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MDM2 — RELA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MDM2 — RELA (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: MDM2 — RELA (physical association, two hybrid array) Wang et al., Molecular systems biology 2011

Text-mined interactions from Literome

Gu et al., Blood 2002 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1 binding sites : a novel, p53 independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia
Hu et al., Zhonghua Er Ke Za Zhi 2003 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : [ Regulation of NF-kappaB/P65 by MDM2 in acute lymphoblastic leukemia in childhood ] ... In the present study, the investigators hypothesized that MDM2 directly affected NF-kappaB expression and function in a P53 independent manner
Cheney et al., Cancer Biol Ther 2008 (Rhabdomyosarcoma) : Previously MDM2 has been shown to activate NFkappaB through activation of transcription of the p65RelA subunit ... Expression of MDM2 in RD cells transcriptionally repressed p65RelA and suppressed NFkappaB activity, resulting in a reduced growth rate and enhanced apoptosis ... Expression of MDM2 in RD cells transcriptionally repressed p65RelA and suppressed NFkappaB activity, resulting in a reduced growth rate and enhanced apoptosis
Batuman et al., Immunopharmacology 1994 : The data indicate that 10 ( -6 ) M DM increased T cell p50 NF-kappa B mRNA levels by four-fold compared to the levels obtained in the absence of DM