Gene interactions and pathways from curated databases and text-mining

◀ Back to HSP90AA1

HSP90AA1 — MAPK8

Text-mined interactions from Literome

Citri et al., J Biol Chem 2006 : Analyzing Hsp90 regulation of two major signaling cascades, the mitogen activated protein kinase and phosphatidylinositol 3-kinase, leads us to propose that the selectivity of the chaperone to specific kinases is functional, namely that Hsp90 controls kinases that function as hubs integrating multiple inputs
LaFayette et al., PLoS Pathog 2010 : We identified an additional level of regulatory control in the C. albicans circuitry linking PKC signaling, Hsp90, and calcineurin as genetic reduction of Hsp90 led to depletion of the terminal MAPK , Mkc1. Deletion of C. albicans PKC1 rendered fungistatic ergosterol biosynthesis inhibitors fungicidal and attenuated virulence in a murine model of systemic candidiasis
Antonopoulou et al., Comp Biochem Physiol A Mol Integr Physiol 2013 (MAP Kinase Signaling System) : In the white muscle, Hsp90 levels decreased and the phosphorylation of p38 MAPK increased in both feeding regimes compared to control