Gene interactions and pathways from curated databases and text-mining

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MAP3K14 — NFKB1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Jue et al., J Korean Med Sci 1999 (Arthritis, Rheumatoid) : Aspirin and sodium salicylate inhibit activation of NF-KB by blocking IkappaB kinase , a key enzyme in NF-kappaB activation
Hehner et al., J Immunol 1999 : The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex
Zamanian-Daryoush et al., Mol Cell Biol 2000 : NF-kappaB activation by double-stranded-RNA activated protein kinase ( PKR ) is mediated through NF-kappaB inducing kinase and IkappaB kinase
Gil et al., Oncogene 2000 : Activation of NF-kappa B by the dsRNA dependent protein kinase, PKR involves the I kappa B kinase complex
Matsushima et al., J Exp Med 2001 : Both nuclear factor (NF)-kappaB inducing kinase ( NIK ) and inhibitor of kappaB (IkappaB) kinase ( IKK ) have been implicated as essential components for NF-kappaB activation in response to many external stimuli
Donepudi et al., J Immunol 2001 (Mast-Cell Sarcoma) : Moreover, exposure of P815 tumor cells to a cell-permeable peptide that selectively inhibits NF-kappaB activation by blocking the activation of the IkappaB-kinase complex was found to inhibit the L-PAM induced B7-1 mRNA accumulation, indicating that NF-kappaB activation is essential for the L-PAM induced B7-1 gene expression
Zingarelli et al., FASEB J 2002 (Myocardial Infarction...) : These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ), activation of IkappaB kinase complex (IKK) and c-Jun-NH2-terminal kinase (JNK), and subsequently activation of nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) as early as 15 min after reperfusion
Wong et al., Shock 2002 (Hyperoxia...) : Hyperoxia prolongs tumor necrosis factor-alpha mediated activation of NF-kappaB : role of IkappaB kinase
Anest et al., Nature 2003 : NF-kappaB is a principal transcriptional regulator of diverse cytokine mediated processes and is tightly controlled by the IkappaB kinase complex ( IKK-alpha/beta/gamma )
Park et al., J Biol Chem 2003 : Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha induced NF-kappa B activation
Channavajhala et al., J Biol Chem 2003 (MAP Kinase Signaling System) : This inhibition is specific to Cot, because Ras induced ERK and IkappaB kinase induced NF-kappaB activation are not significantly affected by hKSR-2 co-expression
Prajapati et al., J Biol Chem 2004 : Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity
Eickhoff et al., J Biol Chem 2004 (Cytomegalovirus Infections) : A stable inhibitor of NF-kappaB ( IkappaB ) reverses the RICK inhibitory effect, and activation of NF-kappaB by IkappaB kinase beta expression is inhibitory to HCMV, demonstrating that NF-kappaB activation is part of a potent anti-HCMV response
Huang et al., J Biol Chem 2004 : Activation of NFkappaB requires the activity of IkappaB kinase , a kinase complex that contains two catalytic subunits, IKKalpha and IKKbeta, and a non-enzymatic regulatory subunit, IKKgamma
Watanabe et al., Proc Natl Acad Sci U S A 2004 (MAP Kinase Signaling System) : The NF-kappaB translocation dependent pathway involves NF-kappaB inducing kinase-IkappaB kinase beta/gamma dependent phosphorylation and degradation of IkappaBalpha, whereas the NF-kappaB translocation independent pathway involves mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase kinase 1-dependent activation of MAPK kinase 3/6-p38 MAPK pathway
Lamkanfi et al., J Biol Chem 2004 (MAP Kinase Signaling System) : We demonstrate that caspase-1 interacts with RIP2 and that dominant negative forms of RIP2 and IkappaB kinase complex-beta inhibit caspase-1 mediated NF-kappaB activation
Khoshnan et al., J Neurosci 2004 (Nerve Degeneration) : In inducible PC12 cells and in HD transgenic mice, mutant Htt activates the IkappaB kinase complex (IKK) , a key regulator of NF-kappaB
Chan et al., Biochem Biophys Res Commun 2005 : Tpl2/COT1 was shown to participate in CD40 signaling based on the ability of a catalytically inactive mutant to suppress CD40 mediated IkappaB kinase activation and induction of NFkappaB-responsive promoters, without affecting signaling by TNF
Mortaz et al., Biochem Pharmacol 2005 : We thus propose that the anti-inflammatory effects of ASA in mast cells are due to suppression of IkappaB kinase activity, thereby inhibiting subsequent phosphorylation and degradation of IkappaB-alpha, activation of NF-kappaB , and transcription of proinflammatory cytokines
