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AKT1 — MIF

Text-mined interactions from Literome

Lue et al., Oncogene 2007 (Breast Neoplasms...) : MIF enhanced Akt activity in primary and immortalized fibroblasts ( MEF and NIH/3T3 ), HeLa cervix carcinoma cells and various breast cancer cell lines ... Akt was activated by exogenous rMIF and autocrine MIF action, as revealed by experiments in MIF ( -/- ) MEFs and antibody blockade ... siRNA knockdown of CSN5/JAB1, a tumor marker and MIF binding protein, showed that JAB1 controls autocrine MIF mediated Akt signaling by inhibition of MIF secretion ... Akt activation by MIF led to phosphorylation of the proapoptotic proteins BAD and Foxo3a
Kim et al., Clin Exp Immunol 2008 (Scleroderma, Systemic) : Furthermore, MIF increased the expression of Bcl-2, phospho-ERK and phospho-Akt activity in dermal fibroblasts
Schwartz et al., FEBS Lett 2009 : Finally, MIF stimulated CD74 dependent AKT activation was blocked by anti-CXCR4 and anti-CD74 antibodies and AMD3100, whereas CXCL12 stimulated AKT activation was not reduced by anti-CD74
Ouertatani-Sakouhi et al., Biochemistry 2009 (Autoimmune Diseases...) : These changes in tertiary structure and the loss of catalytic activity translated into a reduction in MIF receptor binding activity, MIF mediated glucocorticoid overriding, and MIF induced Akt phosphorylation
Ouertatani-Sakouhi et al., J Biol Chem 2010 : Importantly, all inhibitors demonstrated total inhibition of MIF mediated glucocorticoid overriding and AKT phosphorylation, whereas ebselen, a trimer disrupting inhibitor, additionally acted as a potent hyperagonist in MIF mediated chemotactic migration
Maharshak et al., World J Gastroenterol 2010 (Colonic Neoplasms) : CD74 was also expressed on the CT26 colon carcinoma cell line and its stimulation by MIF resulted in enhanced cell survival, up-regulation of Akt phosphorylation and Bcl-2 expression
Hussain et al., Mol Cancer Ther 2013 : In vitro, the selected candidate antibodies BaxG03, BaxB01, and BaxM159 reduced cell growth and viability by inhibiting MIF induced phosphorylation of the central kinases p44/42 mitogen activated protein kinase [ extracellular signal regulated kinase-1 and -2 ( ERK1/2 ) ] and protein kinase B ( AKT ) ... In vitro, the selected candidate antibodies BaxG03, BaxB01, and BaxM159 reduced cell growth and viability by inhibiting MIF induced phosphorylation of the central kinases p44/42 mitogen activated protein kinase [ extracellular signal regulated kinase-1 and -2 ( ERK1/2 ) ] and protein kinase B ( AKT )