Gene interactions and pathways from curated databases and text-mining

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MAPK12 — STAT3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Liang et al., J Biol Chem 1999 : In addition, we show that Ang II-induced serine phosphorylation of STAT3 in VSMCs is mediated by mitogen activated protein kinase and that dephosphorylation is mediated by protein phosphatase 2A (PP2A)
van Puijenbroek et al., Exp Cell Res 1999 (Carcinoma, Embryonal) : Using a dominant negative p21ras construct and a specific inhibitor of mitogen activated protein kinase kinase ( MEK ; PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase ( MAPK ) pathway, while CNTF induced MAPK activation was p21ras- and MEK dependent
Wang et al., Oncogene 2000 : PD180970 did not affect MAPK activation by PDGF or the JAK dependent activation of Stat3 by interleukin-6
Tancredi et al., J Neurochem 2000 (Synaptic Transmission) : The IL-6 induced inhibition of PTP and LTP was accompanied by a simulation of STAT3 tyrosine phosphorylation and an inhibition of MAPK/ERK dual phosphorylation, in the absence of changes in the state of activation of SAPK/JNK
Boeuf et al., J Biol Chem 2001 : We have shown that LIF induced phosphorylation of RSKs in ES cells is dependent on ERKs, whereas STAT3 phosphorylation is not mediated by any known MAPK activities
Frost et al., Endocrinology 2002 : The tyrosine kinase inhibitors, genistein, PP1, and AG-490, and the MAPK kinase inhibitor, PD98059, did not block Stat3 or Stat5 phosphorylation
Xu et al., Mol Cell Biol 2003 : Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen activated protein kinase mediated serine 727 phosphorylation of Stat1 and Stat3
Sumimoto et al., J Exp Med 2006 (MAP Kinase Signaling System...) : Furthermore, specific DNA binding and transcriptional activity of STAT3 were not affected by down-regulation of the MAPK signaling with the BRAF RNAi
Horie et al., Microbiol Immunol 2007 (Burkitt Lymphoma) : A specific inhibitor of p38 MAPK , SB203580, blocked simultaneously STAT3 DNA binding activity, and IL-10 mRNA expression, IL-10 production, and then the cell growth was inhibited
Wang et al., Am J Physiol Endocrinol Metab 2007 (Myocardial Reperfusion Injury...) : Interestingly, EC STAT3 deficiency decreased myocardial STAT3 activation but increased myocardial p38 MAPK activation in both sexes ; however, this was seen to a greater degree in females ... This observation was associated with decreased activation of myocardial STAT3 and increased activation of p38 MAPK in EC STAT3KO heart after I/R
Kreis et al., Mol Cancer Res 2007 (Carcinoma, Hepatocellular...) : Using a specific JAK inhibitor, sustained STAT3 activation was completely abrogated in all tested melanoma lines, whereas inhibition of Src or mitogen activated protein kinase/extracellular signal regulated kinase kinase 1/2 had no effect on constitutively tyrosine phosphorylated STAT3 levels
Liu et al., Int J Mol Med 2008 (Nasopharyngeal Neoplasms) : Demonstration of the involvement of different kinases in LMP1 induced STAT3 activation supports the involvement of the JAK/STAT and mitogen activated protein kinase ( MAPK ) /ERK signaling pathways in the regulation of STAT3 activation by LMP1
Weng et al., Alcohol 2008 : Inhibition of p42/44MAPK also increased STAT3 DNA binding activity
Shamsasenjan et al., Int J Hematol 2009 (Multiple Myeloma) : Cucurbitacin I ( STAT3 inhibitor ), but not U0126 ( MAPK inhibitor ), could abolish the effect of IL-6
Souza et al., Toxicol Lett 2009 : MAPK promotes STAT3 phosphorylation that could induce a protective mechanism against Cd toxicity
Schaljo et al., J Immunol 2009 (Inflammation) : We found that IL-10 initiates a Stat3 dependent increase of TTP expression accompanied by a delayed decrease of p38 MAPK activity
Akasaka et al., Biochim Biophys Acta 2010 : JAK2 or p38 MAPK inhibitor suppressed leptin induced lipid oxidation and decreased STAT3 phosphorylation in both types of myotube, respectively
Bhattacharjee et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Further, we found that Src tyrosine kinase mediated activation of p38 MAPK is required for Stat1 and Stat3 serine 727 phosphorylation in alternatively activated monocytes/macrophages
Imataki et al., J Immunol 2012 : IL-21 can supplement suboptimal Lck independent MAPK activation in a STAT-3 dependent manner in human CD8 ( + ) T cells
Pijet et al., Cytokine 2013 (MAP Kinase Signaling System) : Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both JAK/STAT3 and MEK/MAPK but not PI3-K/AKT/GSK-3ß signaling pathways were activated by leptin, and that STAT3 ( Y ( 705 ) P-STAT3 ) and MEK ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) mediate these effects
Tkach et al., Endocr Relat Cancer 2013 (Breast Neoplasms) : p42/p44 MAPK mediated Stat3Ser727 phosphorylation is required for progestin induced full activation of Stat3 and breast cancer growth
Andrés et al., Exp Dermatol 2013 (MAP Kinase Signaling System...) : TNFa, 12-O-Tetradecanoylphorbol 13-acetate ( TPA ) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity
Jain et al., Oncogene 1998 : Repression of Stat3 activity by activation of mitogen activated protein kinase ( MAPK )