Aggarwal et al., Mol Pharmacol 2006 (Neoplasm Metastasis) : Curcumin also suppressed NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR)1, TNFR2, NF-kappaB inducing kinase, IkappaB kinase complex (IKK) , and the p65 subunit of NF-kappaB
Song et al., Proc Natl Acad Sci U S A 2006 : Because IRAK1 is upstream of TRAF6 in IL-1 activation of NF-kappaB, the potential role of IRAK1 in LMP1 mediated NF-kappaB activation through TRAF6 and inhibitor of kappaB (IkappaB) kinase ( IKK ) was initially investigated
Neumann et al., Biol Chem 2006 : Furthermore, we show that mitogen activated protein kinase kinase kinases ( MAP3K ), like TPL2 ( tumour progression locus 2 ) and transforming growth factor beta activated kinase 1 ( TAK1 ), have no impact on H. pylori induced activation of NF-kappaB
Adli et al., J Biol Chem 2006 (Inflammation) : NF-kappaB activation downstream of lipopolysaccharide or cytokine stimulation is controlled by the IkappaB kinase complex , which contains IKKalpha and IKKbeta
Gilmore et al., Oncogene 2006 : NF-kappaB signaling is primarily regulated by inhibitor kappaB ( IkappaB ) proteins and the IkappaB kinase complex through two major pathways : the canonical and non-canonical NF-kappaB pathways
Zhang et al., PloS one 2006 : Both phenotypes are rescued by injection of RNA encoding the anti-apoptotic protein Bcl-xL ; Bcl-xL 's effects are dependent upon IkappaB kinase mediated activation of the bipartite transcription factor NF-kappaB
Gohda et al., Biochem Biophys Res Commun 2007 : These results strongly suggest that unlike cytokine signaling, Tax induced NFkappaB activation does not involve K63 polyubiquitination mediated MAP3K activation
Tudhope et al., J Immunol 2007 : The role of IkappaB kinase 2, but not activation of NF-kappaB , in the release of CXCR3 ligands from IFN-gamma stimulated human bronchial epithelial cells
Shultz et al., J Interferon Cytokine Res 2007 : Activation of NF-kappaB requires the inhibitor of kappaB (IkappaB) kinase ( IKK) complex, which is made up of two functional kinases, IKKalpha and IKKbeta, and the scaffolding protein IKKgamma
Teruya et al., BMC microbiology 2007 : Collectively, these results suggest that L. pneumophila induces activation of NF-kappaB through an intracellular signaling pathway that involves NF-kappaB inducing kinase and IkappaB kinase , leading to IL-8 gene transcription, and that hsp90 acts as a crucial regulator in L. pneumophila induced IL-8 expression, presumably contributing to immune response in L. pneumophila
Kim et al., Mol Pharmacol 2008 (Inflammation...) : Here, we demonstrate that the novel small-molecule benzoxathiole 6,6-dimethyl-2- ( phenylimino ) -6,7-dihydro-5H-benzo- [ 1,3 ] oxathiol-4-one ( BOT-64 ) inhibits NF-kappaB activation with an IC ( 50 ) value of 1 muM by blocking inhibitory kappaB(IkappaB) kinase beta ( IKKbeta ), and suppresses NF-kappaB regulated expression of inflammatory genes in lipopolysaccharide (LPS) activated RAW 264.7 macrophages
Boersma et al., Science signaling 2008 : Transcriptional activation by NF-kappaB and chromatin remodeling by inhibitor of kappaB (IkappaB) kinase complex ( IKK ) have been linked to recall and reconsolidation of conditioned fear memories in the mammalian central nervous system
Ragheb et al., Biochem Biophys Res Commun 2008 (Disease Models, Animal...) : Interestingly, IkappaB-kinase beta (IKKbeta) dependent NF-kappaB was activated in hepatocytes from the fructose fed hamster as an indication for PKC activation
Hagemann et al., J Exp Med 2008 (Neoplasms) : We show that macrophages are polarized via interleukin (IL)-1R and MyD88 to an immunosuppressive `` alternative '' phenotype that requires IkappaB kinase beta mediated NF-kappaB activation
Kim et al., Mol Cancer Res 2008 (Glioma) : Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is mediated by IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation
Fan et al., J Biol Chem 2009 (MAP Kinase Signaling System...) : The ability of Src to enhance SF stimulation of NF-kappaB activity was due, in part, to its ability to stimulate Akt and IkappaB kinase activity ; and Src mediated stimulation of NF-kappaB was due , in part, to a Rac1/MKK3/6/p38 pathway and was Akt dependent
Tanabe et al., Journal of neuroinflammation 2010 (Glioma) : Wedelolactone, an inhibitor of IkappaB kinase , suppressed both TNF-alpha induced IkappaB phosphorylation and NFkappaB phosphorylation at Ser 536 and Ser 468
Uhlik et al., J Biol Chem 1998 : NF-kappaB inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax mediated NF-kappaB activation