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Herraiz et al., FEBS Lett 2009
(Melanoma) :
MC1R activates cAMP and mitogen activated protein kinase ERK1/ERK2 signalling
Dalziel et al., Nucleic Acids Res 2011
:
Significantly, treatment with the MC1R agonist a-MSH or activation of the stress response kinase p38-MAPK , both key molecules associated with ultraviolet radiation dermal insult and subsequent skin tanning, result in a shift in expression from MC1R in favour of chimeric MC1R-TUBB3 isoforms in cultured melanocytes
Chung et al., J Biol Chem 2012
(Melanoma) :
Further, MC1R inhibited the activation of p38 MAPK , subsequently enhancing expression of sydnecan-2, in parallel with an increase in the extent of cell migration