, stimulate the production of interleukin 1 by monocytes or macrophages, and activate cytotoxic cells against virus infected or tumor target cells
Pruimboom et al., Immunol Lett 1994 : LTB4 did not regulate IL-1 beta and IL-6 production