◀ Back to RELA

MAP2K1 — RELA

Text-mined interactions from Literome

Ryan et al., Nature 2000 : Activation of NF-kappaB by p53 was distinct from that mediated by tumour-necrosis factor-alpha and involved MEK1 and the activation of pp90rsk ... Inhibition of MEK1 blocked activation of NF-kappaB by p53 and completely abrogated p53 induced cell death
Abraham et al., J Immunol 2001 (Endotoxemia...) : In contrast, alpha-adrenergic blockade before endotoxemia was associated with decreased activation of MEK1/2 , ERK2, and CREB, but increased activation of NF-kappa B
Chakravortty et al., J Immunol 2001 : The dominant negative mutant of MAP kinase kinase 1 inhibited both NO production and NF-kappaB activation in LPS stimulated RAW cells
Ludwig et al., Cancer Res 2001 (Carcinoma, Medullary...) : RET induced NF-kappaB and IKKbeta activity requires Ras function but does neither involve the classical mitogen activated protein kinase kinase/extracellular signal regulated kinase nor the phosphoinositide 3-kinase/Akt pathways
Kolonics et al., Cell Signal 2001 (MAP Kinase Signaling System) : The GM-CSF promoted cell survival and proliferation correlated with MEK-1 dependent ERK1/2, Elk-1 and CREB phosphorylation and Egr-1, c-Fos expression as well as with increased STAT-5, AP-1, c-Myb and NF-kappaB DNA binding
Chen et al., J Biol Chem 2004 (Crohn Disease) : In this study, we determined that mitogen activated protein kinase kinase transforming growth factor ( TGF)-beta activated kinase 1 (TAK1 ) interacts with Nod2 and is required for Nod2 mediated NF-kappaB activation
Schmid et al., Infect Immun 2004 (MAP Kinase Signaling System) : The Inv triggered beta1 integrin signaling involves the small GTPase Rac ; the activation of MAP kinases, such as p38, MEK1 , and JNK ; and the activation of the transcription factor NF-kappaB
Joo et al., J Biol Chem 2008 (Lung Neoplasms) : Our results indicate that the induction of inflammatory genes by farnesol is mediated by the activation of the NF-kappaB pathway and involves MEK1/2-ERK1/2-MSK1 dependent phosphorylation of p65/RelA ( Ser ( 276 ) )
Rodríguez-Calvo et al., Diabetes 2008 : Because mitogen activated protein kinase-extracellular signal related kinase ( ERK ) 1/2 ( MEK1/2 ) is involved in LPS induced NF-kappaB activation in adipocytes, we explored whether PPARbeta/delta prevented NF-kappaB activation by inhibiting this pathway
Hsieh et al., Biochim Biophys Acta 2008 : Moreover, thrombin stimulated activation of NF-kappaB , AP-1, and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR, MEK1/2 , AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Merino et al., Nephrol Dial Transplant 2008 (Kidney Diseases) : This inflammatory response was mediated by intracellular signalling dependent on NF-kappaB , p38 MARK or c-Jun PI3K but not by MEK1/2 activation
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation, and nuclear factor-kappaB (NF-kappaB) p65 translocation were attenuated by the inhibitors of MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids
Larner-Svensson et al., Respir Res 2010 : We have shown that IL-1beta induced miR-146a expression in HASM and that this was regulated at the transcriptional level by NF-kappaB and at the post-transcriptional level by the MEK-1/2 and JNK-1/2
Rescigno et al., J Exp Med 1998 : In addition, we found that LPS activated the extracellular signal regulated kinase ( ERK ), and that specific inhibition of MEK1 , the kinase which activates ERK, abrogated the ability of LPS to prevent apoptosis but did not inhibit DC maturation or NF-kappaB nuclear translocation