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HDAC1 — MEFV
Text-mined interactions from Literome
Wu et al., J Clin Invest 2002
(Myotonia Congenita) :
These findings suggest that the combined effects of class II
HDAC deficiency and p38 MAPK activation
lead to potent upregulation of
MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles
Liu et al., J Physiol 2009
:
The protein kinase PKD1 has recently been linked to slow fibre-type gene expression in fast skeletal muscle through phosphorylation of class II histone deacetylase (HDAC) molecules, resulting in nuclear efflux of
HDAC and consequent
activation of the transcription factor
MEF2
Chen et al., J Cell Biochem 2011
:
HDAC inhibition
increases the up-regulation of GATA4,
MEF2C , Nkx2.5, cardiac actin, and a-SMA mRNA and protein levels that were abrogated by MG132