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AKT1 — MET
Text-mined interactions from Literome
Xiao et al., Proc Natl Acad Sci U S A 2001
(MAP Kinase Signaling System) :
Akt is also
activated by active tumorigenic forms of
Met , i.e., ligand independent Tpr-Met, a truncated and constitutively dimerized form of Met, and a mutationally activated version of Met corresponding to that found in human hereditary papillary renal carcinoma ... Furthermore, transiently transfected
Tpr-Met activates
Akt ( both Akt1 and Akt2 ) and protects cells from apoptosis
Taher et al., Biochem Biophys Res Commun 2002
(Arteriosclerosis...) :
Stimulation with HGF led to activation of
Met as well as to
activation of PI3-K,
PKB/Akt , MEK, and the MAP kinases Erk1 and -2 ... Stimulation with HGF led to activation of
Met as well as to
activation of PI3-K,
PKB/Akt , MEK, and the MAP kinases Erk1 and -2
Bae et al., J Immunol 2003
:
Among the HXYLPM analogues, His-Arg-Tyr-Leu-Pro-Met ( HRYLPM ) activated a broad spectrum of cellular signaling events, including an intracellular Ca ( 2+ ) concentration increase, phosphoinositide 3-kinase, extracellular signal regulated kinase, and Akt activation, however,
His-Glu-Tyr-Leu-Pro-Met ( HEYLPM )
activated only intracellular Ca ( 2+ ) concentration and
Akt but did not increase Ca ( 2+ )
Bigelow et al., Oncogene 2006
(Breast Neoplasms...) :
Pretreatment of cells with concentrations of EGCG as low as 0.3 microM inhibited HGF induced
Met phosphorylation and downstream
activation of
AKT and ERK
Watson et al., Neoplasia (New York, N.Y.) 2006
(Adenocarcinoma...) :
We conclude that inhibition of c-Met may be a useful therapeutic strategy for EA. Factors other than receptor overexpression, such as
c-Met dependent
PI3K/Akt signaling, may be predictive of an individual tumor 's response to c-Met inhibition
Wang et al., Cancer Lett 2007
(Neoplasm Invasiveness...) :
CHM-1 also suppressed HGF induced
Akt phosphorylation, and NF-kappaB activation, the downstream
regulators of
HGF/c-Met signaling, resulting in the inhibition of MMP-9
Lee et al., Am J Physiol Lung Cell Mol Physiol 2008
:
Treatment of HBEpC with HGF resulted in phosphorylation of the
HGF receptor ( c-Met ),
activation of
Akt , and upregulation of COX-2 mRNA
Lim et al., Cell Signal 2008
:
Conversely, pharmacological inhibition of
c-Met with its specific inhibitor, PHA-665752, or genetic knock-down of c-Met with short hairpin RNAs ( shRNAs )
suppressed HGF induced phosphorylation of
Akt and GSK-3beta, increased phosphorylation of MAP2, and reduced dendrite number and length in cultured hippocampal neurons
Labbé et al., J Nutr 2009
(Medulloblastoma) :
Interestingly, the inhibitory effects of quercetin on the tyrosine kinase receptor Met [ half-maximal inhibitory effect ( IC ( 50 ) ) of 12 micromol/L ] or on the
Met induced activation of
Akt ( IC ( 50 ) of 2.5 micromol/L ) occurred at concentrations achievable through dietary approaches
Wang et al., Cell cycle (Georgetown, Tex.) 2009
(Neoplasms) :
In both cell lines,
c-Met dependent
Akt , Erk and/or STAT3 signaling, as well as activation of the EGFR family, resumed shortly after treatment with c-Met TKI despite sustained c-Met inhibition
Moore et al., Carcinogenesis 2009
(Adenoma...) :
Pharmacological inhibition of MEK and PI3K suggested that both extracellular signal regulated kinase ( ERK ) and
AKT signalling are
required for COX-2 protein up-regulation and 15-PGDH down-regulation downstream of
Met
Grotegut et al., Int J Oncol 2010
(Hepatoblastoma...) :
Here, we demonstrate that HGF has no impact on overall cell viability and proliferation of HB cells, although signal transduction occurs downstream of HGF, such as
c-Met phosphorylation,
activation of phosphoinositide 3-kinase
(PI3K)/AKT and mitogen activated protein kinase ( MAPK ) /ERK-1/2 signaling
Dai et al., Mol Cancer Ther 2010
(Neoplasm Invasiveness...) :
Mechanistically, nanomolar doses of BMS-777607 potently blocked HGF stimulated
c-Met autophosphorylation and downstream
activation of
Akt and extracellular signal regulated kinase
Lee et al., Hepatology 2010
(Carcinoma, Hepatocellular...) :
We found coordinated down-regulation of Spry2 protein expression and
activation of
c-Met as well as its downstream effectors extracellular signal regulated kinase ( ERK ) and v-akt murine thymoma viral oncogene homolog (
AKT ) in a subset of human HCC samples with poor outcome ... In HCC cell lines, Spry2 overexpression inhibits
c-Met induced cell proliferation as well as ERK and
AKT activation, whereas loss of Spry2 potentiates c-Met signaling
Tan et al., Cancer Res 2010
(Ovarian Neoplasms) :
Intriguingly, downregulation of IRS-2 and
MET contributed to the suppression of
AKT signaling
Yoshizawa et al., Oncol Rep 2011
(Endometrial Neoplasms) :
Here, we report that i ) treatment of RL95-2 cells with HGF resulted in phosphorylation of the
HGF receptor c-Met,
activation of
Akt and I?B, translocation of NF-?B into the nucleus, and up-regulation of COX-2 mRNA ; ii ) the I?B-a phosphorylation inhibitor BAY11-7082 and the selective COX-2 inhibitor CAY10452 blocked HGF mediated anoikis resistance in RL95-2 cells ; and iii ) HGF induced migration and invasion in RL95-2 cells, while the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and CAY10452 blocked these effects of HGF stimulation
Brevet et al., J Thorac Oncol 2011
(Mesothelioma...) :
MET , EGFR, and insulin-like growth factor 1 receptor were the main RTKs activated after mTOR inhibition and
contributed to
AKT feedback activation
Brusevold et al., J Oral Pathol Med 2012
(Carcinoma, Squamous Cell...) :
In the E10 cell line, EGF and HGF
induced phosphorylation of EGF receptor (EGFR) and
Met , respectively, phosphorylation of ERK1/2, p38 and
Akt , and dose dependent activation of cell migration
Soong et al., J Cell Sci 2013
:
Functional studies showed that blockade of Shp2 activity abrogated
MET dependent activation of Erk1/Erk2 and
Akt in melanocytes